{"id":"https://openalex.org/W4405040679","doi":"https://doi.org/10.1182/blood-2024-205044","title":"All-Trans Retinoic Acid Enhances CS1-BCMA Dual-Target CAR-T Cells in Multiple Myeloma","display_name":"All-Trans Retinoic Acid Enhances CS1-BCMA Dual-Target CAR-T Cells in Multiple Myeloma","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405040679","doi":"https://doi.org/10.1182/blood-2024-205044"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-205044","doi":"https://doi.org/10.1182/blood-2024-205044","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-205044","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/2052/2335324/blood-4799-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/2052/2335324/blood-4799-main.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012360415","display_name":"Yinqiang Zhang","orcid":"https://orcid.org/0000-0002-5423-1774","observed_orcids":["https://orcid.org/0000-0002-5423-1774"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinqiang Zhang","raw_affiliation_strings":["1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045645758","display_name":"Zhuolin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Zhuolin","raw_affiliation_strings":["1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044870711","display_name":"Wenjing Luo","orcid":"https://orcid.org/0000-0002-6847-0629","observed_orcids":["https://orcid.org/0000-0002-6847-0629"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Luo","raw_affiliation_strings":["1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102924568","display_name":"Chenggong Li","orcid":"https://orcid.org/0009-0005-3119-0147","observed_orcids":["https://orcid.org/0009-0005-3119-0147"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenggong Li","raw_affiliation_strings":["1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048815633","display_name":"Heng Mei","orcid":"https://orcid.org/0000-0001-7941-2443","observed_orcids":["https://orcid.org/0000-0001-7941-2443"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng Mei","raw_affiliation_strings":["2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","3Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China","institution_ids":[]},{"raw_affiliation_string":"3Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"2052","last_page":"2052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.9300000071525574},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tumor-cell-lysis","display_name":"tumor cell lysis","score":0.5379999876022339},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7059999704360962},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.701155424118042},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5599192380905151},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4992866516113281},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4515978693962097},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.43518128991127014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36597347259521484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35634079575538635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28439974784851074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15551131963729858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11137655377388},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-205044","doi":"https://doi.org/10.1182/blood-2024-205044","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-205044","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/2052/2335324/blood-4799-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1182/blood-2024-205044","doi":"https://doi.org/10.1182/blood-2024-205044","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2024-205044","pdf_url":"https://ashpublications.org/blood/article-pdf/144/Supplement 1/2052/2335324/blood-4799-main.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4405040679.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1515050147","https://openalex.org/W2156515185","https://openalex.org/W2954216173","https://openalex.org/W2155689725","https://openalex.org/W3014164753","https://openalex.org/W2139860903","https://openalex.org/W3208991347","https://openalex.org/W2235585012","https://openalex.org/W2935425301","https://openalex.org/W4231738628"],"abstract_inverted_index":{"Background:CS1-BCMA":[0],"dual-target":[1,71,111,200,281],"chimeric":[2],"antigen":[3],"receptor":[4],"T":[5,82],"cell":[6,134,138,170],"(CAR-T)":[7],"has":[8,43],"exhibited":[9],"superior":[10],"efficacy":[11],"in":[12,32,36,116,119,140,165,192,207,217],"multiple":[13],"myeloma":[14],"(MM).":[15],"However,":[16],"there":[17],"are":[18],"still":[19],"obstacles":[20],"such":[21],"as":[22],"target":[23],"down-regulation":[24],"and":[25,52,65,91,102,118,216,260,290,306,312],"barriers":[26],"to":[27,46,151,160,226,316],"immune":[28],"infiltration,":[29],"which":[30,189],"results":[31],"refractory":[33],"or":[34],"relapse":[35],"certain":[37],"patients.":[38],"All-trans":[39],"retinoic":[40],"acid":[41,257],"(ATRA)":[42],"been":[44],"reported":[45],"upregulate":[47],"the":[48,54,153,193,218,230,255,263,271,277,286,292],"expression":[49,85,180,287],"of":[50,79,99,106,155,176,224,232,248,262,279,288,295],"CD38":[51],"modulate":[53],"tumor":[55,300],"microenvironment":[56],"(TME),":[57],"but":[58,237],"its":[59,238],"synergistic":[60],"effect":[61,294],"on":[62,270],"CS1-BCMA":[63,110,199,280],"CAR-T":[64,72,112,161,201,233,282],"potential":[66],"mechanism":[67,154,273],"remains":[68],"unexplored.":[69],"Methods:CS1-BCMA":[70],"cells":[73,101,113,159,202,205,228,250,283],"were":[74],"generated":[75],"by":[76,88,129,186,234,242,284],"lentiviral":[77],"transduction":[78],"healthy":[80],"donor":[81],"cells.":[83],"BCMA/CS1":[84],"was":[86,114,127,149,190,240],"measured":[87],"flow":[89,187],"cytometry":[90],"quantitative":[92],"real-time":[93],"PCR":[94],"after":[95],"24":[96],"hours":[97],"coculture":[98],"MM":[100,137,158,169,204,227,249],"ATRA.":[103],"Tumor":[104],"lysis":[105],"ATRA":[107,156,173,243,253,275],"combined":[108],"with":[109,136,172,304],"assessed":[115],"vitro":[117,166,208],"NXG":[120,194,219],"xenograft":[121,195,220],"models.":[122],"Cancer":[123],"related":[124],"fibroblast":[125],"(CAF)":[126],"induced":[128],"bone":[130],"marrow":[131],"mesenchymal":[132],"stem":[133],"coculturing":[135],"lines":[139,171],"transwell":[141],"inserts":[142],"(0.4um)":[143],"for":[144,213],"48":[145],"hours.":[146],"Transcriptome":[147,245],"sequencing":[148,246],"conducted":[150],"reveal":[152],"sensibilizing":[157],"therapy.":[162],"Results:":[163],"Experiments":[164],"demonstrated":[167],"thatcoculturing":[168],"at":[174,184,211],"concentrations":[175],"10nM-1000nM":[177],"upregulated":[178,254],"BCMA":[179,289],"(MM.1S:":[181,209],"1.5-fold,":[182],"P<0.01":[183,210],"1000nM":[185,212],"cytometry),":[188],"verified":[191],"model.":[196,221],"ARTA":[197],"synergized":[198],"against":[203],"both":[206],"6-hour":[214],"coculturing)":[215],"The":[222],"addition":[223],"CAF":[225],"impaired":[229],"cytotoxicity":[231,278],"27%":[235],"(P<0.05)":[236],"immunosuppression":[239],"reversed":[241],"(P<0.05).":[244],"analysis":[247],"showed":[251],"that":[252,274,299],"arachidonic":[256],"metabolism":[258,305],"pathway":[259],"down-regulated":[261],"TGF-\u03b2":[264,307],"pathway..":[265],"Conclusion:":[266],"Our":[267],"study":[268],"expands":[269],"hypothesized":[272],"promotes":[276],"upregulating":[285],"reversing":[291],"immunosuppressive":[293],"CAF.":[296],"Sequencing":[297],"demonstrates":[298],"sensitivity":[301],"is":[302],"associated":[303],"pathway.":[308],"Further":[309],"underlying":[310],"mechanisms":[311],"clinical":[313],"translation":[314],"need":[315],"be":[317],"explored.":[318]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}