{"id":"https://openalex.org/W4405586874","doi":"https://doi.org/10.1152/ajpendo.00353.2024","title":"Exploring CTRP6: a biomarker and therapeutic target in metabolic diseases","display_name":"Exploring CTRP6: a biomarker and therapeutic target in metabolic diseases","publication_year":2024,"publication_date":"2024-12-19","ids":{"openalex":"https://openalex.org/W4405586874","doi":"https://doi.org/10.1152/ajpendo.00353.2024","pmid":"https://pubmed.ncbi.nlm.nih.gov/39701154","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185134"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00353.2024","doi":"https://doi.org/10.1152/ajpendo.00353.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpendo.00353.2024","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1152/ajpendo.00353.2024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jeevotham Senthil Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeevotham Senthil Kumar","raw_affiliation_strings":["Oklahoma State University","Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma State University","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064628954","display_name":"Muhammad Zubair Mehboob","orcid":"https://orcid.org/0000-0002-5659-5192","observed_orcids":["https://orcid.org/0000-0002-5659-5192"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Zubair Mehboob","raw_affiliation_strings":["Oklahoma State University","Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma State University","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101857164","display_name":"Xia Lei","orcid":"https://orcid.org/0000-0003-4241-6576","observed_orcids":["https://orcid.org/0000-0003-4241-6576"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xia Lei","raw_affiliation_strings":["Oklahoma State University","Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA","Tel: 405-744-2067"],"raw_orcid":"https://orcid.org/0000-0003-4241-6576","affiliations":[{"raw_affiliation_string":"Oklahoma State University","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Tel: 405-744-2067","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101857164"],"corresponding_institution_ids":["https://openalex.org/I115475287"],"apc_list":null,"apc_paid":null,"fwci":0.2903,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.36339133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"328","issue":"2","first_page":"E139","last_page":"E147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctrp6","display_name":"CTRP6","score":1.0},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9160000085830688},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.828000009059906},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7089999914169312},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.6304434537887573},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.502251148223877},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4778406322002411},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.47446662187576294},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4730699956417084},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46485885977745056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4378758668899536},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4339381456375122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43301844596862793},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.419063001871109},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37057948112487793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34628695249557495},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34260591864585876},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.27577951550483704},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.27328452467918396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1578291356563568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10176929831504822}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpendo.00353.2024","doi":"https://doi.org/10.1152/ajpendo.00353.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpendo.00353.2024","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:39701154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39701154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12185134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185134","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12185134/pdf/nihms-2084919.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:10994765","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12185134","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1152/ajpendo.00353.2024","doi":"https://doi.org/10.1152/ajpendo.00353.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajpendo.00353.2024","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G971254862","display_name":"Immunometabolic Regulation of Adipose Tissue by CTRP6","funder_award_id":"R15DK136102","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309482","display_name":"Oklahoma State University","ror":"https://ror.org/045ntgf29"},{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405586874.pdf","grobid_xml":"https://content.openalex.org/works/W4405586874.