{"id":"https://openalex.org/W4404877348","doi":"https://doi.org/10.1016/j.heliyon.2024.e40812","title":"Investigating the NF-\u03baB signaling pathway in heart failure: Exploring potential therapeutic approaches","display_name":"Investigating the NF-\u03baB signaling pathway in heart failure: Exploring potential therapeutic approaches","publication_year":2024,"publication_date":"2024-11-30","ids":{"openalex":"https://openalex.org/W4404877348","doi":"https://doi.org/10.1016/j.heliyon.2024.e40812","pmid":"https://pubmed.ncbi.nlm.nih.gov/39717608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664283"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e40812","doi":"https://doi.org/10.1016/j.heliyon.2024.e40812","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e40812","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e40812","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010821617","display_name":"Mohsen Ghiasi","orcid":"https://orcid.org/0000-0003-2834-5804","observed_orcids":["https://orcid.org/0000-0003-2834-5804"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohsen Ghiasi","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010821617"],"corresponding_institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.4219,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.84596376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"23","first_page":"e40812","last_page":"e40812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6718999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.953000009059906},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/gene-modulation","display_name":"gene modulation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.563619077205658},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5215394496917725},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5058245658874512},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.45766785740852356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3972547650337219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29268115758895874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2394050657749176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23798316717147827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21010935306549072},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18202617764472961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12132051587104797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e40812","doi":"https://doi.org/10.1016/j.heliyon.2024.e40812","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e40812","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11664283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664283","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11664283/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:39717608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39717608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6ac88640df8946dab94e6ebc2bc18580","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6ac88640df8946dab94e6ebc2bc18580","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 23, Pp e40812- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e40812","doi":"https://doi.org/10.1016/j.heliyon.2024.e40812","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e40812","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404877348.pdf","grobid_xml":"https://content.openalex.org/works/W4404877348.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1507627511","https://openalex.org/W1971240021","https://openalex.org/W1975023935","https://openalex.org/W1992241296","https://openalex.org/W1992912936","https://openalex.org/W1996733544","https://openalex.org/W1998986309","https://openalex.org/W2004487378","https://openalex.org/W2006897495","https://openalex.org/W2006968633","https://openalex.org/W2008854574","https://openalex.org/W2010237936","https://openalex.org/W2010802338","https://openalex.org/W2025620210","https://openalex.org/W2031034134","https://openalex.org/W2049184223","https://openalex.org/W2050817230","https://openalex.org/W2054898931","https://openalex.org/W2058365901","https://openalex.org/W2064711537","https://openalex.org/W2071791283","https://openalex.org/W2074688366","https://openalex.org/W2100108710","https://openalex.org/W2101615512","https://openalex.org/W2103133890","https://openalex.org/W2111826006","https://openalex.org/W2148857686","https://openalex.org/W2151690149","https://openalex.org/W2155018999","https://openalex.org/W2169724245","https://openalex.org/W2299099463","https://openalex.org/W2335650918","https://openalex.org/W2463195288","https://openalex.org/W2470223656","https://openalex.org/W2574819148","https://openalex.org/W2596947530","https://openalex.org/W2605665581","https://openalex.org/W2620769476","https://openalex.org/W2754593417","https://openalex.org/W2853743497","https://openalex.org/W2883608176","https://openalex.org/W2888719982","https://openalex.org/W2903924542","https://openalex.org/W