{"id":"https://openalex.org/W4405073718","doi":"https://doi.org/10.7554/elife.93493.3.sa3","title":"Author response: Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus","display_name":"Author response: Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus","publication_year":2024,"publication_date":"2024-12-05","ids":{"openalex":"https://openalex.org/W4405073718","doi":"https://doi.org/10.7554/elife.93493.3.sa3"},"language":"en","primary_location":{"id":"doi:10.7554/elife.93493.3.sa3","doi":"https://doi.org/10.7554/elife.93493.3.sa3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.93493.3.sa3","pdf_url":"https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvOTM0OTMvZWxpZmUtOTM0OTMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzkzNDkz/elife-93493-v1.pdf?_hash=6VushtNRV2HPDSF9EnR6z80tZgJmF0NZSJ5zq0jf2aI%3D","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvOTM0OTMvZWxpZmUtOTM0OTMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzkzNDkz/elife-93493-v1.pdf?_hash=6VushtNRV2HPDSF9EnR6z80tZgJmF0NZSJ5zq0jf2aI%3D","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091343156","display_name":"Jasmine Rowell","orcid":"https://orcid.org/0000-0001-7040-8528","observed_orcids":["https://orcid.org/0000-0001-7040-8528"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jasmine Rowell","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046938903","display_name":"Ching\u2010In Lau","orcid":"https://orcid.org/0000-0002-7597-3478","observed_orcids":["https://orcid.org/0000-0002-7597-3478"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ching-In Lau","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102084992","display_name":"Susan E. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan Ross","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020970949","display_name":"Diana C. Y\u00e1nez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Diana Yanez","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028193821","display_name":"Oscar A Pe\u00f1a","orcid":"https://orcid.org/0000-0002-2582-0238","observed_orcids":["https://orcid.org/0000-0002-2582-0238"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oscar A Pe\u00f1a","raw_affiliation_strings":["University of Bristol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038209629","display_name":"Benny Chain","orcid":"https://orcid.org/0000-0002-7417-3970","observed_orcids":["https://orcid.org/0000-0002-7417-3970"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benny Chain","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059378933","display_name":"Tessa Crompton","orcid":"https://orcid.org/0000-0002-8973-4021","observed_orcids":["https://orcid.org/0000-0002-8973-4021"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tessa Crompton","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7310000061988831},{"id":"https://openalex.org/keywords/adult-thymus","display_name":"adult thymus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mhc-restriction","display_name":"MHC restriction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/traj","display_name":"traJ","score":0.9900000095367432},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.5559999942779541},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.8508989214897156},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5672938823699951},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5551368594169617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48348790407180786},{"id":"https://openalex.org/C197695756","wikidata":"https://www.wikidata.org/wiki/Q1750372","display_name":"MHC restriction","level":5,"score":0.44224974513053894},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4216785728931427},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.40290915966033936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3701944947242737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34504234790802},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20214492082595825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.93493.3.sa3","doi":"https://doi.org/10.7554/elife.93493.3.sa3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.93493.3.sa3","pdf_url":"https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvOTM0OTMvZWxpZmUtOTM0OTMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzkzNDkz/elife-93493-v1.pdf?_hash=6VushtNRV2HPDSF9EnR6z80tZgJmF0NZSJ5zq0jf2aI%3D","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.93493.3.sa3","doi":"https://doi.org/10.7554/elife.93493.3.sa3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.93493.3.sa3","pdf_url":"https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvOTM0OTMvZWxpZmUtOTM0OTMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzkzNDkz/elife-93493-v1.pdf?_hash=6VushtNRV2HPDSF9EnR6z80tZgJmF0NZSJ5zq0jf2aI%3D","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1443375439","display_name":"Impact of Hedgehog signalling on the T cell receptor (TCR) repertoire","funder_award_id":"1903458","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1536507898","display_name":"Hedgehog signalling in gamma delta T-cell differentiation","funder_award_id":"BB/T020970/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5967751213","display_name":"Foxa1/A2, Shh and Gli3 in T lymphocyte development","funder_award_id":"MR/S037764/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7779453469","display_name":"Hedgehog signalling in peripheral T cell differentiation and function","funder_award_id":"MR/P000843/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334734","display_name":"Great Ormond Street Institute of Child Health","ror":"https://ror.org/02jx3x895"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405073718.pdf","grobid_xml":"https://content.openalex.org/works/W4405073718.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392460097","https://openalex.org/W1979836429","https://openalex.org/W2022860720","https://openalex.org/W2093454386","https://openalex.org/W7098240000","https://openalex.org/W2085115144","https://openalex.org/W7098080303","https://openalex.org/W7095987721","https://openalex.org/W2064670841","https://openalex.org/W2097815590"],"abstract_inverted_index":{"This":[0],"important":[1],"manuscript":[2],"provides":[3],"an":[4],"extensive":[5],"and":[6,12,59],"convincing":[7],"analysis":[8],"of":[9,22,50],"the":[10,17,23,27],"foetal":[11],"adult":[13],"TCR":[14,60],"repertoire":[15],"in":[16,45],"mouse":[18],"thymus.A":[19],"potential":[20],"implication":[21],"work":[24],"is":[25],"that":[26,37],"earliest":[28],"appearing":[29,43],"T":[30,56],"cells":[31],"during":[32],"ontogeny":[33],"may":[34],"have":[35],"properties":[36],"are":[38],"fundamentally":[39],"distinct":[40],"from":[41],"those":[42],"later":[44],"life.The":[46],"study":[47],"will":[48],"be":[49],"interest":[51],"to":[52],"immunologists":[53],"concerned":[54],"with":[55],"cell":[57],"development":[58],"repertoires.":[61]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2024-12-06T00:00:00"}
