{"id":"https://openalex.org/W4405595482","doi":"https://doi.org/10.1002/ptr.8408","title":"Natural Compounds and Their Analogs as Antivirals Against Dengue Virus: A Review","display_name":"Natural Compounds and Their Analogs as Antivirals Against Dengue Virus: A Review","publication_year":2024,"publication_date":"2024-12-19","ids":{"openalex":"https://openalex.org/W4405595482","doi":"https://doi.org/10.1002/ptr.8408","pmid":"https://pubmed.ncbi.nlm.nih.gov/39697048"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.8408","doi":"https://doi.org/10.1002/ptr.8408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.8408","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026930619","display_name":"Amalina Ghaisani Komarudin","orcid":"https://orcid.org/0000-0002-6325-7079","observed_orcids":["https://orcid.org/0000-0002-6325-7079"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]},{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Amalina Ghaisani Komarudin","raw_affiliation_strings":["Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Kabupaten Bogor, Jawa Barat, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-6325-7079","affiliations":[{"raw_affiliation_string":"Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Kabupaten Bogor, Jawa Barat, Indonesia","institution_ids":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042156962","display_name":"Azis Adharis","orcid":"https://orcid.org/0000-0002-7463-3148","observed_orcids":["https://orcid.org/0000-0002-7463-3148"]},"institutions":[{"id":"https://openalex.org/I4387153834","display_name":"Universitas Pertamina","ror":"https://ror.org/0266sez77","country_code":"ID","type":"education","lineage":["https://openalex.org/I194343955","https://openalex.org/I4387153834"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Azis Adharis","raw_affiliation_strings":["Department of Chemistry, Faculty of Science and Computer Science, Universitas Pertamina (UPER), Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-7463-3148","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science and Computer Science, Universitas Pertamina (UPER), Jakarta, Indonesia","institution_ids":["https://openalex.org/I4387153834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039176752","display_name":"R. Tedjo Sasmono","orcid":"https://orcid.org/0000-0003-0986-2590","observed_orcids":["https://orcid.org/0000-0003-0986-2590"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]},{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"R. Tedjo Sasmono","raw_affiliation_strings":["Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Kabupaten Bogor, Jawa Barat, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-0986-2590","affiliations":[{"raw_affiliation_string":"Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Kabupaten Bogor, Jawa Barat, Indonesia","institution_ids":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042156962"],"corresponding_institution_ids":["https://openalex.org/I4387153834"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.8116,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65538914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"39","issue":"2","first_page":"888","last_page":"921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":1.0},{"id":"https://openalex.org/keywords/natural-antiviral-compounds","display_name":"natural antiviral compounds","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.550000011920929},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.9279999732971191},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.9330000281333923},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9679999947547913},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycosides","display_name":"glycosides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.765999972820282},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dengue-hemorrhagic-fever","display_name":"dengue hemorrhagic fever","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dengue-shock-syndrome","display_name":"dengue shock syndrome","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.8881036043167114},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8687616586685181},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.6600484848022461},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5228093862533569},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4936426877975464},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.4596950113773346},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4523811936378479},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3904363512992859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3613266944885254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34097084403038025},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.14163699746131897},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.1410064995288849},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.11612042784690857},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1078157126903534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062385","descriptor_name":"Hydroxybenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ptr.8408","doi":"https://doi.org/10.1002/ptr.8408","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.8408","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:39697048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39697048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W1462606079","https://openalex.org/W1546964919","https://openalex.org/W1550537678","https://openalex.org/W1599389506","https://openalex.org/W1813667843","https://openalex.org/W1964700702","https://openalex.org/W1967404435","https://openalex.org/W1976308168","https://openalex.org/W1982595019","https://openalex.org/W1990647489","https://openalex.org/W1992258115","https://openalex.org/W2008216856","https://openalex.org/W2024970900","https://openalex.org/W2028141760","https://openalex.org/W2030271084","https://openalex.org/W2037730319","https://openalex.org/W2042479028","https://openalex.org/W2049401308","https://openalex.org/W2064558921","https://openalex.org/W2