{"id":"https://openalex.org/W4405048843","doi":"https://doi.org/10.1182/blood-2024-203547","title":"Interaction between Cell Adhesion Molecule Integrin \u03b16 and Extracellular Matrix Laminin Promotes Myeloma Progression Via Akt Signaling","display_name":"Interaction between Cell Adhesion Molecule Integrin \u03b16 and Extracellular Matrix Laminin Promotes Myeloma Progression Via Akt Signaling","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405048843","doi":"https://doi.org/10.1182/blood-2024-203547"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-203547","doi":"https://doi.org/10.1182/blood-2024-203547","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-203547","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026520459","display_name":"Ayane Ohmori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayane Ohmori","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059390771","display_name":"Nobuhiko Kobayashi","orcid":"https://orcid.org/0000-0002-3341-5566","observed_orcids":["https://orcid.org/0000-0002-3341-5566"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Kobayashi","raw_affiliation_strings":["2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055230328","display_name":"Ikuko Matsumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuko Matsumura","raw_affiliation_strings":["3Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075585483","display_name":"Rei Ishihara","orcid":"https://orcid.org/0009-0007-3442-7538","observed_orcids":["https://orcid.org/0009-0007-3442-7538"]},"institutions":[{"id":"https://openalex.org/I4210155297","display_name":"Gunma University of Health and Welfare","ror":"https://ror.org/059hx7q04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210155297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rei Ishihara","raw_affiliation_strings":["4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan","institution_ids":["https://openalex.org/I4210155297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069450738","display_name":"Yuki Murakami","orcid":"https://orcid.org/0000-0002-7085-4832","observed_orcids":["https://orcid.org/0000-0002-7085-4832"]},"institutions":[{"id":"https://openalex.org/I4210155297","display_name":"Gunma University of Health and Welfare","ror":"https://ror.org/059hx7q04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210155297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Murakami","raw_affiliation_strings":["4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan","institution_ids":["https://openalex.org/I4210155297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061403783","display_name":"Akira Matsumoto","orcid":"https://orcid.org/0000-0002-3719-8597","observed_orcids":["https://orcid.org/0000-0002-3719-8597","https://orcid.org/0009-0003-5873-3549"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Matsumoto","raw_affiliation_strings":["2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Asumi Kojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asumi Kojima","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miri Kitamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miri Kitamura","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038969373","display_name":"Natsuki Shiraishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuki Shiraishi","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045468792","display_name":"Nanami Gotoh","orcid":"https://orcid.org/0000-0002-2381-319X","observed_orcids":["https://orcid.org/0000-0002-2381-319X"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nanami Gotoh","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036146222","display_name":"Tetsuhiro Kasamatsu","orcid":"https://orcid.org/0000-0002-7943-9176","observed_orcids":["https://orcid.org/0000-0002-7943-9176"]},"institutions":[{"id":"https://openalex.org/I4210155297","display_name":"Gunma University of Health and Welfare","ror":"https://ror.org/059hx7q04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210155297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuhiro Kasamatsu","raw_affiliation_strings":["4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan","institution_ids":["https://openalex.org/I4210155297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081426498","display_name":"Takayuki