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W310323566","https://openalex.org/W1566841623","https://openalex.org/W1973093792","https://openalex.org/W1987081490","https://openalex.org/W2003619028","https://openalex.org/W2012034410","https://openalex.org/W2024670158","https://openalex.org/W2052777370","https://openalex.org/W2054584654","https://openalex.org/W2056499061","https://openalex.org/W2057465207","https://openalex.org/W2062162775","https://openalex.org/W2067913177","https://openalex.org/W2079538512","https://openalex.org/W2091673549","https://openalex.org/W2095022880","https://openalex.org/W2108102649","https://openalex.org/W2111422464","https://openalex.org/W2128900030","https://openalex.org/W2167898988","https://openalex.org/W2207283323","https://openalex.org/W2303037955","https://openalex.org/W2344710934","https://openalex.org/W2516125728","https://openalex.org/W2593662149","https://openalex.org/W2617815764","https://openalex.org/W2739475813","https://openalex.org/W2792296299","https://openalex.org/W2801433865","https://openalex.org/W2885342001","https://openalex.org/W2894425317","https://openalex.org/W2897714751","https://openalex.org/W2901824420","https://openalex.org/W2909840920","https://openalex.org/W2911933963","https://openalex.org/W2955108563","https://openalex.org/W2955854920","https://openalex.org/W2968789530","https://openalex.org/W2972448234","https://openalex.org/W2998747952","https://openalex.org/W3005723652","https://openalex.org/W3008850883","https://openalex.org/W3011035841","https://openalex.org/W3023699349","https://openalex.org/W3023720879","https://openalex.org/W3033761899","https://openalex.org/W3093349278","https://openalex.org/W3108372566","https://openalex.org/W3134053136","https://openalex.org/W3155824129","https://openalex.org/W3157654347","https://openalex.org/W3159803161","https://openalex.org/W3165374440","https://openalex.org/W3177828909","https://openalex.org/W3188452318","https://openalex.org/W3196747782","https://openalex.org/W3205019595","https://openalex.org/W3211795435","https://openalex.org/W3215459563","https://openalex.org/W4200284287","https://openalex.org/W4200326176","https://openalex.org/W4210582716","https://openalex.org/W4223488708","https://openalex.org/W4281690468","https://openalex.org/W4288684700","https://openalex.org/W4296754581","https://openalex.org/W4304812331","https://openalex.org/W4307843054","https://openalex.org/W4315927621","https://openalex.org/W4323530556","https://openalex.org/W4362668273","https://openalex.org/W4381377965","https://openalex.org/W4386566060","https://openalex.org/W4389719910","https://openalex.org/W4398140216"],"related_works":["https://openalex.org/W2885342001","https://openalex.org/W3165374440","https://openalex.org/W2901057945","https://openalex.org/W3213144207","https://openalex.org/W3031935718","https://openalex.org/W7127612731","https://openalex.org/W2599036729","https://openalex.org/W4375954936","https://openalex.org/W7052468862","https://openalex.org/W2897378284"],"abstract_inverted_index":{"The":[0],"rising":[1],"prevalence":[2,246],"of":[3,94,117,205,231,247],"metabolic":[4,20,44,67,226],"diseases":[5],"is":[6,22,28,70,137],"a":[7,114,221],"significant":[8],"global":[9],"health":[10],"concern.":[11],"Beyond":[12],"lifestyle":[13],"management,":[14],"targeting":[15],"key":[16,115],"molecules":[17],"involved":[18],"in":[19,43,66,99,122,133,140,163],"regulation":[21],"essential.":[23],"C1q/TNF-related":[24],"protein":[25,60],"6":[26],"(CTRP6)":[27],"notably":[29],"associated":[30],"with":[31,36,81,101,196],"glucose":[32],"and":[33,64,76,103,119,127,147,171,182],"lipid":[34],"metabolism,":[35],"numerous":[37],"studies":[38,155],"highlighting":[39],"its":[40,56,89,120,208],"regulatory":[41],"functions":[42],"diseases.":[45,68,227,249],"This":[46],"review":[47],"summarizes":[48],"the":[49,82,235,244],"current":[50],"knowledge":[51],"on":[52,55,211],"CTRP6,":[53,206],"focusing":[54],"gene":[57,62],"expression":[58],"profiles,":[59],"structure,":[61],"regulation,":[63],"role":[65],"CTRP6":[69,95,118,136,159,218,232],"widely":[71],"expressed":[72],"across":[73],"various":[74],"tissues":[75],"features":[77],"four":[78],"distinct":[79],"domains,":[80],"C1q":[83],"domain":[84],"predicted":[85],"to":[86,88,188,238,242],"bind":[87],"receptor.":[90],"Notably,":[91],"serum":[92,203],"levels":[93,204],"are":[96],"significantly":[97],"elevated":[98,202],"patients":[100],"obesity":[102],"type":[104,141],"2":[105],"diabetes.":[106],"In":[107,216],"these":[108,193,248],"conditions,":[109],"adipose":[110,123],"tissue":[111,124],"serves":[112],"as":[113,179,220],"source":[116],"involvement":[121],"expansion,":[125],"inflammation,":[126],"nutrient":[128],"sensing":[129],"has":[130,160],"been":[131],"observed":[132],"several":[134],"studies.":[135,194],"also":[138],"implicated":[139],"1":[142],"diabetes,":[143],"gestational":[144],"diabetes":[145],"mellitus,":[146],"diabetic":[148,151],"complications,":[149],"particularly":[150],"nephropathy.":[152],"Although":[153],"some":[154],"have":[156],"suggested":[157],"that":[158],"protective":[161],"roles":[162],"atherosclerotic":[164],"cell":[165],"models,":[166,170,175],"myocardial":[167],"infarction":[168],"rat":[169],"ischemia/reperfusion":[172],"injury":[173],"mouse":[174],"methodological":[176],"issues":[177],"such":[178],"unreliable":[180],"antibodies":[181],"unstrict":[183],"controls":[184],"make":[185],"it":[186],"difficult":[187],"draw":[189],"accurate":[190],"conclusions":[191],"from":[192],"Patients":[195],"polycystic":[197],"ovary":[198],"syndrome":[199],"(PCOS)":[200],"exhibit":[201],"although":[207],"direct":[209],"impact":[210],"PCOS":[212],"phenotypes":[213],"remains":[214],"unclear.":[215],"conclusion,":[217],"emerges":[219],"promising":[222],"therapeutic":[223],"target":[224],"for":[225],"A":[228],"deeper":[229],"understanding":[230],"will":[233],"empower":[234],"scientific":[236],"community":[237],"develop":[239],"effective":[240],"interventions":[241],"address":[243],"increasing":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-12-20T00:00:00"}
