{"id":"https://openalex.org/W4404526484","doi":"https://doi.org/10.1073/pnas.2407648121","title":"CD4 + T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model","display_name":"CD4 + T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model","publication_year":2024,"publication_date":"2024-11-19","ids":{"openalex":"https://openalex.org/W4404526484","doi":"https://doi.org/10.1073/pnas.2407648121","pmid":"https://pubmed.ncbi.nlm.nih.gov/39560641","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11621630"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2407648121","doi":"https://doi.org/10.1073/pnas.2407648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2407648121","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2407648121","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2407648121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071598727","display_name":"Alexia Vereertbrugghen","orcid":"https://orcid.org/0000-0002-4210-2916","observed_orcids":["https://orcid.org/0000-0002-4210-2916"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alexia Vereertbrugghen","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-4210-2916","affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018015970","display_name":"Manuela Pizzano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Manuela Pizzano","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092672516","display_name":"Agostina Cernutto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Agostina Cernutto","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019516093","display_name":"Florencia Sabbione","orcid":"https://orcid.org/0000-0002-9220-2210","observed_orcids":["https://orcid.org/0000-0002-9220-2210"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Florencia Sabbione","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081845870","display_name":"Irene Ang\u00e9lica Keitelman","orcid":"https://orcid.org/0000-0002-7093-5712","observed_orcids":["https://orcid.org/0000-0002-7093-5712"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Irene A. Keitelman","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069768056","display_name":"Douglas Vera Aguilar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Douglas Vera Aguilar","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065498492","display_name":"Ariel Podhorzer","orcid":"https://orcid.org/0000-0002-4861-5333","observed_orcids":["https://orcid.org/0000-0002-4861-5333"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ariel Podhorzer","raw_affiliation_strings":["Flow Cytometry Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-4861-5333","affiliations":[{"raw_affiliation_string":"Flow Cytometry Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090839911","display_name":"Federico Fuentes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Federico Fuentes","raw_affiliation_strings":["Confocal Microscopy Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Confocal Microscopy Unit, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037302529","display_name":"Celia Corral-V\u00e1zquez","orcid":"https://orcid.org/0000-0002-0621-4590","observed_orcids":["https://orcid.org/0000-0002-0621-4590"]},"institutions":[{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celia Corral-V\u00e1zquez","raw_affiliation_strings":["Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain","institution_ids":["https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mauricio Guzm\u00e1n","orcid":"https://orcid.org/0000-0002-4447-2064","observed_orcids":["https://orcid.org/0000-0002-4447-2064"]},"institutions":[{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mauricio Guzm\u00e1n","raw_affiliation_strings":["Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4447-2064","affiliations":[{"raw_affiliation_string":"Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona 08003, Spain","institution_ids":["https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077715792","display_name":"Mirta Giordano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mirta N. Giordano","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004158319","display_name":"Analia Silvina Trevani","orcid":"https://orcid.org/0000-0001-7254-1082","observed_orcids":["https://orcid.org/0000-0001-7254-1082"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Anal\u00eda Trevani","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119261","display_name":"Cintia Sade de Paiva","orcid":"https://orcid.org/0000-0002-9057-5494","observed_orcids":["https://orcid.org/0000-0002-9057-5494"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cintia S. de Paiva","raw_affiliation_strings":["Ocular Surface Center, Baylor College of Medicine, Houston, TX 77030"],"raw_orcid":"https://orcid.org/0000-0002-9057-5494","affiliations":[{"raw_affiliation_string":"Ocular Surface Center, Baylor College of Medicine, Houston, TX 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015742189","display_name":"Jerem\u00edas G. Galletti","orcid":"https://orcid.org/0000-0002-5118-2540","observed_orcids":["https://orcid.org/0000-0002-5118-2540"]},"institutions":[{"id":"https://openalex.org/I14429277","display_name":"Academia Nacional de Medicina","ror":"https://ror.org/05k2xsz75","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I14429277"]},{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Jerem\u00edas G. Galletti","raw_affiliation_strings":["Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-5118-2540","affiliations":[{"raw_affiliation_string":"Innate Immunity Laboratory, Institute of Experimental Medicine (National Scientific and Technical Research Council/National Academy of Medicine of Buenos Aires), Buenos Aires 1425, Argentina","institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015742189"],"corresponding_institution_ids":["https://openalex.org/I14429277","https://openalex.org/I151201029"],"apc_list":null,"apc_paid":null,"fwci":9.8898,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.98917513,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"121","issue":"48","first_page":"e2407648121","last_page":"e2407648121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/corneal-nerve-damage","display_name":"corneal