Saitoh","orcid":"https://orcid.org/0000-0001-5524-7455","observed_orcids":["https://orcid.org/0000-0001-5524-7455"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Saitoh","raw_affiliation_strings":["1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066174292","display_name":"Hiroshi Handa","orcid":"https://orcid.org/0000-0003-3753-9862","observed_orcids":["https://orcid.org/0000-0003-3753-9862"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Handa","raw_affiliation_strings":["2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"6818","last_page":"6818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.09300000220537186,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha6","display_name":"CD49f","score":0.9160000085830688},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.5389999747276306},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.781000018119812},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4970000088214874},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.5329999923706055},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/monoclonal-gammopathy-of-undetermined-significance","display_name":"monoclonal gammopathy of undetermined significance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5490000247955322},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.7656576633453369},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6837753057479858},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.6040757298469543},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5692571401596069},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5598456859588623},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5438007712364197},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5413825511932373},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4209340810775757},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4076935350894928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4025686979293823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39828118681907654},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3954031765460968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3717712163925171},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36094340682029724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11546632647514343}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-203547","doi":"https://doi.org/10.1182/blood-2024-203547","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-203547","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1606990197","https://openalex.org/W2084400975","https://openalex.org/W2008309108","https://openalex.org/W2759937010","https://openalex.org/W3141718880","https://openalex.org/W2115146277","https://openalex.org/W2578712640","https://openalex.org/W4233935642","https://openalex.org/W2089721281","https://openalex.org/W2041262306"],"abstract_inverted_index":{"Background:":[0],"Integrins":[1],"are":[2,440],"cell":[3,8,18,23,142,161,170,420],"surface":[4,162,549],"proteins":[5],"and":[6,26,48,54,67,104,107,139,151,174,186,204,220,227,244,251,260,292,300,313,320,336,343,385,405,413,437,453,482,494,506,524,530,546,570,574],"major":[7],"adhesion":[9,19],"transmembrane":[10],"receptors":[11],"that":[12,356,537,577],"play":[13],"an":[14,45],"important":[15],"role":[16,63],"in":[17,22,51,58,71,90,120,177,196,201,215,234,237,317,340,377,409,419,509,521,527,543,581],"andmultifaceted":[20],"roles":[21],"growth,":[24,52],"survival,":[25],"cytoskeleton":[27],"formation":[28],"by":[29,110,118,165,289,362,375,423,488,492,500,504,556,560,566],"transmitting":[30],"stimuli":[31],"from":[32,124,306,329,395],"ligands":[33,442],"to":[34,56,102,241,297,308,311,315,331,334,338,397,400,403,407,429,460],"the":[35,62,84,97,159,183,197,202,216,283,298,347,389,424,449,478],"cell.":[36],"Integrin":[37],"\u03b16":[38,66,88,101,157,287,358,371,393,428,458,471,514,539,553],"acts":[39],"as":[40,323,346],"a":[41,364,522,590],"receptor":[42],"for":[43,443],"laminin,":[44],"extracellular":[46],"matrix,":[47],"is":[49,360,373,554,579,589],"involved":[50,176,542,580],"invasion,":[53],"resistance":[55],"therapy":[57],"many":[59],"cancers.":[60],"However,":[61],"of":[64,86,99,155,285,391,426,451,480,517,551,563],"integrin":[65,87,100,156,286,357,370,392,427,444,457,470,513