{"id":"https://openalex.org/W4405035644","doi":"https://doi.org/10.1093/braincomms/fcag283","title":"Enhancing brain age estimation with structural MRI and synthesized cerebral blood volume maps","display_name":"Enhancing brain age estimation with structural MRI and synthesized cerebral blood volume maps","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W4405035644","doi":"https://doi.org/10.1093/braincomms/fcag283","pmid":"https://pubmed.ncbi.nlm.nih.gov/42683072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13532576"},"language":"en","primary_location":{"id":"doi:10.1093/braincomms/fcag283","doi":"https://doi.org/10.1093/braincomms/fcag283","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcag283","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/braincomms/fcag283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114469960","display_name":"Jordan Jomsky","orcid":"https://orcid.org/0009-0008-0168-4893","observed_orcids":["https://orcid.org/0009-0008-0168-4893"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Jomsky","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":"https://orcid.org/0009-0008-0168-4893","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134589066","display_name":"Zongyu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zongyu Li","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067845292","display_name":"Kay Chioma Igwe","orcid":"https://orcid.org/0000-0002-9909-9930","observed_orcids":["https://orcid.org/0000-0002-9909-9930"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kay C Igwe","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":"https://orcid.org/0000-0002-9909-9930","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005519874","display_name":"Yiren Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiren Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143457744","display_name":"Max Lashley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Lashley","raw_affiliation_strings":["Zuckerman Institute, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zuckerman Institute, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077532905","display_name":"Tal Nuriel","orcid":"https://orcid.org/0000-0002-5252-8048","observed_orcids":["https://orcid.org/0000-0002-5252-8048"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tal Nuriel","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University , New York, NY ,","Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY ,"],"raw_orcid":"https://orcid.org/0000-0002-5252-8048","affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University , New York, NY ,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112824158","display_name":"Andrew Laine","orcid":"https://orcid.org/0000-0003-3797-0628","observed_orcids":["https://orcid.org/0000-0003-3797-0628"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Laine","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":"https://orcid.org/0000-0003-3797-0628","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940166","display_name":"Scott A. Small","orcid":"https://orcid.org/0000-0002-4777-1502","observed_orcids":["https://orcid.org/0000-0002-4777-1502"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A Small","raw_affiliation_strings":["Department of Neurology, Columbia University , New York, NY 10027 ,","Department of Psychiatry, Columbia University , New York, NY 10027 ,","Department of Radiology, Columbia University , New York, NY ,","New York State Psychiatric Institute , New York, NY ,","Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY ,"],"raw_orcid":"https://orcid.org/0000-0002-4777-1502","affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University , New York, NY 10027 ,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Psychiatry, Columbia University , New York, NY 10027 ,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Radiology, Columbia University , New York, NY ,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute , New York, NY ,","institution_ids":["https://openalex.org/I4388891851"]},{"raw_affiliation_string":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY ,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088747610","display_name":"Jia Lei Guo","orcid":"https://orcid.org/0000-0002-0556-0491","observed_orcids":["https://orcid.org/0000-0002-0556-0491","https://orcid.org/0000-0003-4803-0279"]},"institutions":[{"id":"https://openalex.org/I4405270606","display_name":"Mortimer B. Zuckerman Mind Brain Behavior Institute","ror":"https://ror.org/0110mmp98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270606"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jia Guo","raw_affiliation_strings":["Department of Psychiatry, Columbia University , New York, NY 10027 ,","Zuckerman Institute, Columbia University , New York, NY 10027-7041 ,"],"raw_orcid":"https://orcid.org/0000-0003-4803-0279","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University , New York, NY 10027 ,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Zuckerman Institute, Columbia University , New York, NY 10027-7041 ,","institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106733559","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Frontotemporal Lobar Degeneration Neuroimaging Initiative and for the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143422038","display_name":"Howard Rosen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086955468","display_name":"Bradford Clark Dickerson","orcid":"https://orcid.org/0000-0002-5958-3445","observed_orcids":["https://orcid.org/0000-0002-5958-3445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradford C