{"id":"https://openalex.org/W4404961099","doi":"https://doi.org/10.36311/jhgd.v34.16849","title":"Use of autologous tissue regeneration matrix (pro prf) in the treatment of diabetic ulcers: case series","display_name":"Use of autologous tissue regeneration matrix (pro prf) in the treatment of diabetic ulcers: case series","publication_year":2024,"publication_date":"2024-11-30","ids":{"openalex":"https://openalex.org/W4404961099","doi":"https://doi.org/10.36311/jhgd.v34.16849"},"language":"en","primary_location":{"id":"doi:10.36311/jhgd.v34.16849","doi":"https://doi.org/10.36311/jhgd.v34.16849","is_oa":true,"landing_page_url":"https://doi.org/10.36311/jhgd.v34.16849","pdf_url":"https://revistas.marilia.unesp.br/index.php/jhgd/article/download/16849/17963","source":{"id":"https://openalex.org/S2738579626","display_name":"Journal of Human Growth and Development","issn_l":"0104-1282","issn":["0104-1282","2175-3598"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Human Growth and Development","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4404961099"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revistas.marilia.unesp.br/index.php/jhgd/article/download/16849/17963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000517270","display_name":"Rafael Vilhena de Carvalho F\u00fcrst","orcid":"https://orcid.org/0000-0001-6167-0372","observed_orcids":["https://orcid.org/0000-0001-6167-0372"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Vilhena de Carvalho F\u00fcrst","raw_affiliation_strings":["a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil;  b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil;","a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil","b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil"],"raw_orcid":"https://orcid.org/0000-0001-6167-0372","affiliations":[{"raw_affiliation_string":"a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil;  b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil;","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060099379","display_name":"Roberto Lichtsztejn Fech","orcid":"https://orcid.org/0000-0002-9898-8584","observed_orcids":["https://orcid.org/0000-0002-9898-8584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Lichtztejn Fech","raw_affiliation_strings":["d Departamento de Cirurgia Bucomaxilofacil, Centro Hospitalar de Santo Andr\u00e9, S\u00e3o Paulo, Brasil"],"raw_orcid":"https://orcid.org/0000-0002-9898-8584","affiliations":[{"raw_affiliation_string":"d Departamento de Cirurgia Bucomaxilofacil, Centro Hospitalar de Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Felipe Jiung Jun Lee","orcid":"https://orcid.org/0009-0008-5811-3207","observed_orcids":["https://orcid.org/0009-0008-5811-3207"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Felipe Jiung Jun Lee","raw_affiliation_strings":["c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil"],"raw_orcid":"https://orcid.org/0009-0008-5811-3207","affiliations":[{"raw_affiliation_string":"c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023433470","display_name":"Rub\u00e9n David dos Reis Zuniga","orcid":"https://orcid.org/0000-0001-6860-2647","observed_orcids":["https://orcid.org/0000-0001-6860-2647"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ruben Zuniga","raw_affiliation_strings":["c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil"],"raw_orcid":"https://orcid.org/0000-0001-6860-2647","affiliations":[{"raw_affiliation_string":"c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061270543","display_name":"Jo\u00e3o Ant\u00f4nio Corr\u00eaa","orcid":"https://orcid.org/0000-0002-3192-3436","observed_orcids":["https://orcid.org/0000-0002-3192-3436","https://orcid.org/0000-0002-8642-9814"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Antonio Corr\u00eaa","raw_affiliation_strings":["a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil;  b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil;  c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil","b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil"],"raw_orcid":"https://orcid.org/0000-0002-3192-3436","affiliations":[{"raw_affiliation_string":"a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil;  b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil;  c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"a Laborat\u00f3rio de Delineamento de Estudos e Escrita Cientifica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"b Departamento de Cirurgia, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, Brasil. Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]},{"raw_affiliation_string":"c Programa de Inicia\u00e7\u00e3o Cient\u00edfica, Centro Universit\u00e1rio FMABC, Santo Andr\u00e9, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I4210143330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2619,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.498998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"3","first_page":"482","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/platelet-rich-fibrin","display_name":"platelet-rich fibrin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6539999842643738},{"id":"https://openalex.org/keywords/chronic-skin-wounds","display_name":"chronic skin wounds","score":0.871999979019165},{"id":"https://openalex.org/keywords/ulcer-size-reduction","display_name":"ulcer size