{"id":"https://openalex.org/W4405516554","doi":"https://doi.org/10.1007/s10439-024-03667-x","title":"Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity","display_name":"Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity","publication_year":2024,"publication_date":"2024-12-18","ids":{"openalex":"https://openalex.org/W4405516554","doi":"https://doi.org/10.1007/s10439-024-03667-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/39695002","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11836148"},"language":"en","primary_location":{"id":"doi:10.1007/s10439-024-03667-x","doi":"https://doi.org/10.1007/s10439-024-03667-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-024-03667-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073339094","display_name":"Annika R. Bergstrom","orcid":"https://orcid.org/0000-0002-1775-092X","observed_orcids":["https://orcid.org/0000-0002-1775-092X"]},"institutions":[{"id":"https://openalex.org/I7863295","display_name":"Villanova University","ror":"https://ror.org/02g7kd627","country_code":"US","type":"education","lineage":["https://openalex.org/I7863295"]},{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annika R. Bergstrom","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","Department of Chemical and Biological Engineering, Villanova University, Villanova, PA, 19085, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Villanova University, Villanova, PA, 19085, USA","institution_ids":["https://openalex.org/I7863295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014577334","display_name":"Matthew G. Glimm","orcid":"https://orcid.org/0009-0004-1813-4135","observed_orcids":["https://orcid.org/0009-0004-1813-4135"]},"institutions":[{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Glimm","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056842256","display_name":"Eden A. Houske","orcid":"https://orcid.org/0000-0002-1439-4085","observed_orcids":["https://orcid.org/0000-0002-1439-4085"]},"institutions":[{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eden A. Houske","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035208484","display_name":"Gwendolyn Cooper","orcid":"https://orcid.org/0000-0003-3548-3551","observed_orcids":["https://orcid.org/0000-0003-3548-3551"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwendolyn Cooper","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA","Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010811881","display_name":"Ethan Viles","orcid":"https://orcid.org/0000-0002-2854-5569","observed_orcids":["https://orcid.org/0000-0002-2854-5569"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Viles","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA","Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marrin Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marrin Chapman","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104616959","display_name":"Katherine Bourekis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Bourekis","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000511408","display_name":"Hope D. Welhaven","orcid":"https://orcid.org/0000-0001-9330-6903","observed_orcids":["https://orcid.org/0000-0001-9330-6903"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope D. Welhaven","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA","Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Molecular Biosciences Program, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005565609","display_name":"Priyanka P. Brahmachary","orcid":"https://orcid.org/0009-0007-6899-9139","observed_orcids":["https://orcid.org/0009-0007-6899-9139"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka P. Brahmachary","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044485513","display_name":"Alyssa K. Hahn","orcid":"https://orcid.org/0000-0002-8884-2610","observed_orcids":["https://orcid.org/0000-0002-8884-2610"]},"institutions":[{"id":"https://openalex.org/I80565981","display_name":"Carroll College","ror":"https://ror.org/00x5b2p37","country_code":"US","type":"education","lineage":["https://openalex.org/I80565981"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alyssa K. Hahn","raw_affiliation_strings":["Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA. alyssahahn19@gmail.com","Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA"],"raw_orcid":"https://orcid.org/0000-0002-8884-2610","affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA. alyssahahn19@gmail.com","institution_ids":["https://openalex.org/I80565981"]},{"raw_affiliation_string":"Department of Biological and Environmental Science, Carroll College, 1601 N Benton Ave, Helena, MT, 59625, USA","institution_ids":["https://openalex.org/I80565981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021030176","display_name":"Ronald K. June","orcid":"https://orcid.org/0000-0003-0752-4109","observed_orcids":["https://orcid.org/0000-0003-0752-4109"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald K. June","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA. rjune@montana.edu","Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA"],"raw_orcid":"https://orcid.org/0000-0003-0752-4109","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA. rjune@montana.edu","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA","institution_ids":["https://openalex.org/I23732399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021030176","https://openalex.org/A5044485513"],"corresponding_institution_ids":["https://openalex.org/I23732399","https://openalex.org/I80565981"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.3638,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75795585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"53","issue":"3","first_page":"785","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.47699999809265137},{"id":"https://openalex.org/keywords/rotating-wall-vessel-bioreactor","display_name":"rotating