Dickerson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106420198","display_name":"Kimoko Domoto-Reilly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimoko Domoto-Reilly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Knopman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066352714","display_name":"Bradley F. Boeve","orcid":"https://orcid.org/0000-0002-4153-8187","observed_orcids":["https://orcid.org/0000-0002-4153-8187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley F Boeve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019555711","display_name":"Adam L. Boxer","orcid":"https://orcid.org/0000-0002-1215-5064","observed_orcids":["https://orcid.org/0000-0002-1215-5064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam L Boxer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027791567","display_name":"John Kornak","orcid":"https://orcid.org/0000-0002-0089-0619","observed_orcids":["https://orcid.org/0000-0002-0089-0619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Kornak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046120768","display_name":"Bruce L. Miller","orcid":"https://orcid.org/0000-0002-2152-4220","observed_orcids":["https://orcid.org/0000-0002-2152-4220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce L Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074694043","display_name":"William W. Seeley","orcid":"https://orcid.org/0000-0003-1410-2027","observed_orcids":["https://orcid.org/0000-0003-1410-2027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William W Seeley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112433790","display_name":"Maria\u2010Luisa Gorno\u2010Tempini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria-Luisa Gorno-Tempini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185871","display_name":"Scott M. McGinnis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott McGinnis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061783753","display_name":"Maria Luisa Mandelli","orcid":"https://orcid.org/0000-0002-2518-2520","observed_orcids":["https://orcid.org/0000-0002-2518-2520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Luisa Mandelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088747610"],"corresponding_institution_ids":["https://openalex.org/I4405270606","https://openalex.org/I78577930"],"apc_list":{"value":3051,"currency":"GBP","value_usd":4024},"apc_paid":{"value":3051,"currency":"GBP","value_usd":4024},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00105681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"fcag283","last_page":"fcag283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-volume","display_name":"cerebral blood volume","score":0.6489999890327454},{"id":"https://openalex.org/keywords/structural-mri","display_name":"structural MRI","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9340000152587891},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neurodegeneration-markers","display_name":"neurodegeneration biomarkers","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cerebrovascular-dysfunction","display_name":"cerebrovascular dysfunction","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hypoperfusion","display_name":"hypoperfusion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/saliency-maps","display_name":"saliency maps","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dementia-risk-stratification","display_name":"dementia risk stratification","score":0.6549999713897705},{"id":"https://openalex.org/keywords/non-contrast-mri","display_name":"non-contrast MRI","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cognitive-decline-prediction","display_name":"cognitive decline prediction","score":0.5640000104904175},{"id":"https://openalex.org/keywords/white-matter-atrophy","display_name":"white matter atrophy","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cortical-atrophy","display_name":"cortical atrophy","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.6395388841629028},{"id":"https://openalex.org/C2982720008","wikidata":"https://www.wikidata.org/wiki/Q70680914","display_name":"Cerebral blood volume","level":3,"score":0.6112391948699951},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5380164980888367},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.52711421251297},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4870510399341583},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4788613021373749},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4373151361942291},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4217495024204254},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30280447006225586},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2857881784439087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27008935809135437},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22000643610954285},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12758073210716248},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0942227840423584},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.049749016761779785},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/braincomms/fcag283","doi":"https://doi.org/10.1093/braincomms/fcag283","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcag283","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},{"id":"pmid:42683072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42683072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13532576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13532576/pdf/fcag283.