{"id":"https://openalex.org/W4405048839","doi":"https://doi.org/10.1182/blood-2024-210536","title":"Long-Term Immunological Consequences of CD19 CAR T Cell Therapy: Analysis of Infectious Complications and Immune Reconstitution","display_name":"Long-Term Immunological Consequences of CD19 CAR T Cell Therapy: Analysis of Infectious Complications and Immune Reconstitution","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405048839","doi":"https://doi.org/10.1182/blood-2024-210536"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-210536","doi":"https://doi.org/10.1182/blood-2024-210536","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-210536","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/7248/2324406/blood-10073-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/7248/2324406/blood-10073-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044112222","display_name":"Andreas Riedel","orcid":"https://orcid.org/0000-0003-3091-7373","observed_orcids":["https://orcid.org/0000-0003-3091-7373"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Riedel","raw_affiliation_strings":["1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061306214","display_name":"Jan Frederic Weller","orcid":"https://orcid.org/0000-0003-4880-0915","observed_orcids":["https://orcid.org/0000-0003-4880-0915"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Frederic Weller","raw_affiliation_strings":["2Department for Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department for Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076245092","display_name":"Laurent Phely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laurent Phely","raw_affiliation_strings":["1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060960713","display_name":"Stefan Hug","orcid":"https://orcid.org/0009-0006-9961-2972","observed_orcids":["https://orcid.org/0009-0006-9961-2972"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Hug","raw_affiliation_strings":["1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103872928","display_name":"Christoph Faul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Faul","raw_affiliation_strings":["1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088208446","display_name":"Claudia Lengerke","orcid":"https://orcid.org/0000-0001-5442-2805","observed_orcids":["https://orcid.org/0000-0001-5442-2805"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Lengerke","raw_affiliation_strings":["3Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Oncology, Hematology, Clinical Immunology, and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023183268","display_name":"Wolfgang Andreas Bethge","orcid":"https://orcid.org/0000-0001-6052-2618","observed_orcids":["https://orcid.org/0000-0001-6052-2618"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Andreas Bethge","raw_affiliation_strings":["1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"7248","last_page":"7248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.746999979019165},{"id":"https://openalex.org/keywords/infectious-complications","display_name":"infectious complications","score":0.8799999952316284},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cytopenia","display_name":"cytopenia","score":0.7409999966621399},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.5870000123977661},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.6449999809265137},{"id":"https://openalex.org/keywords/central-line-associated-infection","display_name":"central line-associated