{"id":"https://openalex.org/W4404631270","doi":"https://doi.org/10.1101/2024.11.21.624719","title":"Loss of neuronal Imp induces seizure behavior through Syndecan function","display_name":"Loss of neuronal Imp induces seizure behavior through Syndecan function","publication_year":2024,"publication_date":"2024-11-22","ids":{"openalex":"https://openalex.org/W4404631270","doi":"https://doi.org/10.1101/2024.11.21.624719","pmid":"https://pubmed.ncbi.nlm.nih.gov/39605343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601543"},"language":"en","primary_location":{"id":"doi:10.1101/2024.11.21.624719","doi":"https://doi.org/10.1101/2024.11.21.624719","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.11.21.624719","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601543","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075499024","display_name":"Paula R. Roy","orcid":"https://orcid.org/0000-0002-5321-2010","observed_orcids":["https://orcid.org/0000-0002-5321-2010"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula R. Roy","raw_affiliation_strings":["University of Utah"],"raw_orcid":"https://orcid.org/0000-0002-5321-2010","affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014527691","display_name":"Nichole Link","orcid":"https://orcid.org/0000-0002-4825-9615","observed_orcids":["https://orcid.org/0000-0002-4825-9615"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nichole Link","raw_affiliation_strings":["University of Utah"],"raw_orcid":"https://orcid.org/0000-0002-4825-9615","affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014527691"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecans","display_name":"syndecans","score":0.9049999713897705},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7200000286102295},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.8930000066757202},{"id":"https://openalex.org/keywords/drosophila-neurons","display_name":"Drosophila neurons","score":0.6940000057220459},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/genetic-basis-of-epilepsy","display_name":"genetic basis of epilepsy","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.8321176767349243},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5948652625083923},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.530414879322052},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.4797876477241516},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.4129258990287781},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4120532274246216},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4011942148208618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3605627119541168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3447566330432892},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.18371716141700745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13867884874343872},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09017953276634216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2024.11.21.624719","doi":"https://doi.org/10.1101/2024.11.21.624719","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.11.21.624719","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39605343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39605343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11601543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11601543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000881208","display_name":"Training Program in Genomic Medicine","funder_award_id":"T32HG008962","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000888715","display_name":"Molecular mechanisms linking viral replication and neuropathogenesis","funder_award_id":"R01AI170857","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913502","display_name":"Developmental Biology Training