{"id":"https://openalex.org/W4405409746","doi":"https://doi.org/10.1186/s40779-024-00581-0","title":"Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations","display_name":"Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations","publication_year":2024,"publication_date":"2024-12-15","ids":{"openalex":"https://openalex.org/W4405409746","doi":"https://doi.org/10.1186/s40779-024-00581-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/39676169","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11648306"},"language":"en","primary_location":{"id":"doi:10.1186/s40779-024-00581-0","doi":"https://doi.org/10.1186/s40779-024-00581-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40779-024-00581-0","pdf_url":"https://mmrjournal.biomedcentral.com/counter/pdf/10.1186/s40779-024-00581-0","source":{"id":"https://openalex.org/S2739160569","display_name":"Military Medical Research","issn_l":"2054-9369","issn":["2054-9369","2095-7467"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Military Medical Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://mmrjournal.biomedcentral.com/counter/pdf/10.1186/s40779-024-00581-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046932917","display_name":"Jiqian Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Qian Xu","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718896","display_name":"Wanying Zhang","orcid":"https://orcid.org/0000-0003-0703-0416","observed_orcids":["https://orcid.org/0000-0003-0703-0416"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan-Ying Zhang","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108926410","display_name":"Jiaji Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Ji Fu","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110916626","display_name":"Xiangzhi Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Zhi Fang","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng-Gang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Gang Gao","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Li","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334844","display_name":"Yao L\u00fc","orcid":"https://orcid.org/0000-0002-3380-7762","observed_orcids":["https://orcid.org/0000-0002-3380-7762"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yao","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046836513","display_name":"Qing Li","orcid":"https://orcid.org/0009-0004-1816-9071","observed_orcids":["https://orcid.org/0009-0004-1816-9071"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-Lan Li","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101804593","display_name":"Xiaobo Yang","orcid":"https://orcid.org/0000-0001-9866-7724","observed_orcids":["https://orcid.org/0000-0001-9866-7724"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Bo Yang","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006469478","display_name":"Lehao Ren","orcid":"https://orcid.org/0000-0001-9890-6932","observed_orcids":["https://orcid.org/0000-0001-9890-6932"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le-Hao Ren","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045760438","display_name":"Huaqing Shu","orcid":"https://orcid.org/0000-0002-5964-9360","observed_orcids":["https://orcid.org/0000-0002-5964-9360"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Qing Shu","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081728299","display_name":"Ke Peng","orcid":"https://orcid.org/0000-0003-0172-8725","observed_orcids":["https://orcid.org/0000-0003-0172-8725"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Peng","raw_affiliation_strings":["State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692858","display_name":"Ying Wu","orcid":"https://orcid.org/0000-0002-6751-9953","observed_orcids":["https://orcid.org/0000-0002-6751-9953"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wu","raw_affiliation_strings":["State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, 430072, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004013679","display_name":"Ding-Yu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ding-Yu Zhang","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015539974","display_name":"Yang Qiu","orcid":"https://orcid.org/0000-0001-5152-1242","observed_orcids":["https://orcid.org/0000-0001-5152-1242","https://orcid.org/0000-0002-2351-6494"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Qiu","raw_affiliation_strings":["State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112624917","display_name":"Xi Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xi Zhou","raw_affiliation_strings":["State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China. zhouxi@wh.iov.cn","State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China. zhouxi@wh.iov.