{"id":"https://openalex.org/W4405035181","doi":"https://doi.org/10.1182/blood-2024-212240","title":"Predictors of Individual Symptom Scores in Myeloproliferative Neoplasms: A Real-World Retrospective Cohort Study","display_name":"Predictors of Individual Symptom Scores in Myeloproliferative Neoplasms: A Real-World Retrospective Cohort Study","publication_year":2024,"publication_date":"2024-11-05","ids":{"openalex":"https://openalex.org/W4405035181","doi":"https://doi.org/10.1182/blood-2024-212240"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2024-212240","doi":"https://doi.org/10.1182/blood-2024-212240","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-212240","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048326664","display_name":"Muhammad Ali Khan","orcid":"https://orcid.org/0000-0003-3956-3698","observed_orcids":["https://orcid.org/0000-0003-3956-3698"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Ali Khan","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067550666","display_name":"Syed Arsalan Ahmed Naqvi","orcid":"https://orcid.org/0000-0002-3131-2088","observed_orcids":["https://orcid.org/0000-0002-3131-2088"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Arsalan Naqvi","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019005291","display_name":"Cecilia Arana Yi","orcid":"https://orcid.org/0000-0001-5420-3514","observed_orcids":["https://orcid.org/0000-0001-5420-3514","https://orcid.org/0000-0002-7441-5140"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Y. Arana Yi","raw_affiliation_strings":["2Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055454241","display_name":"John Kelly Camoriano","orcid":"https://orcid.org/0000-0002-2957-5356","observed_orcids":["https://orcid.org/0000-0002-2957-5356"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Camoriano","raw_affiliation_strings":["3Mayo Clinic Scottsdale, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Mayo Clinic Scottsdale, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111084151","display_name":"Joshua L. Blocher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Blocher","raw_affiliation_strings":["4Mayo Clinic, Phoenix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Mayo Clinic, Phoenix","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090382799","display_name":"Jennifer Andres","orcid":"https://orcid.org/0000-0002-5537-980X","observed_orcids":["https://orcid.org/0000-0002-5537-980X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Andres","raw_affiliation_strings":["4Mayo Clinic, Phoenix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Mayo Clinic, Phoenix","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018306647","display_name":"Irbaz Bin Riaz","orcid":"https://orcid.org/0000-0003-4249-0311","observed_orcids":["https://orcid.org/0000-0003-4249-0311"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irbaz Bin Riaz","raw_affiliation_strings":["1Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057941081","display_name":"Jeanne M. Palmer","orcid":"https://orcid.org/0000-0002-2185-1504","observed_orcids":["https://orcid.org/0000-0002-2185-1504"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanne Palmer","raw_affiliation_strings":["5Mayo Clinic - Arizona, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Mayo Clinic - Arizona, Scottsdale, AZ","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"Supplement 1","first_page":"5195","last_page":"5195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.996999979019165},{"id":"https://openalex.org/keywords/symptom-burden","display_name":"symptom burden","score":0.9100000262260437},{"id":"https://openalex.org/keywords/total-symptom-score","display_name":"total symptom score","score":0.9430000185966492},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9259999990463257},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":1.0},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.9629999995231628},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5519999861717224},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.3199999928474426},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6669999957084656},{"id":"https://openalex.org/keywords/bone-pain","display_name":"bone pain","score":0.31200000643730164},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6179999709129333},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.5199999809265137},{"id":"https://openalex.org/keywords/night-sweats","display_name":"night sweats","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.7149999737739563},{"id":"https://openalex.org/keywords/concentration-problems","display_name":"concentration difficulties","score":0.5789999961853027},{"id":"https://openalex.org/keywords/inactivity","display_name":"inactivity","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.631236732006073},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.593573808670044},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5324023365974426},{"id":"https://openalex.org/C2908731994","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Hematologic