{"id":"https://openalex.org/W4405486830","doi":"https://doi.org/10.1038/s41375-024-02499-x","title":"Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement","display_name":"Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement","publication_year":2024,"publication_date":"2024-12-17","ids":{"openalex":"https://openalex.org/W4405486830","doi":"https://doi.org/10.1038/s41375-024-02499-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/39690182"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-024-02499-x","doi":"https://doi.org/10.1038/s41375-024-02499-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02499-x","pdf_url":"https://www.nature.com/articles/s41375-024-02499-x.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41375-024-02499-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115010823","display_name":"Jana Nabki","orcid":"https://orcid.org/0009-0008-6891-4825","observed_orcids":["https://orcid.org/0009-0008-6891-4825"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jana Nabki","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0009-0008-6891-4825","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115010971","display_name":"Bashar Al Deeban","orcid":"https://orcid.org/0000-0002-4218-1917","observed_orcids":["https://orcid.org/0000-0002-4218-1917"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bashar Al Deeban","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4218-1917","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115010968","display_name":"Abel Mehari Sium","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Abel Mehari Sium","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054656463","display_name":"Chiara Cosentino","orcid":"https://orcid.org/0000-0001-8199-4593","observed_orcids":["https://orcid.org/0000-0001-8199-4593"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Cosentino","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8199-4593","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036371667","display_name":"Mohammad Almasri","orcid":"https://orcid.org/0000-0002-0048-3845","observed_orcids":["https://orcid.org/0000-0002-0048-3845"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mohammad Almasri","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0048-3845","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009552281","display_name":"Bassel Awikeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bassel Awikeh","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034428665","display_name":"Nawar Maher","orcid":"https://orcid.org/0009-0007-9307-1965","observed_orcids":["https://orcid.org/0009-0007-9307-1965"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nawar Maher","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092640289","display_name":"Matteo Bellia","orcid":"https://orcid.org/0009-0004-9709-4935","observed_orcids":["https://orcid.org/0009-0004-9709-4935"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Bellia","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079506646","display_name":"Riccardo Dondolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Dondolin","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084053548","display_name":"Samir Mouhssine","orcid":"https://orcid.org/0000-0002-0389-3268","observed_orcids":["https://orcid.org/0000-0002-0389-3268"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Samir Mouhssine","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0389-3268","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024569193","display_name":"Donatella Talotta","orcid":"https://orcid.org/0009-0004-5875-8508","observed_orcids":["https://orcid.org/0009-0004-5875-8508"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Talotta","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069346522","display_name":"Eleonora Secomandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Secomandi","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060065080","display_name":"Sreekar Kogila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sreekar Kogila","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087922992","display_name":"Joseph Ghanej","orcid":"https://orcid.org/0000-0002-9515-5827","observed_orcids":["https://orcid.org/0000-0002-9515-5827"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Joseph Ghanej","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115010972","display_name":"Francesca Maiellaro","orcid":"https://orcid.org/0009-0003-0725-2876","observed_orcids":["https://orcid.org/0009-0003-0725-2876"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Maiellaro","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0009-0003-0725-2876","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115010970","display_name":"Luca Cividini","orcid":"https://orcid.org/0009-0007-8096-7391","observed_orcids":["https://orcid.org/0009-0007-8096-7391"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Cividini","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0009-0007-8096-7391","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053429265","display_name":"Silvia Rasi","orcid":"https://orcid.org/0000-0003-4935-3918","observed_orcids":["https://orcid.org/0000-0003-4935-3918"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Rasi","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038163660","display_name":"Annalisa Chiarenza","orcid":"https://orcid.org/0000-0002-8759-4854","observed_orcids":["https://orcid.org/0000-0002-8759-4854"]},"institutions":[{"id":"https://openalex.org/I4210102357","display_name":"Ferrarotto Hospital","ror":"https://ror.org/00nz9t738","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210102357"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Chiarenza","raw_affiliation_strings":["Division of Haematology, Ferrarotto Hospital, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology, Ferrarotto Hospital, Catania, Italy","institution_ids":["https://openalex.org/I4210102357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064275500","display_name":"Jacopo Olivieri","orcid":"https://orcid.org/0000-0002-2582-3500","observed_orcids":["https://orcid.org/0000-0002-2582-3500"]},"institutions":[{"id":"https://openalex.org/I4210126152","display_name":"Ospedale Santa Maria della Misericordia di