{"id":"https://openalex.org/W4405316207","doi":"https://doi.org/10.1016/j.ijbiomac.2024.138614","title":"Visualizing gaussian-chain like structural models of human \u03b1-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis","display_name":"Visualizing gaussian-chain like structural models of human \u03b1-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis","publication_year":2024,"publication_date":"2024-12-12","ids":{"openalex":"https://openalex.org/W4405316207","doi":"https://doi.org/10.1016/j.ijbiomac.2024.138614","pmid":"https://pubmed.ncbi.nlm.nih.gov/39674478"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2024.138614","doi":"https://doi.org/10.1016/j.ijbiomac.2024.138614","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.138614","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/10/2024.07.07.602212.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Madhumita Dey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhumita Dey","raw_affiliation_strings":["CSIR - Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR - Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046100948","display_name":"Arpit Kumar Gupta","orcid":"https://orcid.org/0000-0002-6378-7440","observed_orcids":["https://orcid.org/0000-0002-6378-7440"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arpit Gupta","raw_affiliation_strings":["CSIR - Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR - Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026978564","display_name":"Maulik D. Badmalia","orcid":"https://orcid.org/0000-0002-3384-6550","observed_orcids":["https://orcid.org/0000-0002-3384-6550"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Maulik D. Badmalia","raw_affiliation_strings":["CSIR - Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR - Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ashish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ashish","raw_affiliation_strings":["CSIR - Institute of Microbial Technology, Chandigarh, India. Electronic address: ashgang@imtech.res.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR - Institute of Microbial Technology, Chandigarh, India. Electronic address: ashgang@imtech.res.in","institution_ids":["https://openalex.org/I4210147764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101463648","display_name":"Deepak Sharma","orcid":"https://orcid.org/0000-0003-1104-575X","observed_orcids":["https://orcid.org/0000-0003-1104-575X"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Deepak Sharma","raw_affiliation_strings":["CSIR - Institute of Microbial Technology, Chandigarh, India. Electronic address: deepaks@imtech.res.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR - Institute of Microbial Technology, Chandigarh, India. Electronic address: deepaks@imtech.res.in","institution_ids":["https://openalex.org/I4210147764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101463648"],"corresponding_institution_ids":["https://openalex.org/I4210147764"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":0.556,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55161162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"288","issue":null,"first_page":"138614","last_page":"138614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gaussian-chain-model","display_name":"Gaussian chain model","score":0.4909999966621399},{"id":"https://openalex.org/keywords/twist-conformation","display_name":"twisted conformation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/protein-intrinsic-disorder","display_name":"protein disorder","score":0.3240000009536743},{"id":"https://openalex.org/keywords/normal-mode-analysis","display_name":"normal mode analysis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"molecular dynamics","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C131888329","wikidata":"https://www.wikidata.org/wiki/Q3027679","display_name":"Small-angle X-ray scattering","level":3,"score":0.8335533738136292},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.6563253402709961},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.620750904083252},{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.49277427792549133},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4566764533519745},{"id":"https://openalex.org/C166550679","wikidata":"https://www.wikidata.org/wiki/Q263400","display_name":"Gaussian network model","level":3,"score":0.44122153520584106},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42769503593444824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39898693561553955},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3789437711238861},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3662445843219757},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3384554088115692},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.323644757270813},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2649229168891907},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.22018226981163025},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20074233412742615},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.1765957474708557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16275525093078613},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09027841687202454},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0709245502948761},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijbiomac.2024.138614","doi":"https://doi.org/10.1016/j.ijbiomac.2024.138614","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.138614","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"doi:10.1101/2024.07.07.602212","doi":"https://doi.org/10.1101/2024.07.07.602212","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.07.602212","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/10/2024.07.07.602212.