{"id":"https://openalex.org/W4404961997","doi":"https://doi.org/10.3390/molecules29235669","title":"Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)2 and Application in Late-Stage Drug Functionalization","display_name":"Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)2 and Application in Late-Stage Drug Functionalization","publication_year":2024,"publication_date":"2024-11-29","ids":{"openalex":"https://openalex.org/W4404961997","doi":"https://doi.org/10.3390/molecules29235669","pmid":"https://pubmed.ncbi.nlm.nih.gov/39683829"},"language":"en","primary_location":{"id":"doi:10.3390/molecules29235669","doi":"https://doi.org/10.3390/molecules29235669","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235669","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5669/pdf?version=1732898236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/29/23/5669/pdf?version=1732898236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109734619","display_name":"Subban Kathiravan","orcid":"https://orcid.org/0000-0003-0774-2528","observed_orcids":["https://orcid.org/0000-0003-0774-2528"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Subban Kathiravan","raw_affiliation_strings":["Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0774-2528","affiliations":[{"raw_affiliation_string":"Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074450207","display_name":"Prakriti Dhillon","orcid":"https://orcid.org/0000-0001-7683-2928","observed_orcids":["https://orcid.org/0000-0001-7683-2928"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Prakriti Dhillon","raw_affiliation_strings":["Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-7683-2928","affiliations":[{"raw_affiliation_string":"Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707910","display_name":"Tianshu Zhang","orcid":"https://orcid.org/0009-0002-4870-5416","observed_orcids":["https://orcid.org/0009-0002-4870-5416"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tianshu Zhang","raw_affiliation_strings":["Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden"],"raw_orcid":"https://orcid.org/0009-0002-4870-5416","affiliations":[{"raw_affiliation_string":"Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087230960","display_name":"Ian A. Nicholls","orcid":"https://orcid.org/0000-0002-0407-6542","observed_orcids":["https://orcid.org/0000-0002-0407-6542"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ian A. Nicholls","raw_affiliation_strings":["Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0407-6542","affiliations":[{"raw_affiliation_string":"Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden","institution_ids":["https://openalex.org/I223464139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109734619"],"corresponding_institution_ids":["https://openalex.org/I223464139"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2316,"currency":"EUR","value_usd":2497},"fwci":1.1131,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73792303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"29","issue":"23","first_page":"5669","last_page":"5669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.05209999904036522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phi-oac-2","display_name":"PhI(OAc)2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hypervalent-iodine-reagents","display_name":"hypervalent iodine reagents","score":0.9409999847412109},{"id":"https://openalex.org/keywords/transition-metal-free-coupling","display_name":"metal-free coupling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/benzamide","display_name":"benzamide","score":0.8790000081062317},{"id":"https://openalex.org/keywords/amines","display_name":"amines","score":0.7649999856948853},{"id":"https://openalex.org/keywords/urea-synthesis","display_name":"urea synthesis","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.8098506927490234},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5987052321434021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5220146775245667},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.49507394433021545},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20412367582321167},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules29235669","doi":"https://doi.org/10.3390/molecules29235669","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235669","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5669/pdf?version=1732898236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:39683829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39683829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11643609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11643609","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11643609/pdf/molecules-29-05669.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:lnu-134333","doi":null,"is_oa":true,"landing_page_url":"https://lnu.diva-portal.org/smash/get/diva2:1927142/FULLTEXT01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401598","display_name":"DiVA (Linnaeus University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I223464139","host_organization_name":"Linnaeus University","host_organization_lineage":["https://openalex.org/I223464139"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e30096eae04b4606949402462ce89344","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e30096eae04b4606949402462ce89344","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 29, Iss 23, p 5669 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules29235669","doi":"https://doi.org/10.3390/molecules29235669","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235669","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5669/pdf?version=1732898236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6800000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G131616655","display_name":"From Eutectic Mixtures to Hierarchical Material Architectures: Fundamental Studies and Applications","funder_award_id":"2014-04573","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2699679000","display_name":null,"funder_award_id":"2019-0318","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2892066324","display_name":null,"funder_award_id":"2020-0775","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3138340194","display_name":null,"funder_award_id":"2019-0925","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G37902070","display_name":"Re-engineering Templated Nano-materials for Biomacromolecular Recognition in Diagnostic Development","funder_award_id":"2023-03406","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G814324237","display_name":null,"funder_award_id":"2022-0317","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404961997.pdf","grobid_xml":"https://content.openalex.org/works/W4404961997.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1983066351","https://openalex.org/W1988031825","https://openalex.org/W1998267363","https://openalex.org/W2007493752","https://openalex.org/W2059852007","https://openalex.org/W2078611209","https://openalex.org/W2078614198","https://openalex.org/W2082284438","https://openalex.org/W2090706058","https://openalex.org/W2131029190","https://openalex.org/W2140802449","https://openalex.org/W2155004885","https://openalex.org/W2314919322","https://openalex.org/W2317484991","https://openalex.org/W2325072690","https://openalex.org/W2599306944","https://openalex.org/W2771336703","https://openalex.org/W2771944433","https://openalex.org/W2797168824","https://openalex.org/W2942883292","https://openalex.org/W2951185063","https://openalex.org/W2983844592","https://openalex.org/W2991251974","https://openalex.org/W2991644693","https://openalex.org/W3017739092","https://openalex.org/W3176823685","https://openalex.org/W3180015469","https://openalex.org/W3206947169","https://openalex.org/W4304630330","https://openalex.org/W4379616814","https://openalex.org/W4400315995","https://openalex.org/W4402504130"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W3155560266","https://openalex.org/W4392953055"],"abstract_inverted_index":{"Unsymmetrical":[0],"urea":[1,30,47],"derivatives":[2,31,48],"are":[3],"essential":[4],"structural":[5],"motifs":[6],"in":[7,124],"a":[8,39,62,103],"wide":[9],"array":[10],"of":[11,28,45,52,121],"biologically":[12],"significant":[13,115],"compounds.":[14],"Despite":[15],"the":[16,26,43,50,68,118],"well-established":[17],"methods":[18],"for":[19,25,42,70,108,117],"synthesizing":[20,109],"symmetrical":[21],"ureas,":[22],"efficient":[23],"strategies":[24],"synthesis":[27,44],"unsymmetrical":[29,46,110],"remain":[32],"limited.":[33],"In":[34],"this":[35,65],"study,":[36],"we":[37],"present":[38],"novel":[40],"approach":[41],"through":[49],"coupling":[51,63],"amides":[53],"and":[54,75,84,92,95,105],"amines.":[55],"Utilizing":[56],"hypervalent":[57],"iodine":[58],"reagent":[59],"PhI(OAc)2":[60],"as":[61],"mediator,":[64],"method":[66],"circumvents":[67],"need":[69],"metal":[71],"catalysts,":[72],"high":[73],"temperatures,":[74],"inert":[76],"atmosphere.":[77],"The":[78],"reaction":[79],"proceeds":[80],"under":[81],"mild":[82],"conditions":[83],"demonstrates":[85],"broad":[86],"substrate":[87],"scope,":[88],"including":[89],"various":[90],"primary":[91,96],"secondary":[93],"amines":[94],"benzamides.":[97],"This":[98],"protocol":[99],"not":[100],"only":[101],"offers":[102],"practical":[104],"versatile":[106],"route":[107],"ureas":[111],"but":[112],"also":[113],"shows":[114],"potential":[116],"late-stage":[119],"functionalization":[120],"complex":[122],"molecules":[123],"drug":[125],"development.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}