Udine","ror":"https://ror.org/02zpc2253","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126152"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jacopo Olivieri","raw_affiliation_strings":["Clinica Ematologica, Centro Trapianti e Terapie Cellulari \"Carlo Melzi\" DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Ematologica, Centro Trapianti e Terapie Cellulari \"Carlo Melzi\" DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy","institution_ids":["https://openalex.org/I4210126152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016021915","display_name":"Massimo Gentile","orcid":"https://orcid.org/0000-0002-5256-0726","observed_orcids":["https://orcid.org/0000-0002-5256-0726"]},"institutions":[{"id":"https://openalex.org/I4210102769","display_name":"Azienda Ospedaliera di Cosenza","ror":"https://ror.org/01884b046","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210102769"]},{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Gentile","raw_affiliation_strings":["Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy","Hematology Unit AO of Cosenza, Cosenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"Hematology Unit AO of Cosenza, Cosenza, Italy","institution_ids":["https://openalex.org/I4210102769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039006383","display_name":"Francesco F. Zaja","orcid":"https://orcid.org/0000-0003-3995-8817","observed_orcids":["https://orcid.org/0000-0003-3995-8817"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Zaja","raw_affiliation_strings":["Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046702889","display_name":"Maria Ilaria Del Principe","orcid":"https://orcid.org/0000-0002-3958-0669","observed_orcids":["https://orcid.org/0000-0002-3958-0669"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Ilaria Del Principe","raw_affiliation_strings":["Hematology, Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070335233","display_name":"Luca Laurenti","orcid":"https://orcid.org/0000-0002-4527-4131","observed_orcids":["https://orcid.org/0000-0002-4527-4131","https://orcid.org/0000-0002-8327-1396"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Laurenti","raw_affiliation_strings":["Dipartimento di Science di Laboratorio ed Ematologiche, Area di Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore-Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Science di Laboratorio ed Ematologiche, Area di Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore-Roma, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091091710","display_name":"Riccardo Bomben","orcid":"https://orcid.org/0000-0002-8746-9404","observed_orcids":["https://orcid.org/0000-0002-8746-9404"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Bomben","raw_affiliation_strings":["Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8746-9404","affiliations":[{"raw_affiliation_string":"Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436810","display_name":"Filippo Vit","orcid":"https://orcid.org/0000-0002-0195-0978","observed_orcids":["https://orcid.org/0000-0002-0195-0978"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Vit","raw_affiliation_strings":["Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022728189","display_name":"Tamara Bittolo","orcid":"https://orcid.org/0000-0003-3674-4362","observed_orcids":["https://orcid.org/0000-0003-3674-4362"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tamara Bittolo","raw_affiliation_strings":["Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022748609","display_name":"Antonella Zucchetto","orcid":"https://orcid.org/0000-0003-2812-6345","observed_orcids":["https://orcid.org/0000-0003-2812-6345","https://orcid.org/0000-0003-3678-5957"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Zucchetto","raw_affiliation_strings":["Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073179633","display_name":"Valter Gattei","orcid":"https://orcid.org/0000-0001-5933-9680","observed_orcids":["https://orcid.org/0000-0001-5933-9680"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valter Gattei","raw_affiliation_strings":["Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5933-9680","affiliations":[{"raw_affiliation_string":"Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041745367","display_name":"Gianluca Ga\u00efdano","orcid":"https://orcid.org/0000-0002-4681-0151","observed_orcids":["https://orcid.org/0000-0002-4681-0151"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Gaidano","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4681-0151","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026766394","display_name":"Riccardo Moia","orcid":"https://orcid.org/0000-0001-7393-1138","observed_orcids":["https://orcid.org/0000-0001-7393-1138"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Riccardo Moia","raw_affiliation_strings":["Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy. riccardo.moia@uniupo.it","Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7393-1138","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy. riccardo.moia@uniupo.it","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"Division of Hematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5026766394"],"corresponding_institution_ids":["https://openalex.org/I123338534"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.9137,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74274399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"39","issue":"3","first_page":"643","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunoglobulin-light-chain-genes","display_name":"immunoglobulin light chain genes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ighv-mutation-status","display_name":"IGHV mutation status","score":0.7979999780654907},{"id":"https://openalex.org/keywords/time-to-first-treatment","display_name":"time to first treatment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/treatment-free-survival","display_name":"treatment-free survival","score":0.7609999775886536},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6620000004768372},{"id":"https://openalex.org/keywords/early-stage-cll","display_name":"early-stage