{"id":"https://openalex.org/W4404536699","doi":"https://doi.org/10.1080/1061186x.2024.2431316","title":"siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model","display_name":"siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model","publication_year":2024,"publication_date":"2024-11-20","ids":{"openalex":"https://openalex.org/W4404536699","doi":"https://doi.org/10.1080/1061186x.2024.2431316","pmid":"https://pubmed.ncbi.nlm.nih.gov/39565138"},"language":"en","primary_location":{"id":"doi:10.1080/1061186x.2024.2431316","doi":"https://doi.org/10.1080/1061186x.2024.2431316","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1061186x.2024.2431316","pdf_url":null,"source":{"id":"https://openalex.org/S100629371","display_name":"Journal of drug targeting","issn_l":"1026-7158","issn":["1026-7158","1029-2330","1061-186X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Targeting","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005967056","display_name":"Moqbel Ali Moqbel Redhwan","orcid":"https://orcid.org/0000-0002-7546-8295","observed_orcids":["https://orcid.org/0000-0002-7546-8295"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Moqbel Ali Moqbel Redhwan","raw_affiliation_strings":["Basic Science Research Center (Off-Campus), KLE College of Pharmacy","Department of Pharmacology, KLE College of Pharmacy","Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005030482","display_name":"Hariprasad M.G","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hariprasad M. G.","raw_affiliation_strings":["Basic Science Research Center (Off-Campus), KLE College of Pharmacy","Department of Pharmacology, KLE College of Pharmacy","Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088953304","display_name":"Suman Samaddar","orcid":"https://orcid.org/0000-0003-1475-0227","observed_orcids":["https://orcid.org/0000-0003-1475-0227"]},"institutions":[{"id":"https://openalex.org/I4210150676","display_name":"BGS Global Hospital","ror":"https://ror.org/058qp7v13","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210150676"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Suman Samaddar","raw_affiliation_strings":["BGS GIMS Research Institute, BGS Global Institute of Medical Sciences","BGS GIMS Research Institute, BGS Global Institute of Medical Sciences, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGS GIMS Research Institute, BGS Global Institute of Medical Sciences","institution_ids":["https://openalex.org/I4210150676"]},{"raw_affiliation_string":"BGS GIMS Research Institute, BGS Global Institute of Medical Sciences, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210150676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099361573","display_name":"Duaa Abdullah Bafail","orcid":"https://orcid.org/0009-0001-6882-0625","observed_orcids":["https://orcid.org/0009-0001-6882-0625"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Duaa Bafail","raw_affiliation_strings":["Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University","Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University","institution_ids":["https://openalex.org/I185163786"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092150293","display_name":"Sumaia Abdulbari Ahmed Ali Hard","orcid":"https://orcid.org/0009-0008-8435-0820","observed_orcids":["https://orcid.org/0009-0008-8435-0820"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumaia Abdulbari Ahmed Ali Hard","raw_affiliation_strings":["Basic Science Research Center (Off-Campus), KLE College of Pharmacy","Department of Pharmaceutics, KLE College of Pharmacy","Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028343711","display_name":"Sourav Guha","orcid":"https://orcid.org/0000-0002-2274-2158","observed_orcids":["https://orcid.org/0000-0002-2274-2158"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sourav Guha","raw_affiliation_strings":["Basic Science Research Center (Off-Campus), KLE College of Pharmacy","Department of Pharmacology, KLE College of Pharmacy","Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093870589","display_name":"Apurwa Dhavale","orcid":"https://orcid.org/0000-0002-4009-1424","observed_orcids":["https://orcid.org/0000-0002-4009-1424"]},"institutions":[{"id":"https://openalex.org/I4210125823","display_name":"KLE Academy of Higher Education and Research","ror":"https://ror.org/03aam9155","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210125823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apurwa Dhavale","raw_affiliation_strings":["Basic Science Research Center (Off-Campus), KLE College of Pharmacy","Department of Pharmacology, KLE