{"id":"https://openalex.org/W4404963705","doi":"https://doi.org/10.1201/9781003573760-14","title":"New Techniques for the Isolation and Identification of Phorbol Esters and Structurally Related Diterpenes","display_name":"New Techniques for the Isolation and Identification of Phorbol Esters and Structurally Related Diterpenes","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4404963705","doi":"https://doi.org/10.1201/9781003573760-14"},"language":"en","primary_location":{"id":"doi:10.1201/9781003573760-14","doi":"https://doi.org/10.1201/9781003573760-14","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003573760-14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Natural Toxins","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4404962233","display_name":"Handbook of Natural Toxins"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013002429","display_name":"Alan Douglas Kinghorn","orcid":"https://orcid.org/0000-0002-6647-8707","observed_orcids":["https://orcid.org/0000-0002-6647-8707"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Douglas Kinghorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013002429"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48844612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"217","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":1.0},{"id":"https://openalex.org/keywords/diterpenes","display_name":"diterpenoids","score":0.8949999809265137},{"id":"https://openalex.org/keywords/croton-tiglium","display_name":"Croton tiglium","score":0.906000018119812},{"id":"https://openalex.org/keywords/croton-oil","display_name":"croton oil","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.4650000035762787},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8600000143051147},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/structural-system-identification","display_name":"structural identification","score":0.6639999747276306},{"id":"https://openalex.org/keywords/toxic-constituents","display_name":"toxic constituents","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.7445179224014282},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7428046464920044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47482261061668396},{"id":"https://openalex.org/C3017695315","wikidata":"https://www.wikidata.org/wiki/Q37713691","display_name":"Phorbol ester","level":4,"score":0.4440808892250061},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4229480028152466},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38012999296188354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2922332286834717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2295190393924713},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.12463906407356262},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.107269287109375},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0367254912853241},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781003573760-14","doi":"https://doi.org/10.1201/9781003573760-14","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003573760-14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Natural Toxins","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4236051802","https://openalex.org/W4238519329","https://openalex.org/W2073867893","https://openalex.org/W1487590933","https://openalex.org/W2803486257","https://openalex.org/W142183552","https://openalex.org/W2063183684","https://openalex.org/W2734966936","https://openalex.org/W2097031376","https://openalex.org/W7028690737"],"abstract_inverted_index":{"The":[0,115],"purification":[1],"and":[2,55,71,111,151,176,220],"structural":[3],"determination":[4],"of":[5,9,15,46,48,74,94,103,148,203,251],"the":[6,12,31,49,69,121,141,187,249],"toxic":[7],"constituents":[8],"croton":[10,75,95],"oil,":[11,76],"seed":[13],"oil":[14,96],"Croton":[16],"tiglium":[17],"L.":[18],"(Euphorbiaceae),":[19],"presented":[20],"a":[21,43,99,104,145,194,201],"major":[22],"challenge":[23],"to":[24,33,63,98,138,191,193],"natural":[25],"products":[26],"chemists":[27],"that":[28,39,197,209,228],"took":[29],"until":[30],"1960s":[32],"resolve,":[34],"when":[35],"it":[36],"was":[37],"established":[38],"these":[40],"substances":[41],"are":[42,118],"complex":[44],"mixture":[45],"esters":[47,60,117,143,189,234],"tetracyclic":[50],"diterpene":[51],"phorbol":[52,116,142,188,233],"(":[53,106,130,180,254],"Hecker":[54,110],"Schmidt,":[56,112],"1974":[57,113],").":[58,114,135,185,260],"Phorbol":[59],"were":[61,86],"found":[62],"be":[64],"responsible":[65],"not":[66],"only":[67],"for":[68,79,127,155,217,241],"purgative":[70],"skin-irritant":[72],"effects":[73],"but":[77],"also":[78],"its":[80],"tumor-promoting":[81,229],"(cocarcinogenic)":[82],"properties,":[83],"wherein":[84],"carcinomas":[85],"produced":[87,247],"on":[88],"mouse":[89,128],"skin":[90,129],"after":[91],"repeated":[92],"doses":[93],"subsequent":[97],"single":[100],"subeffective":[101],"dose":[102],"carcinogen":[105],"Berenblum,":[107],"1941":[108],";":[109,257],"still":[119],"among":[120],"most":[122],"potent":[123],"tumor":[124,139],"promoters":[125],"known":[126],"Itai":[131],"et":[132],"al.,":[133],"1988":[134,259],"In":[136],"addition":[137],"promotion,":[140],"exhibit":[144,177],"wide":[146],"range":[147],"other":[149,221],"biochemical":[150],"cellular":[152],"effects,":[153],"and,":[154],"example,":[156],"alter":[157],"cell":[158],"morphology,":[159],"serve":[160],"as":[161,232],"lymphocyte":[162],"mitogens,":[163],"induce":[164],"platelet":[165],"aggregation,":[166],"elevate":[167],"cyclic":[168],"guanosine":[169],"5\u2019-monophosphate":[170],"(GMP)":[171],"levels,":[172],"stimulate":[173],"ornithine":[174],"decarboxylase,":[175],"antileukemic":[178],"activity":[179],"Blumberg,":[181,258],"1980":[182],",":[183],"1981":[184],"Mechanistically,":[186],"appear":[190],"bind":[192],"receptor":[195],"site":[196],"is":[198,226,245],"represented":[199],"by":[200,239],"portion":[202],"protein":[204,236],"kinase":[205,237],"C,":[206],"an":[207,211],"enzyme":[208],"has":[210],"important":[212],"role":[213],"in":[214,248],"signal":[215],"transduction":[216],"several":[218],"hormones":[219],"biologically":[222],"active":[223],"substances.":[224],"It":[225],"thought":[227],"agents":[230],"such":[231],"activate":[235],"C":[238],"substituting":[240],"endogenous":[242],"diacylglycerol,":[243],"which":[244],"normally":[246],"turnover":[250],"inositol":[252],"phospholipids":[253],"Nishizuka,":[255],"1984":[256]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2024-12-04T00:00:00"}