Program","funder_award_id":"T32HD007491","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1771972286","https://openalex.org/W1820062186","https://openalex.org/W1970967446","https://openalex.org/W1972882396","https://openalex.org/W1978007139","https://openalex.org/W1982237691","https://openalex.org/W1984075220","https://openalex.org/W1986410420","https://openalex.org/W1987102738","https://openalex.org/W2047148095","https://openalex.org/W2048790780","https://openalex.org/W2071299742","https://openalex.org/W2072500831","https://openalex.org/W2084617736","https://openalex.org/W2090936207","https://openalex.org/W2102012932","https://openalex.org/W2121538061","https://openalex.org/W2135623109","https://openalex.org/W2141316727","https://openalex.org/W2142603652","https://openalex.org/W2149631006","https://openalex.org/W2150561062","https://openalex.org/W2160413016","https://openalex.org/W2163211542","https://openalex.org/W2225257929","https://openalex.org/W2309560234","https://openalex.org/W2332075290","https://openalex.org/W2416932547","https://openalex.org/W2560556363","https://openalex.org/W2569390976","https://openalex.org/W2605749037","https://openalex.org/W2752481219","https://openalex.org/W2950016845","https://openalex.org/W2950808283","https://openalex.org/W2999282536","https://openalex.org/W3039508055","https://openalex.org/W3082753866","https://openalex.org/W3091406593","https://openalex.org/W3195536570","https://openalex.org/W3212443359","https://openalex.org/W3213100801","https://openalex.org/W4200575426","https://openalex.org/W4244630643","https://openalex.org/W4249933270","https://openalex.org/W4281639857","https://openalex.org/W4296045310","https://openalex.org/W4297627084","https://openalex.org/W4306946876","https://openalex.org/W4311552106","https://openalex.org/W4319990318","https://openalex.org/W4321094754","https://openalex.org/W4378672871","https://openalex.org/W4389148965","https://openalex.org/W4390579397"],"related_works":["https://openalex.org/W4409640483","https://openalex.org/W1970967446","https://openalex.org/W2768556895","https://openalex.org/W2163371585","https://openalex.org/W2111591372","https://openalex.org/W1967122819","https://openalex.org/W7162580709","https://openalex.org/W2104653131","https://openalex.org/W7131620981","https://openalex.org/W2042768626"],"abstract_inverted_index":{"ABSTRACT":[0],"Seizures":[1],"affect":[2,95],"a":[3,209,222],"large":[4],"proportion":[5],"of":[6,39,70,75,101,157,164],"the":[7,18,36,54,68,128],"global":[8],"population":[9],"and":[10,23,48,155,195,205,215],"occur":[11,42],"due":[12],"to":[13,27,34,43,57,67,105,126,136,178,229],"abnormal":[14],"neuronal":[15,97,116,139,203,223],"activity":[16,140],"in":[17,77,108,134,166,193,208,234],"brain.":[19],"Unfortunately,":[20],"widespread":[21],"genetic":[22,37],"phenotypic":[24],"heterogeneity":[25],"contribute":[26,228],"insufficient":[28],"treatment":[29],"options.":[30],"It":[31],"is":[32,65,88,103,120,176,199],"critical":[33],"identify":[35,58,127],"underpinnings":[38],"how":[40],"seizures":[41,80,107],"better":[44],"understand":[45],"seizure":[46,171,211,230],"disorders":[47],"improve":[49],"therapeutic":[50],"development.":[51],"We":[52,144,185],"used":[53],"Drosophila":[55],"model":[56],"that":[59,131,146,174,187,226],"IGF-II":[60],"mRNA":[61,129,192],"Binding":[62],"Protein":[63],"(Imp)":[64],"linked":[66],"onset":[69],"this":[71,196],"phenotype.":[72],"Specific":[73],"reduction":[74,156],"Imp":[76,91,102,119,132,147,167,188,214],"neurons":[78,135,169],"causes":[79,160],"after":[81,141,182],"mechanical":[82,142,183],"stimulation.":[83],"Importantly,":[84],"gross":[85],"motor":[86],"behavior":[87,181,207],"unaffected,":[89],"showing":[90,173],"loss":[92,100],"does":[93],"not":[94],"general":[96],"activity.":[98],"Developmental":[99],"sufficient":[104,177],"cause":[106],"adults,":[109],"thus":[110],"Imp-modulated":[111],"neuron":[112],"development":[113],"affects":[114],"mature":[115],"function.":[117],"Since":[118,213],"an":[121],"RNA-binding":[122],"protein,":[123],"we":[124],"sought":[125],"target":[130],"regulates":[133],"ensure":[137],"proper":[138],"stress.":[143,184],"find":[145],"protein":[148,189],"binds":[149,190],"Syndecan":[150],"(":[151],"Sdc":[152,158,165,175,191,216],")":[153],"mRNA,":[154],"also":[159],"mechanically-induced":[161,210],"seizures.":[162],"Expression":[163],"deficient":[168],"rescues":[170],"defects,":[172],"restore":[179],"normal":[180,202],"suggest":[186],"neurons,":[194],"functional":[197],"interaction":[198],"important":[200],"for":[201],"biology":[204],"animal":[206],"model.":[212],"are":[217],"conserved,":[218],"our":[219],"work":[220],"highlights":[221],"specific":[224],"pathway":[225],"might":[227],"disorder":[231],"when":[232],"mutated":[233],"humans.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-11-23T00:00:00"}