College of Pharmacy","Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Basic Science Research Center (Off-Campus), KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]},{"raw_affiliation_string":"Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210125823"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088953304"],"corresponding_institution_ids":["https://openalex.org/I4210150676"],"apc_list":null,"apc_paid":null,"fwci":1.6334,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79776375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"3","first_page":"424","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-peripheral-neuropathy","display_name":"diabetic peripheral neuropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.7559999823570251},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intrathecal-drug-delivery","display_name":"intrathecal drug delivery","score":0.7639999985694885},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9419999718666077},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.734000027179718},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nerve-conduction-velocity","display_name":"nerve conduction velocity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sciatic-functional-index","display_name":"sciatic functional index","score":0.6679999828338623},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8279825448989868},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.7521487474441528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6600540280342102},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6019976139068604},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5371487736701965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5216527581214905},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.47324973344802856},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.4661373496055603},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.435586154460907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25992563366889954},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.224229097366333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18060630559921265},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.1741662621498108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1723828911781311},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.16528800129890442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09393766522407532},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08278173208236694},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.08100199699401855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071137","descriptor_name":"Poly (ADP-Ribose) Polymerase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/1061186x.2024.2431316","doi":"https://doi.org/10.1080/1061186x.2024.2431316","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1061186x.2024.2431316","pdf_url":null,"source":{"id":"https://openalex.org/S100629371","display_name":"Journal of drug targeting","issn_l":"1026-7158","issn":["1026-7158","1029-2330","1061-186X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Targeting","raw_type":"journal-article"},{"id":"pmid:39565138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39565138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drug targeting","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W74386812","https://openalex.org/W191793640","https://openalex.org/W1498636565","https://openalex.org/W1499143025","https://openalex.org/W1520728510","https://openalex.org/W1964146045","https://openalex.org/W1966928113","https://openalex.org/W1970472489","https://openalex.org/W1972171824","https://openalex.org/W2003547116","https://openalex.org/W2017612549","https://openalex.org/W2019613864","https://openalex.org/W2020827950","https://openalex.org/W2025958954","https://openalex.org/W2041400548","https://openalex.org/W2043503204","https://openalex.org/W2046600920","https://openalex.org/W2053054955","https://openalex.org/W2067845216","https://openalex.org/W2068686903","https://openalex.org/W2068942685","https://openalex.org/W2080470349","https://openalex.org/W2083300838","https://openalex.org/W2086531857","https://openalex.org/W2088849426","https://openalex.org/W2092744113","https://openalex.org/W2093363014","https://openalex.org/W2095798342","https://openalex.org/W2096318291","https://openalex.org/W2105731956","https://openalex.org/W2114125742","https://openalex.org/W2116743333","https://openalex.org/W2120064316","https://openalex.org/W2121269493","https://openalex.org/W2121278724","https