{"id":"https://openalex.org/W4405201454","doi":"https://doi.org/10.3389/fcimb.2024.1488527","title":"Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies","display_name":"Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies","publication_year":2024,"publication_date":"2024-12-09","ids":{"openalex":"https://openalex.org/W4405201454","doi":"https://doi.org/10.3389/fcimb.2024.1488527","pmid":"https://pubmed.ncbi.nlm.nih.gov/39717542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11663751"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2024.1488527","doi":"https://doi.org/10.3389/fcimb.2024.1488527","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2024.1488527","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1488527/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1488527/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fei Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yu","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101042227","display_name":"Yue Zhu","orcid":"https://orcid.org/0000-0001-7390-7082","observed_orcids":["https://orcid.org/0000-0001-7390-7082"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhu","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101953091","display_name":"Shenghao Li","orcid":"https://orcid.org/0000-0002-7008-8824","observed_orcids":["https://orcid.org/0000-0002-7008-8824"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenghao Li","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424492","display_name":"Liyuan Hao","orcid":"https://orcid.org/0000-0001-9429-5134","observed_orcids":["https://orcid.org/0000-0001-9429-5134"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Hao","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368158","display_name":"Na Li","orcid":"https://orcid.org/0000-0002-8476-511X","observed_orcids":["https://orcid.org/0000-0002-8476-511X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112472580","display_name":"Fanghang Ye","orcid":"https://orcid.org/0000-0001-8088-6099","observed_orcids":["https://orcid.org/0000-0001-8088-6099"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanghang Ye","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101877631","display_name":"Zhi Dong Jiang","orcid":"https://orcid.org/0000-0002-9390-3342","observed_orcids":["https://orcid.org/0000-0002-9390-3342"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Jiang","raw_affiliation_strings":["School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065731483","display_name":"Xiaoyu Hu","orcid":"https://orcid.org/0000-0002-4289-6998","observed_orcids":["https://orcid.org/0000-0002-4289-6998"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyu Hu","raw_affiliation_strings":["Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065731483"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.658,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54467354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"1488527","last_page":"1488527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9089999794960022},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.7689999938011169},{"id":"https://openalex.org/keywords/b-cell-dysfunction","display_name":"B cell dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-engineering","display_name":"T cell engineering","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hepatitis-b-vaccine","display_name":"hepatitis B vaccine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.921999990940094},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6959167718887329},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6397035121917725},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5934739708900452},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5633071064949036},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.501655101776123},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49020034074783325},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.44134968519210815},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4148273169994354},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3782074451446533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3747694790363312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3726915717124939},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2024.1488527","doi":"https://doi.org/10.3389/fcimb.2024.1488527","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2024.1488527","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1488527/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11663751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11663751","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11663751/pdf/fcimb-14-1488527.