{"id":"https://openalex.org/W4405450060","doi":"https://doi.org/10.3390/genes15121598","title":"Neuroblastoma Breakpoint Family 3mer Higher Order Repeats/Olduvai Triplet Pattern in the Complete Genome of Human and Nonhuman Primates and Relation to Cognitive Capacity","display_name":"Neuroblastoma Breakpoint Family 3mer Higher Order Repeats/Olduvai Triplet Pattern in the Complete Genome of Human and Nonhuman Primates and Relation to Cognitive Capacity","publication_year":2024,"publication_date":"2024-12-13","ids":{"openalex":"https://openalex.org/W4405450060","doi":"https://doi.org/10.3390/genes15121598","pmid":"https://pubmed.ncbi.nlm.nih.gov/39766865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11675761"},"language":"en","primary_location":{"id":"doi:10.3390/genes15121598","doi":"https://doi.org/10.3390/genes15121598","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes15121598","pdf_url":"https://www.mdpi.com/2073-4425/15/12/1598/pdf?version=1734110991","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4425/15/12/1598/pdf?version=1734110991","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001808519","display_name":"Matko Glun\u010di\u0107","orcid":"https://orcid.org/0000-0003-1802-3641","observed_orcids":["https://orcid.org/0000-0003-1802-3641"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Matko Glun\u010di\u0107","raw_affiliation_strings":["Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012379376","display_name":"Ines Vlahovi\u0107","orcid":"https://orcid.org/0000-0002-8534-4245","observed_orcids":["https://orcid.org/0000-0002-8534-4245"]},"institutions":[{"id":"https://openalex.org/I4210102288","display_name":"Algebra Bernays University","ror":"https://ror.org/019m6wk21","country_code":"HR","type":"education","lineage":["https://openalex.org/I4210102288"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Ines Vlahovi\u0107","raw_affiliation_strings":["Department of Interdisciplinary Sciences, Algebra University College, 10000 Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interdisciplinary Sciences, Algebra University College, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I4210102288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015926674","display_name":"Marija Rosandi\u0107","orcid":"https://orcid.org/0000-0002-0548-621X","observed_orcids":["https://orcid.org/0000-0002-0548-621X"]},"institutions":[{"id":"https://openalex.org/I1301669915","display_name":"Croatian Academy of Sciences and Arts","ror":"https://ror.org/03d04qg82","country_code":"HR","type":"government","lineage":["https://openalex.org/I1301669915"]},{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marija Rosandi\u0107","raw_affiliation_strings":["Croatian Academy of Sciences and Arts, 10000 Zagreb, Croatia","Department of Internal Medicine, University Hospital Centre Zagreb, 10000 Zagreb, Croatia"],"raw_orcid":"https://orcid.org/0000-0002-0548-621X","affiliations":[{"raw_affiliation_string":"Croatian Academy of Sciences and Arts, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I1301669915"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Centre Zagreb, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057367194","display_name":"V. Paar","orcid":"https://orcid.org/0000-0001-5349-9886","observed_orcids":["https://orcid.org/0000-0001-5349-9886"]},"institutions":[{"id":"https://openalex.org/I1301669915","display_name":"Croatian Academy of Sciences and Arts","ror":"https://ror.org/03d04qg82","country_code":"HR","type":"government","lineage":["https://openalex.org/I1301669915"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Vladimir Paar","raw_affiliation_strings":["Croatian Academy of Sciences and Arts, 10000 Zagreb, Croatia","Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Croatian Academy of Sciences and Arts, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I1301669915"]},{"raw_affiliation_string":"Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia","institution_ids":["https://openalex.org/I181343428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012379376"],"corresponding_institution_ids":["https://openalex.org/I4210102288"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":0.3931,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4888895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"15","issue":"12","first_page":"1598","last_page":"1598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.361299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/higher-order-repeats","display_name":"higher-order