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 43007, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong-Ming Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong-Ming Yao","raw_affiliation_strings":["Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China. c_ff@sina.com","Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China. c_ff@sina.com","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102502512","display_name":"You Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"You Shang","raw_affiliation_strings":["Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. you_shang@hust.edu.cn","Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. you_shang@hust.edu.cn","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102502512","https://openalex.org/A5112624917"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802939634","https://openalex.org/I4210106882","https://openalex.org/I4210129222","https://openalex.org/I4391768268","https://openalex.org/I47720641"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":2.7016,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-sepsis","display_name":"viral sepsis","score":1.0},{"id":"https://openalex.org/keywords/sepsis-diagnosis","display_name":"sepsis diagnosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sepsis-pathogenesis","display_name":"sepsis pathogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/rig-i-like-receptors","display_name":"RIG-I-like receptors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9549999833106995},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mers-cov","display_name":"MERS-CoV","score":0.8159999847412109},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7282561659812927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7282274961471558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5928820371627808},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5068867802619934},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.4593328535556793},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.41549697518348694}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D017934","descriptor_name":"Coronavirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051192","descriptor_name":"Receptors, Pattern Recognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s40779-024-00581-0","doi":"https://doi.org/10.1186/s40779-024-00581-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40779-024-00581-0","pdf_url":"https://mmrjournal.biomedcentral.com/counter/pdf/10.1186/s40779-024-00581-0","source":{"id":"https://openalex.org/S2739160569","display_name":"Military Medical Research","issn_l":"2054-9369","issn":["2054-9369","2095-7467"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Military Medical Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11648306","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11648306","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11648306/pdf/40779_2024_Article_581.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mil Med Res","raw_type":"Text"},{"id":"pmid:39676169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39676169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Military Medical Research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d5b3335edf444a94b12184a3ec5c4207","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d5b3335edf444a94b12184a3ec5c4207","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Military Medical Research, Vol 11, Iss 1, Pp 1-29 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40779-024-00581-0","doi":"https://doi.org/10.1186/s40779-024-00581-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40779-024-00581-0","pdf_url":"https://mmrjournal.biomedcentral.com/counter/pdf/10.1186/s40779-024-00581-0","source":{"id":"https://openalex.org/S2739160569","display_name":"Military Medical Research","issn_l":"2054-9369","issn":["2054-9369","2095-7467"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Military Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1160300333","display_name":null,"funder_award_id":"82272217","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1393605206","display_name":null,"funder_award_id":"82372176","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G145141908","display_name":null,"funder_award_id":"2021YFC2300200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4540484837","display_name":null,"funder_award_id":"2021YFC2500802","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5101081649","display_name":null,"funder_award_id":"81971818","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7942133514","display