wall vessel bioreactor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.734000027179718},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.7329999804496765},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.7960000038146973},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6908538341522217},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6733751893043518},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.6517142653465271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.614436686038971},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5810333490371704},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5324728488922119},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.5304538607597351},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5153409838676453},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.4757147431373596},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4638647437095642},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4235767722129822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3625611662864685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22750049829483032},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21911028027534485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15730822086334229},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15171653032302856},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13895604014396667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12170109152793884},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018474","descriptor_name":"Weightlessness Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1007/s10439-024-03667-x","doi":"https://doi.org/10.1007/s10439-024-03667-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-024-03667-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},{"id":"doi:10.1101/2024.07.01.601604","doi":"https://doi.org/10.1101/2024.07.01.601604","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.01.601604","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/04/2024.07.01.601604.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11836148","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11836148","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11836148/pdf/10439_2024_Article_3667.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Biomed Eng","raw_type":"Text"},{"id":"pmid:39005264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39005264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:39695002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39695002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of biomedical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.montana.edu:1/19217","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/handle/1/19217","pdf_url":"https://scholarworks.montana.edu/bitstreams/9eda938d-0e09-4116-afb1-2625c9020904/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11245029","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11245029","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11245029/pdf/nihpp-2024.07.01.601604v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10439-024-03667-x","doi":"https://doi.org/10.1007/s10439-024-03667-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-024-03667-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4193542148","display_name":null,"funder_award_id":"1554708","funder_id":"https://openalex.org/F4320337391","funder_display_name":"Division of Civil, Mechanical and Manufacturing Innovation"},{"id":"https://openalex.org/G4250843317","display_name":"Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for Metabolomics","funder_award_id":"S10OD028650","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5859288038","display_name":"Role of Glucose metabolism in Chondrocyte Mechanotransduction","funder_award_id":"R01AR073964","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7709013518","display_name":"CAREER: Metabolomic Analysis of Chondrocyte Mechanotransduction","funder_award_id":"1554708","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8327016629","display_name":null,"funder_award_id":"80NSSC20M0042","funder_id":"https://openalex.org/F4320308708","funder_display_name":"Montana Space Grant Consortium"},{"id":"https://openalex.org/G8730173895","display_name":null,"funder_award_id":"FSU-2017207","funder_id":"https://openalex.org/F4320306203","funder_display_name":"M.J. Murdock Charitable Trust"},{"id":"https://openalex.org/G9000867577","display_name":"MT INBRE: A Multidisciplinary Research Network","funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320306203","display_name":"M.J. Murdock Charitable Trust","ror":"https://ror.org/02hxgd925"},{"id":"https://openalex.org/F4320308708","display_name":"Montana Space Grant Consortium","ror":"https://ror.org/00x0rjj17"},{"id":"https://openalex.org/F4320311310","display_name":"Montana State University","ror":"https://ror.org/02w0trx84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405516554.pdf","grobid_xml":"https://content.openalex.org/works/W4405516554.