{"id":"https://openalex.org/W4405659099","doi":"https://doi.org/10.1007/s12672-024-01726-2","title":"Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets","display_name":"Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets","publication_year":2024,"publication_date":"2024-12-21","ids":{"openalex":"https://openalex.org/W4405659099","doi":"https://doi.org/10.1007/s12672-024-01726-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/39708219"},"language":"en","primary_location":{"id":"doi:10.1007/s12672-024-01726-2","doi":"https://doi.org/10.1007/s12672-024-01726-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01726-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-024-01726-2.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s12672-024-01726-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062932130","display_name":"Tengfei Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tengfei Zhao","raw_affiliation_strings":["Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103443181","display_name":"Yangyang Li","orcid":"https://orcid.org/0009-0003-2578-856X","observed_orcids":["https://orcid.org/0009-0003-2578-856X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yangyang Li","raw_affiliation_strings":["Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086714057","display_name":"Huixue Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huixue Liu","raw_affiliation_strings":["Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032932961","display_name":"Chong-xin Tong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chongxin Tong","raw_affiliation_strings":["Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China. youxiang1631202409@163.com","Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China. youxiang1631202409@163.com","institution_ids":[]},{"raw_affiliation_string":"Obstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032932961"],"corresponding_institution_ids":[],"apc_list":{"value":1590,"currency":"USD","value_usd":1590},"apc_paid":{"value":1590,"currency":"USD","value_usd":1590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24015939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"820","last_page":"820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.7850000262260437},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6729999780654907},{"id":"https://openalex.org/keywords/wisp1","display_name":"WISP1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.875},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.8450000286102295},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/reproductive-cells","display_name":"reproductive cells","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9131799340248108},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.8804284334182739},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5259625911712646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5066302418708801},{"id":"https://openalex.org/C2778093883","wikidata":"https://www.wikidata.org/wiki/Q1137463","display_name":"Sexual dysfunction","level":2,"score":0.5031952261924744},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4780074656009674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4388347566127777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4311474561691284},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.42000311613082886},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39236003160476685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3825241029262543},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2557593584060669},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2462054193019867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19067591428756714},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1273224651813507}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12672-024-01726-2","doi":"https://doi.org/10.1007/s12672-024-01726-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01726-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-024-01726-2.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},{"id":"pmid:39708219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39708219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11663209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11663209","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11663209/pdf/12672_2024_Article_1726.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discov Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:df11edb3f9894fcc93006642addfe3dd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/df11edb3f9894fcc93006642addfe3dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s12672-024-01726-2","doi":"https://doi.org/10.1007/s12672-024-01726-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12672-024-01726-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12672-024-01726-2.pdf","source":{"id":"https://openalex.org/S4210213696","display_name":"Discover Oncology","issn_l":"2730-6011","issn":["2730-6011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405659099.pdf","grobid_xml":"https://content.openalex.org/works/W4405659099.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W3117042391","https://openalex.org/W3180815981","https://openalex.org/W3185036736","https://openalex.org/W3200235505","https://openalex.org/W4399685434","https://openalex.org/W4400226379","https://openalex.org/W4400918440","https://openalex.org/W4401483199","https://openalex.org/W4401634515","https://openalex.org/W4401665733","https://openalex.org/W4401670288","https://openalex.org/W4402011435","https://openalex.org/W4402011880","https://openalex.org/W4402273011","https://openalex.org/W4402321505","https://openalex.org/W4402323473","https://openalex.org/W4402356125","https://openalex.org/W4402388647","https://openalex.org/W4402397863","https://openalex.org/W4402406679","https://openalex.org/W4402415906","https://openalex.org/W4402419866","https://openalex.org/W4402424363","https://openalex.org/W4402461762","https://openalex.org/W4402464230","https://openalex.org/W4402494687","https://openalex.org/W4402533794","https://openalex.org/W4403406009","https://openalex.org/W4404913535","https://openalex.org/W4405088401","https://openalex.org/W4405152541","https://openalex.org/W4405374562","https://openalex.org/W4405557454"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W4404875725","https://openalex.org/W2036527494","https://openalex.org/W2610080820","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2015148400"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sexual":[1],"dysfunction":[2,30,59,89,146],"and":[3,8,19,31,34,60,90,94,100,125,147,150],"cervical":[4,32,61,91,101,115,148],"cancer":[5,116,149],"are":[6,85],"genetically":[7],"molecularly":[9],"two":[10],"complex":[11],"health":[12],"problems.":[13],"Here,":[14],"we":[15,64],"integrate":[16],"genetic":[17,26,54,82,142],"inference":[18],"single-cell":[20,138],"expression":[21,107,139],"analysis":[22],"to":[23,52,140],"identify":[24,53],"potential":[25],"targets":[27,39,143],"for":[28,144],"sexual":[29,58,88,145],"cancer,":[33,92],"assess":[35],"causality":[36],"of":[37,69,108],"these":[38,70,95],"utilizing":[40],"Mendelian":[41,155],"randomization":[42,156],"approaches.":[43],"METHODS:":[44],"We":[45],"performed":[46],"a":[47],"genome-wide":[48],"association":[49],"study":[50,79,134],"(GWAS)":[51],"variants":[55,83],"associated":[56],"with":[57,87,137],"cancer.":[62],"Next,":[63],"examined":[65],"the":[66,109],"cellular":[67],"landscape":[68],"variation":[71],"regions":[72],"based":[73],"on":[74],"scRNAseq":[75],"data.":[76],"RESULTS:":[77],"The":[78,133],"identified":[80],"several":[81],"that":[84],"correlated":[86],"respectively,":[93],"differentially":[96],"expressed":[97,121],"in":[98,114,122],"reproductive":[99],"cells.":[102],"Two-Gene":[103],"Combination":[104],"Panel":[105],"Increased":[106],"WISP1":[110],"gene":[111],"was":[112],"detected":[113],"tissues.":[117],"Twas":[118],"most":[119],"highly":[120],"T":[123],"cells,":[124],"least":[126],"well-":[127],"when":[128],"cells":[129],"were":[130],"proliferating.":[131],"CONCLUSIONS:":[132],"integrates":[135],"genetics":[136],"nominate":[141],"establishes":[151],"causal":[152],"support":[153],"from":[154],"approach.":[157]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