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:39717542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39717542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:74456f1c14fa45d09f5a5b6fa353c481","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/74456f1c14fa45d09f5a5b6fa353c481","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2024.1488527","doi":"https://doi.org/10.3389/fcimb.2024.1488527","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2024.1488527","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1488527/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3665391640","display_name":null,"funder_award_id":"81-973-840","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4005990155","display_name":null,"funder_award_id":"No. 81973840","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329536","display_name":"Sichuan Provincial Administration of Traditional Chinese Medicine","ror":"https://ror.org/03x55t826"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405201454.pdf","grobid_xml":"https://content.openalex.org/works/W4405201454.grobid-xml"},"referenced_works_count":196,"referenced_works":["https://openalex.org/W64833137","https://openalex.org/W963225957","https://openalex.org/W1495069682","https://openalex.org/W1524584328","https://openalex.org/W1550114353","https://openalex.org/W1556179571","https://openalex.org/W1569848285","https://openalex.org/W1604125540","https://openalex.org/W1799137450","https://openalex.org/W1831873206","https://openalex.org/W1910012553","https://openalex.org/W1932769252","https://openalex.org/W1966644185","https://openalex.org/W1969776963","https://openalex.org/W1973341120","https://openalex.org/W1974257643","https://openalex.org/W1974999149","https://openalex.org/W1983251878","https://openalex.org/W1985294654","https://openalex.org/W1986269759","https://openalex.org/W1989174077","https://openalex.org/W1989942521","https://openalex.org/W1993916127","https://openalex.org/W1998759451","https://openalex.org/W2000347349","https://openalex.org/W2003842888","https://openalex.org/W2006774237","https://openalex.org/W2009053589","https://openalex.org/W2010845447","https://openalex.org/W2013759529","https://openalex.org/W2015035059","https://openalex.org/W2015898002","https://openalex.org/W2016909108","https://openalex.org/W2018732549","https://openalex.org/W2020304403","https://openalex.org/W2027160668","https://openalex.org/W2027828064","https://openalex.org/W2031457861","https://openalex.org/W2033239466","https://openalex.org/W2037610638","https://openalex.org/W2037856116","https://openalex.org/W2040080235","https://openalex.org/W2042172298","https://openalex.org/W2042902850","https://openalex.org/W2050155919","https://openalex.org/W2051670577","https://openalex.org/W2051856608","https://openalex.org/W2053427888","https://openalex.org/W2053744043","https://openalex.org/W2054119257","https://openalex.org/W2055897422","https://openalex.org/W2062029576","https://openalex.org/W2066090902","https://openalex.org/W2076027168","https://openalex.org/W2077116159","https://openalex.org/W2080636456","https://openalex.org/W2086397613","https://openalex.org/W2088160623","https://openalex.org/W2088541970","https://openalex.org/W2092233067","https://openalex.org/W2097855813","https://openalex.org/W2098412041","https://openalex.org/W2099311229","https://openalex.org/W2100474263","https://openalex.org/W2101700945","https://openalex.org/W2101844985","https://openalex.org/W2104411113","https://openalex.org/W2104981376","https://openalex.org/W2105853552","https://openalex.org/W2106166533","https://openalex.org/W2106503186","https://openalex.org/W2107598346","https://openalex.org/W2111049347","https://openalex.org/W2112606808","https://openalex.org/W2117407070","https://openalex.org/W2118613671","https://openalex.org/W2119954580","https://openalex.org/W2123781724","https://openalex.org/W2125792818","https://openalex.org/W2129105278","https://openalex.org/W2130992177","https://openalex.org/W2131640081","https://openalex.org/W2132205831","https://openalex.org/W2135847964","https://openalex.org/W2137661705","https://openalex.org/W2139237097","https://openalex.org/W2139591061","https://openalex.org/W2139621564","https://openalex.org/W2140430530","https://openalex.org/W2140821709","https://openalex.org/W2144373841","https://openalex.org/W2147283902","https://openalex.org/W2149121521","https://openalex.org/W2150640296","https://openalex.org/W2152501552","https://openalex.org/W2155233940","https://openalex.org/W2159616534","https://openalex.org/W2161211472","https://openalex.org/W2162097247","https://openalex.org/W2164978829","https://openalex.org/W2167744756","https://openalex.org/W2167827953","https://openalex.org/W2179234980","https://openalex.org/W2179306611","https://openalex.org/W2221555640","https://openalex.org/W2229789789","https://openalex.org/W2301531244","https://openalex.org/W2337600205","https://openalex.org/W2398313845","https://openalex.org/W2404295888","https://openalex.org/W2429956850","https://openalex.org/W2481374159","https://openalex.org/W2481773770","https://openalex.org/W2506616866","https://openalex.org/W2552251488","https://openalex.org/W2593747853","https://openalex.org/W2594333172","https://openalex.org/W2611875906","https://openalex.org/W2737143554","https://openalex.org/W2766842037","https://openalex.org/W2774064974","https://openalex.org/W2785853755","https://openalex.org/W2788975052","https://openalex.org/W2791467214","https://openalex.org/W2791839818","https://openalex.org/W2801167100","https://openalex.org/W2830145191","https://openalex.org/W2885273410","https://openalex.org/W2886930165","https://openalex.org/W2888221155","https://openalex.org/W2890832308","https://openalex.org/W2893004607","https://openalex.org/W2893983296","https://openalex.org/W2900492873","https://openalex.org/W2902093905","https://openalex.org/W2906634874","https://openalex.org/W2933300836","https://openalex.org/W2942765969","https://openalex.org/W2944650546","https://openalex.org/W2950867530","https://openalex.org/W2962219096","https://openalex.org/W2965094856","https://openalex.org/W2971814824","https://openalex.org/W2976125874","https://openalex.org/W2978131638","https://openalex.org/W2983753547","https://openalex.org/W2995147324","https://openalex.org/W2995708175","https://openalex.org/W3007378086","https://openalex.org/W3010530314","https://openalex.org/W3013747805","https://openalex.org/W3018993583","https://openalex.org/W3025321958","https://openalex.org/W3027504226","https://openalex.org/W3036847945","https://openalex.org/W3082987907","https://openalex.org/W3086711508","https://openalex.org/W3108478127","https://openalex.org/W3111908242","https://openalex.org/W3112011385","https://openalex.org/W3116103979","https://openalex.org/W3119060209","https://openalex.org/W3131835893","https://openalex.org/W3157163723","https://openalex.org/W3161173384","https://openalex.org/W3186617101","https://openalex.org/W3193509611","https://openalex.org/W3197695552","https://openalex.org/W3211216779","https://openalex.org/W3215261291","https://openalex.org/W4213451834","https://openalex.org/W4225007514","https://openalex.org/W4233356386","https://openalex.org/W4237552565","https://openalex.org/W4238480525","https://openalex.org/W4239810775","https://openalex.org/W4247769344","https://openalex.org/W4251633039","https://openalex.org/W4280519745","https://openalex.org/W4281678371","https://openalex.org/W4291737435","https://openalex.org/W4296380298","https://openalex.org/W4296808601","https://openalex.org/W4306672691","https://openalex.org/W4311018430","https://openalex.org/W4313682868","https://openalex.org/W4323653103","https://openalex.org/W4362519931","https://openalex.org/W4362521475","https://openalex.org/W4381890104","https://openalex.org/W4386541666","https://openalex.org/W4388692094","https://openalex.org/W4389925050","https://openalex.org/W4400324424","https://openalex.org/W4403806489","https://openalex.org/W6602626647"],"related_works":["https://openalex.org/W2134319200","https://openalex.org/W3208441054","https://openalex.org/W4416029904","https://openalex.org/W4412041731","https://openalex.org/W4210274396","https://openalex.org/W3010259006","https://openalex.org/W3025321958","https://openalex.org/W2512097819","https://openalex.org/W4361212372","https://openalex.org/W4385687565"],"abstract_inverted_index":{"In":[0],"the":[1,10,45,51,95,100,114,160,167],"context":[2],"of":[3,13,38,44,75,103,169],"chronic":[4,78,107],"hepatitis":[5,79],"B":[6,80],"virus":[7,47],"(HBV)":[8],"infection,":[9],"continuous":[11],"replication":[12,29],"HBV":[14,46,108,150],"within":[15],"host":[16],"hepatocytes":[17],"is":[18,48,112],"a":[19,36,176],"characteristic":[20],"feature.":[21],"Rather":[22],"than":[23],"directly":[24],"causing":[25],"hepatocyte":[26],"destruction,":[27],"this":[28],"leads":[30],"to":[31],"immune":[32,40,90],"dysfunction":[33,76],"and":[34,56,65,86,127,135,146,171,183],"establishes":[35],"state":[37],"T-B":[39,104],"tolerance.":[41],"Successful":[42],"clearance":[43],"dependent":[49],"on":[50,113],"close":[52],"collaboration":[53],"between":[54],"humoral":[55],"cellular":[57,66],"immunity.":[58],"Humoral":[59],"immunity,":[60,67],"mediated":[61],"by":[62,69,163],"B-cell":[63],"subpopulations,":[64],"dominated":[68],"T-cell":[70],"subpopulations":[71],"show":[72],"varying":[73],"degrees":[74],"during":[77,106],"(CHB).":[81],"Notably,":[82],"not":[83],"all":[84],"T-":[85],"B-cells":[87],"produce":[88],"positive":[89],"responses.":[91],"This":[92],"review":[93],"examine":[94],"most":[96],"recent":[97],"developments":[98],"in":[99],"mutual":[101],"regulation":[102],"cells":[105],"infection.":[109],"Our":[110],"focus":[111],"prevailing":[115],"immunotherapeutic":[116],"strategies,":[117],"such":[118],"as":[119],"T":[120],"cell":[121],"engineering,":[122],"HBV-related":[123],"vaccines,":[124],"PD-1":[125],"inhibitors,":[126],"Toll-like":[128],"receptor":[129],"agonists.":[130],"While":[131],"nucleos(t)ide":[132],"analogues":[133],"(NUCs)":[134],"interferons":[136],"have":[137,153],"notable":[138],"limitations,":[139],"including":[140],"inadequate":[141],"viral":[142],"suppression,":[143],"drug":[144],"resistance,":[145],"adverse":[147],"reactions,":[148],"several":[149],"entry":[151],"inhibitors":[152],"shown":[154],"promising":[155,177],"clinical":[156],"efficacy.":[157],"To":[158],"overcome":[159],"challenges":[161],"posed":[162],"NUCs":[164],"or":[165],"monotherapy,":[166],"combination":[168],"immunotherapy":[170],"novel":[172],"antiviral":[173],"agents":[174],"presents":[175],"avenue":[178],"for":[179],"future":[180],"CHB":[181],"treatment":[182],"potential":[184],"cure.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-12-10T00:00:00"}
