{"id":"https://openalex.org/W4404867495","doi":"https://doi.org/10.14744/hf.2024.2024.0024","title":"Performance of non-invasive fibrosis markers in biopsy-proven liver disorders","display_name":"Performance of non-invasive fibrosis markers in biopsy-proven liver disorders","publication_year":2024,"publication_date":"2024-11-29","ids":{"openalex":"https://openalex.org/W4404867495","doi":"https://doi.org/10.14744/hf.2024.2024.0024","pmid":"https://pubmed.ncbi.nlm.nih.gov/40255951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12008458"},"language":"en","primary_location":{"id":"doi:10.14744/hf.2024.2024.0024","doi":"https://doi.org/10.14744/hf.2024.2024.0024","is_oa":true,"landing_page_url":"http://dx.doi.org/10.14744/hf.2024.2024.0024","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1736517434-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"1307-5888","issn":["1307-5888","2757-7392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://hepatologyforum.org/storage/upload/pdfs/1736517434-en.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079121688","display_name":"Nilay Dan\u0131\u015f","orcid":"https://orcid.org/0000-0002-3939-3089","observed_orcids":["https://orcid.org/0000-0002-3939-3089"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nilay Danis","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-3939-3089","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043234351","display_name":"Fulya G\u00fcn\u015far","orcid":"https://orcid.org/0000-0002-6002-4819","observed_orcids":["https://orcid.org/0000-0002-6002-4819","https://orcid.org/0000-0001-9020-686X"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fulya Gunsar","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-6002-4819","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030059105","display_name":"Funda Y\u0131lmaz","orcid":"https://orcid.org/0000-0003-1837-6498","observed_orcids":["https://orcid.org/0000-0003-1837-6498"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Funda Yilmaz","raw_affiliation_strings":["Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0003-1837-6498","affiliations":[{"raw_affiliation_string":"Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020889265","display_name":"Den\u0131z Nart","orcid":"https://orcid.org/0000-0002-8100-6978","observed_orcids":["https://orcid.org/0000-0002-8100-6978"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz Nart","raw_affiliation_strings":["Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-8100-6978","affiliations":[{"raw_affiliation_string":"Department of Medical Pathology, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003113347","display_name":"\u0130lker Turan","orcid":"https://orcid.org/0000-0001-8998-1965","observed_orcids":["https://orcid.org/0000-0001-8998-1965"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ilker Turan","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0001-8998-1965","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085605553","display_name":"Zeki A. Karasu","orcid":"https://orcid.org/0000-0002-4974-7944","observed_orcids":["https://orcid.org/0000-0002-4974-7944"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeki Karasu","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-4974-7944","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012855807","display_name":"Galip Ers\u00f6z","orcid":"https://orcid.org/0000-0002-2040-7524","observed_orcids":["https://orcid.org/0000-0002-2040-7524"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Galip Ersoz","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-2040-7524","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083057475","display_name":"Ulus Salih Akarca","orcid":"https://orcid.org/0000-0002-7020-5816","observed_orcids":["https://orcid.org/0000-0002-7020-5816"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ulus Salih Akarca","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-7020-5816","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102727969","display_name":"\u00d6mer \u00d6z\u00fctemiz","orcid":"https://orcid.org/0000-0003-3130-8916","observed_orcids":["https://orcid.org/0000-0003-3130-8916"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Omer Ozutemiz","raw_affiliation_strings":["Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-6960-4043","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, Izmir, Turkiye","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079121688"],"corresponding_institution_ids":["https://openalex.org/I193615760"],"apc_list":null,"apc_paid":null,"fwci":1.2134,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.80705023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"16","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noninvasive-fibrosis-markers","display_name":"non-invasive fibrosis markers","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fibrosis-score","display_name":"fibrosis score","score":0.5649999976158142},{"id":"https://openalex.org/keywords/fib-4-index","display_name":"FIB-4","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apri","display_name":"APRI","score":0.9409999847412109},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9700000286102295},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/overlap-syndrome","display_name":"overlap