{"id":"https://openalex.org/W4405531402","doi":"https://doi.org/10.1016/j.jbc.2024.108109","title":"Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist","display_name":"Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist","publication_year":2024,"publication_date":"2024-12-19","ids":{"openalex":"https://openalex.org/W4405531402","doi":"https://doi.org/10.1016/j.jbc.2024.108109","pmid":"https://pubmed.ncbi.nlm.nih.gov/38915546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11195084"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2024.108109","doi":"https://doi.org/10.1016/j.jbc.2024.108109","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2024.108109","pdf_url":"https://www.jbc.org/article/S0021-9258(24)02611-5/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jbc.org/article/S0021-9258(24)02611-5/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041791356","display_name":"Trung Thanh Thach","orcid":"https://orcid.org/0000-0001-8395-0623","observed_orcids":["https://orcid.org/0000-0001-8395-0623"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trung Thach","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA. Electronic address: ttthach@purdue.edu","Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA. Electronic address: ttthach@purdue.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA. Electronic address: ttthach@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA. Electronic address: ttthach@purdue.edu","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018353130","display_name":"KanagaVijayan Dhanabalan","orcid":"https://orcid.org/0000-0001-8636-2616","observed_orcids":["https://orcid.org/0000-0001-8636-2616"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KanagaVijayan Dhanabalan","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA","Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022230930","display_name":"Prajwal P. Nandekar","orcid":"https://orcid.org/0000-0003-0210-9301","observed_orcids":["https://orcid.org/0000-0003-0210-9301"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prajwal Prabhakarrao Nandekar","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA","Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA"],"raw_orcid":"https://orcid.org/0000-0003-0210-9301","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seth Stauffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118371","display_name":"Elanco (United States)","ror":"https://ror.org/02jg74102","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Stauffer","raw_affiliation_strings":["Elanco Animal Health, Greenfield, Indiana, USA","Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elanco Animal Health, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I4210118371"]},{"raw_affiliation_string":"Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA","institution_ids":["https://openalex.org/I4210118371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003818185","display_name":"Iring Heisler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118371","display_name":"Elanco (United States)","ror":"https://ror.org/02jg74102","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iring Heisler","raw_affiliation_strings":["Elanco Animal Health, Greenfield, Indiana, USA","Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elanco Animal Health, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I4210118371"]},{"raw_affiliation_string":"Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA","institution_ids":["https://openalex.org/I4210118371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014286808","display_name":"Sarah K. Alvarado","orcid":"https://orcid.org/0000-0002-5653-1578","observed_orcids":["https://orcid.org/0000-0002-5653-1578"]},"institutions":[{"id":"https://openalex.org/I4210118371","display_name":"Elanco (United States)","ror":"https://ror.org/02jg74102","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Alvarado","raw_affiliation_strings":["Elanco Animal Health, Greenfield, Indiana, USA","Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elanco Animal Health, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I4210118371"]},{"raw_affiliation_string":"Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA","institution_ids":["https://openalex.org/I4210118371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072598994","display_name":"Jonathan R. Snyder","orcid":"https://orcid.org/0009-0008-2762-934X","observed_orcids":["https://orcid.org/0009-0008-2762-934X"]},"institutions":[{"id":"https://openalex.org/I4210118371","display_name":"Elanco (United States)","ror":"https://ror.org/02jg74102","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Snyder","raw_affiliation_strings":["Elanco Animal Health, Greenfield, Indiana, USA","Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA"],"raw_orcid":"https://orcid.org/0009-0008-2762-934X","affiliations":[{"raw_affiliation_string":"Elanco Animal Health, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I4210118371"]},{"raw_affiliation_string":"Elanco Animal Health, 2500 Innovation Way, Greenfield, IN-46140, USA","institution_ids":["https://openalex.org/I4210118371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064457733","display_name":"Subramanian Ramaswamy","orcid":"https://orcid.org/0000-0003-4102-0983","observed_orcids":["https://orcid.org/0000-0003-4102-0983"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramaswamy Subramanian","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA. Electronic address: subram68@purdue.edu","Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN-47907, USA. Electronic address: subram68@purdue.edu"],"raw_orcid":"https://orcid.org/0000-0002-6709-190X","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA. Electronic address: subram68@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN-47907, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN-47907, USA. Electronic address: subram68@purdue.edu","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041791356","https://openalex.org/A5064457733"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":3.0295,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.9375,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"301","issue":"1","first_page":"108109","last_page":"108109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x3-receptor","display_name":"P2X3 receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atp-gated-ion-channels","display_name":"ATP-gated ion channels","score":0.6800000071525574},{"id":"https://openalex.org/keywords/chronic-cough","display_name":"chronic cough","score":0.7450000047683716},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ion-permeation","display_name":"ion