{"id":"https://openalex.org/W4405044934","doi":"https://doi.org/10.1182/blood-2024-199196","title":"Romidepsin, Azacitidine, Dexamethasone, and Lenalidomide (RAdR) for Relapsed/Refractory T-Cell Lymphoma","display_name":"Romidepsin, Azacitidine, Dexamethasone, and Lenalidomide (RAdR) for Relapsed/Refractory T-Cell Lymphoma","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405044934","doi":"https://doi.org/10.1182/blood-2024-199196"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-199196","doi":"https://doi.org/10.1182/blood-2024-199196","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-199196","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049293438","display_name":"Max J. Gordon","orcid":"https://orcid.org/0000-0003-3940-4451","observed_orcids":["https://orcid.org/0000-0003-3940-4451"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max J Gordon","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119491","display_name":"Milo\u0161 D. Miljkovi\u0107","orcid":"https://orcid.org/0000-0001-5848-6320","observed_orcids":["https://orcid.org/0000-0001-5848-6320"]},"institutions":[{"id":"https://openalex.org/I4405267315","display_name":"Cartesian Therapeutics, Inc. (United States)","ror":"https://ror.org/0254pgf38","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milos D Miljkovic","raw_affiliation_strings":["2Cartesian Therapeutics, Inc., Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cartesian Therapeutics, Inc., Washington, DC","institution_ids":["https://openalex.org/I4405267315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110647265","display_name":"Samuel Y. Ng","orcid":"https://orcid.org/0000-0003-1140-0627","observed_orcids":["https://orcid.org/0000-0003-1140-0627"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Ng","raw_affiliation_strings":["3National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003400270","display_name":"Rahul Lakhotia","orcid":"https://orcid.org/0000-0003-3123-6844","observed_orcids":["https://orcid.org/0000-0003-3123-6844"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Lakhotia","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016988477","display_name":"Christopher Joseph Melani","orcid":"https://orcid.org/0000-0002-9661-4570","observed_orcids":["https://orcid.org/0000-0002-9661-4570"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Melani","raw_affiliation_strings":["4Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Derwood, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Derwood, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066966766","display_name":"Kevin C. Conlon","orcid":"https://orcid.org/0000-0002-3703-7080","observed_orcids":["https://orcid.org/0000-0002-3703-7080"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Conlon","raw_affiliation_strings":["3National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013514926","display_name":"James D. Phelan","orcid":"https://orcid.org/0000-0001-8950-2485","observed_orcids":["https://orcid.org/0000-0001-8950-2485"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Phelan","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040707006","display_name":"Bonita R. Bryant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonita Bryant","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076853103","display_name":"Laura M. Yee","orcid":"https://orcid.org/0000-0002-6104-4985","observed_orcids":["https://orcid.org/0000-0002-6104-4985"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M Yee","raw_affiliation_strings":["5Office of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Office of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002368482","display_name":"Stefania Pittaluga","orcid":"https://orcid.org/0000-0001-7688-1439","observed_orcids":["https://orcid.org/0000-0001-7688-1439"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefania Pittaluga","raw_affiliation_strings":["6Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089779163","display_name":"Elaine S. Jaffe","orcid":"https://orcid.org/0000-0003-4632-0301","observed_orcids":["https://orcid.org/0000-0003-4632-0301"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine S. Jaffe","raw_affiliation_strings":["6Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025942951","display_name":"Louis M. Staudt","orcid":"https://orcid.org/0000-0002-1735-2892","observed_orcids":["https://orcid.org/0000-0002-1735-2892"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis M. Staudt","raw_affiliation_strings":["7Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049385918","display_name":"Wyndham Hopkins Wilson","orcid":"https://orcid.org/0000-0002-2862-9711","observed_orcids":["https://orcid.org/0000-0002-2862-9711"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wyndham H. Wilson","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044366730","display_name":"Mark