{"id":"https://openalex.org/W4404975759","doi":"https://doi.org/10.1158/1535-7163.27951054","title":"Figure S2 from Immunoproteasome Activation Expands the MHC Class I Immunopeptidome, Unmasks Neoantigens, and Enhances T-cell Anti-Myeloma Activity","display_name":"Figure S2 from Immunoproteasome Activation Expands the MHC Class I Immunopeptidome, Unmasks Neoantigens, and Enhances T-cell Anti-Myeloma Activity","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4404975759","doi":"https://doi.org/10.1158/1535-7163.27951054"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.27951054","doi":"https://doi.org/10.1158/1535-7163.27951054","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.27951054","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.27951054","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083063156","display_name":"Priyanka Shailendra Rana","orcid":"https://orcid.org/0000-0001-5774-4383","observed_orcids":["https://orcid.org/0000-0001-5774-4383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyanka S. Rana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5774-4383","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012867231","display_name":"James John Ignatz-Hoover","orcid":"https://orcid.org/0000-0001-8196-2655","observed_orcids":["https://orcid.org/0000-0001-8196-2655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Ignatz-Hoover","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8196-2655","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065393544","display_name":"Chunna Guo","orcid":"https://orcid.org/0000-0001-6075-7441","observed_orcids":["https://orcid.org/0000-0001-6075-7441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunna Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6075-7441","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059619254","display_name":"Amber L. Mosley","orcid":"https://orcid.org/0000-0001-5822-2894","observed_orcids":["https://orcid.org/0000-0001-5822-2894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber L. Mosley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5822-2894","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083283435","display_name":"Ehsan Malek","orcid":"https://orcid.org/0000-0003-4719-4327","observed_orcids":["https://orcid.org/0000-0003-4719-4327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ehsan Malek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4719-4327","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109734528","display_name":"Yuriy Federov","orcid":"https://orcid.org/0000-0001-9513-8341","observed_orcids":["https://orcid.org/0000-0001-9513-8341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuriy Federov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9513-8341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025223840","display_name":"Drew Adams","orcid":"https://orcid.org/0000-0002-3038-336X","observed_orcids":["https://orcid.org/0000-0002-3038-336X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drew J. Adams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3038-336X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035898667","display_name":"James Joseph Driscoll","orcid":"https://orcid.org/0000-0001-8364-0617","observed_orcids":["https://orcid.org/0000-0001-8364-0617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Driscoll","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8364-0617","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3917999863624573,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.3917999863624573,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.09109999984502792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoproteasome-inhibitors","display_name":"immunoproteasome inhibitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/compound-synthesis","display_name":"compound synthesis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tubastatin-a","display_name":"tubastatin A","score":0.8130000233650208},{"id":"https://openalex.org/keywords/acy-1215","display_name":"ACY-1215","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.9610000252723694},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5639917850494385},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5609740614891052},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.5422400832176208},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4854150712490082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45572394132614136},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39221110939979553},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3789904713630676},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3601887822151184},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.32651764154434204},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3048807978630066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27982985973358154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27801209688186646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1937333345413208},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15638816356658936},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15366947650909424},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1433142125606537},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.27951054","doi":"https://doi.org/10.1158/1535-7163.27951054","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.27951054","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.27951054","doi":"https://doi.org/10.1158/1535-7163.27951054","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.27951054","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165013701","https://openalex.org/W4404975781","https://openalex.org/W7165005243","https://openalex.org/W4404975758","https://openalex.org/W4404976104","https://openalex.org/W7165054925","https://openalex.org/W4402072240","https://openalex.org/W4393075364","https://openalex.org/W7164993768","https://openalex.org/W4404975988"],"abstract_inverted_index":{"Figure":[0],"S2.":[1],"Methods":[2],"of":[3,30],"synthesis":[4,29,39],"for":[5,27],"Compounds":[6,14,31],"A-H":[7],"and":[8,12,49,51],"tubastatin-A,":[9],"ACY-738,":[10],"ACY-1215":[11],"nexturastat.":[13],"A":[15,32],"through":[16,33],"H":[17,34],"were":[18,41],"synthesized":[19],"by":[20,47],"ChemDiv":[21,37],"as":[22],"indicated.":[23],"The":[24],"step-by-step":[25],"details":[26],"the":[28],"are":[35],"shown.":[36],"custom":[38],"products":[40],"then":[42],"subjected":[43],"to":[44,55],"quality":[45],"control":[46],"NMR":[48],"LC-MS":[50],"purity":[52],"was":[53],"guaranteed":[54],"be":[56],">90%.":[57]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-12-04T00:00:00"}