{"id":"https://openalex.org/W4404968898","doi":"https://doi.org/10.1016/j.tranon.2024.102204","title":"Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer","display_name":"Indirect targeting of MYC and direct targeting in combination with chemotherapies are more effective than direct mono-targeting in triple negative breast cancer","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4404968898","doi":"https://doi.org/10.1016/j.tranon.2024.102204","pmid":"https://pubmed.ncbi.nlm.nih.gov/39631207"},"language":"en","primary_location":{"id":"doi:10.1016/j.tranon.2024.102204","doi":"https://doi.org/10.1016/j.tranon.2024.102204","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102204","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.tranon.2024.102204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031638368","display_name":"Negesse Mekonnen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I57092466","display_name":"Bahir Dar University","ror":"https://ror.org/01670bg46","country_code":"ET","type":"education","lineage":["https://openalex.org/I57092466"]}],"countries":["ET","KR"],"is_corresponding":false,"raw_author_name":"Negesse Mekonnen","raw_affiliation_strings":["Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, College of Pharmacy, Seoul, South Korea; Department of Veterinary Science, School of Animal Science and Veterinary Medicine, Bahir Dar University, Bahir Dar, Ethiopia. Electronic address: mnegesse@snu.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, College of Pharmacy, Seoul, South Korea; Department of Veterinary Science, School of Animal Science and Veterinary Medicine, Bahir Dar University, Bahir Dar, Ethiopia. Electronic address: mnegesse@snu.ac.kr","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I57092466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023046525","display_name":"Hobin Yang","orcid":"https://orcid.org/0000-0002-4913-2763","observed_orcids":["https://orcid.org/0000-0002-4913-2763"]},"institutions":[{"id":"https://openalex.org/I118722661","display_name":"Kyungsung University","ror":"https://ror.org/05h9pgm95","country_code":"KR","type":"education","lineage":["https://openalex.org/I118722661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hobin Yang","raw_affiliation_strings":["College of Pharmacy, Kyungsung University, Busan, South Korea. Electronic address: hbyang@ks.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kyungsung University, Busan, South Korea. Electronic address: hbyang@ks.ac.kr","institution_ids":["https://openalex.org/I118722661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003616645","display_name":"Nirmal Rajasekaran","orcid":"https://orcid.org/0000-0001-7400-4387","observed_orcids":["https://orcid.org/0000-0001-7400-4387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nirmal Rajasekaran","raw_affiliation_strings":["R&D Center, ABION Inc., Seoul 08394, South Korea. Electronic address: nirmalrajasekaran@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Center, ABION Inc., Seoul 08394, South Korea. Electronic address: nirmalrajasekaran@gmail.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084300952","display_name":"Kyoung\u2010Ho Song","orcid":"https://orcid.org/0000-0002-4517-3840","observed_orcids":["https://orcid.org/0000-0002-4517-3840"]},"institutions":[{"id":"https://openalex.org/I65832422","display_name":"Duksung Women's University","ror":"https://ror.org/01h6frr69","country_code":"KR","type":"education","lineage":["https://openalex.org/I65832422"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyoung Song","raw_affiliation_strings":["College of Pharmacy, Duksung Women's University, Seoul, South Korea. Electronic address: songseoul17@duksung.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Duksung Women's University, Seoul, South Korea. Electronic address: songseoul17@duksung.ac.kr","institution_ids":["https://openalex.org/I65832422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003089475","display_name":"Yoon\u2010La Choi","orcid":"https://orcid.org/0000-0002-5788-5140","observed_orcids":["https://orcid.org/0000-0002-5788-5140","https://orcid.org/0000-0001-8485-8933"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon-La Choi","raw_affiliation_strings":["Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea; Laboratory of Molecular Pathology and Theranostics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: ylachoi@skku.