{"id":"https://openalex.org/W4405050008","doi":"https://doi.org/10.1182/blood-2024-209403","title":"Application of a Phenotype-Based Predictive Analytic in a Phase Ib Study of Selinexor and Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia","display_name":"Application of a Phenotype-Based Predictive Analytic in a Phase Ib Study of Selinexor and Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405050008","doi":"https://doi.org/10.1182/blood-2024-209403"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-209403","doi":"https://doi.org/10.1182/blood-2024-209403","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-209403","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/6012/2321872/blood-8840-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/6012/2321872/blood-8840-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040675080","display_name":"Somedeb Ball","orcid":"https://orcid.org/0000-0002-1754-1204","observed_orcids":["https://orcid.org/0000-0002-1754-1204"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somedeb Ball","raw_affiliation_strings":["1Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040815890","display_name":"Michael Thomas Byrne","orcid":"https://orcid.org/0000-0002-2966-4877","observed_orcids":["https://orcid.org/0000-0002-2966-4877"]},"institutions":[{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Byrne","raw_affiliation_strings":["2Tennessee Oncology, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tennessee Oncology, Nashville, TN","institution_ids":["https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064840115","display_name":"Melissa Ann Fischer","orcid":"https://orcid.org/0000-0003-2664-3541","observed_orcids":["https://orcid.org/0000-0003-2664-3541","https://orcid.org/0000-0001-6931-6087"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A Fischer","raw_affiliation_strings":["3Department of Medicine, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059854479","display_name":"Farrukh Tauseef Awan","orcid":"https://orcid.org/0000-0003-1813-9812","observed_orcids":["https://orcid.org/0000-0003-1813-9812"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farrukh T. Awan","raw_affiliation_strings":["4Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105988528","display_name":"Ben Kent Tomlinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben K. Tomlinson","raw_affiliation_strings":["5Department of Hematology and Stem Cell Transplant, University Hospitals Seidman Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Hematology and Stem Cell Transplant, University Hospitals Seidman Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4210119077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056037255","display_name":"Tess Stopczynski","orcid":"https://orcid.org/0000-0001-5530-5045","observed_orcids":["https://orcid.org/0000-0001-5530-5045"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tess Stopczynski","raw_affiliation_strings":["6Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lokesh Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130485","display_name":"Notable Labs (United States)","ror":"https://ror.org/03b9h7664","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130485"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lokesh Patil","raw_affiliation_strings":["7Notable Labs, Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Notable Labs, Foster City, CA","institution_ids":["https://openalex.org/I4210130485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031373184","display_name":"Christine J. Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130485","display_name":"Notable Labs (United States)","ror":"https://ror.org/03b9h7664","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130485"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine J. Gu","raw_affiliation_strings":["7Notable Labs, Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Notable Labs, Foster City, CA","institution_ids":["https://openalex.org/I4210130485"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chris Leonardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130485","display_name":"Notable Labs (United States)","ror":"https://ror.org/03b9h7664","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130485"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Leonardi","raw_affiliation_strings":["7Notable Labs, Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Notable Labs, Foster