{"id":"https://openalex.org/W4405113360","doi":"https://doi.org/10.70905/bmcj.04.02.0155","title":"Efficacy of Oral Methotrexate in the treatment of Plaque Psoriasis in a local population","display_name":"Efficacy of Oral Methotrexate in the treatment of Plaque Psoriasis in a local population","publication_year":2023,"publication_date":"2023-12-20","ids":{"openalex":"https://openalex.org/W4405113360","doi":"https://doi.org/10.70905/bmcj.04.02.0155"},"language":"en","primary_location":{"id":"doi:10.70905/bmcj.04.02.0155","doi":"https://doi.org/10.70905/bmcj.04.02.0155","is_oa":true,"landing_page_url":"https://doi.org/10.70905/bmcj.04.02.0155","pdf_url":null,"source":{"id":"https://openalex.org/S5407031307","display_name":"BMC Journal of Medical Sciences","issn_l":"2790-3419","issn":["2790-3419","2790-3427"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.70905/bmcj.04.02.0155","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091542830","display_name":"Attiya Tareen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Attiya Tareen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016237530","display_name":"Sohaib Asghar","orcid":"https://orcid.org/0000-0001-8276-0131","observed_orcids":["https://orcid.org/0000-0001-8276-0131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sohaib Asghar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073239564","display_name":"Uzma Dost Muhammad Rajar","orcid":"https://orcid.org/0009-0004-2633-5391","observed_orcids":["https://orcid.org/0009-0004-2633-5391","https://orcid.org/0000-0001-5164-1009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uzma Rajar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Hadia Yaqub Khan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hadia Yaqub Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010694287","display_name":"Dujanah Siddique Bhatti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dujanah Bhatti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Maryam Asad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maryam Asad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"2","first_page":"52","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oral-methotrexate","display_name":"oral methotrexate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pasi-score","display_name":"PASI score","score":0.8529999852180481},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.8809999823570251},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.722000002861023},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.925000011920929},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6639999747276306},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/pakistani-patients","display_name":"Pakistani patients","score":0.4259999990463257},{"id":"https://openalex.org/keywords/rawalpindi","display_name":"Rawalpindi","score":0.44200000166893005},{"id":"https://openalex.org/keywords/lahore","display_name":"Lahore","score":0.31200000643730164},{"id":"https://openalex.org/keywords/islamabad","display_name":"Islamabad","score":0.3529999852180481},{"id":"https://openalex.org/keywords/peshawar","display_name":"Peshawar","score":0.6309999823570251},{"id":"https://openalex.org/keywords/faisalabad","display_name":"Faisalabad","score":0.6179999709129333},{"id":"https://openalex.org/keywords/multan","display_name":"Multan","score":0.5339999794960022},{"id":"https://openalex.org/keywords/kashmir-valley","display_name":"Kashmir Valley","score":0.49399998784065247},{"id":"https://openalex.org/keywords/kashmiri-pandits","display_name":"Kashmiri Pandits","score":0.382999986410141},{"id":"https://openalex.org/keywords/kashmiri-muslims","display_name":"Kashmiri Muslims","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C3020604521","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Plaque psoriasis","level":3,"score":0.8606400489807129},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7805414199829102},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7660315036773682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6543705463409424},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5812329649925232},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44519880414009094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2782089114189148},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07171645760536194}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.70905/bmcj.04.02.0155","doi":"https://doi.org/10.70905/bmcj.04.02.0155","is_oa":true,"landing_page_url":"https://doi.org/10.70905/bmcj.04.02.0155","pdf_url":null,"source":{"id":"https://openalex.org/S5407031307","display_name":"BMC Journal of Medical Sciences","issn_l":"2790-3419","issn":["2790-3419","2790-3427"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Journal of Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.70905/bmcj.04.02.0155","doi":"https://doi.org/10.70905/bmcj.04.02.0155","is_oa":true,"landing_page_url":"https://doi.org/10.70905/bmcj.04.02.0155","pdf_url":null,"source":{"id":"https://openalex.org/S5407031307","display_name":"BMC Journal of Medical