{"id":"https://openalex.org/W4404588147","doi":"https://doi.org/10.21203/rs.3.rs-4926839/v1","title":"Maternal ancestry reveals cyclical aging of the mammary gland.","display_name":"Maternal ancestry reveals cyclical aging of the mammary gland.","publication_year":2024,"publication_date":"2024-11-21","ids":{"openalex":"https://openalex.org/W4404588147","doi":"https://doi.org/10.21203/rs.3.rs-4926839/v1","pmid":"https://pubmed.ncbi.nlm.nih.gov/39606444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601869"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-4926839/v1","doi":"https://doi.org/10.21203/rs.3.rs-4926839/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4926839/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.21203/rs.3.rs-4926839/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033039574","display_name":"Doris Germain","orcid":"https://orcid.org/0000-0001-6597-0196","observed_orcids":["https://orcid.org/0000-0001-6597-0196"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris Germain","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036561161","display_name":"Thelma Mashaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thelma Mashaka","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109356730","display_name":"Mrittika Chattopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrittika Chattopadhyay","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114739312","display_name":"Dmitry Polushakov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry Polushakov","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074812948","display_name":"Miguel Torres\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0003-1589-8936","observed_orcids":["https://orcid.org/0000-0003-1589-8936"]},"institutions":[{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Torres-Martin","raw_affiliation_strings":["Barcelona Institute of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona Institute of Science and Technology","institution_ids":["https://openalex.org/I4210132884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021050825","display_name":"Daniela Sia","orcid":"https://orcid.org/0000-0002-9000-611X","observed_orcids":["https://orcid.org/0000-0002-9000-611X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Sia","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102980683","display_name":"Edmund Charles Jenkins","orcid":"https://orcid.org/0000-0002-6448-090X","observed_orcids":["https://orcid.org/0000-0002-6448-090X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund Jenkins","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-ancestry","display_name":"maternal ancestry","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mammary-gland-involution","display_name":"mammary gland involution","score":0.8240000009536743},{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bimodal-age-distribution","display_name":"bimodal age distribution","score":0.7599999904632568},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/oncogenic-mutations","display_name":"oncogenic mutations","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.6167160272598267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4407205283641815},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3800691068172455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24547553062438965},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21203/rs.3.rs-4926839/v1","doi":"https://doi.org/10.21203/rs.3.rs-4926839/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4926839/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:39606444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39606444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11601869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11601869","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11601869/pdf/nihpp-rs4926839v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4926839/v1","doi":"https://doi.org/10.21203/rs.3.rs-4926839/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4926839/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000918186","display_name":"Understanding the influence of Mitochondrial DNA haplotypes on breast aging and cancer","funder_award_id":"R01AG075589","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404588147.pdf","grobid_xml":"https://content.openalex.org/works/W4404588147.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1561387023","https://openalex.org/W1580867012","https://openalex.org/W1989674299","https://openalex.org/W2005301839","https://openalex.org/W2040303536","https://openalex.org/W2070050178","https://openalex.org/W2112299930","https://openalex.org/W2114589445","https://openalex.org/W2121966499","https://openalex.org/W2129769202","https://openalex.org/W2130898689","https://openalex.org/W2138600889","https://openalex.org/W2143268930","https://openalex.org/W2150959753","https://openalex.org/W2152710582","https://openalex.org/W2161661351","https://openalex.org/W2269399094","https://openalex.org/W2281758534","https://openalex.org/W2345356016","https://openalex.org/W2399225295","https://openalex.org/W2475166975","https://openalex.org/W2533210290","https://openalex.org/W2535649952","https://openalex.org/W2584978674","https://openalex.org/W2766819754","https://openalex.org/W2789456434","https://openalex.org/W2790539001","https://openalex.org/W2795761254","https://openalex.org/W2896823683","https://openalex.org/W2974419980","https://openalex.org/W3116649600","https://openalex.org/W3209962259","https://openalex.org/W4207043531","https://openalex.org/W4242676220","https://openalex.org/W4283723802","https://openalex.org/W4286251110","https://openalex.org/W4296035303","https://openalex.org/W4313199537","https://openalex.org/W4362657000","https://openalex.org/W4376604893","https://openalex.org/W4380224994"],"related_works":["https://openalex.org/W7202031214","https://openalex.org/W2415187123","https://openalex.org/W7125705042","https://openalex.org/W4405079650","https://openalex.org/W6987856614","https://openalex.org/W4317104762","https://openalex.org/W2283911818","https://openalex.org/W1984731912","https://openalex.org/W2401899187","https://openalex.org/W4223479544"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"present":[2],"provocative":[3],"data":[4],"that":[5,130],"in":[6,19,49,75,81,120],"addition":[7],"to":[8,87,151],"the":[9,95,106,128,137],"expected":[10],"progressive":[11],"age-related":[12],"involution,":[13],"mammary":[14,32,96],"gland":[15],"aging":[16,84,117,145],"can":[17],"occur":[18],"a":[20,67,112],"cyclical":[21,30,83,116,144],"pattern":[22],"and":[23,36,43,58,77,100],"is":[24,118],"dictated":[25],"by":[26,111],"maternal":[27],"ancestry.":[28],"In":[29],"aging,":[31],"glands":[33,97],"of":[34,63,90],"11":[35],"19":[37],"months":[38,102],"old":[39],"mice":[40,121],"share":[41],"genetic":[42],"proteomic":[44],"signatures,":[45],"which":[46],"are":[47,54,134],"enriched":[48],"breast":[50,64],"cancer-related":[51],"pathways,":[52],"but":[53],"absent":[55],"at":[56,71,98],"3":[57,99],"14":[59,101],"months.":[60],"Since":[61,115],"incidence":[62],"cancer":[65,91],"shows":[66],"bimodal":[68],"age":[69],"distribution":[70],"45":[72],"(~":[73,79],"11m":[74],"mice)":[76],"65":[78],"19m":[80],"mice),":[82],"may":[85,146],"contribute":[86],"these":[88,125],"peaks":[89,108],"susceptibility.":[92],"Conversely,":[93],"since":[94],"cluster":[103],"together":[104],"hierarchically,":[105],"cancer-associated":[107],"seem":[109],"separated":[110],"rejuvenation":[113,142],"phase.":[114],"observed":[119],"with":[122],"extended":[123,152],"lifespan,":[124],"findings":[126],"raise":[127],"possibility":[129],"if":[131],"oncogenic":[132],"mutations":[133],"avoided":[135],"during":[136],"pro-oncogenic":[138],"phases,":[139],"through":[140],"its":[141],"phase,":[143],"impact":[147],"multiple":[148],"organs":[149],"leading":[150],"longevity.":[153]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-11-22T00:00:00"}