{"id":"https://openalex.org/W4404539873","doi":"https://doi.org/10.1002/mco2.70012","title":"Gut microbiota in health and disease: advances and future prospects","display_name":"Gut microbiota in health and disease: advances and future prospects","publication_year":2024,"publication_date":"2024-11-20","ids":{"openalex":"https://openalex.org/W4404539873","doi":"https://doi.org/10.1002/mco2.70012","pmid":"https://pubmed.ncbi.nlm.nih.gov/39568773","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11577303"},"language":"en","primary_location":{"id":"doi:10.1002/mco2.70012","doi":"https://doi.org/10.1002/mco2.70012","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.70012","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mco2.70012","source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mco2.70012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070150750","display_name":"Yusheng Zhang","orcid":"https://orcid.org/0009-0001-0660-4337","observed_orcids":["https://orcid.org/0009-0001-0660-4337"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yusheng Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work"],"raw_orcid":"https://orcid.org/0009-0001-0660-4337","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]},{"raw_affiliation_string":"Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yiwei Sang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Sang","raw_affiliation_strings":["Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]},{"raw_affiliation_string":"Yusheng Zhang, Hong Wang, and Yiwei Sang contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Liu","raw_affiliation_strings":["Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434902","display_name":"Q\u012bng W\u00e1ng","orcid":"https://orcid.org/0000-0003-3997-6767","observed_orcids":["https://orcid.org/0000-0003-3997-6767","https://orcid.org/0009-0008-5258-7049","https://orcid.org/0000-0002-3652-9411"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063633828","display_name":"Hongjun Yang","orcid":"https://orcid.org/0000-0001-5501-3288","observed_orcids":["https://orcid.org/0000-0001-5501-3288"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongjun Yang","raw_affiliation_strings":["State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081787708","display_name":"Xianyu Li","orcid":"https://orcid.org/0000-0001-9625-8476","observed_orcids":["https://orcid.org/0000-0001-9625-8476","https://orcid.org/0009-0005-6658-6096"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianyu Li","raw_affiliation_strings":["Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063633828","https://openalex.org/A5081787708"],"corresponding_institution_ids":["https://openalex.org/I4210141683"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.5964,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.9310945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"12","first_page":"e70012","last_page":"e70012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":1.0},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6620000004768372},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9580000042915344},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/microbiome-gut-brain-axis","display_name":"microbiome-gut-brain axis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/spatial-metabolomics","display_name":"spatial metabolomics","score":1.0}],"concepts":[{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.76374351978302},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7368546724319458},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.6892398595809937},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6648444533348083},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6229551434516907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6227947473526001},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6082912087440491},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44687020778656006},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.44394010305404663},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4186103343963623},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3625027537345886},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3436959385871887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23152902722358704},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.1128690242767334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/mco2.70012","doi":"https://doi.org/10.1002/mco2.70012","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.70012","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mco2.70012","source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11577303","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11577303","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11577303/pdf/MCO2-5-e70012.