CLL","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.9416559934616089},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7657846212387085},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.725531816482544},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.629243016242981},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.5735692381858826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5446497797966003},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5238965749740601},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.5070106983184814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5042654275894165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4309285283088684},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40696024894714355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3453514575958252},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33991023898124695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33922284841537476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29523766040802},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.10677069425582886}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41375-024-02499-x","doi":"https://doi.org/10.1038/s41375-024-02499-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02499-x","pdf_url":"https://www.nature.com/articles/s41375-024-02499-x.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:39690182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39690182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/396741","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2108/396741","pdf_url":"https://art.torvergata.it/bitstream/2108/396741/1/Nabki%20J%20et%20al.2024.pdf","source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11879880","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11879880","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11879880/pdf/41375_2024_Article_2499.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmh:oai:arts.units.it:11368/3136103","doi":null,"is_oa":true,"landing_page_url":"https://www.nature.com/articles/s41375-024-02499-x","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/379356","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11770/379356","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41375-024-02499-x","doi":"https://doi.org/10.1038/s41375-024-02499-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-024-02499-x","pdf_url":"https://www.nature.com/articles/s41375-024-02499-x.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4099999964237213,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2406870047","display_name":null,"funder_award_id":"#21198","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G255694563","display_name":null,"funder_award_id":"5\u00d71000","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G935287255","display_name":null,"funder_award_id":"IG-21687","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405486830.pdf","grobid_xml":"https://content.openalex.org/works/W4405486830.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1243376384","https://openalex.org/W1429374962","https://openalex.org/W2010013828","https://openalex.org/W2032553162","https://openalex.org/W2055001224","https://openalex.org/W2077980507","https://openalex.org/W2116324811","https://openalex.org/W2116911597","https://openalex.org/W2132832238","https://openalex.org/W2556824914","https://openalex.org/W2790385276","https://openalex.org/W2811343643","https://openalex.org/W2978887976","https://openalex.org/W2998390959","https://openalex.org/W3006590330","https://openalex.org/W3014127006","https://openalex.org/W3090488793","https://openalex.org/W3092193830","https://openalex.org/W3100688200","https://openalex.org/W4200276175","https://openalex.org/W4213165578","https://openalex.org/W4281485894","https://openalex.org/W4390234147","https://openalex.org/W4391885958","https://openalex.org/W4392385144","https://openalex.org/W4400298506"],"related_works":["https://openalex.org/W4311367181","https://openalex.org/W2260771575","https://openalex.org/W2767669578","https://openalex.org/W4315796090","https://openalex.org/W344354797","https://openalex.org/W2606039306","https://openalex.org/W2558613206","https://openalex.org/W3165521618","https://openalex.org/W2146523291","https://openalex.org/W2079957181"],"abstract_inverted_index":{"The":[0,150],"mutational":[1,148,187],"status":[2,188],"of":[3,93,110,153,172,189,198],"immunoglobulin":[4],"(IG)":[5],"light":[6,30,56,101,125,163,191],"chain":[7,31,57,102,126,164,192],"genes":[8,58,103,119,127,165,178,193],"in":[9,34,87,201],"chronic":[10],"lymphocytic":[11],"leukemia":[12],"(CLL)":[13],"and":[14,63],"its":[15],"clinical":[16],"impact":[17],"have":[18],"not":[19],"been":[20,38],"extensively":[21],"studied.":[22],"To":[23],"assess":[24],"their":[25],"prognostic":[26,141],"significance,":[27],"the":[28,45,67,78,94,139,186,190],"IG":[29,55],"gene":[32],"repertoire":[33],"CLL":[35,91,203],"patients":[36,92,157],"has":[37],"evaluated":[39],"using":[40],"a":[41,105,133,167],"training-validation":[42],"approach.":[43],"In":[44],"training":[46,95],"cohort":[47,152],"(N":[48],"=":[49],"573":[50],"CLL),":[51],"92.5%":[52],"showed":[53],"productive":[54],"rearrangements,":[59],"with":[60,98,116,132,161],"IGKV4-1":[61],"(20.5%)":[62],"IGLV3-21":[64],"(19.0%)":[65],"being":[66],"most":[68],"common.":[69],"A":[70,90],"99.0%":[71],"somatic":[72],"hypermutation":[73],"cut-off":[74],"was":[75],"identified":[76],"as":[77],"best":[79],"predictor":[80,197],"for":[81,114,138,176],"time":[82],"to":[83],"first":[84],"treatment":[85,107,169],"(TTFT)":[86],"414":[88],"Binet":[89],"cohort.":[96],"Patients":[97],"unmutated":[99],"(UM)":[100],"displayed":[104],"10-year":[106],"free":[108,170],"probability":[109,171],"32.4%":[111],"versus":[112,174],"73.2%":[113],"those":[115],"mutated":[117],"(M)":[118],"(p":[120,179],"<":[121,180],"0.0001).":[122,181],"Importantly,":[123],"UM":[124,162],"maintained":[128],"an":[129,195],"independent":[130,196],"association":[131],"shorter":[134,199],"TTFT":[135,200],"when":[136],"adjusted":[137],"IPS-E":[140],"model":[142],"variables,":[143],"that":[144,185],"also":[145],"includes":[146],"IGHV":[147],"status.":[149],"validation":[151],"343":[154],"Rai":[155],"0":[156],"confirmed":[158],"these":[159],"findings,":[160],"predicting":[166],"7-year":[168],"42.0%":[173],"73.7%":[175],"M":[177],"These":[182],"results":[183],"indicate":[184],"is":[194],"early-stage":[202],"patients.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}