{"id":"https://openalex.org/W4404886869","doi":"https://doi.org/10.31557/apjcb.2024.9.4.661-665","title":"Unveiling the Anticarcinogenic Efficacy of Nirgundi with Emphasis on Oral Cancer: A Comprehensive Review","display_name":"Unveiling the Anticarcinogenic Efficacy of Nirgundi with Emphasis on Oral Cancer: A Comprehensive Review","publication_year":2024,"publication_date":"2024-11-23","ids":{"openalex":"https://openalex.org/W4404886869","doi":"https://doi.org/10.31557/apjcb.2024.9.4.661-665"},"language":"en","primary_location":{"id":"doi:10.31557/apjcb.2024.9.4.661-665","doi":"https://doi.org/10.31557/apjcb.2024.9.4.661-665","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31557/apjcb.2024.9.4.661-665","pdf_url":"http://waocp.com/journal/index.php/apjcb/article/download/1519/2827","source":{"id":"https://openalex.org/S4210179172","display_name":"Asian Pacific Journal of Cancer Biology","issn_l":"2538-4635","issn":["2538-4635"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://waocp.com/journal/index.php/apjcb/article/download/1519/2827","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084711930","display_name":"R. Ashwini","orcid":"https://orcid.org/0000-0003-1652-598X","observed_orcids":["https://orcid.org/0000-0003-1652-598X","https://orcid.org/0000-0002-2342-0759"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashwini Ravi","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020950557","display_name":"V Vasanthi","orcid":"https://orcid.org/0000-0001-9710-7469","observed_orcids":["https://orcid.org/0000-0001-9710-7469"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vasanthi V","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090296670","display_name":"K. B. Vinitha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinitha K B","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037097633","display_name":"Gopikrishna Padmanabhan","orcid":"https://orcid.org/0009-0007-2129-2283","observed_orcids":["https://orcid.org/0009-0007-2129-2283"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gopikrishna Padmanabhan","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037975868","display_name":"Shruthi Venkatkumar","orcid":"https://orcid.org/0000-0002-1943-6862","observed_orcids":["https://orcid.org/0000-0002-1943-6862"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shruthi Venkatkumar","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050608831","display_name":"Rajkumar Krishnan","orcid":"https://orcid.org/0000-0002-6875-0663","observed_orcids":["https://orcid.org/0000-0002-6875-0663"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajkumar K","raw_affiliation_strings":["Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210101314"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15708154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4","first_page":"661","last_page":"665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitex-negundo","display_name":"Vitex negundo","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticarcinogenic-activity","display_name":"anticarcinogenic activity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8119999766349792},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7300000190734863},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.800000011920929},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tobacco-use","display_name":"tobacco use","score":0.6480000019073486},{"id":"https://openalex.org/keywords/herbal-formula","display_name":"herbal formula","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C177454536","wikidata":"https://www.wikidata.org/wiki/Q578290","display_name":"Emphasis (telecommunications)","level":2,"score":0.700102686882019},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5799650549888611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4442176818847656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2139524221420288},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20761370658874512},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31557/apjcb.2024.9.4.661-665","doi":"https://doi.org/10.31557/apjcb.2024.9.4.661-665","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31557/apjcb.2024.9.4.661-665","pdf_url":"http://waocp.com/journal/index.php/apjcb/article/download/1519/2827","source":{"id":"https://openalex.org/S4210179172","display_name":"Asian Pacific Journal of Cancer Biology","issn_l":"2538-4635","issn":["2538-4635"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31557/apjcb.2024.9.4.661-665","doi":"https://doi.org/10.31557/apjcb.2024.9.4.661-665","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31557/apjcb.2024.9.4.661-665","pdf_url":"http://waocp.com/journal/index.php/apjcb/article/download/1519/2827","source":{"id":"https://openalex.org/S4210179172","display_name":"Asian Pacific Journal of Cancer Biology","issn_l":"2538-4635","issn":["2538-4635"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404886869.pdf","grobid_xml":"https://content.openalex.org/works/W4404886869.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1980447614","https://openalex.org/W1980850140","https://openalex.org/W1999907608","https://openalex.org/W2069920532","https://openalex.org/W2084633330","https://openalex.org/W2089675534","https://openalex.org/W2171467033","https://openalex.org/W2289349330","https://openalex.org/W2735767394","https://openalex.org/W2744607430","https://openalex.org/W2750104704","https://openalex.org/W3010979518","https://openalex.org/W3088830090","https://openalex.org/W3157858580","https://openalex.org/W3164416447","https://openalex.org/W4221040717","https://openalex.org/W4246997339","https://openalex.org/W4378471629"],"related_works":["https://openalex.org/W2811085415","https://openalex.org/W4400732116","https://openalex.org/W2969761212","https://openalex.org/W4407761217","https://openalex.org/W4385984186","https://openalex.org/W3096597839","https://openalex.org/W4225258788","https://openalex.org/W7220860809","https://openalex.org/W4385805730","https://openalex.org/W7125693801"],"abstract_inverted_index":{"India":[0],"contributes":[1],"one-third":[2],"to":[3,12,67,77,84],"the":[4,13,16,22,28,35,56,90,95,103,141,155],"global":[5],"cancer":[6,26],"burden,":[7],"which":[8],"may":[9],"be":[10],"attributed":[11],"fact":[14],"that":[15,102],"diagnosis":[17],"is":[18,27],"usually":[19],"made":[20],"in":[21,39,42,129,135,160],"advanced":[23],"stage.":[24],"Oral":[25],"most":[29],"common":[30],"cancer,":[31],"predominantly":[32],"caused":[33],"by":[34,88,109],"use":[36],"of":[37,46,143,158],"tobacco":[38],"middle-aged":[40],"males":[41],"India.":[43],"The":[44,150],"concept":[45],"chemotherapy":[47],"initially":[48],"emerged":[49],"after":[50],"systemic":[51],"mustard":[52],"gas":[53],"poisoning":[54],"damaged":[55],"bone":[57],"marrow":[58],"and":[59,93,123,147],"lymphatic":[60],"tissues.":[61],"Traditional":[62],"medicine":[63],"has":[64,132],"been":[65,82,133],"proven":[66],"have":[68,81,100],"medicinal":[69],"value":[70],"with":[71,120,163],"fewer":[72],"side":[73],"effects":[74,87],"as":[75],"compared":[76],"allopathic":[78],"drugs.":[79],"Phytochemicals":[80],"reported":[83],"exert":[85,106],"anticancer":[86],"modulating":[89],"immune":[91],"response":[92],"targeting":[94],"molecular":[96],"mechanisms.":[97],"Few":[98],"studies":[99],"demonstrated":[101],"traditional":[104],"herbs":[105],"antitumor":[107],"efficacy":[108,157],"inducing":[110],"cytotoxicity,":[111],"promoting":[112],"apoptosis,":[113],"regulating":[114],"epigenetic":[115],"modifications,":[116],"inhibiting":[117],"metastasis":[118],"along":[119],"their":[121],"antioxidant":[122],"anti-inflammatory":[124],"activity.":[125],"Nirgundi":[126,159],"(Vitex":[127],"negundo)":[128],"various":[130,161],"composition":[131],"used":[134],"producing":[136],"commercial":[137],"pharmaceutical":[138],"products":[139],"for":[140],"management":[142],"both":[144],"oral":[145,167],"health":[146],"general":[148],"health.":[149],"present":[151],"review":[152],"focuses":[153],"on":[154,166],"antitumorigenic":[156],"cancers,":[162],"an":[164],"emphasis":[165],"cancer.":[168]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-12-01T00:00:00"}