://openalex.org/W2126493585","https://openalex.org/W2133771754","https://openalex.org/W2147294760","https://openalex.org/W2151689386","https://openalex.org/W2153112493","https://openalex.org/W2165085297","https://openalex.org/W2167253239","https://openalex.org/W2189420219","https://openalex.org/W2239349310","https://openalex.org/W2287994218","https://openalex.org/W2319104174","https://openalex.org/W2766868128","https://openalex.org/W2811133902","https://openalex.org/W2950395934","https://openalex.org/W2964813970","https://openalex.org/W2970441691","https://openalex.org/W2995641421","https://openalex.org/W3007168360","https://openalex.org/W3016717170","https://openalex.org/W3036363721","https://openalex.org/W3048467449","https://openalex.org/W3128956245","https://openalex.org/W3206760826","https://openalex.org/W4205560699","https://openalex.org/W4221015967","https://openalex.org/W4238538758","https://openalex.org/W4289711908","https://openalex.org/W4306960859","https://openalex.org/W4309724059","https://openalex.org/W4311220986","https://openalex.org/W4366684918","https://openalex.org/W4379534604","https://openalex.org/W4380421856","https://openalex.org/W4383744929","https://openalex.org/W4387728279","https://openalex.org/W4389509440","https://openalex.org/W4392361412","https://openalex.org/W4400608016","https://openalex.org/W4403838306"],"related_works":["https://openalex.org/W1990693543","https://openalex.org/W4256415000","https://openalex.org/W2072703289","https://openalex.org/W2359312460","https://openalex.org/W1997441748","https://openalex.org/W2968509334","https://openalex.org/W2067845216","https://openalex.org/W2153112493","https://openalex.org/W3175694367","https://openalex.org/W2041609920"],"abstract_inverted_index":{"Diabetic":[0],"peripheral":[1],"neuropathy":[2],"(DPN)":[3],"is":[4],"a":[5,48,200],"debilitating":[6],"complication":[7],"of":[8,14,35,38,186,194],"diabetes":[9],"mellitus,":[10],"affecting":[11],"nearly":[12],"50%":[13],"diabetic":[15,73],"patients":[16],"and":[17,23,26,85,100,133,147,154,161,173],"leading":[18],"to":[19,44,67,107],"chronic":[20],"pain,":[21],"numbness,":[22],"progressive":[24],"sensory":[25],"motor":[27,93],"function":[28],"loss.":[29],"This":[30],"study":[31],"investigates":[32],"the":[33,183,192,207],"potential":[34,193],"siRNA-mediated":[36],"silencing":[37,121],"poly":[39],"(ADP-ribose)":[40],"polymerase":[41],"1":[42],"(PARP1)":[43],"alleviate":[45],"DPN":[46,126],"in":[47,61,72,125,140],"rat":[49],"model.":[50],"PARP1":[51,120,187,198],"overactivation,":[52],"driven":[53],"by":[54],"hyperglycemia-induced":[55],"oxidative":[56,141],"stress,":[57],"exacerbates":[58],"neuronal":[59],"damage":[60],"DPN.":[62],"Using":[63],"chitosan":[64],"nanoparticles":[65],"(ChNPs)":[66],"deliver":[68],"PARP1-targeting":[69],"siRNA":[70,118],"intrathecally":[71],"rats":[74,127],"induced":[75],"with":[76,117,212],"streptozotocin":[77],"(STZ)":[78],"55":[79],"mg/kg":[80],"intraperitoneally,":[81],"we":[82],"conducted":[83],"behavioral":[84],"physiological":[86],"assessments,":[87],"including":[88,151,164],"Sciatic":[89],"Functional":[90],"Index":[91],"(SFI),":[92],"nerve":[94],"conduction":[95],"velocity":[96],"(MNCV),":[97],"grip":[98],"strength,":[99],"pain":[101],"sensitivity":[102],"tests,":[103],"alongside":[104],"qRT-PCR":[105],"analyses,":[106],"evaluate":[108],"therapeutic":[109,202],"outcomes.":[110],"Our":[111],"findings":[112],"indicate":[113],"statistically":[114],"significant":[115,177],"improvements,":[116],"ChNPs-mediated":[119],"alleviating":[122],"neuropathic":[123],"symptoms":[124],"(p":[128,156,179],"<":[129,157,180],"0.001":[130],"for":[131,204,209],"SFI":[132],"MNCV":[134],"improvements).":[135],"Biochemical":[136],"analyses":[137],"revealed":[138],"reductions":[139,178],"stress":[142],"markers,":[143,163],"such":[144],"as":[145,199],"MDA,":[146],"increased":[148],"antioxidant":[149],"levels,":[150],"GSH,":[152],"CAT,":[153],"SOD":[155],"0.001).":[158],"Pro-inflammatory":[159],"cytokines":[160],"apoptotic":[162],"NF-\u03baB,":[165],"IL6,":[166],"IL1\u03b2,":[167],"TNFa,":[168],"TGF-\u03b2,":[169],"CAS3,":[170],"CAS9,":[171],"BAK,":[172],"BAX,":[174],"also":[175],"showed":[176],"0.01),":[181],"confirming":[182],"neuroprotective":[184],"effects":[185],"inhibition.":[188],"These":[189],"results":[190],"highlight":[191],"siRNA-based":[195],"therapies":[196],"targeting":[197],"promising":[201],"approach":[203],"DPN,":[205],"paving":[206],"way":[208],"future":[210],"research":[211],"clinical":[213],"applications.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-11-21T00:00:00"}