infection","score":0.6269999742507935},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6140240430831909},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5843225717544556},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5825506448745728},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.49893951416015625},{"id":"https://openalex.org/C2780366003","wikidata":"https://www.wikidata.org/wiki/Q246147","display_name":"Cytopenia","level":3,"score":0.46505650877952576},{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.4476546049118042},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4318659007549286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3482188582420349},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31988900899887085},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.14230698347091675}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-210536","doi":"https://doi.org/10.1182/blood-2024-210536","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-210536","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/7248/2324406/blood-10073-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2024-210536","doi":"https://doi.org/10.1182/blood-2024-210536","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-210536","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/7248/2324406/blood-10073-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405048839.pdf","grobid_xml":"https://content.openalex.org/works/W4405048839.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088669070","https://openalex.org/W2011720472","https://openalex.org/W1557367249","https://openalex.org/W2394201010","https://openalex.org/W2340237593","https://openalex.org/W2020684972","https://openalex.org/W2041921061","https://openalex.org/W3030597314","https://openalex.org/W1572148375","https://openalex.org/W2379544873"],"abstract_inverted_index":{"Introduction":[0],"Anti-CD19":[1],"chimeric":[2],"antigen":[3],"receptor":[4],"(CAR)":[5],"T":[6,33,44,64,134,159,380,438,459,541,573,597],"cells":[7,34,45,55,439,448],"have":[8],"been":[9],"a":[10,48,98,119,186,263,277,282,293,318,434,492],"major":[11],"improvement":[12],"for":[13,273,279,361,565,624],"the":[14,26,36,79,93,104,175,183,219,244,266,329,333,339,427,476,481,488,496,500,514,532,551,561,575],"treatment":[15,485],"of":[16,31,50,103,118,185,218,232,243,247,307,345,429,436,483,513,538,563,570,595],"relapsed":[17,148],"and":[18,29,56,127,194,230,256,300,350,368,402,406,420,443,445,454,465,470,535,567,602,606,616,630,640],"refractory":[19,150],"B":[20,51,153,447,600],"cell":[21,65,135,160,223,460],"neoplasia.":[22],"Despite":[23,505],"its":[24],"success,":[25],"long-term":[27,195,330,362,536,625],"effects":[28],"sequela":[30],"CAR":[32,43,63,133,158,295,379,477,540,572],"on":[35,297,495],"immune":[37,73,81,128,220],"system":[38],"remain":[39],"poorly":[40],"understood.":[41],"CD19":[42,131,378,539],"lead":[46],"to":[47,71,101,110,168,253,356,547,560,580,635],"depletion":[49],"cells,":[52,574,598,601],"CD19-positive":[53],"plasma":[54],"subsequent":[57],"hypogammaglobulinemia.":[58],"Furthermore,":[59,216,315],"cytopenia":[60],"seen":[61],"after":[62,130,503,518,609],"therapy,":[66],"which":[67,556],"is":[68,90,108],"often":[69],"attributed":[70,109,252,559],"an":[72,395,591],"effector":[74],"cell-associated":[75],"hematotoxicity":[76,569],"(ICAHT),":[77],"aggravates":[78],"underlying":[80],"deficiency":[82,435],"in":[83,162,174,240,265,335,373,426,511,550,588,644],"these":[84,248,336,415],"patients.":[85,245],"Moreover,":[86,332],"this":[87,139,645],"immunosuppressed":[88],"condition":[89],"exacerbated":[91],"by":[92,210],"previous":[94],"cytotoxic":[95],"therapies.":[96],"As":[97],"result,":[99],"up":[100],"50%":[102,242],"nonrelapse":[105],"mortality":[106],"(NRM)":[107],"infectious":[111,125,198,249,274,301],"complications.":[112,199],"Here,":[113],"we":[114,143,316,612,627],"report":[115],"our":[116,163],"results":[117,423,530],"one-year":[120,187],"follow-up":[121],"single-center":[122],"analysis":[123,176,272,383],"investigating":[124],"complications":[126,250,275,302],"reconstitution":[129,221,498,594],"targeted":[132],"therapy.":[136],"Methods":[137],"In":[138],"retrospective":[140],"observational":[141],"study,":[142],"analyzed":[144],"36":[145],"patients":[146,280,337,375,515],"with":[147,206,281,342,377,590],"or":[149,181,213,261],"Diffuse":[151],"Large":[152],"Cell":[154],"Lymphoma":[155],"(DLBCL)":[156],"receiving":[157],"infusion":[161],"institution":[164],"from":[165,320],"May":[166],"2019":[167],"March":[169],"2023.":[170],"Patients":[171],"were":[172,201,234,251,257,462],"included":[173],"until":[177],"progressive":[178],"disease":[179],"(PD)":[180