J. Roschewski","orcid":"https://orcid.org/0000-0003-0278-2635","observed_orcids":["https://orcid.org/0000-0003-0278-2635"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Roschewski","raw_affiliation_strings":["1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"984","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.42800000309944153},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5099999904632568},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.652999997138977},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/anaplastic-large-cell-lymphoma","display_name":"anaplastic large cell lymphoma","score":0.843999981880188},{"id":"https://openalex.org/keywords/mycosis-fungoides","display_name":"mycosis fungoides","score":0.9269999861717224},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4790000021457672},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.8764622211456299},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.799521803855896},{"id":"https://openalex.org/C2781462825","wikidata":"https://www.wikidata.org/wiki/Q7363205","display_name":"Romidepsin","level":5,"score":0.794481635093689},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6849361062049866},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6069276332855225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5539339780807495},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5041829347610474},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4883672595024109},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.412527859210968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10874202847480774},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.07202228903770447},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-199196","doi":"https://doi.org/10.1182/blood-2024-199196","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-199196","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7133507457","https://openalex.org/W4399814099","https://openalex.org/W4401876526","https://openalex.org/W4401876716","https://openalex.org/W2599549966","https://openalex.org/W3208807022","https://openalex.org/W3182442681","https://openalex.org/W3096412339","https://openalex.org/W4417019357","https://openalex.org/W2567648097"],"abstract_inverted_index":{"Mature":[0],"T-cell":[1,306,326],"lymphomas":[2],"(TCL)":[3],"are":[4,563,690],"a":[5,11,80,148,505,677],"heterogeneous":[6],"group":[7],"of":[8,65,79,92,100,122,151,163,196,209,237,250,331,373,413,418,431,509,551,568,680,703],"diseases":[9],"with":[10,39,60,97,111,216,261,573,668],"poor":[12],"prognosis,":[13],"particularly":[14,682],"in":[15,408,477,542,672],"the":[16,193,197,200,204,223,229,246,251,300,371,427,470,478,487,577,617,629,684,700],"relapsed/refractory":[17],"(r/r)":[18],"setting.":[19],"Drugs":[20],"targeting":[21],"epigenetic":[22],"regulation":[23],"and":[24,30,44,51,54,103,114,168,178,180,199,253,276,293,314,321,343,362,397,405,411,452,454,473,496,523,539,586,603,626,638,655,675,706],"immunomodulation":[25],"such":[26],"as":[27],"romidepsin,":[28,101],"azacitidine":[29,61,102,170],"lenalidomide":[31,93,152,181,374,471],"have":[32,56,125],"single":[33],"agent":[34],"activity":[35],"against":[36],"r/r":[37,112,262,673],"TCL":[38,113,263,297,575,674,704],"objective":[40,189],"response":[41,46],"rates":[42,47,64],"(ORR)":[43],"complete":[45,688],"(CR)":[48],"around":[49],"30%":[50],"10%.":[52],"Lenalidomide":[53],"romidepsin":[55,164],"each":[57,447],"been":[58],"combined":[59],"showing":[62],"improved":[63],"CR,":[66],"but":[67,686],"extended":[68],"treatment":[69],"schedules":[70],"add":[71],"toxicity.":[72],"We":[73,88],"hypothesized":[74],"that":[75],"cyclic,":[76],"time-limited":[77],"administration":[78],"multi-targeted":[81],"combination":[82],"regimen":[83,198,696],"would":[84],"induce":[85],"durable":[86,687],"remissions.":[87],"tested":[89],"escalating":[90],"doses":[91,99],"(5":[94],"to":[95,159,191,377,440,444,449,457,713],"20mg)":[96],"fixed":[98],"dexamethasone.":[104],"Eligible":[105],"patients":[106,220,232,260,345,462,482,536,558,572,614],"were":[107,233,264,278,284,287,299,333,353,420],"\u226518":[108],"years":[109,273,280],"old":[110],"had":[115,319,324,338,346],"received":[116,147,339,347,484,560],"at":[117,222,235,256,358,367,565,616,683],"least":[118],"1":[119,167,177,361],"prior":[120,329,341,348],"line":[121],"therapy":[123,332,545,667],"(must":[124],"included":[126,386,476],"brentuximab":[127],"vedotin":[128],"if":[129],"anaplastic":[130],"large":[131],"cell":[132],"lymphoma":[133,307],"[ALCL]":[134],"or":[135],"CD30+":[136],"mycosis":[137],"fungoides":[138],"[MF]).":[139],"Prior":[140],"allogeneic":[141,238],"transplantation":[142,239],"was":[143,190,203,214,226,243,254,271,375,474,489,516,528,579,596,606,631,648,658],"allowed.":[144],"Patients