{"id":"https://openalex.org/W4404728455","doi":"https://doi.org/10.3389/fnmol.2024.1526357","title":"Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects","display_name":"Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects","publication_year":2024,"publication_date":"2024-11-26","ids":{"openalex":"https://openalex.org/W4404728455","doi":"https://doi.org/10.3389/fnmol.2024.1526357","pmid":"https://pubmed.ncbi.nlm.nih.gov/39660171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11628495"},"language":"en","primary_location":{"id":"doi:10.3389/fnmol.2024.1526357","doi":"https://doi.org/10.3389/fnmol.2024.1526357","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2024.1526357","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1526357/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1526357/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025785531","display_name":"Isabella Zanella","orcid":"https://orcid.org/0000-0003-3902-3376","observed_orcids":["https://orcid.org/0000-0003-3902-3376"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Isabella Zanella","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","Medical Genetics Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Medical Genetics Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027150103","display_name":"Daniela Zizioli","orcid":"https://orcid.org/0000-0003-0451-8029","observed_orcids":["https://orcid.org/0000-0003-0451-8029"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Zizioli","raw_affiliation_strings":["Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033592492","display_name":"Eugenia Quir\u00f3s-Rold\u00e1n","orcid":"https://orcid.org/0000-0003-1452-9100","observed_orcids":["https://orcid.org/0000-0003-1452-9100"]},"institutions":[{"id":"https://openalex.org/I4210103289","display_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","ror":"https://ror.org/015rhss58","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210103289"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenia Quiros-Roldan","raw_affiliation_strings":["Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy","Division of Infectious and Tropical Diseases, ASST Spedali Civili di Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Division of Infectious and Tropical Diseases, ASST Spedali Civili di Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I4210103289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018546819","display_name":"Aditya N. Bade","orcid":"https://orcid.org/0000-0003-2511-4461","observed_orcids":["https://orcid.org/0000-0003-2511-4461"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya N. Bade","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025785531"],"corresponding_institution_ids":["https://openalex.org/I4210103289","https://openalex.org/I79940851"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1526357","last_page":"1526357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.7789999842643738},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/neurodevelopmental-effects","display_name":"neurodevelopmental effects","score":0.6859999895095825},{"id":"https://openalex.org/keywords/integrase-strand-transfer-inhibitors","display_name":"integrase strand transfer inhibitors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/elvitegravir","display_name":"elvitegravir","score":0.9940000176429749},{"id":"https://openalex.org/keywords/raltegravir","display_name":"raltegravir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6000000238418579},{"id":"https://openalex.org/keywords/ipsc-derived-cortical-neurons","display_name":"iPSC-derived cortical neurons","score":0.8299999833106995},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.7089999914169312},{"id":"https://openalex.org/keywords/forebrain-organoids","display_name":"forebrain organoids","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2780404665","wikidata":"https://www.wikidata.org/wiki/Q421552","display_name":"Raltegravir","level":5,"score":0.6287723183631897},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5874097347259521},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.5873489379882812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5708900094032288},{"id":"https://openalex.org/C2777068322","wikidata":"https://www.wikidata.org/wiki/Q2740966","display_name":"Elvitegravir","level":5,"score":0.48657381534576416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4721401035785675},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.432378888130188},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3607505261898041},