{"id":"https://openalex.org/W4405049564","doi":"https://doi.org/10.1016/j.tips.2024.11.002","title":"Therapeutic targeting of exportin-1 beyond nuclear export","display_name":"Therapeutic targeting of exportin-1 beyond nuclear export","publication_year":2024,"publication_date":"2024-12-05","ids":{"openalex":"https://openalex.org/W4405049564","doi":"https://doi.org/10.1016/j.tips.2024.11.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/39643565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11711008"},"language":"en","primary_location":{"id":"doi:10.1016/j.tips.2024.11.002","doi":"https://doi.org/10.1016/j.tips.2024.11.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tips.2024.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.tips.2024.11.002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100405144","display_name":"Yifan Chen","orcid":"https://orcid.org/0000-0002-7757-4462","observed_orcids":["https://orcid.org/0000-0002-7757-4462"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi Fan Chen","raw_affiliation_strings":["Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: yifan.chen9@case.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: yifan.chen9@case.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025223840","display_name":"Drew Adams","orcid":"https://orcid.org/0000-0002-3038-336X","observed_orcids":["https://orcid.org/0000-0002-3038-336X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Drew J. Adams","raw_affiliation_strings":["Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: drew.adams@case.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: drew.adams@case.edu","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025223840","https://openalex.org/A5100405144"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.5508,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.51140905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"46","issue":"1","first_page":"20","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xpo1","display_name":"CRM1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.8029999732971191},{"id":"https://openalex.org/keywords/selective-inhibitor-of-nuclear-export","display_name":"selective inhibitor of nuclear export","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitosis-regulation","display_name":"mitosis regulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.7547016143798828},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5347216725349426},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5097169280052185},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.400519460439682},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.2520894408226013},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0833769142627716}],"mesh":[{"descriptor_ui":"D000097606","descriptor_name":"Exportin 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tips.2024.11.002","doi":"https://doi.org/10.1016/j.tips.2024.11.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tips.2024.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11711008","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11711008/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11711008/pdf/nihms-2035486.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends Pharmacol Sci","raw_type":"Text"},{"id":"pmid:39643565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39643565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11561972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11711008","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.tips.2024.11.002","doi":"https://doi.org/10.1016/j.tips.2024.11.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tips.2024.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S31167473","display_name":"Trends in Pharmacological Sciences","issn_l":"0165-6147","issn":["0165-6147","1873-3735"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2382820488","display_name":null,"funder_award_id":"AI171104","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3554347561","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4306634993","display_name":null,"funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320310281","funder_display_name":"Case Western Reserve University"},{"id":"https://openalex.org/G5361767522","display_name":null,"funder_award_id":"T32GM135081","funder_id":"https://openalex.org/F4320310281","funder_display_name":"Case Western Reserve University"},{"id":"https://openalex.org/G8390813922","display_name":"Functional Genomics Training Program (FGTP)","funder_award_id":"T32GM135081","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000886901","display_name":"Medical Scientist Training Program at Case Western Reserve University","funder_award_id":"T32GM152319","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000904747","display_name":"Selective Inhibitors of T Cell Activation Target Exportin-1 at Cys528 to Suppress Pathological T Cell Activation","funder_award_id":"R01AI171104","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320310622","display_name":"School of Medicine, Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320310642","display_name":"Dr. Ralph and Marian Falk Medical Research Trust","ror":"https://ror.org/01ctnwa22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334294","display_name":"Harrington Discovery Institute, University Hospitals","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405049564.pdf","grobid_xml":"https://content.openalex.org/works/W4405049564.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1492131844","https://openalex.org/W1884072983","https://openalex.org/W1967903543","https://openalex.org/W1971961101","https://openalex.org/W1973642076","https://openalex.org/W1973879755","https://openalex.org/W1986258908","https://openalex.org/W1987019783","https://openalex.org/W1987530377","https://openalex.org/W1988100051","https://openalex.org/W1997117872","https://openalex.org/W2006346754","https://openalex.org/W2007755820","https://openalex.org/W2016153572","https://openalex.org/W2029222292","https://openalex.org/W2033348707","https://openalex.org/W2039208569","https://openalex.org/W2042948648","https://openalex.org/W2046497407","https://openalex.org/W2050066772","https://openalex.org/W2061981026","https://openalex.org/W2062233810","https://openalex.org/W2086598626","https://openalex.org/W2100768057","https://openalex.org/W2104580729","https://openalex.org/W2109004633","https://openalex.org/W2114915170","https://openalex.org/W2133661153","https://openalex.org/W2137797307","https://openalex.org/W2159089429","https://openalex.org/W2163495002","https://openalex.org/W2171258458","https://openalex.org/W2172298521","https://openalex.org/W2176782980","https://openalex.org/W2218364825","https://openalex.org/W2227904090","https://openalex.org/W2274069301","https://openalex.org/W2301608130","https://openalex.org/W2419244482","https://openalex.org/W2439067156","https://openalex.org/W2526506448","https://openalex.org/W2564335181","https://openalex.org/W2781469753","https://openalex.org/W2795117887","https://openalex.org/W2803182333","https://openalex.org/W2945437316","https://openalex.org/W2951383255","https://openalex.org/W2969931905","https://openalex.org/W2989618010","https://openalex.org/W2991145481","https://openalex.org/W3028886265","https://openalex.org/W3037697670","https://openalex.org/W3084184455","https://openalex.org/W3103404395","https://openalex.org/W3131251075","https://openalex.org/W3162252392","https://openalex.org/W3212683819","https://openalex.org/W3217286268","https://openalex.org/W4206396309","https://openalex.org/W4221025245","https://openalex.org/W4226136408","https://openalex.org/W4291991763","https://openalex.org/W4310597699","https://openalex.org/W4310602693","https://openalex.org/W4313830611","https://openalex.org/W4318682974","https://openalex.org/W4385406356","https://openalex.org/W4385971174","https://openalex.org/W4387965926","https://openalex.org/W4389895117","https://openalex.org/W4391063553","https://openalex.org/W4391449441","https://openalex.org/W4391682254","https://openalex.org/W4393153050","https://openalex.org/W4399970348","https://openalex.org/W4400659670","https://openalex.org/W4403088803","https://openalex.org/W6717014282","https://openalex.org/W6822902002"],"related_works":["https://openalex.org/W3028886265","https://openalex.org/W7212111557","https://openalex.org/W4200230179","https://openalex.org/W3103404395","https://openalex.org/W4210525006","https://openalex.org/W2096849855","https://openalex.org/W2128267456","https://openalex.org/W7165072515","https://openalex.org/W7170080123","https://openalex.org/W4401154392"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-06T00:00:00"}