073727854","https://openalex.org/W2087541526","https://openalex.org/W2087924154","https://openalex.org/W2093577438","https://openalex.org/W2095247923","https://openalex.org/W2121780828","https://openalex.org/W2129885644","https://openalex.org/W2131222241","https://openalex.org/W2135550231","https://openalex.org/W2180208808","https://openalex.org/W2195096572","https://openalex.org/W2215640744","https://openalex.org/W2267223087","https://openalex.org/W2294476649","https://openalex.org/W2296976831","https://openalex.org/W2507411849","https://openalex.org/W2509777005","https://openalex.org/W2517327983","https://openalex.org/W2565177799","https://openalex.org/W2565383127","https://openalex.org/W2574196417","https://openalex.org/W2585326482","https://openalex.org/W2590119696","https://openalex.org/W2594627984","https://openalex.org/W2599033302","https://openalex.org/W2604849278","https://openalex.org/W2735055777","https://openalex.org/W2751785289","https://openalex.org/W2753111208","https://openalex.org/W2766221612","https://openalex.org/W2768589231","https://openalex.org/W2786989445","https://openalex.org/W2791128717","https://openalex.org/W2801640013","https://openalex.org/W2806906512","https://openalex.org/W2833616835","https://openalex.org/W2883372641","https://openalex.org/W2897904966","https://openalex.org/W2899680214","https://openalex.org/W2901227506","https://openalex.org/W2903329294","https://openalex.org/W2905354856","https://openalex.org/W2925710251","https://openalex.org/W2934794220","https://openalex.org/W2950420258","https://openalex.org/W2954663395","https://openalex.org/W2969377001","https://openalex.org/W2970068576","https://openalex.org/W2970690326","https://openalex.org/W2973308638","https://openalex.org/W2980883584","https://openalex.org/W2985821967","https://openalex.org/W2986342855","https://openalex.org/W2990099028","https://openalex.org/W2990923475","https://openalex.org/W2994875935","https://openalex.org/W2995614801","https://openalex.org/W3007694348","https://openalex.org/W3008873837","https://openalex.org/W3017396243","https://openalex.org/W3021284768","https://openalex.org/W3032588051","https://openalex.org/W3040577530","https://openalex.org/W3045797411","https://openalex.org/W3048948192","https://openalex.org/W3082867047","https://openalex.org/W3084249474","https://openalex.org/W3094279071","https://openalex.org/W3097323030","https://openalex.org/W3097696837","https://openalex.org/W3119724094","https://openalex.org/W3138700959","https://openalex.org/W3140030596","https://openalex.org/W3146952421","https://openalex.org/W3156739899","https://openalex.org/W3161704305","https://openalex.org/W3162572765","https://openalex.org/W3163443158","https://openalex.org/W3163574939","https://openalex.org/W3169893742","https://openalex.org/W3172070999","https://openalex.org/W3175728472","https://openalex.org/W3176231206","https://openalex.org/W3176566252","https://openalex.org/W3181841024","https://openalex.org/W3186928214","https://openalex.org/W3197608470","https://openalex.org/W3200057063","https://openalex.org/W3200072619","https://openalex.org/W3203455658","https://openalex.org/W3204874602","https://openalex.org/W3205168864","https://openalex.org/W3209192108","https://openalex.org/W3210634511","https://openalex.org/W3213087188","https://openalex.org/W3215179314","https://openalex.org/W4200428449","https://openalex.org/W4205471480","https://openalex.org/W4206716109","https://openalex.org/W4211135732","https://openalex.org/W4221066414","https://openalex.org/W4224311686","https://openalex.org/W4229007128","https://openalex.org/W4231879896","https://openalex.org/W4280534390","https://openalex.org/W4281729991","https://openalex.org/W4282974809","https://openalex.org/W4286247376","https://openalex.org/W4291910000","https://openalex.org/W4292357096","https://openalex.org/W4294204190","https://openalex.org/W4294293131","https://openalex.org/W4311440931","https://openalex.org/W4313333148","https://openalex.org/W4317435177","https://openalex.org/W4323664555","https://openalex.org/W4360951770","https://openalex.org/W4382403315","https://openalex.org/W4387420878","https://openalex.org/W4387780871","https://openalex.org/W4395049417","https://openalex.org/W6769396482","https://openalex.org/W7074074359"],"related_works":["https://openalex.org/W4401958800","https://openalex.org/W4402452060","https://openalex.org/W4413833994","https://openalex.org/W7133137599","https://openalex.org/W7217349488","https://openalex.org/W4406562456","https://openalex.org/W1978410163","https://openalex.org/W7165856333","https://openalex.org/W7223444142","https://openalex.org/W7161587325"],"abstract_inverted_index":{"Dengue":[0],"virus":[1],"(DENV)":[2],"continues":[3],"to":[4,107],"pose":[5],"a":[6,98],"significant":[7],"global":[8],"health":[9],"challenge,":[10],"causing":[11],"diseases":[12],"such":[13],"as":[14],"dengue":[15,17,21],"fever,":[16,19],"hemorrhagic":[18],"and":[20,29,47,59,73,84,95],"shock":[22],"syndrome.":[23],"While":[24],"efforts":[25],"in":[26,56,57,60,79],"vaccine":[27],"development":[28],"antiviral":[30,52],"drug":[31],"discovery":[32],"are":[33],"ongoing,":[34],"effective":[35],"therapeutic":[36,109],"options":[37],"remain":[38],"limited.":[39],"In":[40],"this":[41],"review,":[42],"we":[43],"highlight":[44],"natural":[45],"compounds":[46,94],"the":[48,86,96],"analogs":[49],"that":[50],"demonstrated":[51],"activity":[53],"against":[54],"DENV":[55,81,113],"vitro":[58],"vivo":[61],"studies.":[62],"Specifically,":[63],"these":[64,92],"studies":[65],"examine":[66],"alkaloids,":[67],"phenolic":[68],"acids,":[69],"phenols,":[70],"flavonoids,":[71],"terpenoids,":[72],"glycosides":[74],"which":[75],"have":[76],"shown":[77],"potential":[78],"inhibiting":[80],"entry,":[82],"replication,":[83],"reducing":[85],"cytokine":[87],"storm.":[88],"By":[89],"focusing":[90],"on":[91],"bioactive":[93],"analogs,":[97],"comprehensive":[99],"overview":[100],"of":[101],"their":[102],"promising":[103],"roles":[104],"is":[105],"provided":[106],"advance":[108],"strategies":[110],"for":[111],"combating":[112],"infection.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-12-20T00:00:00"}