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2661532759666443},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.26495951414108276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20937445759773254},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2084173560142517},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.16542556881904602},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.15609309077262878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13353323936462402},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.09388360381126404},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnmol.2024.1526357","doi":"https://doi.org/10.3389/fnmol.2024.1526357","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2024.1526357","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1526357/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11628495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11628495","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11628495/pdf/fnmol-17-1526357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Neurosci","raw_type":"Text"},{"id":"pmid:39660171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39660171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular neuroscience","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:1f371eaad79346a4af2222b7ea889ac2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1f371eaad79346a4af2222b7ea889ac2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Neuroscience, Vol 17 (2024)","raw_type":"article"},{"id":"pmh:oai:iris.unibs.it:11379/617045","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11379/617045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fnmol.2024.1526357","doi":"https://doi.org/10.3389/fnmol.2024.1526357","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnmol.2024.1526357","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1526357/pdf","source":{"id":"https://openalex.org/S39538987","display_name":"Frontiers in Molecular Neuroscience","issn_l":"1662-5099","issn":["1662-5099"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404728455.pdf","grobid_xml":"https://content.openalex.org/works/W4404728455.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2341041396","https://openalex.org/W2753599284"],"related_works":["https://openalex.org/W3084093379","https://openalex.org/W4389570253","https://openalex.org/W2753599284","https://openalex.org/W2948268854","https://openalex.org/W4404120160","https://openalex.org/W2972814809","https://openalex.org/W3158123393","https://openalex.org/W4210863251","https://openalex.org/W2332670321","https://openalex.org/W2740884463"],"abstract_inverted_index":{"Several":[0],"anti-viral":[1,1033],"drugs":[2,221],"like":[3,57,615],"those":[4],"used":[5,100,214,382],"to":[6,32,76,89,191,215,366,383,456,528,610,652,684,706,711,731,840,848,906,925,953,1051],"treat":[7],"human":[8,234,249,355,362],"immunodeficiency":[9],"virus":[10,389],"(HIV)":[11],"infections":[12],"have":[13],"been":[14],"associated":[15,882,912],"with":[16,96,231,314,400,483,499,534,857,883,913,939,963],"neurotoxicity":[17],"or":[18,222,402,535,631,773,785,862],"neurodevelopmental":[19,805,886,1030],"impairments":[20,806],"following":[21,689],"in":[22,48,93,109,162,245,284,341,414,449,469,541,559,583,659,675,687,699,720,832,872,888,891,986,995,1011,1018,1046,1054],"utero":[23,721,873],"exposures.":[24],"The":[25,40,98,258,273,434,662,942],"aim":[26],"of":[27,63,84,135,147,158,186,199,204,219,248,268,298,354,361,370,387,407,420,452,466,502,532,556,576,586,591,598,642,656,668,703,749,794,810,821,843,851,970,1005,1032],"this":[28,38,238,378,1019,1047],"special":[29],"issue":[30],"was":[31,153,282,293,380,521,789,911,984],"provide":[33],"an":[34,108,244,859],"updated":[35],"overview":[36],"on":[37,180,390,440,648,780,827,902,1026],"topic.":[39],"published":[41],"articles":[42],"explored":[43,69,817],"the":[44,64,70,77,125,133,173,184,266,296,299,352,368,371,385,405,450,500,530,542,554,574,577,584,589,604,707,732,755,818,849,852,875,903,907,926,947,1003,1014,1022,1027,1041,1055],"argument":[45],"using":[46,719,735],"classical":[47],"vitro":[49,110,246],"and":[50,53,67,112,128,140,143,241,270,289,347,349,375,418,424,443,459,464,472,476,488,511,526,565,567,622,636,640,770,807,815,829,896,917,920,934,957,981,998,1029],"animal":[51],"models,":[52],"new":[54,1042,1052],"emerging":[55,1043],"tools":[56,1044],"cerebral":[58,103],"organoids,":[59],"covering":[60],"several":[61],"aspects":[62],"proposed":[65],"topic.Monnerie":[66],"colleagues":[68,242,350,527,637,816],"possibility":[71],"that":[72,114,130