repeats","score":0.703000009059906},{"id":"https://openalex.org/keywords/tandem-repeats","display_name":"tandem repeats","score":0.5860000252723694},{"id":"https://openalex.org/keywords/human-evolution","display_name":"human evolution","score":0.4790000021457672},{"id":"https://openalex.org/keywords/cognitive-ability","display_name":"cognitive ability","score":0.7799999713897705},{"id":"https://openalex.org/keywords/great-apes","display_name":"great apes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chimpanzees","display_name":"chimpanzees","score":0.7369999885559082},{"id":"https://openalex.org/keywords/gorillas","display_name":"gorillas","score":0.9900000095367432},{"id":"https://openalex.org/keywords/orangutans","display_name":"orangutans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primate-genomes","display_name":"primate genomes","score":0.6930000185966492},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6176488995552063},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.6083243489265442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5594980716705322},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5569943189620972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28958651423454285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13446414470672607},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.13275352120399475}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006071","descriptor_name":"Gorilla gorilla","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015186","descriptor_name":"Hominidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057079","descriptor_name":"Pongo","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/genes15121598","doi":"https://doi.org/10.3390/genes15121598","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes15121598","pdf_url":"https://www.mdpi.com/2073-4425/15/12/1598/pdf?version=1734110991","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11675761","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11675761","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11675761/pdf/genes-15-01598.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes (Basel)","raw_type":"Text"},{"id":"pmid:39766865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39766865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/genes15121598","doi":"https://doi.org/10.3390/genes15121598","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes15121598","pdf_url":"https://www.mdpi.com/2073-4425/15/12/1598/pdf?version=1734110991","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G285569201","display_name":"Variants in higher order repeat structures in centromeric and NBPF regions of human and higher primates genomes","funder_award_id":"IP-2019-04-2757","funder_id":"https://openalex.org/F4320322674","funder_display_name":"Hrvatska Zaklada za Znanost"},{"id":"https://openalex.org/G8308642409","display_name":null,"funder_award_id":"PK.1.1.02","funder_id":"https://openalex.org/F4320322674","funder_display_name":"Hrvatska Zaklada za Znanost"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322674","display_name":"Hrvatska Zaklada za Znanost","ror":"https://ror.org/03n51vw80"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405450060.pdf","grobid_xml":"https://content.openalex.org/works/W4405450060.