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Commun","raw_type":"Text"},{"id":"pmh:oai:arXiv.org:2412.01865","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2412.01865","pdf_url":"https://arxiv.org/pdf/2412.01865","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2412.01865","doi":"https://doi.org/10.48550/arxiv.2412.01865","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2412.01865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1093/braincomms/fcag283","doi":"https://doi.org/10.1093/braincomms/fcag283","is_oa":true,"landing_page_url":"https://doi.org/10.1093/braincomms/fcag283","pdf_url":null,"source":{"id":"https://openalex.org/S4210235363","display_name":"Brain Communications","issn_l":"2632-1297","issn":["2632-1297"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1298807586","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G1554142629","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G1593117279","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G1650819308","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G1880935189","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G1999068260","display_name":"Alzheimer's Disease Neuroimaging Initiative","funder_award_id":"3u01ag024904-10s2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2100670906","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G2152643862","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G2189010064","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G2340207221","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G2423387114","display_name":null,"funder_award_id":"W81XWH-12-2\u20130012","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G2471646051","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327918","funder_display_name":"H. Lundbeck A/S"},{"id":"https://openalex.org/G2522063444","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G2835601961","display_name":null,"funder_award_id":"U01AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G29951154","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3131374986","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3216574877","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320309697","funder_display_name":"Alzheimer's Disease Neuroimaging Initiative"},{"id":"https://openalex.org/G3553156159","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G3608198921","display_name":null,"funder_award_id":"811245","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"},{"id":"https://openalex.org/G3710456697","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G3752451908","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G3870774570","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G3908963977","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G43180419","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G4475667458","display_name":null,"funder_award_id":"W81XWH-12-2-","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4501223628","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G4800177743","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5207404921","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G5209990037","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G528601746","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5365730499","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G5381939979","display_name":"EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)\"","funder_award_id":"W81XWH1220012","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5654639750","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310045","funder_display_name":"BioClinica"},{"id":"https://openalex.org/G5740349702","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G613619302","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G6173816828","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G6210868510","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6371410416","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320308604","funder_display_name":"Biogen"},{"id":"https://openalex.org/G6412110892","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320332193","funder_display_name":"Genentech"},{"id":"https://openalex.org/G6447063303","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320309470","funder_display_name":"Meso Scale Diagnostics"},{"id":"https://openalex.org/G6719828067","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G6792506723","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307115","funder_display_name":"Bristol-Myers Squibb"},{"id":"https://openalex.org/G6899163935","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320322148","funder_display_name":"Eisai"},{"id":"https://openalex.org/G72415811","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320311551","funder_display_name":"Northern California Institute for Research and Education"},{"id":"https://openalex.org/G7298697282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320329118","funder_display_name":"IXICO"},{"id":"https://openalex.org/G764699806","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7799614282","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G781725486","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G8228018387","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G8281378126","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G839208290","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320310388","funder_display_name":"Novartis Pharmaceuticals Corporation"},{"id":"https://openalex.org/G8852128998","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320327235","funder_display_name":"Servier"},{"id":"https://openalex.org/G8895907669","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G8897063270","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G8957659042","display_name":null,"funder_award_id":"W81XWH-12-2-0012","funder_id":"https://openalex.org/F4320307758","funder_display_name":"Eli