,277,290,335,445,494,550,607,627,665,727,792,878,946],"elvitegravir":[73],"(EGV),":[74],"belonging":[75,847],"integrase":[78],"strand":[79],"transfer":[80],"inhibitor":[81,868],"(INSTI)":[82],"class":[83,850],"antiretroviral":[85,220],"drugs,":[86],"may":[87,228,506,1049],"contribute":[88],"white":[90],"matter":[91],"damage":[92,769],"people":[94],"living":[95],"HIV.":[97],"authors":[99,259,274,435,605,663,876],"mature":[101],"rat":[102,286],"cortical":[104,255,364,398],"oligodendrocyte":[105,117,192,200],"cultures":[106,193,288],"as":[107,359,570,572,796,974,976,1008],"model":[111,247,379,520],"found":[113,129,444,606,664,877],"EVG":[115,131,269,278],"reduced":[116,156,415,481,765,921,958],"differentiation,":[118,201],"particularly":[119],"at":[120],"later":[121],"stages.":[122,545],"They":[123],"investigated":[124],"involved":[126,161,340,468,558],"mechanisms":[127],"modulated":[132,553],"expression":[134,157,331,438,547,555,575,969,1000],"sterol":[136],"regulatory":[137],"elementbinding":[138],"protein-1":[139],"-2":[141],"(SREBP-1":[142],"SREBP-2),":[144],"major":[145],"regulators":[146],"cellular":[148,453],"lipid":[149],"metabolism.":[150],"Their":[151],"modulation":[152],"accompanied":[154],"by":[155,295,318,524,633],"key":[159],"enzymes":[160],"fatty":[163,189],"acid":[164,461,538],"synthesis,":[165],"while":[166,202,428,923],"cholesterol":[167],"pathways":[168,463,467],"seemed":[169],"unaffected.":[170],"In":[171],"contrast,":[172],"INSTI":[174],"raltegravir":[175],"(RAL)":[176],"had":[177,430],"no":[178,431],"effect":[179,369,531],"SREBP":[181],"expression.":[182],"Unexpectedly,":[183],"addition":[185,203],"palmitate,":[187],"a":[188,595,833,841,1009],"acid,":[190],"did":[194,207,310],"not":[195,280,311,629],"prevent":[196,208,739,803],"EVG-induced":[197],"inhibition":[198],"serum":[205],"albumin":[206],"these":[209],"effects.Rodent":[210],"models":[211,360],"are":[212,1037],"often":[213],"evaluate":[216],"neuronal":[217,235,772,960],"toxicity":[218,292,313],"HIV-associated":[223],"insults,":[224],"however":[225],"experimental":[226],"observations":[227],"consistently":[229],"coincide":[230],"results":[232],"from":[233,754],"models.To":[236],"overcome":[237],"problem,":[239],"Starr":[240],"established":[243],"induced":[250,496,742,930],"pluripotent":[251],"stem":[252,486,515],"cell":[253,345,508,561,768],"(iPSC)-derived":[254],"glutamatergic":[256],"neurons.":[257,490],"first":[260],"characterized":[261],"their":[262],"model,":[263],"then":[264,944],"assessed":[265],"effects":[267,386,779,820,1031],"RAL":[271,281,403,429],"exposure.":[272],"previously":[275],"demonstrated":[276,493],"but":[279,893,1040],"neurotoxic":[283,1028],"primary":[285],"neuroglial":[287],"its":[291,982],"driven":[294],"activation":[297,498],"integrated":[300],"stress":[301],"response":[302,455],"(ISR)":[303],"(Stern":[304],"et":[305,393],"al.,":[306,394],"2018).":[307],"Here,":[308],"they":[309,492],"observe":[312],"either":[315,858],"drug,":[316],"measured":[317],"microtubule-associated":[319],"protein":[320],"2":[321],"(MAP2)":[322],"staining.":[323],"However,":[324],"electrophysiological":[325],"measures":[326],"suggested":[327],"sub-lethal":[328],"damage.":[329],"RNA":[330,437,546],"analysis":[332,479,548],"further":[333],"revealed":[334,480,549],"both":[336,879,940,987],"INSTIs":[337,372],"downregulated":[338],"genes":[339,557],"extracellular":[342,563],"matrix":[343],"interaction,":[344],"motility":[346],"morphogenesis.LaNoce":[348],"described":[351,1045],"use":[353],"iPSC-based":[356],"forebrain":[357],"organoids":[358,399,442,608],"early":[363],"development":[365,475],"explore":[367],"dolutegravir":[373],"(DTG)":[374],"RAL.":[376],"Previously,":[377],"successfully":[381],"study":[384],"Zika":[388],"neurodevelopment":[391,650],"(Qian":[392],"2016).Researchers":[395],"treated":[396,441],"early-stage":[397],"DTG":[401,411,446,495,533,551,587,611,645,658,673,692,704,714,758,795,811],"within":[404],"range":[406],"cord":[408],"blood":[409],"concentrations.":[410],"exposure":[412,447,540,552,582,730,826,924],"resulted":[413,448,698],"organoid":[416,518],"size":[417],"density":[419],"neural":[421,485],"rosette":[422],"structures":[423],"increased":[425,914],"caspase-3":[426],"staining,":[427],"appreciable":[432],"effects.":[433],"performed":[436],"analyses":[439],"upregulation":[451,501],"stress,":[454,762],"glucose":[457],"starvation":[458],"amino":[460],"stimulus":[462],"downregulation":[465],"neuron":[470],"differentiation":[471],"migration,":[473],"CNS":[474],"neuroblast":[477],"proliferation.Immuno-histological":[478],"neurogenesis":[482