{"id":"https://openalex.org/W4404733915","doi":"https://doi.org/10.1016/j.vetimm.2024.110863","title":"Production of functional bovine IL-22 in a mammalian episomal expression system","display_name":"Production of functional bovine IL-22 in a mammalian episomal expression system","publication_year":2024,"publication_date":"2024-11-26","ids":{"openalex":"https://openalex.org/W4404733915","doi":"https://doi.org/10.1016/j.vetimm.2024.110863","pmid":"https://pubmed.ncbi.nlm.nih.gov/39615285"},"language":"en","primary_location":{"id":"doi:10.1016/j.vetimm.2024.110863","doi":"https://doi.org/10.1016/j.vetimm.2024.110863","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vetimm.2024.110863","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.2139/ssrn.4776654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040276356","display_name":"Laura In\u00e9s Klepp","orcid":"https://orcid.org/0000-0002-6532-1425","observed_orcids":["https://orcid.org/0000-0002-6532-1425"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Laura I. Klepp","raw_affiliation_strings":["Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: klepp.laura@inta.gob.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: klepp.laura@inta.gob.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210153948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061921123","display_name":"Mar\u00eda Mercedes Bigi","orcid":"https://orcid.org/0000-0001-8711-1413","observed_orcids":["https://orcid.org/0000-0001-8711-1413"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Mercedes Bigi","raw_affiliation_strings":["Universidad de Buenos Aires, Facultad de Medicina,\u00a0Argentina. Electronic address: mbigi@fmed.uba.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Medicina,\u00a0Argentina. Electronic address: mbigi@fmed.uba.ar","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159784435","display_name":"Luciana Villafa\u00f1e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Luciana Villafa\u00f1e","raw_affiliation_strings":["Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: villafane.luciana@inta.gob.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: villafane.luciana@inta.gob.ar","institution_ids":["https://openalex.org/I4210153948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060967833","display_name":"Federico Carlos Blanco","orcid":"https://orcid.org/0000-0002-3671-7359","observed_orcids":["https://orcid.org/0000-0002-3671-7359"]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Federico C. Blanco","raw_affiliation_strings":["Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: blanco.federico@inta.gob.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: blanco.federico@inta.gob.ar","institution_ids":["https://openalex.org/I4210153948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008694629","display_name":"Pauline Malinge","orcid":"https://orcid.org/0009-0006-4000-8981","observed_orcids":["https://orcid.org/0009-0006-4000-8981"]},"institutions":[{"id":"https://openalex.org/I4210144390","display_name":"Light Chain Bioscience (Switzerland)","ror":"https://ror.org/03a17f132","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210144390"]},{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR","CH"],"is_corresponding":false,"raw_author_name":"Pauline Malinge l","raw_affiliation_strings":["Light Chain Bioscience - Novimmune SA,\u00a0Switzerland. Electronic address: pauline.malinge@lightchainbio.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Light Chain Bioscience - Novimmune SA,\u00a0Switzerland. Electronic address: pauline.malinge@lightchainbio.com","institution_ids":["https://openalex.org/I4210144390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005809333","display_name":"Fabiana Bigi","orcid":"https://orcid.org/0000-0001-8637-7180","observed_orcids":["https://orcid.org/0000-0001-8637-7180"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210144390","display_name":"Light Chain Bioscience (Switzerland)","ror":"https://ror.org/03a17f132","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210144390"]},{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR","CH"],"is_corresponding":true,"raw_author_name":"Fabiana Bigi","raw_affiliation_strings":["Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: bigi.fabiana@inta.gob.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Agrobiotecnolog\u00eda y Biolog\u00eda Molecular (IABIMO), UEDD INTA-CONICET,\u00a0Argentina; Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria (Institute of Biotechnology, National Institute of Agricultural Technology, Argentina),\u00a0Argentina. Electronic address: bigi.fabiana@inta.gob.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210153948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005809333","https://openalex.org/A5061921123"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I4210144390","https://openalex.org/I4210153948"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":0.1356,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41054323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"279","issue":null,"first_page":"110863","last_page":"110863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9739999771118164},{"id":"https://openalex.org/keywords/bovine-macrophages","display_name":"bovine macrophages","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.42500001192092896},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8906253576278687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3972417712211609},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.354137659072876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34609460830688477}],"mesh":[{"descriptor_ui":"D000097043","descriptor_name":"Interleukin-22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009163","descriptor_name":"Mycobacterium bovis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.vetimm.2024.110863","doi":"https://doi.org/10.1016/j.vetimm.2024.110863","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vetimm.2024.110863","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4776654","doi":"https://doi.org/10.2139/ssrn.4776654","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2139/ssrn.4776654","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:39615285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39615285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary immunology and immunopathology","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/282138","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/282138","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4776654","doi":"https://doi.org/10.2139/ssrn.4776654","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2139/ssrn.4776654","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2760860605","display_name":null,"funder_award_id":"PICT- 2020-1609","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G7682788877","display_name":null,"funder_award_id":"INTA-I116","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320326565","display_name":"Instituto Nacional de Tecnolog\u00eda Agropecuaria","ror":"https://ror.org/04wm52x94"},{"id":"https://openalex.org/F4320337954","display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1568528850","https://openalex.org/W1926103424","https://openalex.org/W1951425617","https://openalex.org/W1963932824","https://openalex.org/W1969366172","https://openalex.org/W1977943216","https://openalex.org/W1983930473","https://openalex.org/W1999169296","https://openalex.org/W1999795586","https://openalex.org/W2002987322","https://openalex.org/W2006677280","https://openalex.org/W2008005165","https://openalex.org/W2023136223","https://openalex.org/W2031579881","https://openalex.org/W2056465423","https://openalex.org/W2063044697","https://openalex.org/W2065330512","https://openalex.org/W2067212685","https://openalex.org/W2070556075","https://openalex.org/W2074616286","https://openalex.org/W2074985870","https://openalex.org/W2082450021","https://openalex.org/W2092548193","https://openalex.org/W2111494418","https://openalex.org/W2134468562","https://openalex.org/W2138168556","https://openalex.org/W2165578318","https://openalex.org/W2169355315","https://openalex.org/W2561144210","https://openalex.org/W2605166577","https://openalex.org/W2899238819","https://openalex.org/W2938341288","https://openalex.org/W3045426270","https://openalex.org/W3195448796","https://openalex.org/W3213725664","https://openalex.org/W4288068337","https://openalex.org/W4321368955","https://openalex.org/W4323655822","https://openalex.org/W6651253139","https://openalex.org/W6800668151"],"related_works":["https://openalex.org/W2789927095","https://openalex.org/W1980940213","https://openalex.org/W2000219282","https://openalex.org/W2074985870","https://openalex.org/W2283396335","https://openalex.org/W4403601992","https://openalex.org/W2078926696","https://openalex.org/W4284973458","https://openalex.org/W2600357521","https://openalex.org/W4399646665"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-11-27T00:00:00"}