_name":null,"funder_award_id":"82002026","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405409746.pdf","grobid_xml":"https://content.openalex.org/works/W4405409746.grobid-xml"},"referenced_works_count":282,"referenced_works":["https://openalex.org/W25083497","https://openalex.org/W586267484","https://openalex.org/W1868708604","https://openalex.org/W1972377680","https://openalex.org/W1988289466","https://openalex.org/W1993374993","https://openalex.org/W1994942139","https://openalex.org/W2000266617","https://openalex.org/W2019446509","https://openalex.org/W2031050014","https://openalex.org/W2031449139","https://openalex.org/W2042433863","https://openalex.org/W2052046406","https://openalex.org/W2056264877","https://openalex.org/W2067493370","https://openalex.org/W2071638524","https://openalex.org/W2078666204","https://openalex.org/W2089728480","https://openalex.org/W2090258227","https://openalex.org/W2093588907","https://openalex.org/W2094534321","https://openalex.org/W2097732601","https://openalex.org/W2098392761","https://openalex.org/W2098836088","https://openalex.org/W2115555188","https://openalex.org/W2117951318","https://openalex.org/W2118882860","https://openalex.org/W2121525530","https://openalex.org/W2122741854","https://openalex.org/W2123559384","https://openalex.org/W2127929928","https://openalex.org/W2129542667","https://openalex.org/W2129749447","https://openalex.org/W2130258295","https://openalex.org/W2133006561","https://openalex.org/W2133701960","https://openalex.org/W2138219153","https://openalex.org/W2142280910","https://openalex.org/W2143981910","https://openalex.org/W2148822770","https://openalex.org/W2153747643","https://openalex.org/W2159763561","https://openalex.org/W2161349806","https://openalex.org/W2166978186","https://openalex.org/W2167944937","https://openalex.org/W2172184476","https://openalex.org/W2258314763","https://openalex.org/W2280404143","https://openalex.org/W2296736194","https://openalex.org/W2357368971","https://openalex.org/W2412511529","https://openalex.org/W2461256631","https://openalex.org/W2475760572","https://openalex.org/W2549455555","https://openalex.org/W2574216202","https://openalex.org/W2582497730","https://openalex.org/W2585379663","https://openalex.org/W2607859602","https://openalex.org/W2607891850","https://openalex.org/W2616753020","https://openalex.org/W2620241325","https://openalex.org/W2732139830","https://openalex.org/W2753107282","https://openalex.org/W2755626276","https://openalex.org/W2761040354","https://openalex.org/W2762816177","https://openalex.org/W2765213553","https://openalex.org/W2769478359","https://openalex.org/W2782221410","https://openalex.org/W2784906428","https://openalex.org/W2785600869","https://openalex.org/W2785715721","https://openalex.org/W2794169242","https://openalex.org/W2795639367","https://openalex.org/W2799420783","https://openalex.org/W2800845950","https://openalex.org/W2803015713","https://openalex.org/W2806521568","https://openalex.org/W2821570464","https://openalex.org/W2884337535","https://openalex.org/W2885679300","https://openalex.org/W2891771349","https://openalex.org/W2894422883","https://openalex.org/W2907544909","https://openalex.org/W2911583817","https://openalex.org/W2921708798","https://openalex.org/W2924696628","https://openalex.org/W2925111228","https://openalex.org/W2939799025","https://openalex.org/W2944974725","https://openalex.org/W2949381594","https://openalex.org/W2950310544","https://openalex.org/W2954783926","https://openalex.org/W2963276598","https://openalex.org/W2963402728","https://openalex.org/W2966097779","https://openalex.org/W2969783143","https://openalex.org/W2997837675","https://openalex.org/W3000678087","https://openalex.org/W3005905966","https://openalex.org/W3009885589","https://openalex.org/W3009976289","https://openalex.org/W3010637630","https://openalex.org/W3011113661","https://openalex.org/W3011498764","https://openalex.org/W3011516015","https://openalex.org/W3011610993","https://openalex.org/W3012379316","https://openalex.org/W3012747666","https://openalex.org/W3016404849","https://openalex.org/W3017944284","https://openalex.org/W3018507926","https://openalex.org/W3020695284","https://openalex.org/W3023088605","https://openalex.org/W3026301261","https://openalex.org/W3026354710","https://openalex.org/W3027918021","https://openalex.org/W3030537287","https://openalex.org/W3034033967","https://openalex.org/W3034883465","https://openalex.org/W3037020655","https://openalex.org/W3038638697","https://openalex.org/W3039233076","https://openalex.org/W3042099270","https://openalex.org/W3042270788","https://openalex.org/W3042482358","https://openalex.org/W3042890801","https://openalex.org/W3043808133","https://