reduction","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8802617788314819},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6551153659820557},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.5943633913993835},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5546214580535889},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.529478907585144},{"id":"https://openalex.org/C2777560349","wikidata":"https://www.wikidata.org/wiki/Q18388934","display_name":"Platelet-rich fibrin","level":3,"score":0.49442243576049805},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.4731646180152893},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.46527335047721863},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.44422170519828796},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.42104285955429077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06492546200752258},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.36311/jhgd.v34.16849","doi":"https://doi.org/10.36311/jhgd.v34.16849","is_oa":true,"landing_page_url":"https://doi.org/10.36311/jhgd.v34.16849","pdf_url":"https://revistas.marilia.unesp.br/index.php/jhgd/article/download/16849/17963","source":{"id":"https://openalex.org/S2738579626","display_name":"Journal of Human Growth and Development","issn_l":"0104-1282","issn":["0104-1282","2175-3598"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Human Growth and Development","raw_type":"journal-article"},{"id":"pmh:oai:ojs.www2.marilia.unesp.br:article/16849","doi":null,"is_oa":true,"landing_page_url":"https://revistas.marilia.unesp.br/index.php/jhgd/article/view/16849","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.36311/jhgd.v34.16849","doi":"https://doi.org/10.36311/jhgd.v34.16849","is_oa":true,"landing_page_url":"https://doi.org/10.36311/jhgd.v34.16849","pdf_url":"https://revistas.marilia.unesp.br/index.php/jhgd/article/download/16849/17963","source":{"id":"https://openalex.org/S2738579626","display_name":"Journal of Human Growth and Development","issn_l":"0104-1282","issn":["0104-1282","2175-3598"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312331","host_organization_name":"University of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312331"],"host_organization_lineage_names":["University of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Human Growth and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323181","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404961099.pdf","grobid_xml":"https://content.openalex.org/works/W4404961099.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2730829347","https://openalex.org/W2738620257","https://openalex.org/W2789589221","https://openalex.org/W3091779311","https://openalex.org/W4213010380","https://openalex.org/W4368359254"],"related_works":["https://openalex.org/W4368359254","https://openalex.org/W4320409839","https://openalex.org/W2774925484","https://openalex.org/W7147125917","https://openalex.org/W4412528661","https://openalex.org/W2119093292","https://openalex.org/W6929975039","https://openalex.org/W1418589030","https://openalex.org/W4323652298","https://openalex.org/W4311355406"],"abstract_inverted_index":{"Introduction:":[0],"diabetes":[1],"mellitus":[2],"significantly":[3],"contributes":[4],"to":[5,23,41,61,196],"chronic":[6,207],"ulcers,":[7,19],"with":[8,71,122,135,188],"over":[9,13],"30%":[10],"of":[11,45,57,65,67,94,113,126,130,142,146,158,160,166,171,183,193],"diabetics":[12],"40":[14],"affected":[15],"by":[16,103],"lower":[17],"limb":[18],"which":[20],"can":[21,37],"lead":[22],"severe":[24],"complications":[25],"if":[26],"untreated.":[27],"The":[28,155],"Progressive":[29],"Platelet":[30],"Rich":[31],"Fibrin":[32],"(PRO-PRF)":[33],"tissue":[34,58,73,87],"regeneration":[35,74,88],"matrix":[36,75,89,101],"be":[38,197],"a":[39,63,78,85,111,123,177],"technique":[40],"improve":[42],"the":[43,46,55,92,131,147,153,181,184,191],"dimensions":[44],"membrane,":[47],"its":[48],"strength":[49],"and":[50,107,168,201],"cell":[51],"distribution,":[52],"aiding":[53],"in":[54,110,180],"treatment":[56,93,161,187],"reconstruction.":[59],"Objective:":[60],"describe":[62],"series":[64,82],"cases":[66],"diabetic":[68,95,211],"ulcers":[69,185],"treated":[70],"autologous":[72,100],"(PRO-PRF).":[76],"Methods:":[77],"prospective,":[79],"interventional":[80],"case":[81],"study":[83],"using":[84],"new":[86],"protocol":[90,112],"for":[91,205],"ulcers.":[96],"This":[97],"is":[98],"an":[99,136,198],"obtained":[102],"collecting":[104],"peripheral":[105],"blood":[106],"centrifuging":[108],"it":[109],"progressively":[114],"increasing":[115],"speeds.":[116],"Results:":[117],"29":[118],"patients":[119],"were":[120,150],"evaluated":[121],"mean":[124],"age":[125],"60.54\u00b19.75":[127],"years.":[128],"82.8%":[129],"sample":[132],"was":[133,162],"male":[134],"average":[137],"body":[138],"mass":[139],"index":[140],"(BMI)":[141],"29.29\u00b18.04Kg/m2":[143],".":[144],"Most":[145],"lesions":[148],"(41.4%)":[149],"located":[151],"on":[152,210],"hallux.":[154],"median":[156],"number":[157],"days":[159],"14":[163],"(25%":[164],"percentile":[165,170],"7":[167],"75%":[169],"63":[172],"days).":[173],"Statistical":[174],"analysis":[175],"showed":[176],"significant":[178],"reduction":[179],"size":[182],"after":[186],"PRO-PRF.":[189],"Conclusion:":[190],"use":[192],"PRO-PRF":[194],"proved":[195],"easy-to-use,":[199],"low-cost":[200],"effective":[202],"therapeutic":[203],"option":[204],"treating":[206],"skin":[208],"wounds":[209],"feet.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-12-04T00:00:00"}