2908630152","https://openalex.org/W2935008902","https://openalex.org/W2964843273","https://openalex.org/W2995162523","https://openalex.org/W3004105709","https://openalex.org/W3005184394","https://openalex.org/W3013304792","https://openalex.org/W3038864252","https://openalex.org/W3042581723","https://openalex.org/W3083717759","https://openalex.org/W3087617819","https://openalex.org/W3088880246","https://openalex.org/W3104157055","https://openalex.org/W3113713374","https://openalex.org/W3126955501","https://openalex.org/W3136961528","https://openalex.org/W3141260294","https://openalex.org/W3177473425","https://openalex.org/W3179082773","https://openalex.org/W3208129514","https://openalex.org/W4206901806","https://openalex.org/W4210260425","https://openalex.org/W4223988200","https://openalex.org/W4284679793","https://openalex.org/W4293860347","https://openalex.org/W4311070848","https://openalex.org/W4327739333","https://openalex.org/W4379932562","https://openalex.org/W4386966436","https://openalex.org/W4387051158","https://openalex.org/W4388211973","https://openalex.org/W4388440329","https://openalex.org/W4390582547","https://openalex.org/W4390788019","https://openalex.org/W4392343318","https://openalex.org/W4396831628","https://openalex.org/W4400036847","https://openalex.org/W4400510043","https://openalex.org/W4401618240","https://openalex.org/W4402000833","https://openalex.org/W6785366843","https://openalex.org/W6846900663"],"related_works":["https://openalex.org/W2059655076","https://openalex.org/W2347217001","https://openalex.org/W2007705378","https://openalex.org/W2054898931","https://openalex.org/W1998986309","https://openalex.org/W2935008902","https://openalex.org/W2391911547","https://openalex.org/W2582154893","https://openalex.org/W4312222928","https://openalex.org/W2037519599"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"syndrome":[3,73],"is":[4,25,48,63],"of":[5,22,42,59,68,87,104,161,181,198,229,253,257,272],"great":[6],"interest":[7],"as":[8],"an":[9],"emerging":[10],"epidemic.":[11],"Due":[12],"to":[13,92,218,223,240,263],"the":[14,19,37,55,65,128,148,159,168,179,194,227,254,269],"increasing":[15,26,251],"elderly":[16],"population":[17],"worldwide,":[18],"total":[20],"number":[21,271],"HF":[23,62,157,248,260],"patients":[24,273],"every":[27],"day.":[28],"This":[29,71,215],"disease":[30],"places":[31],"a":[32,101,108,133,186],"significant":[33],"economic":[34],"burden":[35],"on":[36],"healthcare":[38],"and":[39,45,57,77,122,140,156,164,177,191,206,232,244],"treatment":[40,58],"systems":[41],"developing":[43],"societies,":[44],"this":[46,182,199,213],"situation":[47],"very":[49],"concerning.":[50],"Despite":[51],"many":[52,75,209],"advances":[53],"in":[54,111,116,135,174,212,247,259],"diagnosis":[56],"cardiovascular":[60],"diseases,":[61],"still":[64],"main":[66],"cause":[67],"death":[69],"worldwide.":[70,274],"clinical":[72,94],"has":[74,144],"cellular":[76],"molecular":[78,196],"complications,":[79],"which":[80,90,235],"are":[81,208],"often":[82],"aggravated":[83],"by":[84,184],"increased":[85],"levels":[86],"pro-inflammatory":[88],"cytokines,":[89],"lead":[91,262],"adverse":[93],"outcomes.":[95],"Nuclear":[96],"factor":[97],"kappa":[98],"B":[99],"(NF-\u03baB),":[100],"pivotal":[102],"family":[103],"transcription":[105],"factors,":[106],"plays":[107,132],"crucial":[109],"role":[110,134,256],"various":[112],"biological":[113],"processes,":[114],"particularly":[115],"inflammation,":[117],"immune":[118],"response,":[119],"cell":[120,123,172],"proliferation,":[121],"survival.":[124],"Studies":[125],"show":[126],"that":[127,147],"NF-\u03baB":[129,149,169,258],"signaling":[130,150],"pathway":[131,151,170],"modulating":[136],"cardiac":[137,175,242],"regeneration,":[138],"apoptosis,":[139],"myocardial":[141],"fibrosis.":[142],"It":[143],"been":[145,203],"found":[146],"can":[152,261],"affect":[153],"heart":[154],"function":[155,180],"through":[158],"regulation":[160],"matrix":[162],"metalloproteinases":[163],"fibrotic":[165],"mediators.":[166],"Also,":[167],"regulates":[171,178],"activities":[173],"cardiomyocytes":[176],"organ":[183],"establishing":[185],"precise":[187],"interaction":[188],"between":[189],"apoptosis":[190],"pyroptosis.":[192],"However,":[193],"exact":[195],"mechanisms":[197],"influence":[200],"have":[201],"not":[202],"well":[204],"defined":[205],"there":[207],"scientific":[210],"gaps":[211],"matter.":[214],"review":[216],"tries":[217],"highlights":[219],"potential":[220],"therapeutic":[221],"strategies":[222],"target":[224],"NF-\u03baB,":[225],"including":[226],"use":[228],"anti-inflammatory":[230],"agents":[231],"genetic":[233],"modulation,":[234],"may":[236],"provide":[237],"new":[238],"ways":[239],"reduce":[241],"fibrosis":[243],"improve":[245],"outcomes":[246],"patients.":[249],"Certainly,":[250],"understanding":[252],"multifaceted":[255],"innovative":[264],"treatments":[265],"aimed":[266],"at":[267],"reducing":[268],"growing":[270]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-11-30T00:00:00"}