],"fewer":[484],"cells":[487],"postmitotic":[489],"Further,":[491,745,966],"ISR":[497],"downstream":[503],"effectors,":[504],"which":[505],"disrupt":[507],"cycle":[509],"progression":[510],"impair":[512],"neurogenesis.A":[513],"three-dimensional":[514],"cell-derived":[516],"brain":[517,709,734,752,782,954],"developmental":[519],"also":[522,993],"employed":[523],"Caiaffa":[525],"analyze":[529],"without":[536],"folic":[537],"(FA)":[539],"earliest":[543],"maturation":[544],"neurodevelopment,":[560],"cycle,":[562],"matrix,":[564],"membrane":[566],"motor":[568,830,895],"proteins,":[569],"well":[571,975],"inducing":[573],"folate":[578],"receptor":[579],"FOLR1.":[580],"FA":[581,634],"presence":[585],"attenuated":[588,786],"alteration":[590],"gene":[592,999],"expression,":[593],"suggesting":[594],"protective":[596],"role":[597],"FA.":[599],"Using":[600],"multimodal":[601],"optical":[602],"instruments,":[603],"exposed":[609,839],"presented":[612,1021],"biomechanical":[613],"alterations":[614],"higher":[616],"surface":[617],"stiffness,":[618],"lower":[619,701,728],"internal":[620],"stiffness":[621],"decreased":[623],"volume":[624,1020],"during":[625,812],"maturation,":[626],"were":[628,682,783,838,881,899,937,992],"rescued":[630],"mitigated":[632],"supplementation.Foster":[635],"evaluated":[638],"safety":[639,809],"benefits":[641],"injectable":[643,736,797],"long-acting":[644],"nano-formulation":[646],"(NDTG)":[647,801],"fetal":[649],"compared":[651,710],"daily":[653,690,712],"oral":[654,691,713,756],"administration":[655],"native":[657,740,757],"pregnant":[660,676],"mice.":[661],"intramuscular":[666],"injection":[667],"NDTG":[669,696,737,788],"achieved":[670],"therapeutic":[671],"plasma":[672,679],"concentrations":[674,681],"dams.":[677],"These":[678,776],"drug":[680,729,741],"comparable":[683],"levels":[685,702],"observed":[686,890,985,994],"dams":[688],"administration.":[693,715],"Of":[694],"note,":[695],"injections":[697],"significantly":[700],"biodistribution":[705],"embryo":[708,733,751,781],"T1":[716],"mapping":[717],"evaluations":[718,1001],"magnetic":[722],"resonance":[723],"imaging":[724],"(MRI)":[725],"indicated":[726],"can":[738,802],"oxidative":[743,761],"stress.":[744],"non-targeted":[746],"proteomic":[747],"profiling":[748],"whole":[750],"tissues":[753],"group":[759],"showed":[760,945],"mitochondrial":[763],"dysfunction,":[764],"energy":[766],"production,":[767],"impaired":[771,938],"synaptic":[774],"development.":[775],"drug-induced":[777],"adverse":[778,885],"prevented":[784],"when":[787],"administered,":[790],"signifying":[791],"delivery":[793],"long":[798],"acting":[799],"nanoformulations":[800],"DTG-associated":[804],"improve":[808],"pregnancy.Finally,":[813],"Dhume":[814],"long-term":[819,884],"perinatal":[822],"anti-retroviral":[823],"therapy":[824],"(ART)":[825],"neurocognitive":[828],"performance":[831],"murine":[834],"model.":[835],"Pregnant":[836],"mice":[837],"combination":[842],"ritonavir-boosted":[844],"atazanavir":[845],"(ATV/r),":[846],"HIV":[853],"protease":[854],"inhibitors":[855],"(PIs),":[856],"abacavir/lamivudine":[860],"(ABC/3TC)":[861],"tenofovir/emtricitabine":[863],"(TDF/FTC)":[864],"nucleoside":[865],"reverse":[866],"transcriptase":[867],"(NRTI)":[869],"backbone.":[870],"Following":[871],"exposure,":[874],"regimens":[880],"outcomes":[887],"progeny":[889],"adulthood,":[892],"different":[894],"cognitive":[897],"deficits":[898],"observed,":[900],"dependent":[901],"NRTI":[904],"backbone.Exposure":[905],"regimen":[908,929,951],"containing":[909,928],"TDF/FTC":[910],"locomotor":[915],"activity":[916],"exploratory":[918],"behavior":[919],"anxiety,":[922],"ABC/3TC":[927,948],"greater":[931],"anxiety.":[932],"Working":[933],"social":[935],"memory":[936,964],"regimens.":[941,989],"researchers":[943],"+":[949],"ATV/r":[950],"led":[952],"volumetric":[955],"reduction":[956],"hippocampal":[959,971],"counts,":[961],"correlating":[962],"deficits.":[965],"altered":[967],"mRNA":[968],"neurotransmitter":[972],"receptors":[973,983],"brain-derived":[977],"neurotrophic":[978],"factor":[979,1010],"(BDNF)":[980],"ART":[988],"Sex":[990],"differences":[991],"behavioral":[996],"testing":[997],"highlighting":[1002],"importance":[1004],"including":[1006],"sex":[1007],"analyses.In":[1012],"conclusion,":[1013],"research":[1015],"papers":[1016],"collected":[1017],"most":[1023],"advanced":[1024],"studies":[1025],"drugs.":[1034],"Many":[1035],"questions":[1036],"still":[1038],"open,":[1039],"collection":[1048],"lead":[1050],"knowledge":[1053],"field.":[1056]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-11-27T00:00:00"}