{"id":"https://openalex.org/W4404963472","doi":"https://doi.org/10.3390/ijms252312988","title":"Ulva pertusa Modulated Colonic Oxidative Stress Markers and Clinical Parameters: A Potential Adjuvant Therapy to Manage Side Effects During 5-FU Regimen","display_name":"Ulva pertusa Modulated Colonic Oxidative Stress Markers and Clinical Parameters: A Potential Adjuvant Therapy to Manage Side Effects During 5-FU Regimen","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4404963472","doi":"https://doi.org/10.3390/ijms252312988","pmid":"https://pubmed.ncbi.nlm.nih.gov/39684698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11641785"},"language":"en","primary_location":{"id":"doi:10.3390/ijms252312988","doi":"https://doi.org/10.3390/ijms252312988","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252312988","pdf_url":"https://www.mdpi.com/1422-0067/25/23/12988/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/23/12988/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061879252","display_name":"Alberto Repici","orcid":"https://orcid.org/0009-0001-7224-8158","observed_orcids":["https://orcid.org/0009-0001-7224-8158"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Repici","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059107542","display_name":"Anna Paola Capra","orcid":"https://orcid.org/0000-0002-1428-3609","observed_orcids":["https://orcid.org/0000-0002-1428-3609"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Paola Capra","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1428-3609","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419044","display_name":"Ahmed Hasan","orcid":"https://orcid.org/0000-0003-3771-6910","observed_orcids":["https://orcid.org/0000-0003-3771-6910"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]},{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ahmed Hasan","raw_affiliation_strings":["Center of Neuroscience, School of Advanced Studies, University of Camerino, 62032 Camerino, Italy","Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3771-6910","affiliations":[{"raw_affiliation_string":"Center of Neuroscience, School of Advanced Studies, University of Camerino, 62032 Camerino, Italy","institution_ids":["https://openalex.org/I112859197"]},{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034178951","display_name":"Rossella Basilotta","orcid":"https://orcid.org/0009-0001-6411-5806","observed_orcids":["https://orcid.org/0009-0001-6411-5806"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Basilotta","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065961339","display_name":"Sarah Adriana Scuderi","orcid":"https://orcid.org/0000-0001-8566-9739","observed_orcids":["https://orcid.org/0000-0001-8566-9739"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sarah Adriana Scuderi","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048364314","display_name":"Michela Campolo","orcid":"https://orcid.org/0000-0002-5124-3876","observed_orcids":["https://orcid.org/0000-0002-5124-3876"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Campolo","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073045089","display_name":"Irene Paterniti","orcid":"https://orcid.org/0000-0002-4316-2291","observed_orcids":["https://orcid.org/0000-0002-4316-2291"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Paterniti","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103271143","display_name":"Emanuela Esposito","orcid":"https://orcid.org/0000-0002-2663-6387","observed_orcids":["https://orcid.org/0000-0002-2663-6387"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emanuela Esposito","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2663-6387","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032877685","display_name":"Alessio Ardizzone","orcid":"https://orcid.org/0000-0002-2293-0634","observed_orcids":["https://orcid.org/0000-0002-2293-0634"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Ardizzone","raw_affiliation_strings":["Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2293-0634","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103271143"],"corresponding_institution_ids":["https://openalex.org/I112862951"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":2.3345,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86289647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"25","issue":"23","first_page":"12988","last_page":"12988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulva-pertusa","display_name":"Ulva pertusa","score":1.0},{"id":"https://openalex.org/keywords/seaweed","display_name":"seaweed","score":0.7839999794960022},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7929999828338623},{"id":"https://openalex.org/keywords/colon","display_name":"colon","score":0.6480000019073486},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.49399998784065247},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.5619999766349792},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/green-algae","display_name":"green algae","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8132544755935669},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5852974653244019},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5590065121650696},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.532873809337616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5016679763793945},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.4155048429965973},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4094991087913513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3619530498981476},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19767197966575623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06957852840423584},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D044445","descriptor_name":"Ulva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms252312988","doi":"https://doi.org/10.3390/ijms252312988","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252312988","pdf_url":"https://www.mdpi.com/1422-0067/25/23/12988/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11641785","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11641785","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11641785/pdf/ijms-25-12988.