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W164114645","https://openalex.org/W1660366682","https://openalex.org/W1966135133","https://openalex.org/W1995039844","https://openalex.org/W2010742642","https://openalex.org/W2011038175","https://openalex.org/W2017445971","https://openalex.org/W2027758979","https://openalex.org/W2029351075","https://openalex.org/W2029732523","https://openalex.org/W2031673412","https://openalex.org/W2036806716","https://openalex.org/W2036902507","https://openalex.org/W2048450453","https://openalex.org/W2066934766","https://openalex.org/W2075978331","https://openalex.org/W2086898489","https://openalex.org/W2090171402","https://openalex.org/W2105811065","https://openalex.org/W2122467920","https://openalex.org/W2143893042","https://openalex.org/W2160040618","https://openalex.org/W2163432819","https://openalex.org/W2333762764","https://openalex.org/W2394631798","https://openalex.org/W2425593468","https://openalex.org/W2487256703","https://openalex.org/W2512230684","https://openalex.org/W2586644082","https://openalex.org/W2604174049","https://openalex.org/W2793515649","https://openalex.org/W2800142237","https://openalex.org/W2803664483","https://openalex.org/W2914655303","https://openalex.org/W2925744614","https://openalex.org/W2939739784","https://openalex.org/W2941329961","https://openalex.org/W2973724894","https://openalex.org/W2977150865","https://openalex.org/W2979084451","https://openalex.org/W2993782230","https://openalex.org/W3000563588","https://openalex.org/W3026620083","https://openalex.org/W3115872251","https://openalex.org/W3137470379","https://openalex.org/W3161822984","https://openalex.org/W3202078058","https://openalex.org/W4200412897","https://openalex.org/W4210698503","https://openalex.org/W4214935627","https://openalex.org/W4220952606","https://openalex.org/W4239202739","https://openalex.org/W4292483156","https://openalex.org/W4309482433"],"related_works":["https://openalex.org/W2333762764","https://openalex.org/W3158234094","https://openalex.org/W2750887111","https://openalex.org/W3017448346","https://openalex.org/W7167810166","https://openalex.org/W7125123810","https://openalex.org/W7046760704","https://openalex.org/W2939739784","https://openalex.org/W2914655303","https://openalex.org/W2154687429"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"mechanism":[2],"by":[3,134,168],"which":[4],"chondrocytes":[5,58],"respond":[6],"to":[7,44,66,70,80,94,147,216,226,237,247],"reduced":[8,31,220],"mechanical":[9,221],"loading":[10,33,222],"environments":[11],"and":[12,108,164,180,188,191],"the":[13,30,67,72,97,227,235],"subsequent":[14],"risk":[15,250],"of":[16,23,49,63,124,153,184,229],"developing":[17],"osteoarthritis":[18,45,249],"remains":[19],"unclear.":[20],"This":[21,231],"is":[22],"particular":[24],"concern":[25],"for":[26,84],"astronauts.":[27,252],"In":[28,52],"space":[29],"joint":[32],"forces":[34],"during":[35],"prolonged":[36],"microgravity":[37,82,217],"(10":[38],"\u22126":[39],"g)":[40],"exposure":[41,149,215],"could":[42],"lead":[43,225],"(OA),":[46],"compromising":[47],"quality":[48],"life":[50],"post-spaceflight.":[51],"this":[53],"study,":[54],"we":[55],"encapsulated":[56],"human":[57,208],"in":[59,145,151,171,177,207,242,245,251],"an":[60],"agarose":[61,109],"gel":[62,110,178],"similar":[64],"stiffness":[65],"pericellular":[68],"matrix":[69],"mimic":[71],"cartilage":[73,98],"microenvironment.":[74],"We":[75],"then":[76],"exposed":[77],"agarose-chondrocyte":[78],"constructs":[79,111,179],"simulated":[81],"(SM)":[83],"four":[85],"days":[86],"using":[87],"a":[88,122],"rotating":[89],"wall":[90],"vessel":[91],"(RWV)":[92],"bioreactor":[93],"better":[95],"assess":[96],"health":[99],"risks":[100],"associated":[101],"with":[102,128,156,199],"spaceflight.":[103],"Metabolites":[104],"extracted":[105],"from":[106],"media":[107,181],"were":[112,182,197],"analyzed":[113],"on":[114],"liquid":[115],"chromatography-mass":[116],"spectrometry.":[117],"Global":[118],"metabolomic":[119,205],"profiling":[120],"detected":[121,144],"total":[123],"1205":[125],"metabolite":[126,131],"features,":[127],"497":[129],"significant":[130],"features":[132],"identified":[133,167],"ANOVA":[135],"(FDR-corrected":[136],"p":[137],"-value":[138],"<":[139],"0.05).":[140],"Specific":[141],"metabolic":[142,175,240],"shifts":[143,176,196],"response":[146],"SM":[148],"resulted":[150],"clusters":[152],"co-regulated":[154],"metabolites,":[155],"glutathione,":[157],"nitrogen,":[158],"histidine,":[159],"vitamin":[160],"B":[161],"3":[162],",":[163],"aminosugars":[165],"metabolism":[166],"variable":[169],"importance":[170],"projection":[172],"scores.":[173],"Microgravity-induced":[174],"indicative":[183],"protein":[185],"synthesis,":[186],"energy":[187],"nucleotide":[189],"metabolism,":[190],"oxidative":[192],"catabolism.":[193],"Microgravity":[194],"associated-metabolic":[195],"consistent":[198],"our":[200],"previously":[201],"published":[202],"early":[203],"osteoarthritic":[204],"profiles":[206],"synovial":[209,243],"fluid,":[210],"suggesting":[211],"that":[212],"even":[213],"short-term":[214],"(or":[218],"other":[219],"environments)":[223],"may":[224],"development":[228],"OA.":[230],"work":[232],"further":[233],"suggests":[234],"potential":[236],"detect":[238],"these":[239],"perturbations":[241],"fluid":[244],"vivo":[246],"ascertain":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-12-18T00:00:00"}
