{"id":"https://openalex.org/W4405154939","doi":"https://doi.org/10.1136/emermed-2024-999.31","title":"PP31 Use of a lateral flow assay (LVOne) test for ambulance large vessel occlusion stroke recognition and management: feasibility study protocol (RADIOS)","display_name":"PP31 Use of a lateral flow assay (LVOne) test for ambulance large vessel occlusion stroke recognition and management: feasibility study protocol (RADIOS)","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4405154939","doi":"https://doi.org/10.1136/emermed-2024-999.31"},"language":"en","primary_location":{"id":"doi:10.1136/emermed-2024-999.31","doi":"https://doi.org/10.1136/emermed-2024-999.31","is_oa":true,"landing_page_url":"https://doi.org/10.1136/emermed-2024-999.31","pdf_url":"https://emj.bmj.com/content/emermed/41/Suppl_3/A14.1.full.pdf","source":{"id":"https://openalex.org/S4363604354","display_name":"Poster presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poster presentations","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://emj.bmj.com/content/emermed/41/Suppl_3/A14.1.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076700303","display_name":"Larissa Stella Prothero","orcid":"https://orcid.org/0000-0002-5440-8429","observed_orcids":["https://orcid.org/0000-0002-5440-8429"]},"institutions":[{"id":"https://openalex.org/I4210164636","display_name":"East of England Ambulance Service NHS Trust","ror":"https://ror.org/05anzrg13","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210164636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Larissa Prothero","raw_affiliation_strings":["East of England Ambulance Service NHS Trust, Barton Mills, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East of England Ambulance Service NHS Trust, Barton Mills, UK","institution_ids":["https://openalex.org/I4210164636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051595054","display_name":"Theresa Foster","orcid":"https://orcid.org/0000-0002-6395-0885","observed_orcids":["https://orcid.org/0000-0002-6395-0885"]},"institutions":[{"id":"https://openalex.org/I4210164636","display_name":"East of England Ambulance Service NHS Trust","ror":"https://ror.org/05anzrg13","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210164636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Theresa Foster","raw_affiliation_strings":["East of England Ambulance Service NHS Trust, Barton Mills, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East of England Ambulance Service NHS Trust, Barton Mills, UK","institution_ids":["https://openalex.org/I4210164636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067292795","display_name":"Isuru Induruwa","orcid":"https://orcid.org/0000-0002-7020-8179","observed_orcids":["https://orcid.org/0000-0002-7020-8179"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Isuru Induruwa","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091142062","display_name":"Edoardo Gaude","orcid":"https://orcid.org/0000-0001-8523-7792","observed_orcids":["https://orcid.org/0000-0001-8523-7792"]},"institutions":[{"id":"https://openalex.org/I4405267902","display_name":"PocKit Diagnostics Ltd. (United Kingdom)","ror":"https://ror.org/04xsd6k54","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edoardo Gaude","raw_affiliation_strings":["Upfront TIME IS LIFE, Pockit diagnostics Ltd, Allia Future Business Centre, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upfront TIME IS LIFE, Pockit diagnostics Ltd, Allia Future Business Centre, Cambridge, UK","institution_ids":["https://openalex.org/I4405267902"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069550548","display_name":"Elizabeth A. Warburton","orcid":"https://orcid.org/0000-0003-2575-3255","observed_orcids":["https://orcid.org/0000-0003-2575-3255"]},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Warburton","raw_affiliation_strings":["Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A14.1","last_page":"A14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11095","display_name":"Emergency and Acute Care Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-vessel-occlusion-stroke","display_name":"large vessel occlusion stroke","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lateral-flow-assay","display_name":"lateral flow assay","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ambulance-clinicians","display_name":"ambulance clinicians","score":0.8970000147819519},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thrombectomy","display_name":"thrombectomy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/fast-score","display_name":"FAST score","score":0.5389999747276306},{"id":"https://openalex.org/keywords/feasibility","display_name":"feasibility","score":0.38600000739097595},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.5975741744041443},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5418165326118469},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5204396843910217},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.4917927086353302},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4456508755683899},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.41106516122817993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38939934968948364},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.3808189928531647},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2908323407173157},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17287340760231018},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.09147775173187256},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.074181467294693},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/emermed-2024-999.31","doi":"https://doi.org/10.1136/emermed-2024-999.31","is_oa":true,"landing_page_url":"https://doi.org/10.1136/emermed-2024-999.31","pdf_url":"https://emj.bmj.com/content/emermed/41/Suppl_3/A14.1.full.pdf","source":{"id":"https://openalex.org/S4363604354","display_name":"Poster presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poster presentations","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/emermed-2024-999.31","doi":"https://doi.org/10.1136/emermed-2024-999.31","is_oa":true,"landing_page_url":"https://doi.org/10.1136/emermed-2024-999.31","pdf_url":"https://emj.bmj.com/content/emermed/41/Suppl_3/A14.1.full.pdf","source":{"id":"https://openalex.org/S4363604354","display_name":"Poster presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poster presentations","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405154939.pdf","grobid_xml":"https://content.openalex.org/works/W4405154939.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3086692397","https://openalex.org/W2095216647","https://openalex.org/W4382561102","https://openalex.org/W2299928030","https://openalex.org/W2055533257","https://openalex.org/W4225320867","https://openalex.org/W3151182984","https://openalex.org/W2136340243","https://openalex.org/W2460041365","https://openalex.org/W2408290666"],"abstract_inverted_index":{"Background":[0],"Rapid":[1],"diagnosis":[2,138],"of":[3,35,43,68,175,205,218,267,284],"large":[4,38],"vessel":[5],"occlusion":[6],"(LVO)":[7],"stroke":[8,46,51,77,105,146,239,274],"is":[9],"crucial":[10],"for":[11,54,75,145,180,237],"timely":[12],"thrombectomy":[13,297],"and":[14,25,66,186,277,298],"optimal":[15],"patient":[16,209,299],"outcomes.":[17,300],"The":[18],"LVOne":[19,70,100,160,176,206,270,290],"test":[20,101,161,178,236,271,291],"evaluates":[21],"capillary":[22],"blood":[23,39],"D-dimer":[24],"glial":[26],"fibrillary":[27],"acidic":[28],"protein":[29],"(GFAP)":[30],"to":[31,49,62,102,133,200,225,254,288,296],"determine":[32,63,201],"the":[33,64,99,142,170,202,226,242,265,269,278,282],"presence":[34],"a":[36,44,167],"cerebral":[37],"clot.":[40],"Pre-hospital":[41],"recognition":[42],"LVO":[45],"offers":[47],"opportunities":[48],"reduce":[50],"onset-to-needle":[52],"time":[53],"clot":[55],"removal.":[56],"This":[57,258],"prospective":[58],"feasibility":[59,168,204,212,266],"study":[60,259],"aims":[61],"usability":[65],"practicality":[67],"implementing":[69],"tests":[71],"by":[72],"ambulance":[73,81,90,95,163,208,238,294],"clinicians":[74,91,164],"suspected":[76,104],"patients":[78,115],"receiving":[79],"emergency":[80],"care.":[82],"Methods":[83],"During":[84],"July":[85],"\u2013":[86],"September":[87],"2024,":[88],"15":[89],"from":[92,113],"one":[93],"UK":[94],"service":[96],"will":[97,110,139,165,172,194,213,246,260,280],"deliver":[98],"30":[103],"patients.":[106],"Retrospective":[107],"research":[108],"consent":[109],"be":[111,195,214,247],"sought":[112],"these":[114],"following":[116],"hospital":[117],"admission.":[118],"Patient":[119],"inclusion":[120],"criteria:":[121],"age":[122],"\u2265":[123],"18yrs;":[124],"FAST":[125],"score":[126],"\u22652;":[127],"symptom":[128],"onset":[129],"\u2264":[130],"6hrs,":[131],"conveyed":[132],"thrombectomy-capable":[134],"hospital.":[135],"Expert":[136],"clinician":[137],"serve":[140],"as":[141,216],"reference":[143],"standard":[144],"type":[147],"(ischaemic":[148],"+/-":[149],"LVO,":[150],"intracerebral":[151],"haemorrhage,":[152],"transient":[153],"ischaemic":[154],"attack":[155],"or":[156],"non-stroke":[157],"mimic).":[158],"Following":[159],"completion,":[162],"complete":[166],"questionnaire,":[169],"topics":[171],"include":[173],"ease":[174],"delivery;":[177],"instructions":[179],"use;":[181],"advice":[182],"materials;":[183],"assay":[184],"interpretation":[185],"user":[187],"confidence.":[188],"Results":[189],"Ambulance":[190],"clinicians\u2019":[191],"questionnaire":[192],"responses":[193],"analysed":[196],"using":[197],"qualitative":[198],"approaches":[199],"overall":[203],"during":[207],"assessment.":[210],"Overall":[211],"reported":[215],"percentage":[217],"positive":[219],"(\u2018Yes\u2019)":[220],"vs":[221],"negative":[222],"(\u2018No\u2019)":[223],"opinions":[224],"question:":[227],"\u2018Considering":[228],"your":[229],"answers":[230],"above,":[231],"would":[232],"you":[233],"recommend":[234],"this":[235,255],"assessment":[240],"in":[241],"future?\u2019.":[243],"Acceptance":[244],"criteria":[245],"that":[248],"at":[249],"least":[250],"75%":[251],"answer":[252],"\u2018Yes\u2019":[253],"question.":[256],"Conclusion":[257],"provide":[261],"valuable":[262],"insights":[263],"into":[264,272],"integrating":[268],"pre-hospital":[273],"evaluation":[275],"workflows,":[276],"findings":[279],"inform":[281],"design":[283],"future":[285],"implementation":[286],"studies":[287],"evaluate":[289],"efficacy":[292],"on":[293],"referral":[295]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}