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm (2020)","raw_type":"Text"},{"id":"pmid:39568773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39568773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d1aedcd3467d4e1e8efc0832f9ef5a08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1aedcd3467d4e1e8efc0832f9ef5a08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MedComm, Vol 5, Iss 12, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/mco2.70012","doi":"https://doi.org/10.1002/mco2.70012","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mco2.70012","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mco2.70012","source":{"id":"https://openalex.org/S4210236862","display_name":"MedComm","issn_l":"2688-2663","issn":["2688-2663"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedComm","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1508903036","display_name":null,"funder_award_id":"CI2021B017","funder_id":"https://openalex.org/F4320323485","funder_display_name":"China Academy of Chinese Medical Sciences"},{"id":"https://openalex.org/G2239863202","display_name":null,"funder_award_id":"CI2023C069YLL","funder_id":"https://openalex.org/F4320323485","funder_display_name":"China Academy of Chinese Medical Sciences"},{"id":"https://openalex.org/G7951784487","display_name":null,"funder_award_id":"82174238","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323485","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404539873.pdf","grobid_xml":"https://content.openalex.org/works/W4404539873.grobid-xml"},"referenced_works_count":298,"referenced_works":["https://openalex.org/W1515023627","https://openalex.org/W1589007430","https://openalex.org/W1647551795","https://openalex.org/W1910071664","https://openalex.org/W1964576352","https://openalex.org/W1989628346","https://openalex.org/W2033049524","https://openalex.org/W2048830907","https://openalex.org/W2066709066","https://openalex.org/W2078660933","https://openalex.org/W2089453670","https://openalex.org/W2110215475","https://openalex.org/W2117934122","https://openalex.org/W2128343971","https://openalex.org/W2130743280","https://openalex.org/W2144153346","https://openalex.org/W2159944586","https://openalex.org/W2163940893","https://openalex.org/W2172162633","https://openalex.org/W2283710302","https://openalex.org/W2300697960","https://openalex.org/W2340747659","https://openalex.org/W2345124960","https://openalex.org/W2415604240","https://openalex.org/W2508094018","https://openalex.org/W2517429367","https://openalex.org/W2759694024","https://openalex.org/W2767259469","https://openalex.org/W2788309342","https://openalex.org/W2808457437","https://openalex.org/W2879078868","https://openalex.org/W2887737208","https://openalex.org/W2890744142","https://openalex.org/W2892325781","https://openalex.org/W2897921044","https://openalex.org/W2898348856","https://openalex.org/W2899391538","https://openalex.org/W2903604999","https://openalex.org/W2906319220","https://openalex.org/W2908535595","https://openalex.org/W2915000266","https://openalex.org/W2916032641","https://openalex.org/W2916443881","https://openalex.org/W2917452836","https://openalex.org/W2932683107","https://openalex.org/W2942850710","https://openalex.org/W2944263569","https://openalex.org/W2964066412","https://openalex.org/W2966229683","https://openalex.org/W2967701189","https://openalex.org/W2969829464","https://openalex.org/W2971766156","https://openalex.org/W2975889317","https://openalex.org/W2983383732","https://openalex.org/W2994832736","https://openalex.org/W2999018057","https://openalex.org/W3002248805","https://openalex.org/W3009016294","https://openalex.org/W3012295934","https://openalex.org/W3014092941","https://openalex.org/W3020890805","https://openalex.org/W3021526222","https://openalex.org/W3022440217","https://openalex.org/W3024321726","https://openalex.org/W3027193583","https://openalex.org/W3027931253","https://openalex.org/W3031406356","https://openalex.org/W3032269021","https://openalex.org/W3040804126","https://openalex.org/W3045183878","https://openalex.org/W3047356675","https://openalex.org/W3048573832","https://openalex.org/W3059932186","https://openalex.org/W3083241614","https://openalex.org/W3087390417","https://openalex.org/W3093677051","https://openalex.org/W3099350729","https://openalex.org/W3104326469","https://openalex.org/W3107083588","https://openalex.org/W3108825655","https://openalex.org/W3111810117","https://openalex.org/W3114009994","https://openalex.org/W3114522069","https://openalex.org/W3122402568","https://openalex.org/W3123756955","https://openalex.org/W3124015948","https://openalex.org/W3127839532","https://openalex.org/W3128571085","https://openalex.org/W3132116259","https://openalex.org/W3134788053","https://openalex.org/W3136016299","https://openalex.org/W3136998727","https://openalex.org/W3147763922","https://openalex.org/W3149705980","https://openalex.org/W3157179090","https://openalex.org/W3160274230","https://openalex.org/W3160737645","https://openalex.org/W3164655720","https://openalex.org/W3166362793","https://openalex.org/W3168174218","https://openalex.org/W3173610573","https://openalex.org/W3178716745","https://openalex.org/W3183189600","https://openalex.org/W3183486118","https://openalex.org/W3184875291","https://openalex.org/W3188204143","https://openalex.org/W3192271273","https://openalex.org/W3200941727","https://openalex.org/W3200961345","https://openalex.org/W3201780975","https://openalex.org/W3203227091","https://openalex.org/W3215803129","https://openalex.org/W4200031024","https://openalex.org/W4200173164","https://openalex.org/W4200287074","https://openalex.org/W4200288814","https://openalex.org/W4200355407","https://openalex.org/W4206702370","https://openalex.org/W4210560728","https://openalex.org/W4213430479","https://openalex.org/W4214952207","https://openalex.org/W4220782017","https://openalex.org/W4220880013","https://openalex.org/W4221072979","https://openalex.org/W4223612851","https://openalex.org/W4224291328","https://openalex.org/W4225524175","https://openalex.org/W4229032314","https://openalex.org/W4280541025","https://openalex.org/W4281481956","https://openalex.org/W4281675576","https://openalex.org/W4281774657","https://openalex.org/W4282917711","https://openalex.org/W4283465314","https://openalex.org/W4283795391","https://openalex.org/W4283806705","https://openalex.org/W4283816248","https://openalex.org/W4284889683","https://openalex.org/W4285058162","https://openalex.org/W4285389389","https://openalex.org/W4285413549","https://openalex.org/W4286837275","https://openalex.org/W4289939079","https://openalex.org/W4292260700","https://openalex.org/W4292475227","https://openalex.org/W4296757044","https://openalex.org/W4296806719","https://openalex.org/W4296907956","https://openalex.org/W4297010322","https://openalex.org/W4297121524","https://openalex.org/W4303614593","https://openalex.org/W4304115361","https://openalex.org/W4306292546","https://openalex.org/W4306407465","https://openalex.org/W4306411778","https://openalex.org/W4306810394","https://openalex.org/W4306884940","https://openalex.org/W4307134671","https://openalex.org/W4307948200","https://openalex.org/W4308184608","https://openalex.org/W4310036765","https://openalex.org/W4310601544","https://openalex.org/W4311518511","https://openalex.org/W4312083706","https://openalex.org/W4312211604","https://openalex.org/W4313340206","https://openalex.org/W4315479149","https://openalex.org/W4315648768","https://openalex.org/W4316464939","https://openalex.org/W4316467486","https://openalex.org/W4316499831","https://openalex.org/W4316813078","https://openalex.org/W4318474752","https://openalex.org/W4318481541","https://openalex.org/W4318541220","https://openalex.org/W4318779518","https://openalex.org/W4319294378","https://openalex.org/W4319335056","https://openalex.org/W4319454754","https://openalex.org/W4320730815","https://openalex.org/W4321002135","https://openalex.org/W4321372274","https://openalex.org/W4321374477","https://openalex.org/W4321435582","https://openalex.org/W4321497399","https://openalex.org/W4322489662","https://openalex.org/W4322501030","https://openalex.org/W4328051793","https://openalex.org/W4360617091","https://openalex.org/W4360954521","https://openalex.org/W4361215680","https://openalex.org/W4361292003","https://openalex.org/W4362468548","https://openalex.org/W4362520666","https://openalex.org/W4363645707","https://openalex.org/W4366603674","https://openalex.org/W4366992986","https://openalex.org/W4367601906","https://openalex.org/W4377942224","https://openalex.org/W4378417780","https://openalex.org/W4378782397","https://openalex.org/W4378951980","https://openalex.org/W4379094084","https://openalex.org/W4381431351","https://openalex.org/W4382369455","https://openalex.org/W4382937134","https://openalex.org/W4383197954","https://openalex.org/W4384153463","https://openalex.org/W4384831000","https://openalex.org/W4384913004","https://openalex.org/W4385580357","https://openalex.org/W4385801788","https://openalex.org/W4385986371","https://openalex.org/W4386116682","https://openalex.org/W4386120341","https://openalex.org/W4386499096","https://openalex.org/W4386531382","https://openalex.org/W4386602261","https://openalex.org/W4386813763","https://openalex.org/W4386843581","https://openalex.org/W4386989230","https://openalex.org/W4387357959","https://openalex.org/W4387651074","https://openalex.org/W4387764643","https://openalex.org/W4388589642","https://openalex.org/W4388626424","https://openalex.org/W4388763611","https://openalex.org/W4388771368","https://openalex.org/W4388940494","https://openalex.org/W4388990596","https://openalex.org/W4389051904","https://openalex.org/W4389396166","https://openalex.org/W4389470488","https://openalex.org/W4389752501","https://openalex.org/W4389818430","https://openalex.org/W4389948064","https://openalex.org/W4390097218","https://openalex.org/W4390291345","https://openalex.org/W4390373234","https://openalex.org/W