{"id":"https://openalex.org/W4404586355","doi":"https://doi.org/10.7554/elife.88584.2.sa1","title":"Reviewer #2 (Public review): Spinal neural tube formation and tail development in human embryos","display_name":"Reviewer #2 (Public review): Spinal neural tube formation and tail development in human embryos","publication_year":2024,"publication_date":"2024-11-21","ids":{"openalex":"https://openalex.org/W4404586355","doi":"https://doi.org/10.7554/elife.88584.2.sa1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.88584.2.sa1","doi":"https://doi.org/10.7554/elife.88584.2.sa1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.88584.2.sa1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.88584.2.sa1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109665507","display_name":"Chloe Santos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chloe Santos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027021821","display_name":"Abigail R. Marshall","orcid":"https://orcid.org/0000-0003-4537-747X","observed_orcids":["https://orcid.org/0000-0003-4537-747X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abigail R Marshall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030716003","display_name":"Ailish Murray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ailish Murray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092499841","display_name":"Kate Metcalfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Metcalfe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Priyanka Narayan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyanka Narayan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067990810","display_name":"Sandra C. de Castro","orcid":"https://orcid.org/0000-0002-7002-015X","observed_orcids":["https://orcid.org/0000-0002-7002-015X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra CP de Castro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007039339","display_name":"Eirini Maniou","orcid":"https://orcid.org/0000-0001-9419-7374","observed_orcids":["https://orcid.org/0000-0001-9419-7374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eirini Maniou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053177280","display_name":"Nicholas D. E. Greene","orcid":"https://orcid.org/0000-0002-4170-5248","observed_orcids":["https://orcid.org/0000-0002-4170-5248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas DE Greene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084850253","display_name":"Gabriel L. Galea","orcid":"https://orcid.org/0000-0003-2515-1342","observed_orcids":["https://orcid.org/0000-0003-2515-1342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel L Galea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008657168","display_name":"Andrew J. Copp","orcid":"https://orcid.org/0000-0002-2544-9117","observed_orcids":["https://orcid.org/0000-0002-2544-9117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J Copp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-neurulation","display_name":"primary neurulation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/secondary-neurulation","display_name":"secondary neurulation","score":1.0},{"id":"https://openalex.org/keywords/human-embryo","display_name":"human embryo","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tail-development","display_name":"tail development","score":0.6140000224113464},{"id":"https://openalex.org/keywords/somitogenesis","display_name":"somitogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/segmentation-clock","display_name":"segmentation clock","score":0.9739999771118164},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.8840000033378601},{"id":"https://openalex.org/keywords/fgf8","display_name":"FGF8","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/axial-elongation","display_name":"axial elongation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.9117472171783447},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6775510907173157},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4402368366718292},{"id":"https://openalex.org/C2777551473","wikidata":"https://www.wikidata.org/wiki/Q2093072","display_name":"Tube (container)","level":2,"score":0.41979244351387024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4010615646839142},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39778009057044983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30275553464889526},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21904289722442627},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.09268954396247864}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.88584.2.sa1","doi":"https://doi.org/10.7554/elife.88584.2.sa1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.88584.2.sa1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.88584.2.sa1","doi":"https://doi.org/10.7554/elife.88584.2.sa1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.88584.2.sa1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6299999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2372981175","https://openalex.org/W3142740859","https://openalex.org/W2057129148","https://openalex.org/W2096156362","https://openalex.org/W4315785934","https://openalex.org/W1981543043","https://openalex.org/W1981240410","https://openalex.org/W4377238114","https://openalex.org/W4210534638","https://openalex.org/W4298859413"],"abstract_inverted_index":{"Formation":[0],"of":[1,9,41,54,59,104,118,131,140,163,165,193,199,211,252,269],"the":[2,6,19,39,60,97,112,158,204,216],"nervous":[3],"system":[4],"in":[5,17,33,35,66,85,111,136,157,175,181,189,203,233,236,254,271],"spinal":[7,83,223],"region":[8],"higher":[10],"vertebrates":[11],"involves":[12],"primary":[13,55,92],"and":[14,25,57,183,201,225,243,261],"secondary":[15,64,123,226],"neurulation,":[16,124],"which":[18,125],"neural":[20,105,152],"tube":[21,153],"forms":[22],"by":[23],"closure":[24],"canalisation":[26],"respectively.":[27],"These":[28],"processes":[29],"are":[30,87,246],"incompletely":[31],"understood":[32],"humans,":[34],"part":[36],"due":[37],"to":[38,76,109,122,249],"challenge":[40],"accessing":[42],"neurulation-stage":[43],"embryos":[44,69],"(3-7":[45],"weeks":[46],"post-conception).":[47],"Here":[48],"we":[49,89],"present":[50],"findings":[51,263],"on":[52,81,148],"completion":[53],"neurulation":[56,93,224,253],"formation":[58,130,228],"\u2018secondary":[61],"body\u2019":[62],"(including":[63],"neurulation)":[65],"108":[67],"human":[68,98,166,190,258],"that":[70,91,110,213,221],"span":[71],"Carnegie":[72],"Stages":[73],"(CS)":[74],"10":[75],"18.":[77],"Several":[78],"outstanding":[79],"questions":[80],"low":[82,222],"development":[84],"humans":[86,234],"addressed:":[88],"show":[90],"is":[94,115,155,170],"completed":[95],"at":[96],"posterior":[99],"neuropore":[100],"with":[101,129,178,208],"a":[102,119,132,184,209,230],"pattern":[103,232],"plate":[106],"bending":[107],"similar":[108,231],"mouse.":[113],"There":[114],"no":[116],"evidence":[117],"\u2018transition":[120],"zone\u2019":[121],"proceeds":[126],"from":[127,257],"CS13":[128],"single":[133],"lumen":[134],"as":[135,143,235,241],"mouse,":[137],"not":[138],"coalescence":[139],"multiple":[141],"lumens":[142],"has":[144],"been":[145],"claimed":[146],"based":[147],"chick":[149],"neurulation.":[150],"Secondary":[151],"\u2018splitting\u2019":[154],"seen":[156],"more":[159],"proximal":[160],"tail":[161],"regions":[162],"60%":[164],"embryos.":[167],"A":[168],"somite":[169],"formed":[171],"every":[172],"7":[173],"h":[174,180,186],"human,":[176],"compared":[177],"2":[179],"mice":[182],"5":[185],"\u2018segmentation":[187],"clock\u2019":[188],"organoids.":[191],"Termination":[192],"axial":[194],"elongation":[195],"occurs":[196],"after":[197],"downregulation":[198],"WNT3A":[200],"FGF8":[202],"CS15":[205],"embryonic":[206],"tailbud,":[207],"\u2018burst\u2019":[210],"apoptosis":[212],"may":[214],"remove":[215],"neuro-mesodermal":[217],"progenitors.":[218],"We":[219],"conclude":[220],"body":[227],"follow":[229],"mammalian":[237],"model":[238],"systems":[239],"such":[240,270],"mouse":[242],"rat.":[244],"Investigators":[245],"now":[247],"attempting":[248],"recapitulate":[250],"events":[251],"organoids":[255],"derived":[256],"stem":[259],"cells,":[260],"our":[262],"provide":[264],"\u2018normative":[265],"data\u2019":[266],"for":[267],"interpretation":[268],"vitro":[272],"results.":[273]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
