{"id":"https://openalex.org/W4404872889","doi":"https://doi.org/10.55519/jamc-02-12584","title":"EVALUATION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) EXPRESSION IN UROTHELIAL CARCINOMA: A POSSIBLE PROGNOSTIC ROLE","display_name":"EVALUATION OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) EXPRESSION IN UROTHELIAL CARCINOMA: A POSSIBLE PROGNOSTIC ROLE","publication_year":2024,"publication_date":"2024-06-30","ids":{"openalex":"https://openalex.org/W4404872889","doi":"https://doi.org/10.55519/jamc-02-12584","pmid":"https://pubmed.ncbi.nlm.nih.gov/39609964"},"language":"en","primary_location":{"id":"doi:10.55519/jamc-02-12584","doi":"https://doi.org/10.55519/jamc-02-12584","is_oa":true,"landing_page_url":"https://doi.org/10.55519/jamc-02-12584","pdf_url":"https://jamc.ayubmed.edu.pk/index.php/jamc/article/download/12584/3726","source":{"id":"https://openalex.org/S2764835899","display_name":"Journal of Ayub Medical College Abbottabad","issn_l":"1025-9589","issn":["1025-9589","1819-2718"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800760","host_organization_name":"Ayub Medical College","host_organization_lineage":["https://openalex.org/P4320800760","https://openalex.org/P4404663249"],"host_organization_lineage_names":["Ayub Medical College","Khyber Medical University"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College Abbottabad","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jamc.ayubmed.edu.pk/index.php/jamc/article/download/12584/3726","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038774397","display_name":"Shifa Basharat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268014","display_name":"Rehman Medical Institute","ror":"https://ror.org/05chh3j62","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405268014"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shifa Basharat","raw_affiliation_strings":["Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan","institution_ids":["https://openalex.org/I4405268014"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ayesha Sajjad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268014","display_name":"Rehman Medical Institute","ror":"https://ror.org/05chh3j62","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405268014"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ayesha Sajjad","raw_affiliation_strings":["Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan","institution_ids":["https://openalex.org/I4405268014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020617535","display_name":"Faryal Javaid","orcid":"https://orcid.org/0000-0002-6093-1291","observed_orcids":["https://orcid.org/0000-0002-6093-1291"]},"institutions":[{"id":"https://openalex.org/I4405268014","display_name":"Rehman Medical Institute","ror":"https://ror.org/05chh3j62","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405268014"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faryal Javaid","raw_affiliation_strings":["Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan","institution_ids":["https://openalex.org/I4405268014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062175647","display_name":"Maria R. Khan","orcid":"https://orcid.org/0000-0002-6164-7284","observed_orcids":["https://orcid.org/0000-0002-6164-7284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Khan","raw_affiliation_strings":["Department of Pathology, Pakistan Institute of Cardiology, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Pakistan Institute of Cardiology, Peshawar-Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083687794","display_name":"Maria Tasneem Khattak","orcid":"https://orcid.org/0009-0008-3096-7681","observed_orcids":["https://orcid.org/0009-0008-3096-7681"]},"institutions":[{"id":"https://openalex.org/I4405268014","display_name":"Rehman Medical Institute","ror":"https://ror.org/05chh3j62","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405268014"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Maria Tasneem Khattak","raw_affiliation_strings":["Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan","institution_ids":["https://openalex.org/I4405268014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014924223","display_name":"Iqbal Mohammad Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268014","display_name":"Rehman Medical Institute","ror":"https://ror.org/05chh3j62","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405268014"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Iqbal Muhammad Khan","raw_affiliation_strings":["Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Rehman Medical Institute, Hayatabad, Peshawar-Pakistan","institution_ids":["https://openalex.org/I4405268014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4186,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66729828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"36","issue":"2","first_page":"274","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/egfr-expression","display_name":"EGFR