City, CA","institution_ids":["https://openalex.org/I4210130485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112210889","display_name":"Katherine Jean Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine J. Walsh","raw_affiliation_strings":["6Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013233073","display_name":"Gregory Dan Ayers","orcid":"https://orcid.org/0000-0002-0892-350X","observed_orcids":["https://orcid.org/0000-0002-0892-350X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Dan Ayers","raw_affiliation_strings":["6Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061478349","display_name":"Ashwin Kishtagari","orcid":"https://orcid.org/0000-0003-1149-4571","observed_orcids":["https://orcid.org/0000-0003-1149-4571"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwin Kishtagari","raw_affiliation_strings":["8Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085208978","display_name":"Kateryna Fedorov","orcid":"https://orcid.org/0009-0004-8876-8926","observed_orcids":["https://orcid.org/0009-0004-8876-8926"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kateryna Fedorov","raw_affiliation_strings":["9Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019176812","display_name":"Markus Daniel Lacher","orcid":"https://orcid.org/0000-0003-2597-5704","observed_orcids":["https://orcid.org/0000-0003-2597-5704"]},"institutions":[{"id":"https://openalex.org/I4210130485","display_name":"Notable Labs (United States)","ror":"https://ror.org/03b9h7664","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130485"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus D. Lacher","raw_affiliation_strings":["7Notable Labs, Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Notable Labs, Foster City, CA","institution_ids":["https://openalex.org/I4210130485"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130485","display_name":"Notable Labs (United States)","ror":"https://ror.org/03b9h7664","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130485"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Wagner","raw_affiliation_strings":["7Notable Labs, Foster City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Notable Labs, Foster City, CA","institution_ids":["https://openalex.org/I4210130485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051485142","display_name":"Sanjay Ram Mohan","orcid":"https://orcid.org/0000-0002-6715-6697","observed_orcids":["https://orcid.org/0000-0002-6715-6697"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay R Mohan","raw_affiliation_strings":["10Vanderbilt Ingram Cancer Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Vanderbilt Ingram Cancer Center, Nashville, TN","institution_ids":["https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049400849","display_name":"Michael Robert Savona","orcid":"https://orcid.org/0000-0003-3763-5504","observed_orcids":["https://orcid.org/0000-0003-3763-5504"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Savona","raw_affiliation_strings":["6Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"6012","last_page":"6012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selinexor","display_name":"selinexor","score":0.921999990940094},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":1.0},{"id":"https://openalex.org/keywords/relapsed-refractory-acute-myeloid-leukemia","display_name":"relapsed/refractory acute myeloid leukemia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/xpo1-inhibitor","display_name":"XPO1 inhibitor","score":0.671999990940094},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.36399999260902405},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.621999979019165},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.43799999356269836},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6790000200271606},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.6439999938011169},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.7046909332275391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6758933067321777},{"id":"https://openalex.org/C9583187","wikidata":"https://www.wikidata.org/wiki/Q7919510","display_name":"Ven","level":2,"score":0.6663903594017029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5105963349342346},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5006844997406006},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4873243272304535},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4760981798171997},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.43074357509613037},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4111912250518799},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.37209248542785645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32903391122817993},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3049604296684265},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.20707514882087708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1195492148399353},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-209403","doi":"https://doi.org/10.1182/blood-2024-209403","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-209403","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/6012/2321872/blood-8840-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2024-209403","doi":"https://doi.org/10.1182/blood-2024-209403","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-209403","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/6012/2321872/blood-8840-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405050008.pdf","grobid_xml":"https://content.openalex.org/works/W4405050008.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7134269627","https://openalex.org/W3006596667","https://openalex.org/W2887192840","https://openalex.org/W2713328738","https://openalex.org/W2602169105","https://openalex.org/W4200317107","https://openalex.org/W2980036644","https://openalex.org/W2980098939","https://openalex.org/W4417069304","https://openalex.org/W4413809968"],"abstract_inverted_index":{"Introduction":[0],"Selective":[1],"inhibitor":[2],"of":[3,19,28,90,117,159,220,262,269,314,319,326,376,441,443,475,547,593,619,658],"nuclear":[4,15],"export":[5],"(SINE)":[6],"compounds":[7],"block":[8],"XPO1/elF4E-mediated":[9],"nuclear-cytoplasmic":[10],"transport,":[11],"and":[12,17,25,44,114,140,155,196,207,256,282,306,339,371,399,423,428,445,457,490,514,528,550,560,636],"lead":[13],"to":[14,51,148,233,588,595,643,651],"retention":[16],"activation":[18],"tumor":[20],"suppressor":[21],"proteins":[22,30],"(e.g.,":[23,31],"p53)":[24],"impaired":[26],"translation":[27],"oncogenic":[29],"c-MYC,":[32],"MCL1).":[33],"Our":[34],"preclinical":[35],"studies":[36],"showed":[37,517],"synergistic":[38],"antileukemia":[39],"activity":[40,519,618],"with":[41,48,109,133,136,193,204,218,238,322,402,412,420,425,431,439,512,543,567,607,625],"selinexor":[42],"(SEL)":[43],"venetoclax":[45],"(VEN)":[46],"combination,":[47],"the":[49,118,162,181,199,340,403,532,574,577,580],"potential":[50,590],"overcome":[52,644],"VEN":[53,172,284,427,626,645],"resistance":[54],"by":[55,175,223],"reducing":[56],"MCL1(Fischer":[57],"MA,":[58],"Blood":[59],"Advances,":[60],"2020).":[61],"A":[62],"phase":[63,128,152],"Ib":[64,129],"study":[65,320,350,634],"(NCT03955783)":[66],"evaluated":[67],"SEL-VEN":[68,413,533,568,598],"in":[69,198,293,335,342,573,601,631,660],"relapsed":[70],"or":[71,97],"refractory":[72],"(r/r)":[73],"high-risk":[74],"hematologic":[75],"malignancies.":[76],"Notable":[77],"Labs":[78],"has":[79],"developed":[80],"an":[81,632],"automated":[82],"predictive":[83],"analytic":[84],"(PA)":[85],"for":[86,184,349,656],"high":[87],"throughput":[88],"assessment":[89],"drug":[91],"sensitivity":[92],"on":[93,120,520,531],"bone":[94],"marrow":[95],"(BM)":[96],"blood":[98],"samples.":[99,122],"Here":[100],"we":[101],"report":[102],"clinical":[103,526,561,663],"trial":[104],"data":[105],"from":[106,540,576,582],"patients":[107],"(pts)":[108],"acute":[110],"myeloid":[111],"leukemia":[112,454],"(AML)":[113],"retrospective":[115],"application":[116],"PA":[119,522,558,655],"pt":[121,212,451],"Methods":[123],"In":[124],"this":[125],"investigator-sponsored,":[126],"open-label":[127],"study,":[130],"adult":[131],"pts":[132,237,253,263,273,333,613],"r/r":[134,239],"AML":[135,200,240,505,605,662],"adequate":[137],"performance":[138],"status":[139],"organ":[141],"function":[142],"were":[143,147,191,202,214,241,254,258,334,363],"enrolled.":[144,242],"Primary":[145],"objectives":[146],"determine":[149],"safety,":[150],"recommended":[151,182],"II":[153],"dose,":[154],"preliminary":[156],"response":[157,410,442,462,594],"rate":[158,411],"SEL-VEN.":[160,596,620],"After":[161,470],"dose":[163,183],"escalation":[164],"phase,":[165],"SEL":[166,336,432,513,544],"80":[167,343,433],"mg":[168],"po":[169],"weekly":[170],"plus":[171],"(ramp-up":[173],"followed":[174,222],"400":[176],"mg/d":[177],"continuous)":[178],"was":[179,247,353,414,484,494,599],"deemed":[180],"expansion":[185],"phase.":[186],"Treatment-emergent":