openalex.org/W3043985461","https://openalex.org/W3047775721","https://openalex.org/W3047777875","https://openalex.org/W3080126164","https://openalex.org/W3080427029","https://openalex.org/W3081487801","https://openalex.org/W3082170884","https://openalex.org/W3082355253","https://openalex.org/W3083745354","https://openalex.org/W3085706233","https://openalex.org/W3088646954","https://openalex.org/W3089043805","https://openalex.org/W3090321510","https://openalex.org/W3090929175","https://openalex.org/W3091465752","https://openalex.org/W3092016255","https://openalex.org/W3093711492","https://openalex.org/W3097331958","https://openalex.org/W3097807388","https://openalex.org/W3099192040","https://openalex.org/W3103940138","https://openalex.org/W3108711749","https://openalex.org/W3109926113","https://openalex.org/W3110542218","https://openalex.org/W3111521480","https://openalex.org/W3115893239","https://openalex.org/W3118570342","https://openalex.org/W3119655958","https://openalex.org/W3122166825","https://openalex.org/W3123118461","https://openalex.org/W3126863499","https://openalex.org/W3127051356","https://openalex.org/W3130055273","https://openalex.org/W3130058263","https://openalex.org/W3132128293","https://openalex.org/W3132487837","https://openalex.org/W3132525916","https://openalex.org/W3134257301","https://openalex.org/W3134426702","https://openalex.org/W3134729907","https://openalex.org/W3135076605","https://openalex.org/W3135214460","https://openalex.org/W3136749291","https://openalex.org/W3141133935","https://openalex.org/W3145334405","https://openalex.org/W3153506813","https://openalex.org/W3158953228","https://openalex.org/W3163874714","https://openalex.org/W3165458001","https://openalex.org/W3168470763","https://openalex.org/W3170965404","https://openalex.org/W3171203272","https://openalex.org/W3172366125","https://openalex.org/W3174877434","https://openalex.org/W3175760465","https://openalex.org/W3175941607","https://openalex.org/W3178418858","https://openalex.org/W3182386410","https://openalex.org/W3182774911","https://openalex.org/W3183486118","https://openalex.org/W3183508816","https://openalex.org/W3184805478","https://openalex.org/W3184810728","https://openalex.org/W3186838602","https://openalex.org/W3191928958","https://openalex.org/W3193381896","https://openalex.org/W3193480463","https://openalex.org/W3195465766","https://openalex.org/W3197986920","https://openalex.org/W3198809089","https://openalex.org/W3200053343","https://openalex.org/W3201253246","https://openalex.org/W3201551509","https://openalex.org/W3203036880","https://openalex.org/W3204176899","https://openalex.org/W3204874602","https://openalex.org/W3208106660","https://openalex.org/W3212144275","https://openalex.org/W3213600000","https://openalex.org/W3213886386","https://openalex.org/W3217244291","https://openalex.org/W4200091440","https://openalex.org/W4200206478","https://openalex.org/W4200419303","https://openalex.org/W4200462943","https://openalex.org/W4206205337","https://openalex.org/W4210792795","https://openalex.org/W4211007515","https://openalex.org/W4211119126","https://openalex.org/W4211135732","https://openalex.org/W4212904481","https://openalex.org/W4213034647","https://openalex.org/W4214848801","https://openalex.org/W4220688652","https://openalex.org/W4220736866","https://openalex.org/W4220815932","https://openalex.org/W4223559995","https://openalex.org/W4255974860","https://openalex.org/W4280575933","https://openalex.org/W4282835239","https://openalex.org/W4283325050","https://openalex.org/W4283645756","https://openalex.org/W4285798508","https://openalex.org/W4291000363","https://openalex.org/W4293593841","https://openalex.org/W4294675933","https://openalex.org/W4295094743","https://openalex.org/W4295454078","https://openalex.org/W4297991882","https://openalex.org/W4302774122","https://openalex.org/W4304185430","https://openalex.org/W4306946281","https://openalex.org/W4308179770","https://openalex.org/W4308577033","https://openalex.org/W4309118682","https://openalex.org/W4309162619","https://openalex.org/W4309447702","https://openalex.org/W4309503005","https://openalex.org/W4310582781","https://openalex.org/W4316591179","https://openalex.org/W4316813192","https://openalex.org/W4317394357","https://openalex.org/W4320480889","https://openalex.org/W4324334122","https://openalex.org/W4327682566","https://openalex.org/W4364376300","https://openalex.org/W4366817734","https://openalex.org/W4378901810","https://openalex.org/W4379598187","https://openalex.org/W4380985979","https://openalex.org/W4383198258","https://openalex.org/W4386154648","https://openalex.org/W4386460144","https://openalex.org/W4386913696","https://openalex.org/W4387167915","https