,538,552,585,594],"interaction":[68],"with":[69,127,131,135,172,468,474,511],"laminin":[70,103,111,173,463,475,518,567,578],"multiple":[72],"myeloma":[73,141],"(MM)":[74],"have":[75],"not":[76,256,268,559],"yet":[77],"been":[78],"investigated.":[79],"Therefore,":[80],"we":[81,94,367],"focused":[82,95],"on":[83,96,158],"regulation":[85,284],"expression":[89,115,154,192,213,236,288,359,372,550],"MM":[91,198,221,238,564,582],"cells.":[92],"Additionally,":[93],"binding":[98,425],"examined":[105,368,417],"proliferation":[106,171,421,450,569,583],"signal":[108,178],"transduction":[109,179],"binding.":[112],"Methods:":[113],"ITGA6":[114,190,211,235,262],"was":[116,163,180,193,325,350,354],"measured":[117,164],"RT-qPCR":[119,534],"CD138-positive":[121],"plasma":[122],"cells":[123,380,455,565],"106":[125],"patients":[126,130,134],"MM,":[128],"13":[129],"SMM,":[132,219],"72":[133],"MGUS,":[136,218],"17":[137],"controls,":[138],"human":[140],"lines":[143],"(HMCL):":[144],"KMS27,":[145,318,341],"KMS11,":[146,319,410],"KMS28BM,":[147,321,344],"MM1S,":[148,342],"KMS26,":[149,411],"RPMI8226,":[150,412],"KMM1.":[152],"The":[153,209,248],"HMCL":[160,467],"flow":[166],"cytometry.":[167],"In":[168,466],"HMCL,":[169],"molecules":[175],"evaluated":[181],"using":[182],"CCK-8":[184],"assay":[185],"Western":[187],"blotting.":[188],"Results:":[189],"mRNA":[191,212],"significantly":[194],"higher":[195],"group":[199],"than":[200],"control":[203],"MGUS":[205],"groups":[206,222],"(p":[207],"<0.001).":[208],"median":[210],"levels":[214],"control,":[217],"were":[223,231,295],"0.359,":[224],"2.033,":[225],"35.230,":[226],"7.961,":[228],"respectively.":[229,415,532],"There":[230],"no":[232,512],"differences":[233],"samples":[239],"according":[240],"ISS":[242],"(p=0.772)":[243],"cytogenetic":[245],"risk":[246],"(p=0.371).":[247],"overall":[249],"survival":[250,254],"progression":[252],"free":[253],"did":[255],"differ":[257],"between":[258],"high":[259,469],"low":[261],"expressions":[263],"(OS;":[264],"5.1":[265],"years":[266],"vs":[267,275],"reached;":[269],"p":[270,278],"=":[271,279],"0.394,":[272],"PFS;":[273],"2.1":[274],"2.2":[276],"years;":[277],"0.523).":[280],"To":[281],"examine":[282],"Myc,":[290],"JQ1":[291,324],"Myc":[293,348,557],"inhibitors":[294],"added":[296],"cells,":[299],"mean":[301],"fluorescence":[302],"intensity":[303],"(MFI)":[304],"decreased":[305,328],"7.03":[307],"1.97,":[309],"6.15":[310],"2.54,":[312],"5.71":[314],"2.31":[316],"respectively,":[322,345],"added.":[326,351],"MFI":[327,390],"4.23":[330],"3.08,":[332],"3.32":[333],"2.14,":[335],"3.17":[337],"2.14":[339],"inhibitor":[349],"Since":[352],"it":[353],"reported":[355],"regulated":[361,374,555],"HIF-1\u03b1,":[363],"hypoxia-inducible":[365],"factor,":[366],"whether":[369],"HIF-1\u03b1":[376],"HMCL.":[378],"Comparing":[379],"cultured":[381],"under":[382],"normal":[383],"oxygen":[384],"1%":[386],"O2":[387],"conditions,":[388],"changed":[394],"5.55":[396],"3.43,":[398],"1.43":[399],"1.51,":[401],"1.01":[402],"0.99,":[404],"5.53":[406],"4.40":[408],"KMM1,":[414],"We":[416,431],"changes":[418],"caused":[422,571],"laminin.":[430],"used":[432],"laminins":[433],"111,":[434],"211,":[435],"411,":[436],"511,":[438],"which":[439],"known":[441],"\u03b16.":[445,586],"Laminin":[446],"411":[447,476,519],"promoted":[448],"KMS27":[452,484],"KMS11":[454,496],"expressing":[456],"compared":[459],"those":[461],"without":[462],"(p=0.0207,":[464],"p=0.0532).":[465],"expression,":[472,515],"stimulation":[473,516],"increased":[477,485,497],"phosphorylation":[479],"Akt":[481,487,499,529,573],"Erk1/2.":[483],"phosphorylated":[486,490,498,502,528,572],"12-fold,":[489],"Erk1/2":[491,503],"2-fold,":[493],"6-fold;":[495],"15-fold,":[501],"34-fold,":[505],"11-fold.":[507],"Conversely,":[508],"RPMI8226":[510],"resulted":[520],"0.6-":[523],"1-fold":[525],"increase":[526],"Erk1/2,":[531],"Conclusion:":[533],"results":[535],"suggest":[536],"may":[540],"be":[541],"disease":[544],"onset":[545],"progression.":[547],"Cell":[548],"but":[558],"HIF-1\u03b1.":[561],"Stimulation":[562],"stimulated":[568],"Erk,":[575],"suggesting":[576],"via":[584],"This":[587],"study":[588],"step":[591],"toward":[592],"developing":[593],"\u03b16-targeted":[595],"therapy.":[596]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2024-12-06T00:00:00"}