{"id":"https://openalex.org/W4404732012","doi":"https://doi.org/10.32920/27913434.v1","title":"In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors","display_name":"In situ forming implants exposed to ultrasound enhance therapeutic efficacy in subcutaneous murine tumors","publication_year":2024,"publication_date":"2024-11-27","ids":{"openalex":"https://openalex.org/W4404732012","doi":"https://doi.org/10.32920/27913434.v1"},"language":"en","primary_location":{"id":"doi:10.32920/27913434.v1","doi":"https://doi.org/10.32920/27913434.v1","is_oa":false,"landing_page_url":"https://doi.org/10.32920/27913434.v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/In_situ_forming_implants_exposed_to_ultrasound_enhance_therapeutic_efficacy_in_subcutaneous_murine_tumors/27913434","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024093646","display_name":"Selva Jeganathan","orcid":"https://orcid.org/0000-0002-2208-7229","observed_orcids":["https://orcid.org/0000-0002-2208-7229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selva Jeganathan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065057608","display_name":"Emily Budziszewski","orcid":"https://orcid.org/0000-0002-8008-3496","observed_orcids":["https://orcid.org/0000-0002-8008-3496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Budziszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078969004","display_name":"Peter A. Bielecki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Bielecki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293","observed_orcids":["https://orcid.org/0000-0002-9994-8293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066","observed_orcids":["https://orcid.org/0000-0003-3913-7066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-forming-implants","display_name":"in situ forming implants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-ultrasound","display_name":"ultrasound therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ultrasound-mediated-drug-delivery","display_name":"ultrasound-mediated drug delivery","score":0.5740000009536743},{"id":"https://openalex.org/keywords/drug-survival","display_name":"drug retention","score":0.8389999866485596},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.5509999990463257},{"id":"https://openalex.org/keywords/subcutaneous-tumor","display_name":"subcutaneous tumor","score":0.6800000071525574},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.6499999761581421},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.6790909767150879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5430885553359985},{"id":"https://openalex.org/C2779727089","wikidata":"https://www.wikidata.org/wiki/Q564875","display_name":"Therapeutic ultrasound","level":3,"score":0.4880277216434479},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4794856011867523},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.47165194153785706},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.467435747385025},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4550313949584961},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.43473172187805176},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43430057168006897},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3476037383079529},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3302285671234131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2947198152542114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2901817262172699},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28405922651290894},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1423543393611908},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.32920/27913434.v1","doi":"https://doi.org/10.32920/27913434.v1","is_oa":false,"landing_page_url":"https://doi.org/10.32920/27913434.v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toronto Metropolitan University","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/27913434","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/In_situ_forming_implants_exposed_to_ultrasound_enhance_therapeutic_efficacy_in_subcutaneous_murine_tumors/27913434","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/27913434","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/In_situ_forming_implants_exposed_to_ultrasound_enhance_therapeutic_efficacy_in_subcutaneous_murine_tumors/27913434","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2918774297","https://openalex.org/W2768154379","https://openalex.org/W2768535667","https://openalex.org/W3018650769","https://openalex.org/W2109466809","https://openalex.org/W4388466979","https://openalex.org/W2110715086","https://openalex.org/W1635175664","https://openalex.org/W2770089159","https://openalex.org/W2755563121"],"abstract_inverted_index":{"In":[0,72],"situ":[1],"forming":[2],"implants":[3],"(ISFIs)":[4],"allow":[5],"for":[6,46,238],"a":[7,43,158,166,204,210,218,254],"high":[8],"initial":[9],"intratumoral":[10,35,231],"concentration":[11],"and":[12,33,53,66,82,95,165,174,189,217,250],"sustained":[13],"release":[14],"of":[15,50,57,92,98,153,264],"the":[16,30,64,77,90,93,151,260],"chemotherapeutic.":[17],"However,":[18],"clinical":[19,262],"translation":[20],"is":[21],"impeded":[22],"primarily":[23],"due":[24],"to":[25,89,111,179,225,258],"limited":[26],"drug":[27,36,48,79,163,170,187,245,266],"penetration":[28,49,164,188],"from":[29],"tumor/boundary":[31],"interface":[32],"poor":[34,261],"retention.":[37],"Therapeutic":[38],"ultrasound":[39],"(TUS)":[40],"has":[41],"become":[42],"popular":[44],"approach":[45],"improving":[47],"transdermal":[51],"devices":[52],"increasing":[54],"cellular":[55],"uptake":[56],"nanoparticles.":[58],"These":[59,184],"effects":[60,97],"are":[61],"driven":[62],"by":[63],"mechanical":[65,94],"thermal":[67,96],"bioeffects":[68],"associated":[69],"with":[70,150,199,233,243],"TUS.":[71],"this":[73],"study,":[74],"we":[75],"characterize":[76],"released":[78],"penetration,":[80],"retention,":[81],"overall":[83],"therapeutic":[84,195],"response":[85],"when":[86],"exposing":[87],"ISFI":[88,154,200],"combination":[91,152],"TUS":[99,182,228,234],"(C-TUS).":[100],"ISFIs":[101,180,226,232],"were":[102],"intratumorally":[103],"injected":[104],"into":[105,192],"subcutaneous":[106],"murine":[107],"tumors":[108],"then":[109],"exposed":[110],"C-TUS":[112,156,202],"(exposure:":[113],"5":[114,137],"min,":[115],"duty":[116],"factor:":[117],"0.33,":[118],"frequency:":[119,131],"3":[120],"MHz,":[121],"intensity:":[122,145],"2.2":[123],"W/cm2,":[124],"pulse":[125,129],"duration:":[126],"2":[127],"ms,":[128],"repetition":[130],"165":[132],"Hz,":[133],"effective":[134],"radiating":[135],"area:":[136],"cm2,":[138],"energy":[139],"delivered:":[140],"896":[141],"J,":[142],"time":[143],"average":[144],"0.88":[146],"W/cm2).":[147],"Tumors":[148],"treated":[149,198],"+":[155,201],"demonstrated":[157],"2.5-fold":[159],"increase":[160,168,212,220],"in":[161,169,186,207,213,221,247],"maximum":[162],"3-fold":[167],"retention":[171,190],"at":[172],"5-":[173],"8-days":[175],"post-injection,":[176],"respectively,":[177],"compared":[178,224],"without":[181,227],"exposure.":[183,229],"improvements":[185],"translated":[191],"an":[193],"enhanced":[194],"response.":[196],"Mice":[197],"showed":[203],"62.6%":[205],"reduction":[206],"tumor":[208],"progression,":[209],"50.0%":[211],"median":[214],"survival":[215],"time,":[216],"26.6%":[219],"necrotic":[222],"percentage":[223],"Combining":[230],"may":[235,251],"be":[236],"beneficial":[237],"addressing":[239],"some":[240],"long-standing":[241],"challenges":[242],"local":[244,265],"delivery":[246,267],"cancer":[248],"treatment":[249],"serve":[252],"as":[253],"viable":[255],"noninvasive":[256],"method":[257],"improve":[259],"success":[263],"systems.":[268]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2024-11-27T00:00:00"}