4390589542","https://openalex.org/W4390604700","https://openalex.org/W4390666285","https://openalex.org/W4390779086","https://openalex.org/W4390791776","https://openalex.org/W4390911267","https://openalex.org/W4390918408","https://openalex.org/W4390972061","https://openalex.org/W4391160730","https://openalex.org/W4391244442","https://openalex.org/W4391259673","https://openalex.org/W4391288606","https://openalex.org/W4392056488","https://openalex.org/W4392129076","https://openalex.org/W4392189149","https://openalex.org/W4392379256","https://openalex.org/W4392597090","https://openalex.org/W4392697402","https://openalex.org/W4392768916","https://openalex.org/W4392853372","https://openalex.org/W4393152116","https://openalex.org/W4393433282","https://openalex.org/W4394689773","https://openalex.org/W4394875528","https://openalex.org/W4396801758","https://openalex.org/W4397009020","https://openalex.org/W4398140716","https://openalex.org/W4398761389","https://openalex.org/W4399058858","https://openalex.org/W4399063314","https://openalex.org/W4399321994","https://openalex.org/W4399357744","https://openalex.org/W4399466650","https://openalex.org/W4399509436","https://openalex.org/W4399673640","https://openalex.org/W4399701989","https://openalex.org/W4399749132","https://openalex.org/W4399811536","https://openalex.org/W4400026466","https://openalex.org/W4400181714","https://openalex.org/W4400210577","https://openalex.org/W4400243741","https://openalex.org/W4400369026","https://openalex.org/W4400663680","https://openalex.org/W4400807146","https://openalex.org/W4400815459","https://openalex.org/W4400833284","https://openalex.org/W4400908675","https://openalex.org/W4401167185","https://openalex.org/W4401230191","https://openalex.org/W4401266427","https://openalex.org/W4401433234","https://openalex.org/W4401728973","https://openalex.org/W4401754756","https://openalex.org/W4401793498","https://openalex.org/W4401906869","https://openalex.org/W4401964551","https://openalex.org/W4402757235","https://openalex.org/W4402928431"],"related_works":["https://openalex.org/W7204279977","https://openalex.org/W7221177392","https://openalex.org/W4387357959","https://openalex.org/W7165010283","https://openalex.org/W4405881727","https://openalex.org/W4409943989","https://openalex.org/W7135043586","https://openalex.org/W4387375642","https://openalex.org/W7118605936","https://openalex.org/W4403238283"],"abstract_inverted_index":{"The":[0],"gut":[1,32,90,122,139],"microbiota":[2,33,123,140],"plays":[3],"a":[4,12],"critical":[5],"role":[6,190],"in":[7,31,88,141,151,186,191],"maintaining":[8],"human":[9],"health,":[10],"influencing":[11],"wide":[13],"range":[14],"of":[15,42,79,138,158],"physiological":[16],"processes,":[17],"including":[18,82,175],"immune":[19,70,111],"regulation,":[20],"metabolism,":[21],"and":[22,40,51,53,58,68,84,144,154,165,178],"neurological":[23],"function.":[24],"Recent":[25],"studies":[26],"have":[27,102],"shown":[28],"that":[29],"imbalances":[30],"composition":[34],"can":[35,91],"contribute":[36],"to":[37,76,105],"the":[38,89,116,121,136,156,166,188],"onset":[39],"progression":[41],"various":[43],"diseases,":[44],"such":[45,161],"as":[46,162],"metabolic":[47],"disorders":[48],"(e.g.,":[49,56],"obesity":[50],"diabetes)":[52],"neurodegenerative":[54],"conditions":[55,61],"Alzheimer's":[57],"Parkinson's).":[59],"These":[60],"are":[62,73,181],"often":[63],"accompanied":[64],"by":[65,109],"chronic":[66],"inflammation":[67],"dysregulated":[69],"responses,":[71],"which":[72,120],"closely":[74],"linked":[75],"specific":[77],"forms":[78],"cell":[80,94],"death,":[81],"pyroptosis":[83],"ferroptosis.":[85],"Pathogenic":[86],"bacteria":[87],"trigger":[92],"these":[93,107,114,125,142],"death":[95],"pathways":[96],"through":[97,119],"toxin":[98],"release,":[99],"while":[100],"probiotics":[101],"been":[103],"found":[104],"mitigate":[106],"effects":[108],"modulating":[110],"responses.":[112],"Despite":[113],"insights,":[115],"precise":[117],"mechanisms":[118],"influences":[124],"diseases":[126],"remain":[127],"insufficiently":[128],"understood.":[129],"This":[130],"review":[131],"consolidates":[132],"recent":[133],"findings":[134],"on":[135],"impact":[137],"immune-mediated":[143],"inflammation-associated":[145],"conditions.":[146],"It":[147],"also":[148],"identifies":[149],"gaps":[150],"current":[152],"research":[153],"explores":[155],"potential":[157],"advanced":[159],"technologies,":[160],"organ-on-chip":[163],"models":[164],"microbiome-gut-organ":[167],"axis,":[168],"for":[169,183],"deepening":[170],"our":[171],"understanding.":[172],"Emerging":[173],"tools,":[174],"single-bacterium":[176],"omics":[177],"spatial":[179],"metabolomics,":[180],"discussed":[182],"their":[184],"promise":[185],"elucidating":[187],"microbiota's":[189],"disease":[192],"development.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":28}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-11-21T00:00:00"}