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea; Laboratory of Molecular Pathology and Theranostics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: ylachoi@skku.edu","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002243126","display_name":"Young Kee Shin","orcid":"https://orcid.org/0000-0003-0896-718X","observed_orcids":["https://orcid.org/0000-0003-0896-718X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Kee Shin","raw_affiliation_strings":["Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, College of Pharmacy, Seoul, South Korea; R&D Center, ABION Inc., Seoul 08394, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Graduate School of Convergence Science and Technology, Seoul, South Korea; Bio-MAX/N-Bio, Seoul National University, Seoul, South Korea. Electronic address: ykeeshin@snu.ac.kr"],"raw_orcid":"https://orcid.org/0000-0003-0896-718X","affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University, College of Pharmacy, Seoul, South Korea; R&D Center, ABION Inc., Seoul 08394, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Graduate School of Convergence Science and Technology, Seoul, South Korea; Bio-MAX/N-Bio, Seoul National University, Seoul, South Korea. Electronic address: ykeeshin@snu.ac.kr","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002243126"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3130,"currency":"USD","value_usd":3130},"apc_paid":{"value":3130,"currency":"USD","value_usd":3130},"fwci":0.456,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60970568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"51","issue":null,"first_page":"102204","last_page":"102204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4936999976634979,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4936999976634979,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.15199999511241913,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7590000033378601},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.753000020980835},{"id":"https://openalex.org/keywords/rrm2","display_name":"RRM2","score":0.7440000176429749},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7059999704360962},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dacomitinib","display_name":"dacomitinib","score":0.7379999756813049},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/flip","display_name":"c-FLIP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6850000023841858},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8669220805168152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7489497065544128},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5863639116287231},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5811551809310913},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.465506374835968},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4477185010910034},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.42647719383239746},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.41912081837654114},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39403975009918213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3823637366294861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37848734855651855},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3766128420829773},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.310546338558197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3016822040081024},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.25365766882896423},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.188418447971344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12043115496635437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08257076144218445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tranon.2024.102204","doi":"https://doi.org/10.1016/j.tranon.2024.102204","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102204","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmid:39631207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39631207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11652953","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11652953","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transl Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:65f35894d0d24de1a7064a10295fcd0c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/65f35894d0d24de1a7064a10295fcd0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, Vol 51, Iss , Pp 102204- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tranon.2024.102204","doi":"https://doi.org/10.1016/j.tranon.2024.102204","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.102204","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4852222233","display_name":null,"funder_award_id":"NRF-2022R1A6A1A03046247","funder_id":"https://openalex.org/F4320321408","funder_display_name":"Ministry of