{"id":"https://openalex.org/W4404961179","doi":"https://doi.org/10.3390/molecules29235679","title":"Synergistic Effects of Pyrrosia lingua Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic Escherichia coli: Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments","display_name":"Synergistic Effects of Pyrrosia lingua Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic Escherichia coli: Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments","publication_year":2024,"publication_date":"2024-11-30","ids":{"openalex":"https://openalex.org/W4404961179","doi":"https://doi.org/10.3390/molecules29235679","pmid":"https://pubmed.ncbi.nlm.nih.gov/39683837","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11643949"},"language":"en","primary_location":{"id":"doi:10.3390/molecules29235679","doi":"https://doi.org/10.3390/molecules29235679","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235679","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5679/pdf?version=1732955228","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/29/23/5679/pdf?version=1732955228","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100456229","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-3357-5121","observed_orcids":["https://orcid.org/0000-0002-3357-5121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101989049","display_name":"Fangfang Jiao","orcid":"https://orcid.org/0009-0001-1190-6938","observed_orcids":["https://orcid.org/0009-0001-1190-6938"]},"institutions":[{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Fangfang Jiao","raw_affiliation_strings":["Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China","institution_ids":["https://openalex.org/I49835588"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Derong Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derong Zeng","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101775629","display_name":"Xiang Yu","orcid":"https://orcid.org/0000-0003-0685-0420","observed_orcids":["https://orcid.org/0000-0003-0685-0420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang Yu","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongqiang Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongqiang Zhou","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763214","display_name":"Juan Xue","orcid":"https://orcid.org/0000-0003-1534-7632","observed_orcids":["https://orcid.org/0000-0003-1534-7632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Xue","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101132492","display_name":"Wude Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wude Yang","raw_affiliation_strings":["College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008112425","display_name":"Jingjing Guo","orcid":"https://orcid.org/0000-0002-4632-4364","observed_orcids":["https://orcid.org/0000-0002-4632-4364"]},"institutions":[{"id":"https://openalex.org/I49835588","display_name":"Macao Polytechnic University","ror":"https://ror.org/02sf5td35","country_code":"MO","type":"education","lineage":["https://openalex.org/I49835588"]}],"countries":["MO"],"is_corresponding":true,"raw_author_name":"Jingjing Guo","raw_affiliation_strings":["Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China"],"raw_orcid":"https://orcid.org/0000-0002-4632-4364","affiliations":[{"raw_affiliation_string":"Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China","institution_ids":["https://openalex.org/I49835588"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008112425","https://openalex.org/A5101132492"],"corresponding_institution_ids":["https://openalex.org/I49835588"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":0.542,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54468397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"29","issue":"23","first_page":"5679","last_page":"5679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrrosia-lingua","display_name":"Pyrrosia lingua","score":0.9520000219345093},{"id":"https://openalex.org/keywords/caffeoylquinic-acids","display_name":"caffeoylquinic acids","score":0.8659999966621399},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9890000224113464},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5569999814033508},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c-di-gmp","display_name":"c-di-GMP","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/synergistic-antibacterial-activity","display_name":"synergistic antibacterial activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/swimming-motility","display_name":"swimming motility","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plant-derived-antimicrobials","display_name":"plant-derived antimicrobials","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8000760078430176},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6692278385162354},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5131869912147522},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.4972837269306183},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.461734414100647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42791491746902466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19700056314468384},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.14355677366256714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05318668484687805}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011801","descriptor_name":"Quinic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011801","descriptor_name":"Quinic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011801","descriptor_name":"Quinic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056689","descriptor_name":"Uropathogenic Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064704","descriptor_name":"Levofloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064704","descriptor_name":"Levofloxacin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules29235679","doi":"https://doi.org/10.3390/molecules29235679","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235679","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5679/pdf?version=1732955228","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:39683837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39683837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11643949","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11643949/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:09a51539cc8048d9a53efc266ed36946","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/09a51539cc8048d9a53efc266ed36946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 