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39674478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39674478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2024.07.07.602212","doi":"https://doi.org/10.1101/2024.07.07.602212","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.07.602212","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/10/2024.07.07.602212.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6216177133","display_name":null,"funder_award_id":"50/2023","funder_id":"https://openalex.org/F4320338259","funder_display_name":"CSIR - Institute of Microbial Technology"}],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320338259","display_name":"CSIR - Institute of Microbial Technology","ror":"https://ror.org/055rjs771"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405316207.pdf","grobid_xml":"https://content.openalex.org/works/W4405316207.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1680110353","https://openalex.org/W1966788000","https://openalex.org/W1970826466","https://openalex.org/W1981346588","https://openalex.org/W1983806861","https://openalex.org/W1984394891","https://openalex.org/W1984475766","https://openalex.org/W1989780699","https://openalex.org/W1995191747","https://openalex.org/W2007640520","https://openalex.org/W2008682738","https://openalex.org/W2012438256","https://openalex.org/W2021497129","https://openalex.org/W2026717532","https://openalex.org/W2031964854","https://openalex.org/W2032487213","https://openalex.org/W2041134571","https://openalex.org/W2045062364","https://openalex.org/W2050091361","https://openalex.org/W2050375429","https://openalex.org/W2055021873","https://openalex.org/W2062919641","https://openalex.org/W2066088601","https://openalex.org/W2069349650","https://openalex.org/W2073739993","https://openalex.org/W2073852487","https://openalex.org/W2076344926","https://openalex.org/W2076477508","https://openalex.org/W2080447336","https://openalex.org/W2080751623","https://openalex.org/W2081515875","https://openalex.org/W2089518281","https://openalex.org/W2097021608","https://openalex.org/W2098464924","https://openalex.org/W2099099776","https://openalex.org/W2114823344","https://openalex.org/W2130161623","https://openalex.org/W2130323165","https://openalex.org/W2130939465","https://openalex.org/W2140673705","https://openalex.org/W2149010450","https://openalex.org/W2149885731","https://openalex.org/W2154792548","https://openalex.org/W2157046483","https://openalex.org/W2158977717","https://openalex.org/W2161334375","https://openalex.org/W2161991622","https://openalex.org/W2164361934","https://openalex.org/W2171281715","https://openalex.org/W2177561180","https://openalex.org/W2192911366","https://openalex.org/W2254889442","https://openalex.org/W2320033710","https://openalex.org/W2486245907","https://openalex.org/W2487073173","https://openalex.org/W2555287254","https://openalex.org/W2579037333","https://openalex.org/W2732000326","https://openalex.org/W2775514330","https://openalex.org/W2805168014","https://openalex.org/W2885863704","https://openalex.org/W2886156086","https://openalex.org/W2917354740","https://openalex.org/W2920446224","https://openalex.org/W2981015871","https://openalex.org/W2986878213","https://openalex.org/W2991233657","https://openalex.org/W2993040260","https://openalex.org/W3030540323","https://openalex.org/W3082197166","https://openalex.org/W3087868334","https://openalex.org/W3109413273","https://openalex.org/W3112387204","https://openalex.org/W3113327081","https://openalex.org/W3125782427","https://openalex.org/W3133320426","https://openalex.org/W3133564125","https://openalex.org/W3134523629","https://openalex.org/W3142557622","https://openalex.org/W3157366826","https://openalex.org/W3177828909","https://openalex.org/W3192979615","https://openalex.org/W3201084360","https://openalex.org/W3203844580","https://openalex.org/W3203874483","https://openalex.org/W3211015103","https://openalex.org/W3211531670","https://openalex.org/W4205416135","https://openalex.org/W4211204210","https://openalex.org/W4224437601","https://openalex.org/W4225073124","https://openalex.org/W4283326616","https://openalex.org/W4283713793","https://openalex.org/W4288689840","https://openalex.org/W4292977281","https://openalex.org/W4296773810","https://openalex.org/W4307178925","https://openalex.org/W4309076654","https://openalex.org/W4309844158","https://openalex.org/W4311178496","https://openalex.org/W4321370026","https://openalex.org/W4323275955","https://openalex.org/W4387241684"],"related_works":["https://openalex.org/W3082197166","https://openalex.org/W7096412489","https://openalex.org/W2089518281","https://openalex.org/W4288290235","https://openalex.org/W6920828110","https://openalex.org/W1984475766","https://openalex.org/W7208417393","https://openalex.org/W4213158426","https://openalex.org/W3117457269","https://openalex.org/W6999407663"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-12-13T00:00:00"}
