{"id":"https://openalex.org/W4404621189","doi":"https://doi.org/10.1002/smll.202409038","title":"Dual\u2010Integrin\u2010Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy","display_name":"Dual\u2010Integrin\u2010Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy","publication_year":2024,"publication_date":"2024-11-21","ids":{"openalex":"https://openalex.org/W4404621189","doi":"https://doi.org/10.1002/smll.202409038","pmid":"https://pubmed.ncbi.nlm.nih.gov/39573882"},"language":"en","primary_location":{"id":"doi:10.1002/smll.202409038","doi":"https://doi.org/10.1002/smll.202409038","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.202409038","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387264","display_name":"Bowen Li","orcid":"https://orcid.org/0000-0001-8475-4800","observed_orcids":["https://orcid.org/0000-0001-8475-4800"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bowen Li","raw_affiliation_strings":["School of Pharmacy Anhui Medical University  Hefei 230032 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Anhui Medical University  Hefei 230032 China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011640608","display_name":"Jianwei Bao","orcid":"https://orcid.org/0000-0002-1272-452X","observed_orcids":["https://orcid.org/0000-0002-1272-452X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Bao","raw_affiliation_strings":["School of Pharmacy Anhui Medical University  Hefei 230032 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Anhui Medical University  Hefei 230032 China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050272396","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0002-6587-6607","observed_orcids":["https://orcid.org/0000-0002-6587-6607"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Huang","raw_affiliation_strings":["School of Pharmacy Anhui Medical University  Hefei 230032 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Anhui Medical University  Hefei 230032 China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038159451","display_name":"Jikang Liu","orcid":"https://orcid.org/0000-0003-3218-3393","observed_orcids":["https://orcid.org/0000-0003-3218-3393"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jikang Liu","raw_affiliation_strings":["School of Pharmacy Anhui Medical University  Hefei 230032 China","State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy Anhui Medical University  Hefei 230032 China","institution_ids":["https://openalex.org/I197869895"]},{"raw_affiliation_string":"State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112210807","display_name":"Xuehai Yan","orcid":"https://orcid.org/0000-0002-0890-0340","observed_orcids":["https://orcid.org/0000-0002-0890-0340","https://orcid.org/0000-0002-7696-1487"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuehai Yan","raw_affiliation_strings":["State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China"],"raw_orcid":"https://orcid.org/0000-0002-0890-0340","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067126301","display_name":"Qianli Zou","orcid":"https://orcid.org/0000-0003-0464-4156","observed_orcids":["https://orcid.org/0000-0003-0464-4156"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qianli Zou","raw_affiliation_strings":["Institute of Health and Medicine Hefei Comprehensive National Science Center  Hefei 230061 China","School of Pharmacy Anhui Medical University  Hefei 230032 China"],"raw_orcid":"https://orcid.org/0000-0003-0464-4156","affiliations":[{"raw_affiliation_string":"Institute of Health and Medicine Hefei Comprehensive National Science Center  Hefei 230061 China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy Anhui Medical University  Hefei 230032 China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050272396","https://openalex.org/A5067126301","https://openalex.org/A5112210807"],"corresponding_institution_ids":["https://openalex.org/I197869895","https://openalex.org/I19820366","https://openalex.org/I4210133325"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.7558,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62208005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"21","issue":"15","first_page":"e2409038","last_page":"e2409038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-binding-peptides","display_name":"integrin-binding peptides","score":0.7369999885559082},{"id":"https://openalex.org/keywords/self-assembling-peptides","display_name":"self-assembling peptides","score":0.8769999742507935},{"id":"https://openalex.org/keywords/integrin-alpha5beta1","display_name":"alpha5beta1 integrin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":1.0},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rhein","display_name":"rhein","score":0.7670000195503235},{"id":"https://openalex.org/keywords/nanofibers","display_name":"nanofibers","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hepatic-drug-delivery","display_name":"hepatic drug delivery","score":0.6759999990463257},{"id":"https://openalex.org/keywords/multifunctional-nanomedicine","display_name":"multifunctional