{"id":"https://openalex.org/W4404732248","doi":"https://doi.org/10.32920/27912696.v1","title":"In Vitro Studies of Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging","display_name":"In Vitro Studies of Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging","publication_year":2024,"publication_date":"2024-11-27","ids":{"openalex":"https://openalex.org/W4404732248","doi":"https://doi.org/10.32920/27912696.v1"},"language":"en","primary_location":{"id":"doi:10.32920/27912696.v1","doi":"https://doi.org/10.32920/27912696.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32920/27912696.v1","pdf_url":"https://rshare.library.torontomu.ca/articles/journal_contribution/In_Vitro_Studies_of_Multifunctional_Perfluorocarbon_Nanoemulsions_for_Cancer_Therapy_and_Imaging/27912696/1/files/50821722.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://rshare.library.torontomu.ca/articles/journal_contribution/In_Vitro_Studies_of_Multifunctional_Perfluorocarbon_Nanoemulsions_for_Cancer_Therapy_and_Imaging/27912696/1/files/50821722.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065762287","display_name":"Donald A. Fernandes","orcid":"https://orcid.org/0000-0001-7871-698X","observed_orcids":["https://orcid.org/0000-0001-7871-698X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald A. Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008552372","display_name":"Dennis D. Fernandes","orcid":"https://orcid.org/0000-0001-7018-2637","observed_orcids":["https://orcid.org/0000-0001-7018-2637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis D. Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078061681","display_name":"Claudiu C. Gradinaru","orcid":"https://orcid.org/0000-0002-1897-313X","observed_orcids":["https://orcid.org/0000-0002-1897-313X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudiu\nC. Gradinaru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293","observed_orcids":["https://orcid.org/0000-0002-9994-8293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.13120000064373016,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfluorocarbon-nanoemulsions","display_name":"perfluorocarbon nanoemulsions","score":1.0},{"id":"https://openalex.org/keywords/theranostic-agents","display_name":"theranostic agents","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.8610000014305115},{"id":"https://openalex.org/keywords/co-diffusion","display_name":"CO diffusion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fluorescence-correlation-spectroscopy","display_name":"fluorescence correlation spectroscopy","score":0.796999990940094},{"id":"https://openalex.org/keywords/total-internal-reflection-fluorescence-microscopy","display_name":"total internal reflection fluorescence microscopy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ultrasonography","display_name":"ultrasonography","score":0.41999998688697815},{"id":"https://openalex.org/keywords/photoacoustic-imaging","display_name":"photoacoustic imaging","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.5130000114440918},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.715280294418335},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5630183219909668},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5586107969284058},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5516685247421265},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.46080613136291504},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38710370659828186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31085556745529175},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2926243245601654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13466161489486694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0781623125076294}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.32920/27912696.v1","doi":"https://doi.org/10.32920/27912696.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32920/27912696.v1","pdf_url":"https://rshare.library.torontomu.ca/articles/journal_contribution/In_Vitro_Studies_of_Multifunctional_Perfluorocarbon_Nanoemulsions_for_Cancer_Therapy_and_Imaging/27912696/1/files/50821722.