{"id":"https://openalex.org/W4405315728","doi":"https://doi.org/10.1016/j.exphem.2024.104697","title":"Understanding Human Oncogene Function and Cooperativity in Myeloid Malignancy Using iPSCs","display_name":"Understanding Human Oncogene Function and Cooperativity in Myeloid Malignancy Using iPSCs","publication_year":2024,"publication_date":"2024-12-12","ids":{"openalex":"https://openalex.org/W4405315728","doi":"https://doi.org/10.1016/j.exphem.2024.104697","pmid":"https://pubmed.ncbi.nlm.nih.gov/39674361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12463382"},"language":"en","primary_location":{"id":"doi:10.1016/j.exphem.2024.104697","doi":"https://doi.org/10.1016/j.exphem.2024.104697","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2024.104697","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.exphem.2024.104697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046537479","display_name":"Martina Sarchi","orcid":"https://orcid.org/0000-0002-1557-6577","observed_orcids":["https://orcid.org/0000-0002-1557-6577"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Sarchi","raw_affiliation_strings":["Department of Molecular Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1557-6577","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024928543","display_name":"Sergei R. Doulatov","orcid":"https://orcid.org/0000-0002-1328-364X","observed_orcids":["https://orcid.org/0000-0002-1328-364X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Doulatov","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA. Electronic address: doulatov@uw.edu","Division of Hematology, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA. Electronic address: doulatov@uw.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA. Electronic address: doulatov@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA. Electronic address: doulatov@uw.edu","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.1587,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.22193075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"143","issue":null,"first_page":"104697","last_page":"104697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.9860000014305115},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ipsc-differentiation","display_name":"iPSC differentiation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.703000009059906},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6200906038284302},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6037881374359131},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.5976654291152954},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5386495590209961},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5291483998298645},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.503070056438446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4445362687110901},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42879486083984375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3910790979862213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3211123049259186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24923750758171082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17998754978179932},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.06785166263580322},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.051824718713760376}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.exphem.2024.104697","doi":"https://doi.org/10.1016/j.exphem.2024.104697","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2024.104697","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},{"id":"pmid:39674361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39674361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12463382","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39674361/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Hematol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.exphem.2024.104697","doi":"https://doi.org/10.1016/j.exphem.2024.104697","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2024.104697","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4982223","display_name":"Uncovering epigenetic barriers to hematopoietic stem cell formation","funder_award_id":"DP2HL147126","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000863893","display_name":"The role of lamin B1 in normal and myelodysplastic hematopoiesis","funder_award_id":"R01HL169156","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000870279","display_name":"Development of Innovative Resources to Advance MDS Research","funder_award_id":"RC2DK127989","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000921192","display_name":"Functional and molecular consequences of SF3B1 mutations in human hematopoietic stem