{"id":"https://openalex.org/W4405044328","doi":"https://doi.org/10.1182/blood-2024-199804","title":"Association of Neighbourhood-Level Socioeconomic Deprivation with Mortality Among Patients with Sickle Cell Disease","display_name":"Association of Neighbourhood-Level Socioeconomic Deprivation with Mortality Among Patients with Sickle Cell Disease","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405044328","doi":"https://doi.org/10.1182/blood-2024-199804"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-199804","doi":"https://doi.org/10.1182/blood-2024-199804","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-199804","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033301570","display_name":"Suma X. Vupputuri","orcid":"https://orcid.org/0000-0001-6848-2649","observed_orcids":["https://orcid.org/0000-0001-6848-2649"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suma Vupputuri","raw_affiliation_strings":["1Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlanta States, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlanta States, Rockville, MD","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064423861","display_name":"Seohyun Kim","orcid":"https://orcid.org/0000-0002-2119-6044","observed_orcids":["https://orcid.org/0000-0002-2119-6044","https://orcid.org/0000-0002-7373-0050"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seohyun Kim","raw_affiliation_strings":["2Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018630260","display_name":"Celeena R. Jefferson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celeena Jefferson","raw_affiliation_strings":["2Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015491576","display_name":"Bogdan Dumitriu","orcid":"https://orcid.org/0000-0003-0858-5974","observed_orcids":["https://orcid.org/0000-0003-0858-5974"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bogdan Dumitriu","raw_affiliation_strings":["3Mid-Atlantic Permanente Medical Group, Largo, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Mid-Atlantic Permanente Medical Group, Largo, MD","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021719923","display_name":"Penelope P. Howards","orcid":"https://orcid.org/0000-0001-7539-8701","observed_orcids":["https://orcid.org/0000-0001-7539-8701"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Penelope Howards","raw_affiliation_strings":["4Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"393","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13633","display_name":"Public Health and Social Inequalities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neighborhood-deprivation","display_name":"neighborhood disadvantage","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neighborhood-deprivation-index","display_name":"neighborhood deprivation index","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9419999718666077},{"id":"https://openalex.org/keywords/health-disparities","display_name":"health disparities","score":0.8790000081062317},{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.5220000147819519},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.48899999260902405},{"id":"https://openalex.org/keywords/kaiser-permanente","display_name":"Kaiser Permanente","score":0.6970000267028809},{"id":"https://openalex.org/keywords/geocoded-addresses","display_name":"geocoded addresses","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.6899999976158142},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.7620000243186951},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.4699999988079071},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6063015460968018},{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.5927388668060303},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49886083602905273},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.42328691482543945},{"id":"https://openalex.org/C161677786","wikidata":"https://www.wikidata.org/wiki/Q2478475","display_name":"Neighbourhood (mathematics)","level":2,"score":0.42180973291397095},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.36781829595565796},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3549574017524719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32886382937431335},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3214302659034729},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.24542996287345886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2382504642009735},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-199804","doi":"https://doi.org/10.1182/blood-2024-199804","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-199804","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0},{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.9629999995231628}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161599918","https://openalex.org/W4402984016","https://openalex.org/W4310107639","https://openalex.org/W2981142828","https://openalex.org/W4385405941","https://openalex.org/W4241381760","https://openalex.org/W7165620157","https://openalex.org/W4399047398","https://openalex.org/W2913894271","https://openalex.org/W4397040882"],"abstract_inverted_index":{"Introduction:":[0],"While":[1],"treatment":[2],"advances":[3],"for":[4,12,178,280,295,327,390],"Sickle":[5],"Cell":[6],"Disease":[7],"(SCD)":[8],"have":[9,20,30],"improved":[10],"outcomes":[11],"most":[13,312,413],"patients,":[14,199,405],"some":