29, Iss 23, p 5679 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules29235679","doi":"https://doi.org/10.3390/molecules29235679","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29235679","pdf_url":"https://www.mdpi.com/1420-3049/29/23/5679/pdf?version=1732955228","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1113593686","display_name":null,"funder_award_id":"[QKHF-ZK(2023) G419]","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G1683490461","display_name":null,"funder_award_id":"QKHF-ZK(2023) G420","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G2026930568","display_name":null,"funder_award_id":"[2023]-10","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G2160708103","display_name":null,"funder_award_id":"[QKHF-ZK(2021)G539]","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G306607781","display_name":null,"funder_award_id":"QKHF-ZK(2023)G426","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G3426634742","display_name":null,"funder_award_id":"QKHF-ZK(2021)G518","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"},{"id":"https://openalex.org/G6863309201","display_name":null,"funder_award_id":"RP/CAI-01/2022","funder_id":"https://openalex.org/F4320336617","funder_display_name":"Science and Technology Program of Guizhou Province"}],"funders":[{"id":"https://openalex.org/F4320336617","display_name":"Science and Technology Program of Guizhou Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404961179.pdf","grobid_xml":"https://content.openalex.org/works/W4404961179.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1976499671","https://openalex.org/W2031168104","https://openalex.org/W2031348290","https://openalex.org/W2035687084","https://openalex.org/W2054881399","https://openalex.org/W2064123775","https://openalex.org/W2095719702","https://openalex.org/W2106140689","https://openalex.org/W2113516498","https://openalex.org/W2147993766","https://openalex.org/W2368723714","https://openalex.org/W2404280981","https://openalex.org/W2712120856","https://openalex.org/W2767195716","https://openalex.org/W2816815439","https://openalex.org/W2888638470","https://openalex.org/W2898633757","https://openalex.org/W2973133033","https://openalex.org/W2995581437","https://openalex.org/W3032171173","https://openalex.org/W3092307444","https://openalex.org/W3094431383","https://openalex.org/W3164337408","https://openalex.org/W3185861655","https://openalex.org/W3193846099","https://openalex.org/W4230870976","https://openalex.org/W4239569810","https://openalex.org/W4282974930","https://openalex.org/W4303940766","https://openalex.org/W4304945301","https://openalex.org/W4309278698","https://openalex.org/W4310693136","https://openalex.org/W4313259761","https://openalex.org/W4319868638","https://openalex.org/W4327719397","https://openalex.org/W4362465921","https://openalex.org/W4362472672","https://openalex.org/W4362694466","https://openalex.org/W4365516057","https://openalex.org/W4382069191","https://openalex.org/W4387104789","https://openalex.org/W4389761918","https://openalex.org/W4396746632"],"related_works":["https://openalex.org/W2888462605","https://openalex.org/W3095893579","https://openalex.org/W2171511544","https://openalex.org/W4409820703","https://openalex.org/W2017626258","https://openalex.org/W4417121907","https://openalex.org/W3048749663","https://openalex.org/W4223585208","https://openalex.org/W2067196886","https://openalex.org/W2978804385"],"abstract_inverted_index":{"Urinary":[0],"tract":[1],"infections":[2],"(UTIs),":[3],"primarily":[4],"caused":[5],"by":[6,32,36],"uropathogenic":[7],"Escherichia":[8],"coli":[9],"(UPEC),":[10],"have":[11],"high":[12],"morbidity":[13],"and":[14,44,63,96,104,116,124,157,169],"recurrence":[15],"rates.":[16],"Resistance":[17],"to":[18,146],"levofloxacin":[19,82,110],"hydrochloride":[20,83],"(LEV),":[21],"a":[22,93,163],"commonly":[23],"used":[24,108],"treatment":[25],"for":[26,165,173],"UTIs,":[27],"is":[28],"increasingly":[29],"problematic,":[30],"exacerbated":[31],"biofilm":[33,127],"formation":[34,128],"mediated":[35],"interactions":[37],"between":[38],"cyclic":[39],"di-GMP":[40],"(c-di-GMP":[41],"or":[42],"CDG)":[43],"YcgR.":[45],"In":[46],"this":[47],"study,":[48],"we":[49],"identified":[50],"three":[51],"caffeoylquinic":[52],"acid":[53,58,65,103],"compounds":[54,80,145],"from":[55],"Pyrrosia":[56],"lingua\u2014chlorogenic":[57],"(CGA),":[59],"sibiricose":[60,105],"A5":[61],"(Si-A5),":[62],"3-O-caffeoylquinic":[64],"methyl":[66],"ester":[67],"(CAM)\u2014that":[68],"target":[69],"YcgR":[70,121],"through":[71],"molecular":[72,136],"docking.":[73],"Biological":[74],"assays":[75],"revealed":[76],"that":[77],"combining":[78],"these":[79,144],"with":[81,109],"significantly":[84,119],"enhanced":[85,112],"antibacterial":[86],"activity":[87],"against":[88],"standard":[89],"UPEC":[90,99,130],"strains":[91],"in":[92],"concentration-dependent":[94],"manner":[95],"clinically":[97],"isolated":[98],"strains.":[100],"Notably,":[101],"chlorogenic":[102],"A5,":[106],"when":[107],"hydrochloride,":[111],"intracellular":[113],"c-di-GMP":[114],"levels":[115],"swimming":[117],"motility,":[118],"reduced":[120],"gene":[122],"expression,":[123],"effectively":[125],"inhibited":[126],"of":[129,143,152],"at":[131],"multiple":[132],"time":[133],"points.":[134],"Additionally,":[135],"dynamics":[137],"simulations":[138],"elucidated":[139],"the":[140,149],"strong":[141],"binding":[142],"YcgR,":[147],"underscoring":[148],"critical":[150],"roles":[151],"residues,":[153],"such":[154],"as":[155,162],"Arg118":[156],"Asp145.":[158],"This":[159],"research":[160],"serves":[161],"foundation":[164],"tackling":[166],"antibiotic":[167],"resistance":[168],"developing":[170],"innovative":[171],"therapeutics":[172],"UTIs.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-12-04T00:00:00"}