],"reaching":[182],"endpoint":[184],"follow-up.":[188,331],"We":[189,432],"assessed":[190],"short-term":[191],"(<30":[192],"days)":[193,197],"(>30":[196],"Infections":[200],"defined":[202],"as":[203,621],"pathological":[204],"conditions":[205],"typical":[207],"symptoms,":[208],"supported":[209],"laboratory,":[211],"radiographic":[212],"microbiological":[214],"evidence.":[215],"kinetics":[217],"including":[222],"counts,":[224],"lymphocyte":[225,410,430],"subsets":[226],"(CD19+,":[227],"CD4+,":[228],"CD8+)":[229],"levels":[231,521],"immunoglobulins":[233],"analyzed.":[235],"Results":[236],"Short-term":[237],"infections":[238,324,363,545],"occurred":[239],"almost":[241],"Most":[246],"bacteria":[254],"(46%)":[255],"central":[258],"line-associated":[259],"(32%)":[260],"had":[262,491],"focus":[264,334],"urinary":[267],"tract":[268,341],"(41%).":[269],"Unexpectedly,":[270],"risk":[271,359,389,479,622,638],"revealed":[276],"reduction":[278],"high-risk":[283],"HEMATOTOX":[284,478],"score":[285],"(OR":[286,364],"0.11,":[287],"CI":[288,366,371],"0.02-0.59).":[289],"A":[290],"correlation":[291],"between":[292],"higher":[294],"expansion":[296,306],"day":[298,399],"30":[299,553],"was":[303],"observed":[304,433],"(median":[305],"all":[308,346],"lymphocytes:":[309],"1.0%":[310],"vs.":[311,326],"5.0%,":[312],"p<":[313],"0.02).":[314],"detected":[317],"change":[319],"bacterial":[321,544],"towards":[322],"viral":[323,582],"(19%":[325],"31%)":[327],"during":[328],"became":[338],"respiratory":[340],"approximately":[343],"47%":[344],"infections.":[347,583],"Interestingly,":[348,474],"CRS":[349,615],"ICANS":[351,617],"grading":[352,618],"\u2265":[353,619],"2":[354,620],"seem":[355,546],"be":[357,558],"potential":[358],"factors":[360,623],"4.50":[365],"1.06-19.11":[367],"OR":[369],"4.96":[370],"1.01-24.37)":[372],"DLBCL":[374],"treated":[376],"cells.":[381,542],"Multivariate":[382],"did":[384],"not":[385],"reveal":[386],"independent":[387],"prognostic":[388],"factors.":[390],"Median":[391,457],"neutrophil":[392],"counts":[393,411,461],"showed":[394,522],"adequate":[396],"recovery":[397],"at":[398,414,451,467,604],"90,":[400],"180":[401],"360":[403],"(1780/\u00b5l,":[404],"2040/\u00b5l":[405],"1900/\u00b5l),":[407],"while":[408],"absolute":[409],"remained":[412],"deficient":[413,523,593],"time":[416],"points":[417],"(740/\u00b5l,":[418],"580/\u00b5l":[419],"735/\u00b5l).":[421],"These":[422,584],"are":[424,586,633],"reflected":[425],"composition":[428],"subsets.":[431],"CD4+":[437,596],"(median:":[440,449,525],"162/\u00b5l,":[441],"150/\u00b5l":[442],"208/\u00b5l)":[444],"CD19+":[446,599],"0/\u00b5l)":[450],"90-,":[452],"180-":[453],"360-days":[455],"post-infusion.":[456],"CD8+":[458],"234/\u00b5l,":[463],"233/\u00b5l":[464],"314/\u00b5l":[466],"3,":[468],"6":[469,516,605],"12":[471,607],"months,":[472],"respectively.":[473],"neither":[475],"stratification,":[480],"number":[482],"prior":[484],"lines,":[486],"nor":[487],"progression-free":[489],"survival":[490],"significant":[493],"influence":[494],"cellular":[497],"within":[499],"first":[501,552],"year":[502],"treatment.":[504,610],"frequent":[506],"preemptive":[507],"intravenous":[508],"immunoglobulin":[509],"substitution":[510],"52%":[512],"months":[517,608],"treatment,":[519],"IgG":[520],"values":[524],"478.5":[526],"mg/dl).":[527],"Conclusion":[528],"Our":[529],"underline":[531],"hematological":[533],"short-":[534],"toxicity":[537],"While":[543],"appear":[548],"especially":[549],"days":[554],"post-infusion,":[555],"may":[557],"combination":[562],"chemotherapy":[564],"lymphodepletion":[566],"acute":[568],"expanding":[571],"pathogen":[576],"spectrum":[577],"changes":[578],"later":[579],"mostly":[581],"findings":[585],"well":[587],"line":[589],"accompanied":[592],"hypogammaglobulinemia":[603],"Although":[611],"could":[613],"identify":[614],"infections,":[626],"believe":[628],"further":[629],"larger":[631],"studies":[632],"needed":[634],"characterize":[636],"patient":[637],"groups":[639],"optimize":[641],"prophylactic":[642],"approaches":[643],"cohort.":[646]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