Education"}],"funders":[{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1576222536","https://openalex.org/W1587795035","https://openalex.org/W1964184380","https://openalex.org/W2005895632","https://openalex.org/W2021536610","https://openalex.org/W2025325600","https://openalex.org/W2029938306","https://openalex.org/W2044387885","https://openalex.org/W2044695669","https://openalex.org/W2061001563","https://openalex.org/W2078505025","https://openalex.org/W2097113581","https://openalex.org/W2098791934","https://openalex.org/W2106117033","https://openalex.org/W2106714719","https://openalex.org/W2107277218","https://openalex.org/W2107436374","https://openalex.org/W2156180077","https://openalex.org/W2162923414","https://openalex.org/W2217342753","https://openalex.org/W2375577403","https://openalex.org/W2482465762","https://openalex.org/W2618573553","https://openalex.org/W2623921962","https://openalex.org/W2725659815","https://openalex.org/W2732824490","https://openalex.org/W2769003179","https://openalex.org/W2906879943","https://openalex.org/W2912009567","https://openalex.org/W2912993657","https://openalex.org/W2915572250","https://openalex.org/W2938216505","https://openalex.org/W2954349229","https://openalex.org/W2965991774","https://openalex.org/W3107285902","https://openalex.org/W3112954044","https://openalex.org/W3156985612","https://openalex.org/W3185354749","https://openalex.org/W3187599602","https://openalex.org/W3203628783","https://openalex.org/W3217595020","https://openalex.org/W4200543380","https://openalex.org/W4206759465","https://openalex.org/W4206907302","https://openalex.org/W4221111138","https://openalex.org/W4282941230","https://openalex.org/W4283014430","https://openalex.org/W4286461903","https://openalex.org/W4288081004","https://openalex.org/W4306160423","https://openalex.org/W4308147347","https://openalex.org/W4313255490","https://openalex.org/W4361006991","https://openalex.org/W4366607321","https://openalex.org/W4377564417","https://openalex.org/W4387948497","https://openalex.org/W6764938027"],"related_works":["https://openalex.org/W3147219444","https://openalex.org/W2053380829","https://openalex.org/W2030595392","https://openalex.org/W3152185824","https://openalex.org/W2129762276","https://openalex.org/W2025689023","https://openalex.org/W2003420178","https://openalex.org/W2182522919","https://openalex.org/W4310004332","https://openalex.org/W3030084607"],"abstract_inverted_index":{"\u2022":[0,13,24,32,40],"The":[1,154,173,190],"combined":[2,191],"inhibition":[3,34,272],"of":[4,16,43,67,141,157,169,175,184,193,215],"MYC":[5,17,33,44,53,71,91,143,171,185,188,236,271],"with":[6,100,196,230,270],"EGFR":[7],"or":[8,84,97,103,144,198,276,289],"PARP":[9],"is":[10,18,55],"synthetic":[11,201],"lethal.":[12],"Indirect":[14],"targeting":[15,42,90,278],"more":[19,178],"effective":[20,179],"than":[21,167,180,274],"direct":[22,170,182],"targeting.":[23],"Chemotherapy":[25],"resistant":[26,36,211],"cells":[27,37,121,212,228],"upregulate":[28],"DNA":[29,128],"repair":[30,129],"genes.":[31],"re-sensitize":[35],"to":[38,64,122,208,296],"chemotherapy.":[39],"Direct":[41],"upregulates":[45],"cFLIP":[46,239],"and":[47,49,107,118,149,219,247,253,286,301],"BCL2,":[48,241],"increases":[50],"cell":[51,205,255,259],"survival.":[52],"amplification":[54],"disproportionally":[56],"elevated":[57],"in":[58,98,126,186,203,227,250],"triple-negative":[59],"breast":[60,68],"cancer":[61,257],"(TNBC)":[62],"compared":[63],"other":[65],"subtypes":[66],"cancer.":[69],"Indeed,":[70],"has":[72],"long":[73],"been":[74],"considered":[75],"an":[76],"undruggable":[77],"oncogene":[78],"using":[79,92],"conventional":[80],"drug":[81,132],"design":[82],"strategies":[83],"small":[85],"molecules.":[86],"We":[87,114,233],"hypothesized":[88],"that":[89,138,168,235,268],"asymmetric":[93],"siRNA":[94],"(asiRNA)":[95],"alone":[96],"combination":[99,265],"chemotherapeutic":[101],"agents":[102],"indirectly":[104],"via":[105,279],"BRD4":[106,176,285],"RRM2,":[108,217],"may":[109],"curb":[110],"its":[111],"oncogenic":[112],"behavior.":[113],"developed":[115],"paclitaxel-,":[116],"doxorubicin-,":[117],"cisplatin-resistant":[119],"MDA-MB-231":[120],"study":[123],"MYC's":[124],"role":[125],"upregulating":[127],"genes":[130,288,299],"during":[131],"resistance":[133],"development.":[134],"Our":[135],"results":[136],"showed":[137,213],"the":[139,181,284,293,304],"knockdown":[140,159,174,183,237],"either":[142],"RRM2":[145,158,287],"downregulated":[146,226],"both":[147,251],"RAD51":[148],"PARP1":[150,220],"but":[151,225],"increased":[152],"\u03b3H2AX.":[153],"cytotoxic":[155],"effect":[156],"was":[160,177,200],"significantly":[161],"(":[162],"p":[163],"<":[164],"0.05)":[165],"higher":[166],"knockdown.":[172],"downregulating":[187],"protein.":[189],"use":[192],"asiRNA-VP":[194,231],"(Vinylphosphonate)":[195],"dacomitinib":[197],"talazoparib":[199],"lethal":[202],"TNBC":[204,252],"lines.":[206,260],"Compared":[207],"chemotherapy-sensitive":[209],"cells,":[210],"overexpression":[214],"MYC,":[216],"RAD51,":[218],"proteins":[221],"upon":[222],"chemotherapy":[223],"treatment,":[224],"treated":[229],"combination.":[232],"confirmed":[234],"upregulated":[238],",":[240,243,246],"STAT1":[242],"pSTAT1,":[244],"STAT2":[245],"cleaved":[248],"saspase-3":[249],"non-small":[254],"lung":[256],"(NSCLC)":[258],"Finally,":[261],"we":[262],"recommend":[263],"a":[264],"treatment":[266],"approach":[267],"synergizes":[269],"rather":[273],"monotherapy":[275],"indirect":[277],"upstream":[280],"regulators":[281],"such":[282],"as":[283],"selective":[290],"modulation":[291],"at":[292,303],"protein":[294],"level":[295],"suppress":[297],"anti-apoptotic":[298],"(cFLIP":[300],"BCL2)":[302],"same":[305],"time.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