Sciences","issn_l":"2790-3419","issn":["2790-3419","2790-3427"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171051150","https://openalex.org/W2315730602","https://openalex.org/W4253277696","https://openalex.org/W2912402729","https://openalex.org/W2606543134","https://openalex.org/W4236468298","https://openalex.org/W3201343581","https://openalex.org/W2801966625","https://openalex.org/W2911225966","https://openalex.org/W2048102263"],"abstract_inverted_index":{"Background:":[0],"Plaque":[1],"psoriasis":[2,7,46,57,99,180,483,505],"constitutes":[3],"around":[4],"90%":[5],"of":[6,28,37,119,140,161,174,184,201,248,299,333,358,369,383,395,410,434,448,459,461,471,498],"prevalent":[8],"in":[9,58,121,137,188,198,331,354,365,428,490],"the":[10,29,115,138,157,162,189,193,286,340,366,477,499],"world.":[11],"It\u2019s":[12],"medically":[13],"introduced":[14],"as":[15,92,266],"well":[16],"demarcated":[17],"erythematous":[18],"plaques":[19],"with":[20,181,391,503],"coarse":[21],"silvery":[22],"scales":[23],"predominantly":[24],"involving":[25],"extensor":[26],"surfaces":[27],"knees,":[30],"elbows,":[31],"sacrum,":[32],"scalp,":[33],"nails":[34],"and":[35,47,103,117,126,133,214,232,272,291,307,404],"sites":[36],"injury.":[38],"Methotrexate":[39],"has":[40,474],"been":[41],"widely":[42],"used":[43,53],"to":[44,54,62,74,96,149,171,209,235,256,318,480],"treat":[45,55,97,481],"associated":[48,502],"arthritis,":[49,376],"it":[50],"is":[51,67,79,325,484,488,496],"mainly":[52],"plaque":[56,98,123,178,482,504],"patients":[59,70,168,210,279,386],"not":[60],"responding":[61],"topical":[63,75],"therapy.":[64],"Systemic":[65],"therapy":[66],"required":[68],"for":[69,206,278],"who":[71],"don\u2019t":[72],"respond":[73],"or":[76,218,451],"where":[77],"there":[78],"extensive":[80],"disease.":[81],"These":[82],"include":[83],"photochemotherapy,":[84],"ciclosporin,":[85],"biological":[86],"agents.2,9":[87],"Various":[88],"studies":[89],"show":[90],"methotrexate":[91,120,197,246,418,435,486],"an":[93],"efficient":[94,489],"drug":[95],"by":[100,107,156,339],"reducing":[101,104],"inflammation,":[102],"cell":[105],"proliferation":[106],"exerting":[108],"its":[109],"immunosuppressant":[110],"effect.":[111],"Objective:":[112],"To":[113],"determine":[114],"safety":[116],"efficacy":[118],"treating":[122,491],"psoriasis.":[124],"Materials":[125],"Methods:":[127],"The":[128,304,329,469],"interventional":[129],"descriptive":[130],"single-arm":[131],"pre":[132],"post-study":[134],"was":[135,154,204,251,301,337,352,361],"conducted":[136],"department":[139],"dermatology":[141,212],"Fauji":[142],"Foundation":[143],"Hospital":[144],"Rawalpindi":[145],"from":[146,177,211,315,335],"August":[147],"2018":[148],"January":[150],"2021.":[151],"This":[152],"research":[153],"approved":[155],"ethical":[158],"review":[159],"committee":[160],"hospital.":[163],"One":[164],"hundred":[165],"forty":[166],"two":[167],"between":[169,253],"15":[170],"60":[172],"years":[173],"age":[175,298],"suffering":[176],"type":[179],"PASI":[182,271,310,334,350],"score":[183,311,368,394,416,447,458],">8":[185],"were":[186,264,289,294],"included":[187],"study":[190,473],"after":[191,345,431,465],"taking":[192],"informed":[194],"consent.":[195],"Oral":[196],"a":[199,245,362,438],"dose":[200],"10":[202],"mg/week":[203],"given":[205],"8":[207,346,432,466],"weeks":[208,320,347,433],"outdoor":[213],"Indoor.":[215],"(PASI":[216],"6":[217,378],"greater).Baseline":[219],"blood":[220,222],"counts,":[221],"urea":[223],"nitrogen,":[224],"serum":[225],"creatinine,":[226],"electrolytes,":[227],"alkaline":[228],"phosphatase,":[229],"alanine":[230],"aminotransferase":[231],"chest":[233],"Xray":[234],"rule":[236],"out":[237,382],"latent":[238],"tuberculosis.":[239],"They":[240],"all":[241,285],"got":[242],"cured":[243],"through":[244,485],"dosage":[247],"10mg":[249],"that":[250,380,476],"adjusted":[252],"5":[254,398],"mg":[255,258],"25":[257],"based":[259],"on":[260],"individual":[261],"conditions.":[262],"Outcomes":[263],"measured":[265],"Psoriasis":[267],"Area":[268],"Severity":[269],"Index":[270],"Disease":[273],"Activity":[274],"Score":[275],"DAS":[276,392,414,445],"28":[277,393,415,446],"having":[280,371],"psoriatic":[281,493],"arthritis.":[282,373],"Results:":[283],"Of":[284],"participants":[287,300,370],"116(81.1%)":[288],"female":[290],"26":[292,381],"(18.2%)":[293],"male":[295],"whereas":[296],"mean":[297,305],"41.6":[302],"years.":[303],"pretreatment":[306],"post":[308,321],"treatment":[309,322,436],"shows":[312,379],"significant":[313,327],"drop":[314],"baseline":[316,336],"(13.01+6.02)":[317],"eight":[319],"(5.4+3.2)":[323],"which":[324,487,495],"statistically":[326],"(P=<0.05).":[328],"change":[330],"percentage":[332],"analyzed":[338],"Wilcoxon":[341],"signed":[342],"ranks":[343],"test":[344],"(t=17.29)":[348],"ie":[349,422],"75":[351],"achieved":[353,425],"more":[355],"than":[356,397,412,463],"50%":[357],"participants.":[359],"There":[360],"marked":[363],"improvement":[364],"DAS28":[367,460],"Psoriatic":[372,375,389],"Regarding":[374],"Table":[377],"29":[384],"(96.29%)":[385],"had":[387,402,406,444,456],"moderate":[388,452],"arthritis":[390,494],"less":[396],"while":[399,437,454],"1(3.7%)":[400],"patient":[401],"mild":[403],"2(7.4%)":[405],"severe":[407],"joint":[408,429],"disease":[409,430],"greater":[411,462],"5.1":[413,450,464],"before":[417],"treatment.":[419],"However":[420],"majority":[421],"17/29":[423],"(62.9%)":[424],"complete":[426],"remission":[427,453],"small":[439],"number":[440],"2/29":[441],"(7.4%)":[442],"still":[443],"upto":[449],"none":[455],"high":[457],"weeks.":[467],"Conclusion:":[468],"outcome":[470],"this":[472],"shown":[475],"effective":[478],"way":[479],"coexisting":[492],"one":[497],"important":[500],"commodities":[501]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-12-07T00:00:00"}