nerve damage","score":0.9309999942779541},{"id":"https://openalex.org/keywords/corneal-epitheliopathy","display_name":"corneal epitheliopathy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/t-cell-deficient-mice","display_name":"T cell-deficient mice","score":0.746999979019165},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tear-cytokines","display_name":"tear cytokines","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5864742994308472},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5474373698234558},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5281645655632019},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5114230513572693},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.504946768283844},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47762078046798706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4747653007507324},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4650973081588745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4480658769607544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35207366943359375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3163890838623047},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2746773362159729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1073/pnas.2407648121","doi":"https://doi.org/10.1073/pnas.2407648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2407648121","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2407648121","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2024.03.22.586336","doi":"https://doi.org/10.1101/2024.03.22.586336","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.03.22.586336","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/26/2024.03.22.586336.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11621630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11621630","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11621630/pdf/pnas.202407648.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:10896212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11621630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:39560641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39560641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/265359","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/265359","pdf_url":"https://ri.conicet.gov.ar/bitstream/11336/265359/2/CONICET_Digital_Nro.52fc9b0e-70e0-4ed7-b185-35baac8727f0_B.pdf","source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-6405","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/baylor_docs/5514","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"},{"id":"pmh:oai:repositori.upf.edu:10230/72576","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10230/72576","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2407648121","doi":"https://doi.org/10.1073/pnas.2407648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2407648121","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2407648121","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1036594449","display_name":null,"funder_award_id":"PICT 2018-02911","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G254578218","display_name":"Neuroimmune pathophysiological mechanisms of ocular surface disease","funder_award_id":"221859/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3244354378","display_name":null,"funder_award_id":"PICT 2018","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G3398938731","display_name":null,"funder_award_id":"PICT 2021","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G6209573815","display_name":null,"funder_award_id":"PICT 2018-02911 PICT 2020-00138 PICT 2021-00109","funder_id":"https://openalex.org/F4320331467","funder_display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n"},{"id":"https://openalex.org/G6979882363","display_name":null,"funder_award_id":"PICT 2021-00109","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G7285168502","display_name":null,"funder_award_id":"PICT 2020-00138","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G7763907200","display_name":null,"funder_award_id":"PICT 2020-00138","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G9000856439","display_name":"Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland","funder_award_id":"R01EY035333","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000893429","display_name":"Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuit","funder_award_id":"U01EY034692","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G985406477","display_name":null,"funder_award_id":"PICT 2021-00109","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320331467","display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337954","display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4404526484.pdf","grobid_xml":"https://content.openalex.org/works/W4404526484.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W22349765","https://openalex.org/W1643889104","https://openalex.org/W1857016869","https://openalex.org/W1949785099","https://openalex.org/W1971369241","https://openalex.org/W1976536758","https://openalex.org/W1980597708","https://openalex.org/W1996421122","https://openalex.org/W1998321598","https://openalex.org/W1999554027","https://openalex.org/W2002180108","https://openalex.org/W2002339775","https://openalex.org/W2011596309","https://openalex.org/W2011777137","https://openalex.org/W2015620265","https://openalex.org/W2023306844","https://openalex.org/W2035315924","https://openalex.org/W2043416239","https://openalex.org/W2049207532","https://openalex.org/W2070876163","https://openalex.org/W2073200435","https://openalex.org/W2074357311","https://openalex.org/W2078911996","https://openalex.org/W2084459830","https://openalex.org/W2095815384","https://openalex.org/W2135358480