{"id":"https://openalex.org/W4404732166","doi":"https://doi.org/10.32920/27912777","title":"Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy","display_name":"Bursting Microbubbles: How Nanobubble Contrast Agents Can Enable the Future of Medical Ultrasound Molecular Imaging and Image-Guided Therapy","publication_year":2024,"publication_date":"2024-11-27","ids":{"openalex":"https://openalex.org/W4404732166","doi":"https://doi.org/10.32920/27912777"},"language":"en","primary_location":{"id":"doi:10.32920/27912777","doi":"https://doi.org/10.32920/27912777","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912777","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.32920/27912777","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066","observed_orcids":["https://orcid.org/0000-0003-3913-7066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293","observed_orcids":["https://orcid.org/0000-0002-9994-8293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11401","display_name":"Minerals Flotation and Separation Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanobubbles","display_name":"nanobubbles","score":0.8640000224113464},{"id":"https://openalex.org/keywords/contrast-enhanced-ultrasound","display_name":"contrast-enhanced ultrasound","score":0.7419999837875366},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.781000018119812},{"id":"https://openalex.org/keywords/ultrasound-molecular-imaging","display_name":"ultrasound molecular imaging","score":0.6349999904632568},{"id":"https://openalex.org/keywords/image-guided-therapy","display_name":"image-guided therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/extravasation","display_name":"extravasation","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.9108117818832397},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.7691405415534973},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6147211194038391},{"id":"https://openalex.org/C2986892559","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasound imaging","level":3,"score":0.5420947074890137},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5258020758628845},{"id":"https://openalex.org/C2992165143","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Medical ultrasound","level":3,"score":0.4533230662345886},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.41948026418685913},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.366901159286499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34750795364379883},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34142059087753296},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.32797595858573914},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31650087237358093},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2547420859336853},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22693318128585815}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32920/27912777","doi":"https://doi.org/10.32920/27912777","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912777","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.32920/27912777","doi":"https://doi.org/10.32920/27912777","is_oa":true,"landing_page_url":"https://doi.org/10.32920/27912777","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3160960949","https://openalex.org/W4404160229","https://openalex.org/W2588139209","https://openalex.org/W1996401428","https://openalex.org/W2351541891","https://openalex.org/W3104442667","https://openalex.org/W2389567647","https://openalex.org/W1825487942","https://openalex.org/W3135131725","https://openalex.org/W2768716981"],"abstract_inverted_index":{"The":[0],"field":[1,89,129],"of":[2,13,46,73,112,120],"medical":[3,113],"ultrasound":[4,48],"has":[5],"undergone":[6],"a":[7,35,101,135],"significant":[8],"evolution":[9],"since":[10],"the":[11,26,44,69,84,88,110,118,127,148],"development":[12],"microbubbles":[14,23],"as":[15,75,79,95],"contrast":[16],"agents.":[17],"However,":[18],"due":[19],"to":[20,52,92],"their":[21],"size,":[22],"remain":[24],"in":[25,87,126,131,147],"vasculature,":[27],"and":[28,38,71,78,90,100,123,144],"therefore":[29],"have":[30],"limited":[31],"clinical":[32,104],"applications.":[33],"Building":[34],"better":[36],"\u2013":[37,40,57],"smaller":[39],"bubble":[41],"can":[42,107],"expand":[43],"applications":[45],"contrast-enhanced":[47],"by":[49],"allowing":[50],"bubbles":[51],"extravasate":[53],"from":[54],"blood":[55],"vessels":[56],"creating":[58],"new":[59],"opportunities.":[60],"In":[61],"this":[62,132],"review,":[63],"we":[64],"summarize":[65],"recent":[66],"research":[67],"on":[68],"formulation":[70],"use":[72],"NBs":[74,94],"imaging":[76],"agents":[77],"therapeutic":[80],"vehicles.":[81],"We":[82,115],"discuss":[83],"ongoing":[85],"debates":[86],"reluctance":[91],"accepting":[93],"an":[96],"acoustically":[97],"active":[98],"construct":[99],"potentially":[102],"impactful":[103],"tool":[105],"that":[106,117,138],"help":[108,140],"shape":[109],"future":[111],"ultrasound.":[114],"hope":[116],"overview":[119],"key":[121],"experimental":[122],"theoretical":[124],"findings":[125],"NB":[128],"presented":[130],"paper":[133],"provides":[134],"fundamental":[136],"framework":[137],"will":[139],"clarify":[141],"NB-ultrasound":[142],"interactions":[143],"inspire":[145],"engagement":[146],"field.":[149]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-11-27T00:00:00"}