{"id":"https://openalex.org/W4405245488","doi":"https://doi.org/10.1016/j.jve.2024.100451","title":"PP1.2 \u2013 00165 Inhibition of ARP2/3 by HIV Nef Leads to Impaired CD4+ T Cell Function & Dysregulation of Immunity within Progressors but not all HIV Controllers","display_name":"PP1.2 \u2013 00165 Inhibition of ARP2/3 by HIV Nef Leads to Impaired CD4+ T Cell Function & Dysregulation of Immunity within Progressors but not all HIV Controllers","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4405245488","doi":"https://doi.org/10.1016/j.jve.2024.100451"},"language":"en","primary_location":{"id":"doi:10.1016/j.jve.2024.100451","doi":"https://doi.org/10.1016/j.jve.2024.100451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2024.100451","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jve.2024.100451","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D. Dunn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Dunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051858785","display_name":"Jeffrey M. Malgady","orcid":"https://orcid.org/0000-0002-1129-2155","observed_orcids":["https://orcid.org/0000-0002-1129-2155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Malgady","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B. Lima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085924688","display_name":"Jacqueline M. Crater","orcid":"https://orcid.org/0009-0008-5535-6748","observed_orcids":["https://orcid.org/0009-0008-5535-6748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. Crater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025300750","display_name":"Perla M. Del R\u00edo Estrada","orcid":"https://orcid.org/0000-0003-3366-3268","observed_orcids":["https://orcid.org/0000-0003-3366-3268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.M. Del R\u00edo Estrada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076048870","display_name":"Fernanda Torres-Ruiz","orcid":"https://orcid.org/0000-0002-4296-3740","observed_orcids":["https://orcid.org/0000-0002-4296-3740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.F. Torres-Ruiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022887767","display_name":"Yara Andrea Luna-Villalobos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y.A. Luna-Villalobos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040923362","display_name":"M. Gonz\u00e1lez-Navarro","orcid":"https://orcid.org/0000-0001-7710-9774","observed_orcids":["https://orcid.org/0000-0001-7710-9774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Gonz\u00e1lez-Navarro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060164015","display_name":"Colin M Kovacs","orcid":"https://orcid.org/0000-0003-3932-6545","observed_orcids":["https://orcid.org/0000-0003-3932-6545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Kovacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039882839","display_name":"Chunsheng Kang","orcid":"https://orcid.org/0000-0002-3255-3369","observed_orcids":["https://orcid.org/0000-0002-3255-3369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027559931","display_name":"R. Dyche Mullins","orcid":"https://orcid.org/0000-0002-0871-5479","observed_orcids":["https://orcid.org/0000-0002-0871-5479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Mullins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082333058","display_name":"Paul Jolicoeur","orcid":"https://orcid.org/0000-0002-4623-8001","observed_orcids":["https://orcid.org/0000-0002-4623-8001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Jolicoeur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S. \u00c1vila-R\u00edos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. \u00c1vila-R\u00edos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055252960","display_name":"Douglas F. Nixon","orcid":"https://orcid.org/0000-0002-2801-1786","observed_orcids":["https://orcid.org/0000-0002-2801-1786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.F. Nixon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061892862","display_name":"Robert L. Furler O\u2019Brien","orcid":"https://orcid.org/0000-0001-5706-4871","observed_orcids":["https://orcid.org/0000-0001-5706-4871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.L. Furler O\u2019Brien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2730,"currency":"USD","value_usd":2730},"apc_paid":{"value":2730,"currency":"USD","value_usd":2730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"39","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-nef","display_name":"HIV Nef","score":0.9120000004768372},{"id":"https://openalex.org/keywords/arp2-3-complex","display_name":"Arp2/3 complex","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hiv-controllers","display_name":"HIV controllers","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hiv-disease-progression","display_name":"HIV disease progression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6931056976318359},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48671939969062805},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4561937749385834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3652380108833313},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29399582743644714},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24941280484199524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19418415427207947},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16818666458129883}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jve.2024.100451","doi":"https://doi.org/10.1016/j.jve.2024.100451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2024.100451","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jve.2024.100451","doi":"https://doi.org/10.1016/j.jve.2024.100451","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2024.100451","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416449850","https://openalex.org/W4385374797","https://openalex.org/W7143448149","https://openalex.org/W4404174570","https://openalex.org/W2169992693","https://openalex.org/W3044573776","https://openalex.org/W7098472972","https://openalex.org/W3041135657","https://openalex.org/W2506550543","https://openalex.org/W2999153425"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-12-11T00:00:00"}