{"id":"https://openalex.org/W4404551663","doi":"https://doi.org/10.3389/fcvm.2024.1477858","title":"Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study","display_name":"Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study","publication_year":2024,"publication_date":"2024-11-20","ids":{"openalex":"https://openalex.org/W4404551663","doi":"https://doi.org/10.3389/fcvm.2024.1477858","pmid":"https://pubmed.ncbi.nlm.nih.gov/39635263"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2024.1477858","doi":"https://doi.org/10.3389/fcvm.2024.1477858","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2024.1477858","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcvm.2024.1477858","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100373749","display_name":"Xiaodong Chen","orcid":"https://orcid.org/0000-0003-0737-3099","observed_orcids":["https://orcid.org/0000-0003-0737-3099"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Chen","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pengxin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengxin Liu","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011398352","display_name":"Fangge Zhu","orcid":"https://orcid.org/0009-0006-9762-3889","observed_orcids":["https://orcid.org/0009-0006-9762-3889"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengzheng Zhu","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695434","display_name":"Dong Wang","orcid":"https://orcid.org/0000-0003-4415-1102","observed_orcids":["https://orcid.org/0000-0003-4415-1102","https://orcid.org/0000-0001-5579-8572"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Wang","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sumin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sumin Yang","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002444654","display_name":"Wenlong Yan","orcid":"https://orcid.org/0000-0001-5602-3269","observed_orcids":["https://orcid.org/0000-0001-5602-3269"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlong Yan","raw_affiliation_strings":["Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.5443,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72719601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"11","issue":null,"first_page":"1477858","last_page":"1477858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":1.0},{"id":"https://openalex.org/keywords/postoperative-atrial-fibrillation","display_name":"postoperative atrial fibrillation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.9890000224113464},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction-recovery","display_name":"left ventricular ejection fraction recovery","score":0.8859999775886536},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.9350000023841858},{"id":"https://openalex.org/keywords/arrhythmia-prevention","display_name":"arrhythmia prevention","score":0.6660000085830688},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.5199999809265137},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8514928817749023},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7477843165397644},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.6300925016403198},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5964882373809814},{"id":"https://openalex.org/C2775999527","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril, Valsartan","level":4,"score":0.5767012238502502},{"id":"https://openalex.org/C2776754050","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril","level":4,"score":0.4931747317314148},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4639911651611328},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.4611058831214905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44116532802581787},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3786226511001587},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.175965815782547}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2024.1477858","doi":"https://doi.org/10.3389/fcvm.2024.1477858","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2024.1477858","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:39635263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39635263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11614794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11614794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5ab34f20f1824fdc82f2d69a63849b3a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5ab34f20f1824fdc82f2d69a63849b3a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2024.1477858","doi":"https://doi.org/10.3389/fcvm.2024.1477858","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2024.1477858","pdf_url":null,"source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1966040437","https://openalex.org/W2029976163","https://openalex.org/W2086704957","https://openalex.org/W2100009005","https://openalex.org/W2595010755","https://openalex.org/W2741986532","https://openalex.org/W2917884932","https://openalex.org/W3045981486","https://openalex.org/W3081487506","https://openalex.org/W3088773047","https://openalex.org/W3120871902","https://openalex.org/W3132485503","https://openalex.org/W4283220494","https://openalex.org/W4295038029","https://openalex.org/W4302275226","https://openalex.org/W4318754243","https://openalex.org/W4376286474","https://openalex.org/W4385552359","https://openalex.org/W4386147387","https://openalex.org/W4386583401","https://openalex.org/W4392244750","https://openalex.org/W4400124471"],"related_works":["https://openalex.org/W3188325112","https://openalex.org/W2914028752","https://openalex.org/W2776335933","https://openalex.org/W3195938057","https://openalex.org/W4235888460","https://openalex.org/W2945205947","https://openalex.org/W4393381953","https://openalex.org/W4323356027","https://openalex.org/W4392647697","https://openalex.org/W2789864715"],"abstract_inverted_index":{"Background":[0],"The":[1,77,103,189,238],"mechanism":[2],"underlying":[3],"new-onset":[4],"postoperative":[5],"atrial":[6],"fibrillation":[7],"(POAF)":[8],"in":[9,43,48,125,137,148,169,180,191,193,206,228],"adult":[10,49,62],"cardiac":[11,50,66,236],"surgery":[12,51,67],"is":[13,215],"not":[14,247],"well":[15],"understood.":[16],"However,":[17],"efficient":[18],"pharmacological":[19],"methods":[20],"to":[21,85,183,220],"prevent":[22],"and":[23,38,57,96,120,224,231,260,269,276],"treat":[24],"arrhythmic":[25],"complications":[26],"are":[27],"still":[28],"lacking.":[29],"In":[30,166],"the":[31,36,44,69,90,97,108,126,138,149,162,170,186,194,207,216,222,229],"present":[32],"study,":[33],"we":[34],"explored":[35],"efficacy":[37,223],"safety":[39,225],"of":[40,46,72,110,133,185,226,233],"sacubitril/valsartan":[41],"(sac/val)":[42],"control":[45,98,139,187,208,259],"POAF":[47,134,159,234,258],"patients.":[52],"Methods":[53],"Between":[54],"January":[55],"2021":[56],"December":[58],"2021,":[59],"667":[60],"eligible":[61],"patients":[63,168,244],"who":[64,245,252],"underwent":[65],"at":[68],"Affiliated":[70],"Hospital":[71],"Qingdao":[73],"University":[74],"were":[75,79,107],"enrolled.":[76],"participants":[78],"divided":[80],"into":[81],"two":[82],"groups":[83],"according":[84],"whether":[86],"sac/val":[87,91,127,150,171,195,227,249],"was":[88,197],"used:":[89],"group":[92,99,128,140,151,172,196,209],"(N":[93,100],"=":[94,101,145,211],"101)":[95],"566).":[102],"main":[104],"observational":[105,218],"endpoints":[106],"incidence":[109,132,160],"POAF,":[111],"left":[112],"ventricular":[113],"ejection":[114],"fraction":[115],"(LVEF)":[116],"recovery,":[117,176],"in-hospital":[118],"mortality,":[119],"short-term":[121],"mortality.":[122],"Results":[123],"Patients":[124,147],"had":[129],"a":[130,154],"lower":[131],"than":[135],"those":[136,251],"(26/101":[141],"vs.":[142],"204/566,":[143],"P":[144],"0.045).":[146],"also":[152],"showed":[153,173,256],"higher":[155],"communicative":[156],"risk":[157],"for":[158],"using":[161,272],"Kaplan\u2013Meier":[163],"survival":[164],"analysis.":[165],"addition,":[167],"better":[174,257],"LVEF":[175,181,192,261],"with":[177,202,243],"dynamic":[178],"changes":[179],"superior":[182],"that":[184,241],"group.":[188],"change":[190],"1.78":[198],"\u00b1":[199,204],"5.41,":[200],"compared":[201,242],"\u22121.19":[203],"10.92":[205],"(P":[210],"0.008).":[212],"Conclusions":[213],"This":[214],"first":[217],"study":[219],"evaluate":[221],"prevention":[230],"treatment":[232,255],"after":[235],"surgery.":[237],"results":[239,264],"demonstrated":[240],"did":[246],"receive":[248],"treatment,":[250],"received":[253],"Sac/val":[254],"recovery.":[262],"These":[263],"should":[265],"be":[266],"cautiously":[267],"interpreted":[268],"further":[270],"confirmed":[271],"larger":[273],"sample":[274],"sizes":[275],"prospective":[277],"randomized":[278],"controlled":[279],"trials.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}