{"id":"https://openalex.org/W4404751367","doi":"https://doi.org/10.32920/27912774","title":"Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components","display_name":"Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components","publication_year":2024,"publication_date":"2024-11-27","ids":{"openalex":"https://openalex.org/W4404751367","doi":"https://doi.org/10.32920/27912774"},"language":"en","primary_location":{"id":"doi:10.32920/27912774","doi":"https://doi.org/10.32920/27912774","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912774","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.32920/27912774","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293","observed_orcids":["https://orcid.org/0000-0002-9994-8293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034574618","display_name":"Michaela B. Cooley","orcid":"https://orcid.org/0000-0002-7955-3745","observed_orcids":["https://orcid.org/0000-0002-7955-3745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela\nB. Cooley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045673141","display_name":"Eric Abenojar","orcid":"https://orcid.org/0000-0002-2733-4006","observed_orcids":["https://orcid.org/0000-0002-2733-4006"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric C. Abenojar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091705120","display_name":"Dana Wegierak","orcid":"https://orcid.org/0000-0003-1758-2417","observed_orcids":["https://orcid.org/0000-0003-1758-2417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana Wegierak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070140867","display_name":"Anirban Sen Gupta","orcid":"https://orcid.org/0000-0002-5773-0667","observed_orcids":["https://orcid.org/0000-0002-5773-0667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirban Sen Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066","observed_orcids":["https://orcid.org/0000-0003-3913-7066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanobubbles","display_name":"nanobubbles","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ultrasound-contrast-agents","display_name":"ultrasound contrast agents","score":0.9800000190734863},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.5839999914169312},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.6819999814033508},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.7229999899864197},{"id":"https://openalex.org/keywords/blood-circulation-time","display_name":"blood circulation time","score":0.5830000042915344},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.7003873586654663},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6987835168838501},{"id":"https://openalex.org/C3020437955","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Human blood","level":2,"score":0.5267143845558167},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.4499446451663971},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4171460270881653},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3782249391078949},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2836153209209442},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18805530667304993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18172302842140198},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.13663357496261597},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32920/27912774","doi":"https://doi.org/10.32920/27912774","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912774","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.32920/27912774","doi":"https://doi.org/10.32920/27912774","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912774","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166407284","https://openalex.org/W2747447422","https://openalex.org/W4388467049","https://openalex.org/W2069228336","https://openalex.org/W7132930457","https://openalex.org/W4404160229","https://openalex.org/W2157387668","https://openalex.org/W3160960949","https://openalex.org/W3029765211","https://openalex.org/W2004482616"],"abstract_inverted_index":{"Nanoscale":[0],"ultrasound":[1,137],"contrast":[2],"agents,":[3],"or":[4,115,132,219],"nanobubbles,":[5],"are":[6,27],"being":[7],"explored":[8],"in":[9,22,63,95,103,109,158,167,192,194,225,253],"preclinical":[10],"applications":[11],"ranging":[12],"from":[13,100],"vascular":[14],"and":[15,44,82,200,249],"cardiac":[16],"imaging":[17],"to":[18,38,107,125,210,244,264],"targeted":[19],"drug":[20,254],"delivery":[21,266],"cancer.":[23],"These":[24],"sub-micron":[25],"particles":[26],"approximately":[28],"10x":[29],"smaller":[30],"than":[31],"clinically":[32],"available":[33],"microbubbles.":[34],"This":[35,239],"allows":[36],"them":[37],"effectively":[39],"traverse":[40],"compromised":[41],"physiological":[42],"barriers":[43],"circulate":[45],"for":[46,76,235],"extended":[47],"periods":[48],"of":[49,54,85,98,135,207,213,221,228],"time.":[50],"While":[51],"various":[52],"aspects":[53],"nanobubble":[55,89,101,246],"behavior":[56,62],"have":[57],"been":[58,70],"previously":[59],"examined,":[60,75],"their":[61],"human":[64,127],"whole":[65,104,128,195],"blood":[66,86,105,117],"has":[67,250],"not":[68],"yet":[69],"explored.":[71],"Accordingly,":[72],"herein":[73],"we":[74],"the":[77,80,96,133,176,182,208,211,226,236],"first":[78],"time,":[79],"short":[81],"long-term":[83],"effects":[84],"components":[87],"on":[88,223],"acoustic":[90],"response.":[91],"We":[92],"observed":[93,237],"differences":[94],"kinetics":[97],"backscatter":[99],"suspensions":[102],"compared":[106],"bubbles":[108],"phosphate":[110],"buffered":[111],"saline":[112],"(PBS),":[113],"plasma,":[114],"red":[116],"cell":[118],"solutions":[119],"(RBCs).":[120],"Specifically,":[121],"after":[122],"introducing":[123],"nanobubbles":[124,157,209,222],"fresh":[126],"blood,":[129],"signal":[130,163],"enhancement,":[131],"magnitude":[134],"nonlinear":[136],"signal,":[138],"gradually":[139],"increased":[140],"by":[141],"22.8":[142],"\u00b1":[143,170,189],"13.1%":[144],"throughout":[145],"our":[146],"experiment,":[147],"with":[148,164,181,259],"peak":[149],"intensity":[150,168],"reached":[151],"within":[152],"145":[153],"s.":[154],"In":[155],"contrast,":[156],"PBS":[159],"had":[160],"a":[161,187,232],"stable":[162],"negligible":[165],"change":[166],"(-1.7":[169],"3.2%)":[171],"over":[172],"8":[173],"min.":[174],"Under":[175],"same":[177,183],"conditions,":[178],"microbubbles":[179],"made":[180],"lipid":[184],"formulation":[185],"showed":[186],"-56.8":[188],"6.1%":[190],"decrease":[191],"enhancement":[193],"blood.":[196],"Subsequent":[197],"confocal,":[198],"fluorescent,":[199],"scanning":[201],"electron":[202],"microscopy":[203],"analysis":[204],"revealed":[205],"attachment":[206],"surface":[212],"RBCs,":[214],"suggesting":[215],"that":[216],"direct":[217],"interactions,":[218],"hitchhiking,":[220],"RBCs":[224],"presence":[227],"plasma":[229],"may":[230],"be":[231,242,262],"possible":[233],"mechanism":[234],"effects.":[238],"phenomenon":[240],"could":[241,261],"key":[243],"extending":[245],"circulation":[247],"time":[248],"broad":[251],"implications":[252],"delivery,":[255],"where":[256],"RBC":[257],"interaction":[258],"nanoparticles":[260],"exploited":[263],"improve":[265],"efficiency.":[267]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-11-27T00:00:00"}