syndrome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.9919999837875366},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cryptogenic-liver-disease","display_name":"cryptogenic liver disease","score":0.7680000066757202},{"id":"https://openalex.org/keywords/fibrosis-staging","display_name":"fibrosis staging","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.777179479598999},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.7482745051383972},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.6707116961479187},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5464977622032166},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.532619833946228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5276359915733337},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4912962317466736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4475227892398834},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3851664066314697}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.14744/hf.2024.2024.0024","doi":"https://doi.org/10.14744/hf.2024.2024.0024","is_oa":true,"landing_page_url":"http://dx.doi.org/10.14744/hf.2024.2024.0024","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1736517434-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"1307-5888","issn":["1307-5888","2757-7392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12008458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12008458","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12008458/pdf/hf-6-016.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatol Forum","raw_type":"Text"},{"id":"pmid:40255951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40255951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology forum","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.14744/hf.2024.2024.0024","doi":"https://doi.org/10.14744/hf.2024.2024.0024","is_oa":true,"landing_page_url":"http://dx.doi.org/10.14744/hf.2024.2024.0024","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1736517434-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"1307-5888","issn":["1307-5888","2757-7392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404867495.pdf","grobid_xml":"https://content.openalex.org/works/W4404867495.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3202320441","https://openalex.org/W7161197712","https://openalex.org/W2065980097","https://openalex.org/W4403081716","https://openalex.org/W4390604701","https://openalex.org/W4280639304","https://openalex.org/W4396770659","https://openalex.org/W7162804521","https://openalex.org/W4415547314","https://openalex.org/W1922063514"],"abstract_inverted_index":{"Background":[0],"and":[1,7,20,29,48,112,126,137,141,144,178,203],"Aim:":[2],"(FS)":[3],"measurements,":[4,46],"Fibrosis-4":[5],"(FIB-4),":[6],"the":[8,71,197],"Aspartate":[9],"Aminotransferase":[10],"to":[11,135],"Platelet":[12],"Ratio":[13],"Index":[14],"(APRI)":[15],"scores":[16,50,146],"with":[17,21,54,123,153,165,182,189],"each":[18],"other":[19,113],"liver":[22,60,89],"biopsies":[23],"in":[24,186,201],"predicting":[25],"histological":[26,124,154,183],"fibrosis.":[27],"Materials":[28],"Methods:":[30],"In":[31,139,159,196],"this":[32],"single-center,":[33],"cross-sectional,":[34],"retrospective":[35],"collected":[36],"data":[37],"cohort":[38],"study":[39],"spanning":[40],"seven":[41],"consecutive":[42],"years,":[43],"simultaneous":[44],"FS":[45,127,157,169,179],"FIB-4,":[47,176],"APRI":[49,145],"of":[51,67,70,199],"778":[52],"patients":[53,72],"different":[55],"diagnoses":[56,82,110,114],"who":[57],"had":[58],"undergone":[59],"biopsy":[61],"were":[62,73,83],"evaluated.":[63],"Results:":[64],"A":[65],"total":[66],"417":[68],"(53.6%)":[69],"female.":[74],"The":[75,81],"median":[76],"age":[77],"was":[78],"51":[79],"years.":[80],"HBV":[84],"(n=228),":[85],"metabolic":[86],"dysfunction-associated":[87],"steatotic":[88],"disease":[90],"(MASLD)":[91],"(n=185),":[92],"HCV":[93],"(n=58),":[94],"cryptogenic":[95],"(n=53),":[96],"primary":[97],"biliary":[98],"cholangitis":[99],"(n=40),":[100],"autoimmune":[101],"hepatitis":[102],"(AIH)":[103],"(n=28),":[104],"overlap":[105],"syndrome":[106],"(OS)":[107],"(n=23),":[108],"multiple":[109],"(n=42),":[111],"(n=83).":[115],"All":[116],"three":[117,162],"methods":[118,163],"showed":[119],"a":[120,129,150],"strong":[121],"correlation":[122],"fibrosis,":[125,184],"demonstrated":[128],"statistically":[130],"significantly":[131,172],"superior":[132],"relationship":[133],"compared":[134],"FIB-4":[136,143],"APRI.":[138],"AIH":[140,202],"OS,":[142,204],"do":[147],"not":[148],"show":[149],"consistent":[151],"increase":[152],"stage;":[155],"however,":[156],"does.":[158],"MASLD,":[160,187],"all":[161],"correlate":[164,180],"histologic":[166],"stage,":[167],"but":[168],"measurements":[170],"appear":[171],"superior.":[173],"Conclusion:":[174],"Although":[175],"APRI,":[177],"well":[181],"especially":[185],"evaluation":[188,198],"FS,":[190],"if":[191],"available,":[192],"should":[193,207],"be":[194,208],"preferred.":[195],"fibrosis":[200],"laboratory-based":[205],"indicators":[206],"avoided.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-11-30T00:00:00"}