[187],"adverse":[188],"events":[189],"(TEAE)":[190],"graded":[192],"CTCAE":[194],"v5.0,":[195],"responses":[197],"cohort":[201],"assessed":[203],"IWG":[205],"2003":[206],"ELN":[208],"2022":[209],"criteria.":[210],"Pretreatment":[211],"samples":[213,506],"treated":[215,430],"ex":[216,508,564],"vivo":[217,509,565],"drugs":[219],"interest,":[221],"multiparameter":[224],"flow":[225],"cytometry-based":[226],"blast":[227,464,510,571],"enumeration.":[228],"Results":[229],"From":[230,524],"September":[231],"2019":[232],"December":[234],"2022,":[235],"19":[236],"Median":[243],"age":[244],"at":[245],"enrollment":[246],"67.2":[248],"(range,":[249,316,328,477],"21.1-83.8)":[250],"years;":[251],"18/19":[252],"white":[255],"53%":[257],"male.":[259],"Overall,":[260],"62%":[261],"had":[264,275,460],"received":[265,311],"\u00b33":[266],"prior":[267,276,283,421,426],"lines":[268],"therapies.":[270],"Eight":[271],"(42%)":[272],"each":[274],"allogeneic":[277],"stem":[278],"cell":[279],"transplant":[280],"(allo-SCT)":[281],"exposure.":[285],"Baseline":[286],"next":[287],"generation":[288],"sequencing":[289],"(n=11)":[290],"revealed":[291],"mutations":[292],"NPM1":[294],"(n=3;":[295,298],"23%),":[296,299],"IDH2":[297],"NRAS":[300],"(n=2;":[301,304],"15%),":[302,305],"TP53":[303],"FLT3-ITD":[307],"(n=1;":[308],"8%).":[309],"Pts":[310],"a":[312,323,471,555,602,638,653],"median":[313,324,472,480,491],"3":[315],"1-8)":[317],"cycles":[318],"treatment,":[321],"duration":[325,440],"1.9":[327],"0.3-8.1)":[329],"months.":[330,499],"Seven":[331],"(37%)":[332],"60":[337],"mg/week":[338,344],"rest":[341],"cohorts.":[345],"The":[346],"primary":[347],"reason":[348],"treatment":[351,566],"discontinuation":[352],"disease":[354,468],"progression":[355],"(n=9;":[356],"47%).":[357],"Most":[358],"common":[359],"grade":[360,378,406],"3-5":[361],"TEAEs":[362],"anemia":[364],"(39%),":[365,389],"neutropenia":[366,369],"(33%),":[367,391,393],"febrile":[368],"(28%),":[370,396],"thrombocytopenia":[372],"(28%).":[373],"Non-hematologic":[374],"AEs":[375],"any":[377],"(\u00b3":[379],"20%)":[380],"included":[381],"vomiting":[382],"(50%),":[383],"nausea":[384],"(44%),":[385,387],"anorexia":[386],"diarrhea":[388],"fatigue":[390],"dyspnea":[392],"limb":[394],"edema":[395],"hyponatremia":[397],"(22%)":[398],"dysgeusia":[400],"(22%),":[401],"majority":[404],"being":[405],"1-2":[407],"AEs.":[408],"Overall":[409],"21%.":[415],"Two":[416,612],"(11%)":[417],"pts,":[418],"one":[419,424,458,525,529,581],"allo-SCT":[422],"both":[429],"mg/week,":[434],"experienced":[435,452,614],"complete":[436],"remissions":[437],"(CR),":[438],"7":[444],"9.1":[446],"months,":[447,479],"respectively.":[448],"One":[449],"(5%)":[450],"morphologic":[453],"free":[455,482],"state,":[456],"other":[459],"medullary":[461],"(BM":[463],"<5%)":[465],"but":[466],"extramedullary":[467],"persisted.":[469],"follow":[473],"up":[474],"3.02":[476],"0.62-15.4)":[478],"event":[481],"survival":[483,493],"2.4":[485],"(95%":[486,496],"CI:":[487,497],"1.9-12.1)":[488],"months":[489],"overall":[492],"6.4":[495],"2.5-12.1)":[498],"Using":[500],"commercially":[501],"available,":[502],"fresh":[503],"remnant":[504],"(n=12),":[507],"reductions":[511],"eltanexor":[515],"(ELTA)":[516],"SINE":[518,622,641],"our":[521],"platform.":[523],"responder":[527,578],"non-responder":[530],"trial,":[534],"dose-response":[535],"curves":[536],"could":[537,627],"be":[538],"derived":[539],"cryopreserved":[541],"samples,":[542],"EC50":[545],"values":[546],"8.79":[548],"nM":[549],"17.08":[551],"nM,":[552],"respectively,":[553],"indicating":[554],"correlation":[556],"between":[557],"results":[559],"response.":[562],"Similarly,":[563],"yielded":[569],"lower":[570],"levels":[572],"sample":[575],"than":[579],"non-responder.":[583],"Further":[584],"analysis":[585],"is":[586,649],"ongoing":[587,633,650],"explore":[589],"phenotypic":[591],"predictors":[592],"Conclusions":[597],"feasible":[600],"heavily":[603],"pretreated":[604],"cohort,":[606],"no":[608],"new":[609],"toxicity":[610],"signal.":[611],"durable":[615],"CR,":[616],"confirming":[617],"Second-generation":[621],"compound":[623],"ELTA":[624],"further":[628],"improve":[629],"outcomes":[630],"(NCT06399640)":[635],"provide":[637],"more":[639],"tolerable":[640],"regimen":[642],"resistant":[646],"AML.":[647],"Analysis":[648],"establish":[652],"flow-based":[654],"selection":[657],"participants":[659],"future":[661],"trials.":[664]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-12-06T00:00:00"}