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:39684698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39684698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms252312988","doi":"https://doi.org/10.3390/ijms252312988","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252312988","pdf_url":"https://www.mdpi.com/1422-0067/25/23/12988/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404963472.pdf","grobid_xml":"https://content.openalex.org/works/W4404963472.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1725102234","https://openalex.org/W1998721033","https://openalex.org/W2004997728","https://openalex.org/W2051673024","https://openalex.org/W2055568666","https://openalex.org/W2065443310","https://openalex.org/W2078588075","https://openalex.org/W2108254894","https://openalex.org/W2135989733","https://openalex.org/W2141541834","https://openalex.org/W2164376208","https://openalex.org/W2174838977","https://openalex.org/W2344250097","https://openalex.org/W2412039371","https://openalex.org/W2751318493","https://openalex.org/W2796161215","https://openalex.org/W2807565455","https://openalex.org/W2883336339","https://openalex.org/W2949112913","https://openalex.org/W2954128860","https://openalex.org/W2987691848","https://openalex.org/W2988775248","https://openalex.org/W3081696349","https://openalex.org/W3083950386","https://openalex.org/W3089532746","https://openalex.org/W3092171249","https://openalex.org/W3122254526","https://openalex.org/W3125365132","https://openalex.org/W3131942824","https://openalex.org/W3169168169","https://openalex.org/W3195727339","https://openalex.org/W3198748742","https://openalex.org/W4210395111","https://openalex.org/W4211259900","https://openalex.org/W4213339209","https://openalex.org/W4221040717","https://openalex.org/W4229039463","https://openalex.org/W4281706441","https://openalex.org/W4283027045","https://openalex.org/W4283392173","https://openalex.org/W4283741035","https://openalex.org/W4287837768","https://openalex.org/W4321606344","https://openalex.org/W4367051441","https://openalex.org/W4378349081","https://openalex.org/W4378379572","https://openalex.org/W4384823096","https://openalex.org/W4385295458","https://openalex.org/W4386645137","https://openalex.org/W4389348696","https://openalex.org/W4391055500","https://openalex.org/W4401766189","https://openalex.org/W4401893884","https://openalex.org/W4402230711","https://openalex.org/W6676219097","https://openalex.org/W6715227546"],"related_works":["https://openalex.org/W4367051441","https://openalex.org/W3104743298","https://openalex.org/W4282930576","https://openalex.org/W7020073918","https://openalex.org/W2091378908","https://openalex.org/W2091126984","https://openalex.org/W4361233643","https://openalex.org/W7147714645","https://openalex.org/W4410716814","https://openalex.org/W4409437948"],"abstract_inverted_index":{"One":[0],"of":[1,19,29,66,80,97,101,115,125,154,172,180,227,275],"the":[2,17,47,56,64,81,98,113,140,143,161,177,200,217,225,273,292],"most":[3,82],"used":[4,24,83],"chemotherapy":[5],"agents":[6],"in":[7,16,42,85,105,118,134,199,221,279,295],"clinical":[8,288],"practice":[9],"is":[10,23,88],"5-Fluorouracil":[11],"(5-FU),":[12],"a":[13,27,119,157,259],"fluorinated":[14],"pyrimidine":[15],"category":[18],"antimetabolite":[20],"agents.":[21],"5-FU":[22,120],"to":[25,257,271],"treat":[26],"variety":[28],"cancers,":[30,37],"including":[31,95,185,240],"colon,":[32],"breast,":[33],"pancreatic,":[34],"and":[35,38,50,60,74,103,128,190,203,206,213,224,235,245,287],"stomach":[36],"its":[39,43,53,301],"efficacy":[40,294],"lies":[41],"direct":[44],"impact":[45],"on":[46,211],"patient\u2019s":[48],"DNA":[49],"RNA.":[51,76],"Specifically,":[52],"mechanism":[54],"blocks":[55],"enzymes":[57],"thymidylate":[58],"synthetase":[59],"uracil":[61],"phosphatase,":[62],"inhibiting":[63],"synthesis":[65],"uracil,":[67],"which":[68,164],"cannot":[69],"be":[70,258,269],"incorporated":[71],"into":[72],"nuclear":[73],"cytoplasmic":[75],"Despite":[77],"being":[78],"one":[79],"drugs":[84],"oncology,":[86],"it":[87,267],"associated":[89],"with":[90,151],"several":[91,183],"significant":[92],"side":[93,116,178,197],"effects,":[94,265],"inflammation":[96],"mouth,":[99],"loss":[100],"appetite,":[102],"reduction":[104,114],"blood":[106],"cells.":[107],"In":[108],"our":[109,252],"study,":[110],"we":[111],"examined":[112],"effects":[117,179,198],"regimen":[121],"administered":[122],"at":[123],"doses":[124],"15":[126],"mg/kg":[127,130,153],"6":[129],"for":[131,148],"14":[132],"days":[133],"6-week-old":[135],"male":[136],"Sprague-Dawley":[137],"rats.":[138],"On":[139],"14th":[141],"day,":[142],"rats":[144],"were":[145,209,248],"treated":[146],"orally":[147],"2":[149],"weeks":[150],"100":[152],"Ulva":[155,255],"pertusa,":[156],"well-known":[158],"seaweed":[159],"from":[160,216],"Ulvaceae":[162],"family,":[163],"has":[165],"demonstrated":[166],"powerful":[167],"biological":[168],"properties.":[169],"The":[170],"administration":[171],"this":[173,277],"green":[174],"alga":[175,278],"alleviated":[176],"5-FU,":[181],"improving":[182],"parameters":[184],"body":[186],"weight,":[187],"food":[188],"intake,":[189],"diarrhea":[191],"index.":[192],"It":[193],"also":[194,249],"helped":[195],"reduce":[196,309],"blood,":[201],"kidneys,":[202],"liver.":[204],"Histological":[205],"molecular":[207],"analyses":[208],"conducted":[210],"serum":[212],"colon":[214,222],"tissues":[215],"rats,":[218],"examining":[219],"changes":[220],"structure":[223],"release":[226],"oxidative":[228],"stress":[229],"markers":[230],"such":[231],"as":[232,303],"iNOS,":[233],"COX-2,":[234],"nitrotyrosine.":[236],"Several":[237],"biochemical":[238],"indicators,":[239],"SOD,":[241],"CAT,":[242],"GSH,":[243],"MDA,":[244],"ascorbic":[246],"acid,":[247],"evaluated.":[250],"Overall,":[251],"data":[253],"indicated":[254],"pertusa":[256],"promising":[260],"therapeutic":[261,314],"against":[262],"5-FU\u2019s":[263],"adverse":[264],"therefore,":[266],"could":[268,290],"worthwhile":[270],"investigate":[272],"possibility":[274],"using":[276],"safer":[280],"cancer":[281,297],"treatment":[282,298],"formulations.":[283],"Certainly,":[284],"future":[285],"preclinical":[286],"studies":[289],"assess":[291],"alga\u2019s":[293],"diverse":[296],"regimens,":[299],"exploring":[300],"role":[302],"an":[304],"adjuvant":[305],"therapy":[306],"that":[307],"may":[308],"chemotherapy-related":[310],"toxicity":[311],"without":[312],"compromising":[313],"outcomes.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-04T00:00:00"}