","https://openalex.org/W2142263640","https://openalex.org/W2158415916","https://openalex.org/W2162974040","https://openalex.org/W2236276785","https://openalex.org/W2267931422","https://openalex.org/W2480442846","https://openalex.org/W2521601013","https://openalex.org/W2523416377","https://openalex.org/W2527778140","https://openalex.org/W2552623886","https://openalex.org/W2568094208","https://openalex.org/W2572041771","https://openalex.org/W2623253463","https://openalex.org/W2737439597","https://openalex.org/W2737787547","https://openalex.org/W2739359388","https://openalex.org/W2739410682","https://openalex.org/W2747349398","https://openalex.org/W2763155303","https://openalex.org/W2767773772","https://openalex.org/W2788240672","https://openalex.org/W2802344932","https://openalex.org/W2807439390","https://openalex.org/W2807660320","https://openalex.org/W2808825101","https://openalex.org/W2902811447","https://openalex.org/W2904239415","https://openalex.org/W2923358857","https://openalex.org/W2948322960","https://openalex.org/W2967215964","https://openalex.org/W3007413478","https://openalex.org/W3012365685","https://openalex.org/W3016189064","https://openalex.org/W3038108456","https://openalex.org/W3044238104","https://openalex.org/W3049624931","https://openalex.org/W3091932707","https://openalex.org/W3092845246","https://openalex.org/W3106908696","https://openalex.org/W3113082075","https://openalex.org/W3120634592","https://openalex.org/W3142352408","https://openalex.org/W3160625587","https://openalex.org/W3212477752","https://openalex.org/W4206109700","https://openalex.org/W4213010848","https://openalex.org/W4220722818","https://openalex.org/W4220899795","https://openalex.org/W4221108644","https://openalex.org/W4281386202","https://openalex.org/W4282016052","https://openalex.org/W4283735389","https://openalex.org/W4284693043","https://openalex.org/W4285606169","https://openalex.org/W4293714554","https://openalex.org/W4321243254","https://openalex.org/W4361196926","https://openalex.org/W4362692290","https://openalex.org/W4362692460","https://openalex.org/W4377292313","https://openalex.org/W4378782445","https://openalex.org/W4382776813","https://openalex.org/W4385191040","https://openalex.org/W4388078005","https://openalex.org/W4388979659","https://openalex.org/W4391542153"],"related_works":["https://openalex.org/W6977105582","https://openalex.org/W2930070637","https://openalex.org/W4386923487","https://openalex.org/W4415725904","https://openalex.org/W2758855963","https://openalex.org/W1857016869","https://openalex.org/W4318020592","https://openalex.org/W3044238104","https://openalex.org/W3022983968","https://openalex.org/W1976536758"],"abstract_inverted_index":{"Abstract":[0],"Dry":[1,208],"eye":[2,209],"disease":[3,253,294],"(DED)":[4],"is":[5,172,210,224],"characterized":[6],"by":[7,23,174,226,309],"a":[8,38,65,211],"dysfunctional":[9],"tear":[10,112,269],"film":[11],"in":[12,40,69,106,179,200,215,297],"which":[13,216],"the":[14,43,62,93,107,160,187,219,242,274,314],"cornea":[15],"epithelium":[16,221],"and":[17,26,31,52,72,97,110,153,222,251,268],"its":[18],"abundant":[19],"nerves":[20,223],"are":[21,290],"affected":[22],"ocular":[24,213,238,315],"desiccation":[25],"inflammation.":[27],"Although":[28],"adaptive":[29,79,188],"immunity":[30],"specifically":[32],"CD4":[33,118,145,175,231,278,301],"+":[34,119,146,176,232,279,302],"T":[35,73,120,127,138,147,177,196,233,260,263,280,303,322],"cells":[36,48,121,148,178,247,261,304],"play":[37],"role":[39,276],"DED":[41,67,86,124,156,162],"pathogenesis,":[42],"exact":[44,243],"contribution":[45,244],"of":[46,64,85,95,117,186,245,259,277],"these":[47,246],"to":[49,88,126,218,248,295,299],"corneal":[50,99,131,150,170,181,220,249,286,306],"epithelial":[51,250,293],"neural":[53,252],"damage":[54,133,183,217,288],"remains":[55,254],"undetermined.":[56,255],"To":[57],"address":[58],"this,":[59],"we":[60,272],"explored":[61],"progression":[63],"surgical":[66],"model":[68],"wild-type":[70],"(WT)":[71],"cell-deficient":[74,128,139,264],"mice.":[75],"We":[76],"observed":[77],"that":[78,168,283],"immune-deficient":[80],"mice":[81,90,125,129,140],"developed":[82,149],"all":[83],"aspects":[84],"comparably":[87],"WT":[89,123,161],"except":[91],"for":[92,195,202,292,321,327],"absence":[94],"functional":[96],"morphological":[98],"nerve":[100,102,132,151,287],"changes,":[101],"damage-associated":[103],"transcriptomic":[104],"signature":[105],"trigeminal":[108,266],"ganglia,":[109],"sustained":[111],"cytokine":[113,270],"levels.":[114],"Adoptive":[115],"transfer":[116,258],"from":[122],"reproduced":[130],"but":[134,241,289],"not":[135],"epitheliopathy.":[136],"Conversely,":[137],"reconstituted":[141],"solely":[142],"with":[143],"naive":[144],"impairment":[152,240],"epitheliopathy":[154],"upon":[155],"induction,":[157],"thus":[158],"replicating":[159],"phenotype.":[163],"Collectively,":[164],"our":[165],"data":[166],"show":[167],"while":[169],"neuropathy":[171,307],"driven":[173],"DED,":[180],"epithelia":[182],"develops":[184],"independently":[185],"immune":[189,235],"response.":[190],"These":[191,317],"findings":[192,318],"have":[193,319],"implications":[194,320],"cell-targeting":[197,323],"therapies":[198,324],"currently":[199,325],"use":[201],"DED.":[203],"Graphical":[204],"abstract":[205],"Significance":[206],"Statement":[207],"frequent":[212],"disorder":[214],"triggered":[225],"inadequate":[227],"lubrication.":[228],"The":[229],"local":[230],"cell-predominant":[234],"response":[236,298],"aggravates":[237],"surface":[239],"Using":[256],"adoptive":[257],"into":[262],"mice,":[265],"transcriptomics,":[267],"analysis,":[271],"delineate":[273],"pathogenic":[275],"cells,":[281],"revealing":[282],"they":[284],"drive":[285],"dispensable":[291],"develop":[296],"desiccation.":[300],"promote":[305],"possibly":[308],"releasing":[310],"proinflammatory":[311],"cytokines":[312],"onto":[313],"surface.":[316],"used":[326],"dry":[328],"eye.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-11-20T00:00:00"}
