{"id":"https://openalex.org/W4405454841","doi":"https://doi.org/10.1016/j.jep.2024.119251","title":"6-Shogaol attenuates cisplatin induced emesis by inhibiting the mtDNA-cGAS-STING signaling pathway in a rat pica model","display_name":"6-Shogaol attenuates cisplatin induced emesis by inhibiting the mtDNA-cGAS-STING signaling pathway in a rat pica model","publication_year":2024,"publication_date":"2024-12-16","ids":{"openalex":"https://openalex.org/W4405454841","doi":"https://doi.org/10.1016/j.jep.2024.119251","pmid":"https://pubmed.ncbi.nlm.nih.gov/39694431"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2024.119251","doi":"https://doi.org/10.1016/j.jep.2024.119251","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2024.119251","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4405454841"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shaojun Kan","orcid":"https://orcid.org/0009-0005-1679-3572","observed_orcids":["https://orcid.org/0009-0005-1679-3572"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaojun Kan","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0009-0005-1679-3572","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Binbin Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binbin Ye","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536051","display_name":"Yusu Wang","orcid":"https://orcid.org/0000-0001-5114-8986","observed_orcids":["https://orcid.org/0000-0001-5114-8986"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yusu Wang","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102107699","display_name":"Ziyao Mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyao Mo","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681970","display_name":"Weijian Chen","orcid":"https://orcid.org/0009-0009-9458-8047","observed_orcids":["https://orcid.org/0009-0009-9458-8047"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijian Chen","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101295985","display_name":"Jingrui Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingrui Zheng","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yarong Zhai","orcid":"https://orcid.org/0009-0002-9576-1429","observed_orcids":["https://orcid.org/0009-0002-9576-1429"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yarong Zhai","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0009-0002-9576-1429","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020946235","display_name":"Ke Nie","orcid":"https://orcid.org/0000-0003-4410-7662","observed_orcids":["https://orcid.org/0000-0003-4410-7662"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ke Nie","raw_affiliation_strings":["School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address: knie@gdpu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-4410-7662","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address: knie@gdpu.edu.cn","institution_ids":["https://openalex.org/I190242452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020946235"],"corresponding_institution_ids":["https://openalex.org/I190242452"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":2.0832,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84707921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"340","issue":null,"first_page":"119251","last_page":"119251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.4657999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.4657999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.40059998631477356,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-shogaol","display_name":"6-shogaol","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7670000195503235},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ogg1","display_name":"OGG1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fen1","display_name":"FEN1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9629999995231628},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/gastric-antrum","display_name":"gastric antrum","score":0.6809999942779541},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6244758367538452},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.6143069863319397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4331921935081482},{"id":"https://openalex.org/C2776622089","wikidata":"https://www.wikidata.org/wiki/Q2718629","display_name":"Pica (typography)","level":2,"score":0.4180116355419159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36972588300704956},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.078738272190094},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0658525824546814},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010842","descriptor_name":"Pica","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010842","descriptor_name":"Pica","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010842","descriptor_name":"Pica","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jep.2024.119251","doi":"https://doi.org/10.1016/j.jep.2024.119251","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2024.119251","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:39694431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39694431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6896533019","display_name":null,"funder_award_id":"82174143","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W28107291","https://openalex.org/W1559117436","https://openalex.org/W1567817944","https://openalex.org/W1833739857","https://openalex.org/W2057359553","https://openalex.org/W2070251133","https://openalex.org/W2099610218","https://openalex.org/W2126464410","https://openalex.org/W2130792610","https://openalex.org/W2137816677","https://openalex.org/W2175601630","https://openalex.org/W2527377692","https://openalex.org/W2726372533","https://openalex.org/W2736845474","https://openalex.org/W2742522504","https://openalex.org/W2784856289","https://openalex.org/W2791131687","https://openalex.org/W2801227374","https://openalex.org/W2887501075","https://openalex.org/W2899591997","https://openalex.org/W2912078722","https://openalex.org/W2921822951","https://openalex.org/W2948303250","https://openalex.org/W2965008467","https://openalex.org/W2973265448","https://openalex.org/W2977707523","https://openalex.org/W2995224081","https://openalex.org/W2998972184","https://openalex.org/W3024191006","https://openalex.org/W3028229512","https://openalex.org/W3091137883","https://openalex.org/W3127926824","https://openalex.org/W3145334405","https://openalex.org/W3158544679","https://openalex.org/W3165035209","https://openalex.org/W3212202851","https://openalex.org/W4200105853","https://openalex.org/W4210853074","https://openalex.org/W4211124640","https://openalex.org/W4285098776","https://openalex.org/W4292416215","https://openalex.org/W4308106259","https://openalex.org/W4308460793","https://openalex.org/W4311677544","https://openalex.org/W4312052508","https://openalex.org/W4366984915","https://openalex.org/W4375866038","https://openalex.org/W4385337289","https://openalex.org/W4386419084","https://openalex.org/W4386587993","https://openalex.org/W6601140817"],"related_works":["https://openalex.org/W2990492710","https://openalex.org/W3091137883","https://openalex.org/W2356264695","https://openalex.org/W4313201553","https://openalex.org/W2044696697","https://openalex.org/W1975455729","https://openalex.org/W7169671835","https://openalex.org/W2496000978","https://openalex.org/W2085288893","https://openalex.org/W1831834726"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2024-12-17T00:00:00"}