[15],"studies":[16,504],"(but":[17],"not":[18,251,461],"all)":[19],"demonstrated":[21,383,407],"disparities":[22],"related":[23],"to":[24,45,261,350,371,501,516],"socioeconomic":[25,122,483],"conditions.":[26,283],"Few":[27],"studies,":[28],"however,":[29,258,451],"examined":[31],"associations":[32],"between":[33,93],"sociodemographic":[34],"factors":[35],"and":[36,84,117,158,243,292,298,334,376,438,489],"clinical":[37,514],"outcomes.":[38],"The":[39,97,284],"objective":[40],"of":[41,49,105,148,167,193,256,263,278,301,323,347,385,388,396,402,429,468,472,482,509],"this":[42,400],"analysis":[43],"was":[44,100,124,265,289,305,369,377,431,490],"assess":[46],"the":[47,103,109,130,146,149,179,188,259,271,296,311,332,339,353,362,366,412,444,449,465,469,507],"association":[48],"neighborhood":[50,434],"deprivation":[51,435],"index":[52,98,127,140],"(NDI)":[53],"with":[54,187,315,338,393,433,528],"mortality":[55,181],"among":[56,267,307,526],"SCD":[57,75,198,404],"patients":[58,76,137,337,409,497],"using":[59],"electronic":[60],"health":[61,68,494],"record":[62],"(EHR)":[63],"data":[64],"from":[65,114,138],"a":[66,216,233,343,479,493],"diverse":[67],"system.":[69],"Methods:":[70],"Our":[71,476],"study":[72,110,150,401,477],"population":[73],"included":[74,153,478],"(identified":[77],"by":[78,165],"diagnosis":[79],"codes)":[80],"aged":[81],"18":[82],"years":[83,291,294,322],"older":[85],"enrolled":[86],"at":[87,126,287],"Kaiser":[88],"Permanente":[89],"(KP)":[90],"Mid-Atlantic":[91],"States":[92],"01/01/2004":[94],"-":[95],"12/31/2023.":[96],"date":[99,104,128,141],"defined":[101],"as":[102],"earliest":[106,131],"enrollment":[107],"during":[108],"period.":[111,151],"NDI":[112,279,341,355,473],"(derived":[113],"geocoded":[115],"addresses":[116],"multiple":[118],"census":[119],"tract":[120],"level":[121],"variables)":[123],"extracted":[125],"or":[129,145],"available":[132],"after":[133,320],"index.":[134],"We":[135],"followed":[136],"their":[139,458],"until":[142],"death,":[143],"disenrollment,":[144],"end":[147],"Covariates":[152,249],"age,":[154],"sex,":[155],"insurance,":[156],"comorbidities,":[157],"medication":[159],"use.":[160],"Kaplan-Meier":[161],"curves":[162,317,329],"described":[163],"survival":[164,316,328],"quartiles":[166,255,300,395],"NDI.":[168,194,397],"Extended":[169],"Cox":[170],"proportional":[171],"hazard":[172,175,346],"models":[173,382],"assessed":[174],"ratios":[176],"(HR)":[177],"adjusted":[180,364],"risk":[182,428,445],"(using":[183],"time-varying":[184],"covariates)":[185],"associated":[186,392,432],"highest":[189,272,297,340],"vs.":[190],"lowest":[191,276,299,354],"quartile":[192,277],"Results:":[195],"Among":[196],"1,083":[197],"685":[200],"(63.3%)":[201],"were":[202,206,246],"female,":[203],"894":[204],"(82.6%)":[205],"commercially":[207],"insured,":[208],"437":[209],"(40.4%)":[210],"had":[211,215,221,226,232,239,342,498],"hypertension,":[212],"156":[213],"(14.4%),":[214],"venous":[217],"thromboembolism,":[218],"223":[219],"(20.6%)":[220],"heart":[222],"disease,":[223,242],"137":[224],"(12.7%)":[225],"acute":[227],"chest":[228],"syndrome,":[229],"105":[230],"(9.7%)":[231],"hemorrhagic":[234],"cerebrovascular":[235],"event,":[236],"271":[237],"(25.0%)":[238],"chronic":[240],"kidney":[241],"238":[244],"(22.0%)":[245],"taking":[247],"hydroxyurea.":[248],"did":[250],"significantly":[252,426],"differ":[253],"across":[254],"NDI,":[257,302],"time":[260],"development":[262],"comorbidities":[264],"shorter":[266],"those":[268,308,351,420],"living":[269,309,410],"in":[270,310,352,411,421,436,464,519],"(most":[273],"deprived)":[274],"vs":[275],"virtually":[281],"all":[282],"mean":[285],"age":[286],"death":[288,348,391,430],"60.7":[290],"68.2":[293],"respectively.":[303],"Survival":[304],"worst":[306],"deprived":[313,414,423],"neighborhoods":[314,415],"showing":[318],"separation":[319],"8":[321],"follow-up.":[324],"(Confidence":[325],"intervals":[326],"overlapped).":[330],"In":[331,361,399,441],"age-":[333,437],"sex-adjusted":[335,439],"model,":[336,365],"56%":[344],"increased":[345],"compared":[349],"(HR:":[356],"1.56;":[357],"95%CI:":[358],"1.01,":[359],"2.42).":[360],"fully":[363],"HR":[367],"estimate":[368,446],"reduced":[370],"1.27":[372],"(95%CI:":[373],"0.80,":[374],"2.01)":[375],"no":[378],"longer":[379],"significant.":[380],"Both":[381],"trends":[384],"higher":[386,427],"magnitudes":[387],"HRs":[389],"increasing":[394],"Conclusions:":[398],"adult":[403],"we":[406],"that":[408,521],"are":[416],"dying":[417],"earlier":[418,513],"than":[419],"less":[422],"areas.":[424],"A":[425],"models.":[440],"full":[442],"models,":[443],"moved":[447],"towards":[448],"null,":[450],"since":[452],"comorbid":[453],"conditions":[454,511],"may":[455],"be":[456,462],"mediators,":[457],"adjustment":[459],"would":[460],"appropriate":[463],"causal":[466],"estimation":[467],"total":[470],"effect":[471],"on":[474,512],"mortality.":[475],"robust":[480],"measure":[481],"status,":[484],"extensive":[485],"longitudinal":[486],"EHR":[487],"data,":[488],"conducted":[491],"within":[492],"system":[495],"where":[496],"equal":[499],"access":[500],"care.":[502],"Future":[503],"should":[505],"explore":[506],"impact":[508],"social":[510],"endpoints":[515],"address":[517],"inequities":[518],"care":[520],"could":[522],"potentially":[523],"extend":[524],"life":[525],"persons":[527],"SCD.":[529]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-06T00:00:00"}