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1908059705","https://openalex.org/W1951128322","https://openalex.org/W1976421540","https://openalex.org/W1981172427","https://openalex.org/W1996019688","https://openalex.org/W2017983475","https://openalex.org/W2021804487","https://openalex.org/W2026977699","https://openalex.org/W2073173653","https://openalex.org/W2093062110","https://openalex.org/W2095259929","https://openalex.org/W2099821697","https://openalex.org/W2106714275","https://openalex.org/W2126665603","https://openalex.org/W2128685078","https://openalex.org/W2139257860","https://openalex.org/W2153199777","https://openalex.org/W2158455991","https://openalex.org/W2164143957","https://openalex.org/W2199403564","https://openalex.org/W2308504462","https://openalex.org/W2505758894","https://openalex.org/W2746821572","https://openalex.org/W2751526137","https://openalex.org/W2776761958","https://openalex.org/W2783123388","https://openalex.org/W2945356154","https://openalex.org/W2953174564","https://openalex.org/W2954634837","https://openalex.org/W2990346645","https://openalex.org/W4210809346","https://openalex.org/W4220937793","https://openalex.org/W4220999759","https://openalex.org/W4255067374","https://openalex.org/W4283739297","https://openalex.org/W4306810144","https://openalex.org/W4311528900","https://openalex.org/W4312221480","https://openalex.org/W4386387395","https://openalex.org/W4393870245","https://openalex.org/W4400585293","https://openalex.org/W7096279635"],"related_works":["https://openalex.org/W4306810144","https://openalex.org/W4386387395","https://openalex.org/W4376604395","https://openalex.org/W1981172427","https://openalex.org/W3188990117","https://openalex.org/W2099821697","https://openalex.org/W2774302647","https://openalex.org/W2787774831","https://openalex.org/W7131214130","https://openalex.org/W2990346645"],"abstract_inverted_index":{"BACKGROUND/OBJECTIVES:":[0],"The":[1,114,134],"~1.6":[2],"kb":[3],"NBPF":[4,30,52,77,100,130,161,208,236,271],"repeat":[5,91],"units":[6],"in":[7,23,33,41,46,81,104,140,147,165,170,176,196,200,210,244,248],"neuroblastoma":[8],"breakpoint":[9],"family":[10],"(NBPF)":[11],"genes":[12],"are":[13,18],"specific":[14],"to":[15,69,95,124,168,194,251,276],"humans":[16,34,59,197,211,249],"and":[17,60,73,98,112,172,174,198,212],"associated":[19],"with":[20,186],"cognitive":[21,246],"capacity":[22,247],"higher":[24],"primates.":[25],"While":[26],"the":[27,44,71,89,105,121,148,191,204,229,232,263,266],"number":[28,48,149,268],"of":[29,50,76,108,129,150,235,265,269],"monomers/Olduvai":[31,272],"sequences":[32],"is":[35,63,215],"approximately":[36],"2-3":[37],"times":[38],"greater":[39],"than":[40,188],"great":[42,61,201,213,223,252],"apes,":[43,253],"difference":[45,139],"copy":[47],"values":[49],"canonical":[51,97,153,160],"3mer":[53,78,101,154,162,183,237],"Higher-order":[54],"repeats":[55],"(HORs)/Olduvai":[56],"triplets":[57,80,103,164,185,239],"between":[58,206],"apes":[62,214],"substantially":[64],"larger.":[65],"This":[66,260],"study":[67],"aims":[68],"analyze":[70],"organization":[72,234],"evolutionary":[74,258],"significance":[75],"HORs/Olduvai":[79,102,155,163,184,238],"fully":[82],"sequenced":[83],"primate":[84],"genomes.":[85],"METHODS:":[86],"We":[87],"applied":[88],"global":[90],"map":[92],"(GRM)":[93],"algorithm":[94,123],"identify":[96],"variant":[99],"complete":[106],"genomes":[107],"humans,":[109,166],"chimpanzees,":[110],"gorillas,":[111],"orangutans.":[113],"resulting":[115],"monomer":[116],"arrays":[117],"were":[118],"analyzed":[119],"using":[120],"GRMhor":[122],"generate":[125],"detailed":[126],"schematic":[127],"representations":[128],"HOR":[131],"organization.":[132],"RESULTS:":[133],"analysis":[135],"reveals":[136],"a":[137,241,256,277],"distinct":[138],"NBPF-related":[141],"patterns":[142],"among":[143],"these":[144],"primates,":[145],"particularly":[146],"tandemly":[151,158,181],"organized":[152,159,182],"triplets:":[156],"61":[157],"compared":[167,250],"0":[169,199],"chimpanzees":[171],"orangutans,":[173],"9":[175],"gorillas.":[177],"When":[178],"considering":[179],"only":[180],"more":[187],"three":[189],"copies,":[190],"numbers":[192],"adjust":[193],"36":[195],"apes.":[202,224],"Furthermore,":[203],"divergence":[205],"individual":[207,270],"monomers":[209],"twice":[216],"as":[217,219],"high":[218],"that":[220,231],"observed":[221],"within":[222],"CONCLUSIONS:":[225],"These":[226],"findings":[227],"support":[228],"hypothesis":[230],"tandem":[233],"plays":[240],"crucial":[242],"role":[243],"enhancing":[245],"potentially":[254],"providing":[255],"significant":[257],"advantage.":[259],"effect":[261],"complements":[262],"impact":[264],"increased":[267],"sequences,":[273],"together":[274],"contributing":[275],"synergistic":[278],"amplification":[279],"effect.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-17T00:00:00"}