permeation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/drug-binding-sites","display_name":"drug binding sites","score":0.6669999957084656},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7450000047683716},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5920881032943726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5127397775650024},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48786425590515137},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4522465169429779},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33381980657577515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28256821632385254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2727259397506714}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jbc.2024.108109","doi":"https://doi.org/10.1016/j.jbc.2024.108109","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2024.108109","pdf_url":"https://www.jbc.org/article/S0021-9258(24)02611-5/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2024.06.10.598171","doi":"https://doi.org/10.1101/2024.06.10.598171","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.06.10.598171","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11783113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11783113","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11783113/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:38915546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38915546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:39706278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39706278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11195084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11195084","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11195084/pdf/nihpp-2024.06.10.598171v2.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2024.108109","doi":"https://doi.org/10.1016/j.jbc.2024.108109","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2024.108109","pdf_url":"https://www.jbc.org/article/S0021-9258(24)02611-5/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1516401474","display_name":null,"funder_award_id":"UM1TR004402","funder_id":"https://openalex.org/F4320309408","funder_display_name":"Indiana Clinical and Translational Sciences Institute"},{"id":"https://openalex.org/G9000915594","display_name":"Indiana Clinical and Translational Sciences Institute","funder_award_id":"UM1TR004402","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333372","display_name":"Elanco Animal Health","ror":"https://ror.org/02jg74102"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405531402.pdf","grobid_xml":"https://content.openalex.org/works/W4405531402.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W990723863","https://openalex.org/W1607931568","https://openalex.org/W1983764912","https://openalex.org/W1997082215","https://openalex.org/W1999675593","https://openalex.org/W2001991082","https://openalex.org/W2006815126","https://openalex.org/W2028470175","https://openalex.org/W2031434196","https://openalex.org/W2043901383","https://openalex.org/W2063388276","https://openalex.org/W2076449818","https://openalex.org/W2080876451","https://openalex.org/W2096663326","https://openalex.org/W2115156649","https://openalex.org/W2127376430","https://openalex.org/W2130770638","https://openalex.org/W2132629607","https://openalex.org/W2144081223","https://openalex.org/W2150444353","https://openalex.org/W2330799739","https://openalex.org/W2519597790","https://openalex.org/W2587625522","https://openalex.org/W2593511418","https://openalex.org/W2760901008","https://openalex.org/W2786390877","https://openalex.org/W2800785118","https://openalex.org/W2802723872","https://openalex.org/W2885066448","https://openalex.org/W2924783581","https://openalex.org/W2950967305","https://openalex.org/W3009387622","https://openalex.org/W3083406432","https://openalex.org/W3108495343","https://openalex.org/W3153330655","https://openalex.org/W3163358492","https://openalex.org/W3177828909","https://openalex.org/W3202900199","https://openalex.org/W4206019932","https://openalex.org/W4211196614","https://openalex.org/W4214937922","https://openalex.org/W4238157267","https://openalex.org/W4283208399","https://openalex.org/W4309858927","https://openalex.org/W4362677501","https://openalex.org/W4387616458","https://openalex.org/W4387682039","https://openalex.org/W4388486197","https://openalex.org/W6858240709"],"related_works":["https://openalex.org/W4399478118","https://openalex.org/W7149031035","https://openalex.org/W7118139200","https://openalex.org/W7155173822","https://openalex.org/W2519597790","https://openalex.org/W7164194710","https://openalex.org/W4221029792","https://openalex.org/W4402940303","https://openalex.org/W4403037708","https://openalex.org/W4206019932"],"abstract_inverted_index":{"ATP-activated":[0],"P2X3":[1,35,46,63,110],"receptors":[2],"play":[3,103],"a":[4,43,69,76,104,114,139,149],"pivotal":[5],"role":[6],"in":[7,82,92],"chronic":[8],"cough,":[9],"affecting":[10],"more":[11],"than":[12],"10%":[13],"of":[14,26,41,51,59,72,116,142,146],"the":[15,18,22,39,49,83,93,98],"population.":[16],"Despite":[17],"challenges":[19],"posed":[20],"by":[21],"highly":[23],"conserved":[24],"structure":[25,71],"P2X":[27],"receptors,":[28],"efforts":[29],"to":[30,38,62,113,126],"develop":[31],"selective":[32,45,79,144],"drugs":[33],"targeting":[34,155],"have":[36],"led":[37],"development":[40,154],"camlipixant,":[42],"potent,":[44],"antagonist.":[47],"However,":[48],"mechanisms":[50],"receptor":[52],"desensitization,":[53],"ion":[54],"permeation,":[55],"and":[56,100,130],"structural":[57],"basis":[58],"camlipixant":[60],"binding":[61],"remain":[64],"unclear.":[65],"Here,":[66],"we":[67],"report":[68],"cryo-EM":[70],"camlipixant-bound":[73],"P2X3,":[74,147],"revealing":[75],"previously":[77],"undiscovered":[78],"drug-binding":[80],"site":[81],"receptor.":[84,157],"Our":[85],"findings":[86],"also":[87],"demonstrate":[88],"that":[89],"conformational":[90],"changes":[91],"upper":[94],"body":[95],"domain,":[96],"including":[97],"turret":[99,107,123],"camlipixant-binding":[101],"pocket,":[102],"critical":[105],"role:":[106],"opening":[108],"facilitates":[109],"channel":[111,127],"closure":[112,124],"radius":[115],"0.7":[117],"\u00c5,":[118],"hindering":[119],"cation":[120],"transfer,":[121],"whereas":[122],"leads":[125],"opening.":[128],"Structural":[129],"functional":[131],"studies":[132],"combined":[133],"with":[134],"molecular":[135],"dynamics":[136],"simulations":[137],"provide":[138],"comprehensive":[140],"understanding":[141],"camlipixant's":[143],"inhibition":[145],"offering":[148],"foundation":[150],"for":[151],"future":[152],"drug":[153],"this":[156]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-12-19T00:00:00"}