://openalex.org/W4388500231","https://openalex.org/W4388931300","https://openalex.org/W4389426539","https://openalex.org/W4389780343","https://openalex.org/W4390402308","https://openalex.org/W4391467070","https://openalex.org/W4391685737","https://openalex.org/W4391878282","https://openalex.org/W4392808543","https://openalex.org/W4393281582","https://openalex.org/W4394596779","https://openalex.org/W4395007044","https://openalex.org/W4395049788","https://openalex.org/W4399122971","https://openalex.org/W4400249500","https://openalex.org/W4401152787","https://openalex.org/W4401715713","https://openalex.org/W4403842848","https://openalex.org/W6776583185"],"related_works":["https://openalex.org/W4366984834","https://openalex.org/W7172329890","https://openalex.org/W3043985461","https://openalex.org/W7118305642","https://openalex.org/W4417225221","https://openalex.org/W2894422883","https://openalex.org/W4407636153","https://openalex.org/W4392624958","https://openalex.org/W4391098641","https://openalex.org/W3046474712"],"abstract_inverted_index":{"Sepsis,":[0],"characterized":[1],"as":[2,151,232,234],"life-threatening":[3],"organ":[4,239],"dysfunction":[5],"resulting":[6],"from":[7],"dysregulated":[8],"host":[9],"responses":[10],"to":[11,58,172,187,247,256],"infection,":[12],"remains":[13],"a":[14,188],"significant":[15],"challenge":[16],"in":[17,22,50,97],"clinical":[18,191,200,244],"practice.":[19],"Despite":[20],"advancements":[21],"understanding":[23,260],"host-bacterial":[24],"interactions,":[25],"molecular":[26,228],"responses,":[27],"and":[28,42,60,78,137,165,177,212,226,251],"therapeutic":[29],"approaches,":[30],"the":[31,92,199,210,258],"mortality":[32,46],"rate":[33],"associated":[34],"with":[35],"sepsis":[36,54,115,217],"has":[37],"consistently":[38],"ranged":[39],"between":[40],"10":[41],"16%.":[43],"This":[44,193],"elevated":[45],"highlights":[47],"critical":[48],"gaps":[49],"our":[51],"comprehension":[52],"of":[53,65,94,108,113,160,190,202],"etiology.":[55],"Traditionally":[56],"linked":[57],"bacterial":[59],"fungal":[61],"pathogens,":[62],"recent":[63],"outbreaks":[64],"acute":[66,80],"viral":[67,95,124,216,262],"infections,":[68],"including":[69],"Middle":[70],"East":[71],"respiratory":[72,81],"syndrome":[73,82],"coronavirus":[74,83],"(MERS-CoV),":[75],"influenza":[76],"virus,":[77],"severe":[79],"2":[84],"(SARS-CoV-2),":[85],"among":[86],"other":[87],"regional":[88],"epidemics,":[89],"have":[90],"underscored":[91],"role":[93],"pathogenesis":[96],"sepsis,":[98],"particularly":[99],"when":[100],"critically":[101],"ill":[102],"patients":[103],"exhibit":[104],"classic":[105],"symptoms":[106],"indicative":[107],"sepsis.":[109,263],"However,":[110],"many":[111],"cases":[112],"viral-induced":[114],"are":[116],"frequently":[117],"underdiagnosed":[118],"because":[119],"standard":[120],"evaluations":[121],"typically":[122],"exclude":[123],"panels.":[125],"Moreover,":[126],"these":[127],"viruses":[128],"not":[129],"only":[130],"activate":[131],"conventional":[132],"pattern":[133],"recognition":[134],"receptors":[135,142],"(PRRs)":[136],"retinoic":[138],"acid-inducible":[139],"gene-I":[140],"(RIG-I)-like":[141],"(RLRs)":[143],"but":[144],"also":[145],"initiate":[146],"primary":[147],"antiviral":[148],"pathways":[149],"such":[150],"cyclic":[152],"guanosine":[153],"monophosphate":[154,156],"adenosine":[155],"(GMP-AMP)":[157],"synthase":[158],"(cGAS)-stimulator":[159],"interferon":[161,166],"genes":[162],"(STING)":[163],"signaling":[164],"response":[167],"mechanisms.":[168],"Such":[169],"activations":[170],"lead":[171],"cellular":[173],"stress,":[174],"metabolic":[175],"disturbances,":[176],"extensive":[178],"cell":[179],"damage":[180],"that":[181],"exacerbate":[182],"tissue":[183],"injury":[184],"while":[185,218],"leading":[186],"spectrum":[189],"manifestations.":[192],"complexity":[194],"poses":[195],"substantial":[196],"challenges":[197],"for":[198,215],"management":[201],"affected":[203],"cases.":[204],"In":[205],"this":[206],"review,":[207],"we":[208,242],"elucidate":[209],"definition":[211],"diagnosis":[213],"criteria":[214],"synthesizing":[219],"current":[220],"knowledge":[221],"regarding":[222],"its":[223],"etiology,":[224],"epidemiology,":[225],"pathophysiology,":[227],"mechanisms":[229],"involved":[230],"therein":[231],"well":[233],"their":[235],"impact":[236],"on":[237],"immune-mediated":[238],"damage.":[240],"Additionally,":[241],"discuss":[243],"considerations":[245],"related":[246],"both":[248],"existing":[249],"therapies":[250],"advanced":[252],"treatment":[253],"interventions,":[254],"aiming":[255],"enhance":[257],"comprehensive":[259],"surrounding":[261]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-16T00:00:00"}