Neoplasms","level":3,"score":0.4801154136657715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38204553723335266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23080649971961975}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2024-212240","doi":"https://doi.org/10.1182/blood-2024-212240","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2024-212240","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Introduction":[0],"Symptom":[1],"burden":[2,550],"in":[3,253,318,323,337,350,518,531,538,558,571],"myeloproliferative":[4],"neoplasms":[5],"(MPN)":[6],"is":[7,563],"quantified":[8],"using":[9,119,136],"total":[10],"symptom":[11,151,271,288,549],"scores":[12,18,60],"(TSS)":[13],"calculated":[14],"from":[15,54],"the":[16,55,101,106,127,150,228,239,244,247,268,273,285,298,553,567],"patient-reported":[17],"for":[19],"clinically":[20],"meaningful":[21],"symptoms.":[22],"The":[23,154,166],"impact":[24],"of":[25,61,103,126,169,241,246,347,546,569],"demographic,":[26],"clinical,":[27],"and":[28,36,49,85,98,115,123,174,182,197,211,262,313,325,332,362,377,406,428,454,467,481,503,520,522,526,551],"laboratory":[29,96],"features":[30,88],"on":[31],"these":[32,539,572],"symptoms":[33,63,349,536],"remains":[34],"unclear":[35],"warrants":[37],"further":[38],"investigation.":[39],"Methods":[40],"Patients":[41],"with":[42,149,171,209,222,343,355,372,382,391,414,424,433,443,463,477,491,499,508],"polycythemia":[43],"vera":[44],"(PV),":[45],"essential":[46],"thrombocythemia":[47],"(ET),":[48],"myelofibrosis":[50],"(MF)":[51],"were":[52,112,117,189,213,224,340],"identified":[53,157],"retrospective":[56],"chart":[57,155],"review.":[58],"TSS,":[59],"individual":[62,348],"(fatigue,":[64],"early":[65,373,468,482],"satiety,":[66],"abdominal":[67,395,492],"discomfort,":[68],"inactivity,":[69],"concentration":[70,363,402,447],"difficulties,":[71],"fever,":[72],"night":[73,407,455],"sweats,":[74],"itching,":[75],"bone":[76,434],"pain,":[77],"weight":[78,282],"loss),":[79],"demographic":[80,542],"characteristics":[81],"(race,":[82],"ethnicity,":[83],"age,":[84],"gender),":[86],"clinical":[87,248],"(time":[89],"since":[90,420],"diagnosis,":[91],"depression":[92,242,310,320,326,352,388,440,517],"status,":[93],"obesity":[94],"status),":[95],"results":[97],"season":[99],"at":[100,243,544],"time":[102,245],"visit":[104],"when":[105],"first":[107],"TSS":[108,250,299],"assessment":[109],"was":[110,134,176,251,267,284,353,370,380,389,412,422,431,441,461,475,489,497,506],"performed":[111,135],"recorded.":[113],"Multicollinearity":[114],"homoscedasticity":[116],"assessed":[118],"variance":[120,139],"inflation":[121],"factors":[122],"visual":[124],"inspection":[125],"data,":[128],"respectively.":[129,186],"A":[130,141],"multivariable":[131,300],"regression":[132,301],"analysis":[133,302],"a":[137,145,527,547],"robust":[138],"estimator.":[140],"p-value":[142],"<0.05":[143],"indicated":[144],"statistically":[146],"significant":[147],"association":[148],"scores.":[152],"Results":[153],"review":[156],"557":[158],"(PV:":[159,191,201,215,232,275,289],"201;":[160],"ET:":[161,193,203,217,234,277,291],"191;":[162],"MF:":[163,195,205,236,279,293],"165)":[164],"patients.":[165,265,540,573],"median":[167],"age":[168,305,430],"patients":[170,188,208,221,230,274,339],"PV,":[172,319,351],"ET,":[173,324,387],"MF":[175,223,254,338,532],"65":[177,180],"(range:":[178],"27-93),":[179],"(20-96),":[181],"69":[183],"(27-96)":[184],"years,":[185],"Most":[187,207],"white":[190],"92%;":[192],"90%;":[194],"93%)":[196],"non-Hispanic":[198],"or":[199],"Latino":[200],"93%;":[202],"96%;":[204],"92%).":[206],"PV":[210,260,519],"ET":[212,263,521],"female":[214,504],"51%;":[216],"73%),":[218],"while":[219],"most":[220,269],"male":[225],"(55%).":[226],"Among":[227],"included":[229],"22%":[231],"21%;":[233],"27%;":[235],"18%)":[237],"had":[238],"diagnosis":[240,421],"visit.":[249],"highest":[252],"(mean":[255],"(SD):":[256],"18.1\u00b114.6),":[257],"followed":[258],"by":[259,272],"(15.7\u00b114.5)":[261],"(15.1\u00b114.0)":[264],"Fatigue":[266],"reported":[270,287],"81%;":[276],"82%;":[278],"84%),":[280],"whereas":[281],"loss":[283],"least":[286],"4.5%;":[290],"6.3%;":[292],"16%).":[294],"With":[295],"regards":[296],"to":[297,534,560,565],"showed":[303],"that":[304,516,555],"(beta":[306,357],"coefficient:":[307,358],"0.2;":[308],"p=0.01),":[309],"(7.2;":[311],"0.008),":[312],"low":[314,459,486,524],"hemoglobin":[315,460],"(1.2;":[316,416],"0.003)":[317,502],"(11.7;":[321],"0.001)":[322],"(9.5;":[327],"0.001),":[328,446],"splenomegaly":[329,496],"(6.9;":[330],"0.01),":[331,450],"WBC":[333,368,473,529],"count":[334,369,474,488,530],"(0.16;":[335],"0.048)":[336],"significantly":[341],"associated":[342,354,371,381,390,413,423,432,442,462,476,490,498,507],"TSS.":[344],"In":[345,386,438],"terms":[346],"fatigue":[356,392,415,444,464,478],"1.31;":[359],"p-value:":[360],"0.01)":[361],"difficulties":[364,403,448],"(1.7;":[365],"<0.001),":[366,394,398,401,410],"high":[367,472,528],"satiety":[374,469,483],"(0.09;":[375],"0.03),":[376,417,458,495],"non-white":[378],"race":[379],"fever":[383,451],"(1.4;":[384,397,409],"0.007).":[385],"(1.6;":[393],"discomfort":[396,493],"inactivity":[399,425,500],"(2.5;":[400],"(2.4;":[404],"<0.001)":[405],"sweats":[408,456],"anemia":[411],"fewer":[418],"months":[419],"(0.01;":[426],"0.02)":[427],"young":[429],"pain":[435],"(0.02;":[436],"0.03).":[437],"MF,":[439],"(1.8;":[445],"(1.3;":[449],"(1.1;":[452],"0.02),":[453,485],"(2.2;":[457],"(0.46;":[465],"<0,001)":[466],"(0.31;":[470],"0.003),":[471],"(0.03;":[479],"0.04)":[480],"(0.04;":[484],"platelet":[487],"(0.002;":[494],"(2.27;":[501],"gender":[505],"itching":[509],"(0.57;":[510],"0.01).":[511],"Conclusions":[512],"This":[513],"study":[514],"demonstrates":[515],"depression,":[523],"hemoglobin,":[525],"contribute":[533],"multiple":[535],"seen":[537],"Identifying":[541],"groups":[543],"risk":[545],"higher":[548],"addressing":[552],"comorbidities":[554],"drive":[556],"symptoms,":[557],"addition":[559],"disease-directed":[561],"therapy,":[562],"crucial":[564],"improving":[566],"quality":[568],"life":[570]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}