Lilly and Company"},{"id":"https://openalex.org/G9000039018","display_name":null,"funder_award_id":"U01-AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000122335","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320309470","display_name":"Meso Scale Diagnostics","ror":"https://ror.org/05jgy0m16"},{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320310045","display_name":"BioClinica","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320311551","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517"},{"id":"https://openalex.org/F4320320386","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320329118","display_name":"IXICO","ror":"https://ror.org/00paezp73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405035644.pdf","grobid_xml":"https://content.openalex.org/works/W4405035644.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391121601","https://openalex.org/W4414237426","https://openalex.org/W4412834541","https://openalex.org/W4313528065","https://openalex.org/W3010138595","https://openalex.org/W2979785183","https://openalex.org/W2956113953","https://openalex.org/W4412784767","https://openalex.org/W4412441517","https://openalex.org/W3017066732"],"abstract_inverted_index":{"Abstract":[0],"Brain":[1],"age":[2,144],"gap":[3,145],"estimation":[4,293],"(BrainAGE)":[5],"is":[6],"a":[7,50,67,97,152,252,319,334],"promising":[8],"imaging-derived":[9],"biomarker":[10,337],"of":[11,156,211,238,314],"neurobiological":[12],"ageing":[13,340],"and":[14,35,88,108,119,129,190,197,203,229,294,299,312,332,341],"disease":[15,131,301],"risk,":[16],"yet":[17],"current":[18],"approaches":[19],"rely":[20],"predominantly":[21],"on":[22,84,92,110,165],"T1-weighted":[23],"structural":[24,85,283],"MRI,":[25,48,324],"overlooking":[26],"functional":[27],"vascular":[28,59,276,288],"changes":[29,277],"that":[30,71,217,278],"may":[31],"precede":[32,279],"tissue":[33],"damage":[34],"cognitive":[36,126,232],"decline.":[37],"Deep":[38],"learning-derived":[39,287],"cerebral":[40],"blood":[41],"volume":[42],"(DeepCBV)":[43],"maps,":[44],"synthesized":[45],"from":[46,74,115,322],"non-contrast":[47],"offer":[49],"scalable":[51],"alternative":[52],"to":[53,62,274,297,329],"contrast-enhanced":[54],"perfusion":[55],"imaging":[56],"by":[57,96],"capturing":[58],"information":[60],"relevant":[61],"early":[63,204,310],"neurodegeneration.":[64],"We":[65],"developed":[66],"multimodal":[68,330],"BrainAGE":[69,218,250,292],"framework":[70],"combines":[72],"predictions":[73],"two":[75],"separate":[76],"three-dimensional":[77,99],"convolutional":[78],"neural":[79],"networks:":[80],"one":[81],"trained":[82,90,107,164],"only":[83,91],"MRI":[86,166,186,284],"scans":[87,112],"another":[89],"DeepCBV":[93,173,194],"maps":[94,181],"generated":[95],"pre-trained":[98],"patch-based":[100],"deep":[101,286],"learning":[102],"model.":[103],"Each":[104],"model":[105,138],"was":[106,120],"validated":[109],"2851":[111],"(1507":[113],"females)":[114],"13":[116],"open-source":[117],"datasets":[118],"evaluated":[121],"for":[122,146,338],"concordance":[123],"with":[124,151,208,231,285],"mild":[125],"impairment":[127,233],"(MCI)":[128],"Alzheimer\u2019s":[130,300],"(AD)":[132],"using":[133],"1233":[134],"subjects.":[135],"The":[136],"combined":[137],"achieved":[139],"the":[140],"most":[141],"accurate":[142],"brain":[143],"cognitively":[147],"normal":[148,212],"(CN)":[149],"controls,":[150],"mean":[153],"absolute":[154,168,176],"error":[155,169,177],"3.95":[157],"years":[158],"(R2":[159],"=":[160,170,178,241,247,263,268],"0.943),":[161],"outperforming":[162],"models":[163],"(mean":[167,175],"4.10)":[171],"or":[172],"alone":[174],"4.49).":[179],"Saliency":[180],"revealed":[182],"complementary":[183],"modality":[184],"contributions:":[185],"emphasized":[187],"white":[188],"matter":[189],"cortical":[191],"atrophy,":[192],"while":[193],"highlighted":[195],"vascular-rich":[196],"periventricular":[198],"regions":[199],"implicated":[200],"in":[201,307],"hypoperfusion":[202],"cerebrovascular":[205],"dysfunction,":[206],"consistent":[207],"known":[209],"patterns":[210],"ageing.":[213],"Next,":[214],"we":[215],"observed":[216],"increased":[219],"stepwise":[220],"across":[221],"diagnostic":[222],"strata":[223],"(CN":[224],"<":[225,227],"MCI":[226,260,298],"AD)":[228],"correlated":[230],"(Clinical":[234],"Dementia":[235],"Rating":[236],"Sum":[237],"Boxes":[239],"\u2374":[240,246],"0.403;":[242],"Mini-Mental":[243],"State":[244],"Examination":[245],"\u22120.310).":[248],"DeepCBV-based":[249],"showed":[251],"particularly":[253],"strong":[254],"separation":[255],"between":[256],"stable":[257],"versus":[258],"progressive":[259],"(Mann\u2013Whitney":[261],"U":[262],"2.177":[264],"\u00d7":[265,270],"104,":[266],"P":[267],"4.43":[269],"10\u22128),":[271],"suggesting":[272],"sensitivity":[273,296],"prodromal":[275],"overt":[280],"atrophy.":[281],"Integrating":[282],"measures":[289],"substantially":[290],"enhances":[291],"improves":[295],"progression,":[302],"supporting":[303],"its":[304],"potential":[305],"role":[306],"risk":[308],"stratification,":[309],"detection":[311],"monitoring":[313],"therapeutic":[315],"response.":[316],"By":[317],"enabling":[318],"functional-like":[320],"assessment":[321],"routine":[323],"this":[325],"approach":[326],"lowers":[327],"barriers":[328],"evaluation":[331],"provides":[333],"clinically":[335],"actionable":[336],"large-scale":[339],"dementia":[342],"studies.":[343]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-12-06T00:00:00"}