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/27912696","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/In_Vitro_Studies_of_Multifunctional_Perfluorocarbon_Nanoemulsions_for_Cancer_Therapy_and_Imaging/27912696","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.32920/27912696.v1","doi":"https://doi.org/10.32920/27912696.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.32920/27912696.v1","pdf_url":"https://rshare.library.torontomu.ca/articles/journal_contribution/In_Vitro_Studies_of_Multifunctional_Perfluorocarbon_Nanoemulsions_for_Cancer_Therapy_and_Imaging/27912696/1/files/50821722.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404732248.pdf","grobid_xml":"https://content.openalex.org/works/W4404732248.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6986388120","https://openalex.org/W2061501935","https://openalex.org/W2145507515","https://openalex.org/W2058814607","https://openalex.org/W1966682925","https://openalex.org/W4404732176","https://openalex.org/W2511822851","https://openalex.org/W4385520784","https://openalex.org/W2051310110","https://openalex.org/W7096983563"],"abstract_inverted_index":{"Nanoparticles":[0],"are":[1,65,73],"attractive":[2],"agents":[3,71,156],"for":[4,47,55,90,101,160,179],"cancer":[5,61,236],"therapy":[6],"because":[7,108],"of":[8,60,69,80,104,109,153,210,231],"two":[9],"unique":[10,28,67],"properties.":[11],"First":[12],"is":[13,22,42],"their":[14,27,43,110,133,270],"ability":[15,174],"to":[16,26,75,127,135,138,175,191,222,268],"accumulate":[17],"in":[18,24,106,234],"tumor":[19,91],"tissue.":[20],"This":[21,225],"due":[23],"part":[25],"pharmacokinetics":[29],"allowing":[30],"minimal":[31],"renal":[32],"filtration":[33],"and":[34,52,115,181,243,247,250,262],"evading":[35],"uptake":[36,249],"by":[37,197],"the":[38,84,122,147,208,229],"reticuloendothelial":[39],"system.":[40],"Second":[41],"high":[44,113],"surface-to-volume":[45],"ratios":[46],"carrying":[48],"various":[49,94,129,139,253],"sensors,":[50],"therapeutics":[51],"targeting":[53,59,130],"species":[54],"passive":[56],"or":[57,163,173,205],"active":[58],"cells.":[62],"Perfluorocarbon":[63,97],"nanoemulsions":[64,99,123,233],"a":[66,77,102,151,188,192],"class":[68],"theranostic":[70,273],"which":[72,216],"able":[74],"solubilize":[76],"wide":[78],"variety":[79,152],"therapeutic":[81],"agents,":[82],"at":[83,146],"same":[85,148],"time":[86,149],"have":[87,128],"optical":[88,211],"properties":[89,168],"detection":[92],"using":[93,202,252],"imaging":[95,155,162],"modalities.":[96],"(PFC)":[98],"allow":[100],"range":[103],"functions":[105],"vivo":[107],"biological":[111],"inertness,":[112],"stability,":[114],"reduced":[116],"cytotoxicity.":[117],"Like":[118],"many":[119],"other":[120],"nanoparticles,":[121],"can":[124,145,194,217],"be":[125,195],"designed":[126],"ligands":[131],"on":[132],"surface":[134],"direct":[136],"them":[137],"biomarkers":[140],"associated":[141],"with":[142],"cancer.":[143],"It":[144],"carry":[150],"extrinsic":[154],"such":[157,169],"as":[158,170,220,272],"chromophores":[159],"fluorescence":[161,254,259,266],"use":[164,209],"its":[165,171],"intrinsic":[166],"physical":[167],"density":[172],"vaporize":[176],"upon":[177],"expansion":[178],"ultrasound":[180],"photoacoustic":[182],"imaging.":[183],"Its":[184],"phase":[185],"transition":[186],"from":[187],"liquid":[189],"droplet":[190],"microbubble":[193],"accomplished":[196],"either":[198],"directly":[199],"providing":[200],"energy":[201,219],"acoustic":[203],"waves":[204],"indirectly":[206],"through":[207],"absorbers":[212],"(i.e.":[213,239,256],"gold":[214],"nanoparticles)":[215],"transfer":[218],"heat":[221],"PFC":[223],"nanodroplets.":[224],"work":[226],"will":[227,244],"study":[228],"effect":[230],"perfluorocarbon":[232],"breast":[235],"cell":[237],"lines":[238],"MCF-7,":[240],"MDA-MB":[241],"231)":[242],"quantify":[245],"nanodroplet":[246],"nanoparticle":[248],"co-diffusion":[251],"techniques":[255],"dual":[257],"color":[258],"correlation":[260],"spectroscopy":[261],"total":[263],"internal":[264],"reflection":[265],"microscopy)":[267],"determine":[269],"efficacy":[271],"agents.":[274]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-11-27T00:00:00"}