expression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.875},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8059999942779541},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9175973534584045},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6106976866722107},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5993133783340454},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.5980925559997559},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5672196745872498},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.5485074520111084},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5341538190841675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5266884565353394},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4542466104030609},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.425453245639801},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3968924283981323},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33934447169303894},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32931190729141235},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.55519/jamc-02-12584","doi":"https://doi.org/10.55519/jamc-02-12584","is_oa":true,"landing_page_url":"https://doi.org/10.55519/jamc-02-12584","pdf_url":"https://jamc.ayubmed.edu.pk/index.php/jamc/article/download/12584/3726","source":{"id":"https://openalex.org/S2764835899","display_name":"Journal of Ayub Medical College Abbottabad","issn_l":"1025-9589","issn":["1025-9589","1819-2718"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800760","host_organization_name":"Ayub Medical College","host_organization_lineage":["https://openalex.org/P4320800760","https://openalex.org/P4404663249"],"host_organization_lineage_names":["Ayub Medical College","Khyber Medical University"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College Abbottabad","raw_type":"journal-article"},{"id":"pmid:39609964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39609964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55519/jamc-02-12584","doi":"https://doi.org/10.55519/jamc-02-12584","is_oa":true,"landing_page_url":"https://doi.org/10.55519/jamc-02-12584","pdf_url":"https://jamc.ayubmed.edu.pk/index.php/jamc/article/download/12584/3726","source":{"id":"https://openalex.org/S2764835899","display_name":"Journal of Ayub Medical College Abbottabad","issn_l":"1025-9589","issn":["1025-9589","1819-2718"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800760","host_organization_name":"Ayub Medical College","host_organization_lineage":["https://openalex.org/P4320800760","https://openalex.org/P4404663249"],"host_organization_lineage_names":["Ayub Medical College","Khyber Medical University"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College Abbottabad","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404872889.pdf","grobid_xml":"https://content.openalex.org/works/W4404872889.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206509938","https://openalex.org/W4220836061","https://openalex.org/W2806041148","https://openalex.org/W2338057508","https://openalex.org/W4210689567","https://openalex.org/W2060237267","https://openalex.org/W7147371552","https://openalex.org/W6957762268","https://openalex.org/W2316150147","https://openalex.org/W2010486441"],"abstract_inverted_index":{"BACKGROUND:":[0],"Urothelial":[1],"carcinoma":[2,88,159],"is":[3,19],"a":[4,12,61,141,252,258],"subtype":[5],"of":[6,23,32,41,49,80,83,102,107,126,146,150,157,168,190,193,199,220,223,241,255,260,265],"urinary":[7],"bladder":[8,33],"cancer":[9,34],"which":[10],"carries":[11],"higher":[13,270],"morbidity":[14],"and":[15,52,111,116,137,185,214,235,246,276],"mortality":[16],"worldwide.":[17],"It":[18,59],"estimated":[20],"that":[21],"90%":[22],"the":[24,28,42,47,66,108,127],"patients":[25,84,153,162,195,203,208,216,225,288],"presenting":[26,289],"to":[27,45,74,143,182,211,233],"hospitals":[29],"with":[30,37,86,95,121,140,196,226,248,257,269,283,290],"history":[31],"are":[35],"diagnosed":[36,85],"urothelial":[38,57,87,158,291],"carcinomas.":[39],"Objective":[40],"study":[43,63],"was":[44,60,114,119,129,170],"evaluate":[46],"strength":[48],"EGFR":[50,112,169,256,266],"expression":[51,113,184,189,213,219,240,254,264],"its":[53,273],"prognostic":[54,274],"role":[55,275],"in":[56,91,173,267,287],"carcinoma.":[58,292],"cross-sectional":[62],"conducted":[64],"at":[65],"Rehman":[67],"Medical":[68],"Institute":[69],"Peshawar":[70],"from":[71],"July":[72],"2022":[73],"February":[75],"2023.":[76],"METHODS:":[77],"A":[78,148],"total":[79,149],"98":[81],"specimens":[82,176,179],"were":[89,98],"examined":[90],"histopathology":[92],"department.":[93],"Patients":[94],"other":[96],"malignancies":[97],"excluded.":[99],"Demographic":[100],"characteristics":[101],"participants,":[103],"tumour":[104,228,244],"grading,":[105],"invasion":[106],"surrounding":[109],"structures":[110],"recorded,":[115],"data":[117],"analysis":[118],"performed":[120],"SPSS-23.":[122],"RESULTS:":[123],"Mean":[124],"age":[125],"participants":[128],"58.68\u00b18.61":[130],"years.":[131],"Gender":[132],"distribution":[133],"revealed":[134,180,217,231,238,251],"67(68.4%)":[135],"males":[136],"31(31.6%)":[138],"females":[139],"male":[142],"female":[144],"ratio":[145],"2.1:1.":[147],"61":[151,194],"(62.2%)":[152],"exhibited":[154,204,209],"low":[155,197],"grade":[156,165,198,271],"while":[160,177],"37(37.8%)":[161],"showed":[163,187],"high":[164,227],"malignancy.":[166],"Expression":[167],"not":[171],"observed":[172],"04":[174,201],"(4.1%)":[175],"62(63.3%)":[178],"weak":[181,210,232],"moderate":[183,212,234],"32(32.7%)":[186],"strong":[188,218,239,253],"EGFR.":[191,221,242],"Out":[192,222],"tumour,":[200],"(6.6%)":[202],"no":[205],"expression,":[206],"50(80%)":[207],"07(11.5%)":[215],"37":[224],"grade,":[229],"12(32.4%)":[230],"25":[236],"(67.6%)":[237],"Higher":[243],"grades":[245],"tumours":[247,268],"deeper":[249],"penetration":[250],"p-value":[259],"<0.001.":[261],"CONCLUSIONS:":[262],"Strong":[263],"validates":[272],"can":[277],"be":[278],"utilized":[279],"for":[280],"targeted":[281],"therapy":[282],"potentially":[284],"lifesaving":[285],"consequences":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-11-30T00:00:00"}