":[145],"first":[146],"7-day":[149],"course":[150],"for":[153,436],"correlative":[154],"research":[155],"followed":[156],"by":[157,245],"up":[158,508,553],"six":[160],"28-day":[161],"cycles":[162,419,430],"(12mg/m2;":[165],"days":[166,172,176,183],"10),":[169,179],"(300mg;":[171],"1-10),":[173],"dexamethasone":[174],"(40mg;":[175],"(5-20mg;":[182],"1-10)":[184],"without":[185,554,692],"maintenance.":[186],"The":[187,241,268,415,694],"primary":[188,201],"test":[192],"overall":[194,525],"safety":[195],"endpoint":[202],"maximum":[205],"tolerated":[206],"dose":[207,359,368,464],"(MTD)":[208],"lenalidomide.":[210],"A":[211],"3+3":[212],"design":[213],"used":[215],"an":[217,709],"additional":[218],"9":[219],"treated":[221,615],"MTD.":[224],"Survival":[225],"estimated":[227],"using":[228],"Kaplan-Meier":[230],"method;":[231],"censored":[234],"time":[236],"(SCT).":[240],"study":[242],"supported":[244],"Intramural":[247],"Research":[248],"Program":[249],"NIH":[252],"registered":[255],"Clinicaltrials.gov":[257],"(NCT04447027).":[258],"Twenty-six":[259],"enrolled":[265],"during":[266,469],"2020-2024.":[267],"median":[269,416,506],"age":[270],"61":[272],"(range,":[274,335,422],"28-80)":[275],"23%":[277,438],"\u226570":[279],"old.":[281],"Eighteen":[282],"(69%)":[283],"male,":[285],"42%":[286],"black,":[288],"31%":[289,337],"white,":[290],"15%":[291,410],"Asian":[292],"12%":[294],"Hispanic.":[295],"Nodal":[296],"subtypes":[298,705],"most":[301],"common":[302],"(62%)":[303],"including":[304],"peripheral":[305],"not":[308,475],"otherwise":[309],"specified":[310],"(31%;":[311],"PTCL,":[312,621],"NOS)":[313],"angioimmunoblastic":[315],"(19%).":[316],"Six":[317],"(23%)":[318],"MF":[320],"four":[322],"(15%)":[323],"adult":[325],"leukemia/lymphoma.":[327],"Median":[328],"lines":[330,342],"2":[334,344,623,627],"1-8),":[336],"\u22654":[340],"SCT.":[349],"Two":[350,535],"dose-limiting":[351],"toxicities":[352],"observed,":[354],"grade":[355,363],"4":[356,421],"thrombocytopenia":[357,404],"level":[360,369],"3":[364],"abdominal":[365,450],"pain":[366,451],"2;":[370],"MTD":[372,618],"determined":[376],"be":[378,708],"20mg.":[379],"Grade":[380,401],"\u22653":[381,402],"non-hematologic":[382],"adverse":[383],"events":[384],"(AE)":[385],"hypokalemia":[387],"(12%),":[388],"kidney":[389],"injury,":[390],"adrenal":[391],"insufficiency,":[392],"fatigue,":[393],"anorexia,":[394],"weight":[395],"loss":[396],"infection":[398],"(all,":[399],"8%).":[400],"neutropenia,":[403],"anemia":[406],"occurred":[407],"17%,":[409],"13%":[412],"cycles.":[414],"number":[417],"1-6),":[423],"eight":[424],"(31%)":[425],"completed":[426],"planned":[428],"6":[429],"treatment.":[432],"Ten":[433],"(38%)":[434],"discontinued":[435],"progression,":[437],"due":[439,443,448,456],"toxicity":[441],"(four":[442],"thrombocytopenia,":[445],"one":[446],"anxiety)":[453],"8%":[455],"patient/provider":[458],"preference.":[459],"Seven":[460],"(27%)":[461],"required":[463],"reduction.":[465],"One":[466],"patient":[467],"withdrew":[468],"lead-in":[472],"efficacy":[479],"analyses.":[480],"In":[481,571,613],"who":[483,559],"RAdR":[485,669],"(N=25)":[486],"ORR":[488,578,630],"56%,":[490],"95%":[491,499,518,530,581,589,598,608,633,641,650,660],"CI":[492,500,519,531,582,590,599,609,634,642,651,661],"(34.9%":[493],"-":[494,502,521,533,584,592,601,611,636,644,653,663],"75.6%)":[495],"CR":[497,587,639],"12%,":[498],"(2.5%":[501],"31.2%).":[503],"After":[504],"follow":[507,552,569],"18.2":[510],"months,":[511],"1-year":[512,524,594,604,646,656],"progression-free":[513],"survival":[514,526],"(PFS)":[515],"14.9%,":[517],"(5.4%":[520],"41.1%)":[522],"(OS)":[527],"63.3%,":[529],"(45.8%":[532],"87.4%).":[534],"(PTCL,":[537],"NOS":[538],"MF)":[540,628],"remain":[541],"remission":[543],"off":[544],"after":[546],"more":[547],"than":[548],"36":[549],"months":[550,567],"consolidation.":[555,693],"All":[556],"5":[557,620],"consolidative":[561],"SCT":[562],"alive":[564],"19-39":[566],"up.":[570],"nodal":[574],"(N=16)":[576],"63%,":[580],"(35.4%":[583],"84.8%)":[585],"19%,":[588],"(4.0%":[591],"45.6%).":[593],"PFS":[595,647],"16.9%,":[597],"(5.0%":[600],"57.4%)":[602],"OS":[605,657],"70.3%,":[607],"(49.5%":[610],"99.8%).":[612],"(N=9:":[619],"NOS,":[622],"ALCL,":[624],"ALK-":[625],"89%,":[632],"(51.8%":[635],"99.7%)":[637],"22%,":[640],"(2.8%":[643],"60.0%).":[645],"11.1%,":[649],"(1.8%":[652],"70.5%)":[654],"71.4%,":[659],"(44.7%":[662],"100%).":[664],"Multiagent":[665],"targeted":[666],"is":[670,697],"safe":[671],"induces":[676],"high":[678],"rate":[679],"response,":[681],"MTD,":[685],"responses":[689],"uncommon":[691],"four-drug":[695],"active":[698],"across":[699],"diverse":[701],"spectrum":[702],"may":[707],"effective":[710],"therapeutic":[711],"bridge":[712],"transplantation.":[714]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-12-06T00:00:00"}