nanomedicine","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6951090693473816},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5914345383644104},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.5496623516082764},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.47825753688812256},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.47404977679252625},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45583462715148926},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4450054168701172},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41860127449035645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33312198519706726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21175920963287354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15198013186454773},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.14429858326911926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10974699258804321},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000088962","descriptor_name":"Antifibrotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/smll.202409038","doi":"https://doi.org/10.1002/smll.202409038","is_oa":false,"landing_page_url":"https://doi.org/10.1002/smll.202409038","pdf_url":null,"source":{"id":"https://openalex.org/S94619837","display_name":"Small","issn_l":"1613-6810","issn":["1613-6810","1613-6829"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small","raw_type":"journal-article"},{"id":"pmid:39573882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39573882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Small (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3000476109","display_name":null,"funder_award_id":"22232006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5333890195","display_name":null,"funder_award_id":"2108085J41","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G5347998895","display_name":null,"funder_award_id":"22025207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6475888041","display_name":null,"funder_award_id":"22372002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8658997356","display_name":null,"funder_award_id":"82370591","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1970568982","https://openalex.org/W1972972327","https://openalex.org/W1977036923","https://openalex.org/W2105231460","https://openalex.org/W2127409621","https://openalex.org/W2141862711","https://openalex.org/W2508686416","https://openalex.org/W2511624836","https://openalex.org/W2525308066","https://openalex.org/W2577934459","https://openalex.org/W2776088684","https://openalex.org/W2792807159","https://openalex.org/W2800340823","https://openalex.org/W2838485439","https://openalex.org/W2887528815","https://openalex.org/W2935803696","https://openalex.org/W2952382623","https://openalex.org/W2956093273","https://openalex.org/W3095484986","https://openalex.org/W3126004982","https://openalex.org/W3144734974","https://openalex.org/W3153618119","https://openalex.org/W3155264455","https://openalex.org/W3158305699","https://openalex.org/W3165286527","https://openalex.org/W3206550037","https://openalex.org/W3210042034","https://openalex.org/W4200256525","https://openalex.org/W4212980260","https://openalex.org/W4286001469","https://openalex.org/W4286544533","https://openalex.org/W4315619208","https://openalex.org/W4327697288","https://openalex.org/W4366602123","https://openalex.org/W4379619213","https://openalex.org/W4382011927","https://openalex.org/W4383998871","https://openalex.org/W4386191738","https://openalex.org/W4386253303","https://openalex.org/W4387866058","https://openalex.org/W4390063423","https://openalex.org/W4390943209","https://openalex.org/W4399353344","https://openalex.org/W4401895082"],"related_works":["https://openalex.org/W2557483217","https://openalex.org/W2566459624","https://openalex.org/W2763600075","https://openalex.org/W2886437959","https://openalex.org/W4210421408","https://openalex.org/W2009404409","https://openalex.org/W2339278149","https://openalex.org/W2473829657","https://openalex.org/W2145274768","https://openalex.org/W2328301535"],"abstract_inverted_index":{"The":[0],"integration":[1],"of":[2,14,109],"integrin-binding":[3,25,38],"peptides":[4,111],"within":[5],"self-assembling":[6,34,110],"building":[7],"blocks":[8],"is":[9,44],"crucial":[10],"for":[11,40,123],"the":[12,107],"development":[13],"targeted":[15],"nanoarchitectonics.":[16,126],"However,":[17],"such":[18],"constructs":[19],"typically":[20],"incorporate":[21],"only":[22],"a":[23,31,120],"single":[24],"peptide,":[26],"limiting":[27],"their":[28],"multifunctionality.":[29],"Herein,":[30],"rationally":[32],"designed":[33],"peptide":[35,47],"with":[36,55],"dual":[37],"motifs":[39],"\u03b15\u03b21":[41,84],"and":[42,61,82,85,116],"\u03b1v\u03b23":[43],"presented.":[45],"This":[46],"forms":[48],"highly":[49],"ordered":[50],"nanofibers":[51],"or":[52],"nanoparticles":[53],"(VH-NPs)":[54],"tailored":[56],"secondary":[57],"structures.":[58],"In":[59],"vitro":[60],"in":[62,96],"vivo":[63],"studies":[64],"demonstrate":[65],"that":[66,99,112],"VH-NPs":[67,88],"target":[68],"activated":[69],"hepatic":[70],"stellate":[71],"cells":[72],"via":[73],"dual-integrin":[74],"interactions,":[75,94],"enabling":[76],"selective":[77],"targeting":[78],"to":[79],"fibrotic":[80],"livers":[81],"suppressing":[83],"\u03b1v\u03b23.":[86],"Notably,":[87],"can":[89],"encapsulate":[90],"rhein":[91],"through":[92],"noncovalent":[93],"resulting":[95],"peptide-rhein":[97],"nanoarchitectonics":[98],"display":[100],"augmented":[101],"antifibrotic":[102],"effects.":[103],"These":[104],"findings":[105],"highlight":[106],"potential":[108],"leverage":[113],"multiple":[114],"targets":[115],"therapeutic":[117],"modules":[118],"as":[119],"promising":[121],"strategy":[122],"constructing":[124],"multifunctional":[125]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}