cells","funder_award_id":"R01HL151651","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1755567699","https://openalex.org/W1925667723","https://openalex.org/W1969814510","https://openalex.org/W1971289426","https://openalex.org/W1981379105","https://openalex.org/W1982202983","https://openalex.org/W1983757156","https://openalex.org/W1986438443","https://openalex.org/W1987908519","https://openalex.org/W1991664409","https://openalex.org/W1993236149","https://openalex.org/W1995718960","https://openalex.org/W2005405628","https://openalex.org/W2011687861","https://openalex.org/W2012753533","https://openalex.org/W2053831749","https://openalex.org/W2068825077","https://openalex.org/W2073889874","https://openalex.org/W2074191990","https://openalex.org/W2076031927","https://openalex.org/W2077858999","https://openalex.org/W2083581022","https://openalex.org/W2084225851","https://openalex.org/W2086943348","https://openalex.org/W2121533623","https://openalex.org/W2125987139","https://openalex.org/W2126816979","https://openalex.org/W2138977668","https://openalex.org/W2140419897","https://openalex.org/W2142546147","https://openalex.org/W2144892629","https://openalex.org/W2149858388","https://openalex.org/W2157333131","https://openalex.org/W2157783208","https://openalex.org/W2165928290","https://openalex.org/W2193225046","https://openalex.org/W2339658711","https://openalex.org/W2403002878","https://openalex.org/W2417685891","https://openalex.org/W2419140434","https://openalex.org/W2512063631","https://openalex.org/W2551607099","https://openalex.org/W2553319198","https://openalex.org/W2572857985","https://openalex.org/W2583102591","https://openalex.org/W2586932047","https://openalex.org/W2588979246","https://openalex.org/W2616279709","https://openalex.org/W2728241634","https://openalex.org/W2740846152","https://openalex.org/W2783064655","https://openalex.org/W2830196912","https://openalex.org/W2888214283","https://openalex.org/W2913402023","https://openalex.org/W2941059778","https://openalex.org/W2943291786","https://openalex.org/W3008507884","https://openalex.org/W3032211477","https://openalex.org/W3033618827","https://openalex.org/W3093815480","https://openalex.org/W3094802395","https://openalex.org/W3108971123","https://openalex.org/W3119440663","https://openalex.org/W3123259121","https://openalex.org/W3127957359","https://openalex.org/W3157045659","https://openalex.org/W3162211776","https://openalex.org/W3171577343","https://openalex.org/W3173566368","https://openalex.org/W3203201080","https://openalex.org/W3205701792","https://openalex.org/W3216297786","https://openalex.org/W4200368450","https://openalex.org/W4205578722","https://openalex.org/W4220982881","https://openalex.org/W4225130866","https://openalex.org/W4231048062","https://openalex.org/W4252225072","https://openalex.org/W4280562926","https://openalex.org/W4282959387","https://openalex.org/W4307055159","https://openalex.org/W4308571878","https://openalex.org/W4308648687","https://openalex.org/W4366083990","https://openalex.org/W4366984620","https://openalex.org/W4382679648","https://openalex.org/W4389470507","https://openalex.org/W4391046269","https://openalex.org/W4391219795","https://openalex.org/W4393411138","https://openalex.org/W4399492328","https://openalex.org/W4402126939"],"related_works":["https://openalex.org/W2901443388","https://openalex.org/W2970781067","https://openalex.org/W3094223197","https://openalex.org/W3123259121","https://openalex.org/W7168358992","https://openalex.org/W2891238565","https://openalex.org/W2911023387","https://openalex.org/W2909141047","https://openalex.org/W2918343083","https://openalex.org/W3098542584"],"abstract_inverted_index":{"Myeloid":[0],"malignancies":[1],"are":[2,146],"a":[3,92,147],"spectrum":[4],"of":[5,19,61,95,106,124,134,149],"clonal":[6],"disorders":[7,44],"driven":[8],"by":[9,65],"genetic":[10],"alterations":[11],"that":[12,82,143],"cooperatively":[13],"confer":[14],"aberrant":[15],"self-renewal":[16],"and":[17,22,36,45,59,75,103,128,159],"differentiation":[18],"hematopoietic":[20],"stem":[21,28],"progenitor":[23],"cells":[24,29,156],"(HSPCs).":[25],"Induced":[26],"pluripotent":[27],"(iPSCs)":[30],"can":[31],"be":[32],"differentiated":[33],"into":[34,119],"HSPCs":[35],"have":[37,52],"been":[38,53],"widely":[39],"explored":[40],"for":[41,68,78,109],"modeling":[42,110,151],"hematologic":[43],"cell":[46],"therapies.":[47],"More":[48],"recently,":[49],"iPSC":[50,107,144],"models":[51,81,108,145],"applied":[54],"to":[55,141],"study":[56],"the":[57,66,69,76,96,98,117,120,132],"origins":[58],"pathophysiology":[60],"myeloid":[62,111],"malignancies,":[63],"motivated":[64],"appreciation":[67],"differences":[70],"in":[71],"human":[72,125,155],"oncogene":[73,126],"function":[74,127],"need":[77],"genetically":[79],"defined":[80],"recapitulate":[83],"leukemia":[84,150],"development.":[85],"In":[86],"this":[87],"review,":[88],"we":[89],"will":[90,114],"provide":[91],"broad":[93],"overview":[94],"rationale,":[97],"challenges,":[99],"practical":[100],"aspects,":[101],"history,":[102],"recent":[104],"advances":[105],"neoplasms.":[112],"We":[113],"focus":[115],"on":[116],"insights":[118],"previously":[121],"unknown":[122],"aspects":[123],"cooperativity":[129],"gained":[130],"through":[131],"use":[133],"these":[135],"models.":[136],"It":[137],"is":[138],"now":[139],"safe":[140],"say":[142],"mainstay":[148],"\"toolbox\"":[152],"alongside":[153],"primary":[154],"from":[157],"normal":[158],"patient":[160],"sources.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-12-13T00:00:00"}